US6861422B2
(en)
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
DE102004029784A1
(de)
*
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
DE102004033670A1
(de)
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
US20060035903A1
(en)
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
US7759485B2
(en)
*
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
US7728134B2
(en)
*
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
US20060074088A1
(en)
*
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
EP1632493A1
(de)
|
2004-08-25 |
2006-03-08 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
EP1630163A1
(de)
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
WO2006021548A1
(de)
*
|
2004-08-27 |
2006-03-02 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
|
US7713973B2
(en)
|
2004-10-15 |
2010-05-11 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
DE102004058337A1
(de)
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
US8119655B2
(en)
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
DK1948180T3
(da)
|
2005-11-11 |
2013-05-27 |
Boehringer Ingelheim Int |
Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer
|
US7439358B2
(en)
*
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
AU2012256410B2
(en)
*
|
2006-02-08 |
2016-04-28 |
Boehringer Ingelheim International Gmbh |
Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation
|
WO2007095188A2
(en)
|
2006-02-14 |
2007-08-23 |
Vertex Pharmaceuticals Incorporated |
Dihydrodiazepines useful as inhibitors of protein kinases
|
US20090312336A1
(en)
*
|
2006-05-19 |
2009-12-17 |
Astrazeneca Ab |
Dihydropteridine compounds as anti proliferative agents
|
TW200808325A
(en)
|
2006-07-06 |
2008-02-16 |
Astrazeneca Ab |
Novel compounds
|
MX2009003793A
(es)
|
2006-10-09 |
2009-12-14 |
Takeda Pharmaceutical |
Inhibidores de cinasa.
|
US8916552B2
(en)
|
2006-10-12 |
2014-12-23 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
EP2078016B1
(en)
|
2006-10-19 |
2012-02-01 |
Signal Pharmaceuticals LLC |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
|
CA2672612A1
(en)
*
|
2006-12-14 |
2008-06-26 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as protein kinase inhibitors
|
TW200838517A
(en)
|
2006-12-21 |
2008-10-01 |
Vertex Pharma |
Compounds useful as protein kinases inhibitors
|
EP1953163A1
(en)
*
|
2007-02-01 |
2008-08-06 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Pteridinone derivatives as PI3-kinases inhibitors
|
CA2695406A1
(en)
*
|
2007-08-03 |
2009-02-12 |
Boehringer Ingelheim International Gmbh |
Crystalline form of a dihydropteridione derivative
|
PL2610256T3
(pl)
|
2007-09-28 |
2016-11-30 |
|
Pochodne pirymidyny jako inhibitory kinaz białkowych
|
US20090291938A1
(en)
*
|
2007-11-19 |
2009-11-26 |
Takeda Pharmaceutical Company Limited |
Polo-like kinase inhibitors
|
WO2009071480A2
(en)
*
|
2007-12-04 |
2009-06-11 |
Nerviano Medical Sciences S.R.L. |
Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
|
EP2100894A1
(en)
|
2008-03-12 |
2009-09-16 |
4Sc Ag |
Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
|
EP2112152A1
(en)
|
2008-04-22 |
2009-10-28 |
GPC Biotech AG |
Dihydropteridinones as Plk Inhibitors
|
GB0807452D0
(en)
*
|
2008-04-24 |
2008-05-28 |
Chroma Therapeutics Ltd |
PLK inhibitors
|
AU2009271663B2
(en)
*
|
2008-06-23 |
2014-04-17 |
Vertex Pharmaceuticals Incorporated |
Protein kinase inhibitors
|
US9492417B2
(en)
|
2008-08-21 |
2016-11-15 |
The Johns Hopkins University |
Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
|
US20100075973A1
(en)
*
|
2008-08-28 |
2010-03-25 |
Takeda Pharmaceutical Company Limited |
Polo-like kinase inhibitors
|
US8110578B2
(en)
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
CN102272134B
(zh)
|
2008-12-09 |
2013-10-16 |
吉里德科学公司 |
Toll样受体调节剂
|
EP3828185A3
(en)
*
|
2009-01-06 |
2021-09-01 |
Dana Farber Cancer Institute, Inc. |
Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
|
JP5721706B2
(ja)
|
2009-06-17 |
2015-05-20 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルス複製の阻害剤
|
AU2010292102B2
(en)
|
2009-09-14 |
2015-04-09 |
Gilead Sciences, Inc. |
Modulators of Toll-like receptors
|
CN102020643A
(zh)
*
|
2009-09-22 |
2011-04-20 |
上海恒瑞医药有限公司 |
二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
|
NZ599356A
(en)
|
2009-09-25 |
2013-08-30 |
Vertex Pharma |
Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
|
WO2011038185A2
(en)
|
2009-09-25 |
2011-03-31 |
Vertex Pharmaceuticals Incorporated |
Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
|
NZ599549A
(en)
|
2009-10-26 |
2013-11-29 |
Signal Pharm Llc |
Methods of synthesis and purification of heteroaryl compounds
|
EP2325185A1
(en)
|
2009-10-28 |
2011-05-25 |
GPC Biotech AG |
Plk inhibitor
|
EP2516441B1
(en)
*
|
2009-12-23 |
2015-01-21 |
Elan Pharmaceuticals Inc. |
Pteridinones as inhibitors of polo-like kinase
|
JP5841548B2
(ja)
*
|
2010-02-17 |
2016-01-13 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ジヒドロプテリジノン、その製造方法及び使用
|
CN102190669A
(zh)
*
|
2010-03-19 |
2011-09-21 |
江苏恒瑞医药股份有限公司 |
二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
|
US8609672B2
(en)
|
2010-08-27 |
2013-12-17 |
University Of The Pacific |
Piperazinylpyrimidine analogues as protein kinase inhibitors
|
US8546566B2
(en)
*
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
CN103492381A
(zh)
|
2010-12-16 |
2014-01-01 |
沃泰克斯药物股份有限公司 |
流感病毒复制的抑制剂
|
US20130131069A1
(en)
|
2011-05-13 |
2013-05-23 |
Boehringer Ingelheim International Gmbh |
Method for treatment of solid malignancies including advanced or metastatic solid malignancies
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
WO2013059396A2
(en)
|
2011-10-19 |
2013-04-25 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with tor kinase inhibitors
|
WO2013071217A1
(en)
*
|
2011-11-10 |
2013-05-16 |
OSI Pharmaceuticals, LLC |
Dihydropteridinones
|
CN104093398B
(zh)
|
2011-12-02 |
2017-03-15 |
西格诺药品有限公司 |
7‑(6‑(2‑羟基丙烷‑2‑基)吡啶‑3‑基)‑1‑((反式)‑4‑甲氧基环己基)‑3,4‑二氢吡嗪并[2,3‑b]吡嗪‑2(1h)‑酮、其固体形式的药物组合物及其使用方法
|
JP5807750B2
(ja)
*
|
2012-01-05 |
2015-11-10 |
トヨタ自動車株式会社 |
締付装置及び締付方法
|
US9006226B2
(en)
|
2012-02-23 |
2015-04-14 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones I
|
US8865716B2
(en)
|
2012-02-23 |
2014-10-21 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones II
|
BR112014020786A2
(pt)
|
2012-02-24 |
2020-10-27 |
Signal Pharmaceuticals, Llc |
método para tratamento de câncer de pulmão, método para alcançar um critério de avaliação de resposta em tumores sólidos, método para aumento da sobrevivência
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
US20140154304A1
(en)
|
2012-11-30 |
2014-06-05 |
Boehringer Ingelheim International Gmbh |
Combination therapy with volasertib
|
EP2945636B1
(en)
|
2013-01-16 |
2017-06-28 |
Signal Pharmaceuticals, LLC |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
|
EP2958919B1
(en)
*
|
2013-02-21 |
2019-05-22 |
Boehringer Ingelheim International GmbH |
Dihydropteridinones i
|
JP6072308B2
(ja)
*
|
2013-02-21 |
2017-02-01 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
ジヒドロプテリジノンii
|
WO2014172426A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
EA029072B1
(ru)
|
2013-04-17 |
2018-02-28 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Комбинированная терапия, включающая соединение дигидропиразинопиразина и антагонист рецептора андрогена для лечения рака простаты
|
WO2014172432A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
|
TW201527300A
(zh)
|
2013-04-17 |
2015-07-16 |
Signal Pharm Llc |
關於1-乙基-7-(2-甲基-6-(1H-1,2,4-三唑-3-基)吡啶-3-基)-3,4-二氫吡并[2,3-b]吡-2(1H)-酮之醫藥調配物、方法、固態型式及使用方法
|
MX2015014589A
(es)
|
2013-04-17 |
2016-04-25 |
Signal Pharm Llc |
Tratamiento de cancer con dihidropirazino-pirazinas.
|
BR112015026021A2
(pt)
|
2013-04-17 |
2017-07-25 |
Signal Pharm Llc |
terapia de combinação compreendendo um inibidor de tor quinase e n-(3-(5-flúor-2-(4-(2-met-oxietoxi)fenilamino)pirimidin-4-ilamino)fenil)acrilamida para o tratamento de câncer
|
JP6382949B2
(ja)
|
2013-04-17 |
2018-08-29 |
シグナル ファーマシューティカルズ,エルエルシー |
癌を治療するためのtorキナーゼ阻害剤及び5−置換キナゾリノン化合物を含む組合せ療法
|
NZ629486A
(en)
|
2013-05-29 |
2017-11-24 |
Signal Pharm Llc |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
WO2015011236A1
(en)
|
2013-07-26 |
2015-01-29 |
Boehringer Ingelheim International Gmbh |
Treatment of myelodysplastic syndrome
|
CN105849100B
(zh)
|
2013-11-13 |
2019-07-16 |
沃泰克斯药物股份有限公司 |
流感病毒复制抑制剂
|
SI3421468T1
(sl)
|
2013-11-13 |
2021-03-31 |
Vertex Pharmaceuticals Incorporated |
Postopki za pripravo inhibitorjev replikacije virusov influence
|
EP3099171A4
(en)
*
|
2014-01-31 |
2017-08-09 |
Dana-Farber Cancer Institute, Inc. |
Dihydropteridinone derivatives and uses thereof
|
JP2017504651A
(ja)
|
2014-01-31 |
2017-02-09 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
ジアゼパン誘導体の使用
|
US9512129B2
(en)
|
2014-04-16 |
2016-12-06 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
US9737535B2
(en)
|
2014-04-16 |
2017-08-22 |
Signal Pharmaceuticals, Llc |
Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
|
US9718824B2
(en)
|
2014-04-16 |
2017-08-01 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
|
CN104003989B
(zh)
*
|
2014-05-26 |
2015-11-11 |
苏州明锐医药科技有限公司 |
伏拉塞替及其中间体的制备方法
|
AU2015287773B2
(en)
|
2014-07-11 |
2018-03-29 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors for the treatment of HIV
|
WO2016010886A1
(en)
|
2014-07-14 |
2016-01-21 |
Signal Pharmaceuticals, Llc |
Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
RU2017104897A
(ru)
|
2014-08-08 |
2018-09-10 |
Дана-Фарбер Кэнсер Инститьют, Инк. |
Производные диазепана и их применения
|
JP2017525759A
(ja)
*
|
2014-08-08 |
2017-09-07 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
ジヒドロプテリジノン誘導体およびその使用
|
CN106715431A
(zh)
|
2014-09-16 |
2017-05-24 |
吉利德科学公司 |
Toll样受体调节剂的固体形式
|
CN115043840A
(zh)
|
2014-09-16 |
2022-09-13 |
吉利德科学公司 |
制备toll样受体调节剂的方法
|
US9867831B2
(en)
|
2014-10-01 |
2018-01-16 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
|
JP6857617B2
(ja)
|
2015-05-13 |
2021-04-14 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
AU2016276963C1
(en)
|
2015-06-12 |
2021-08-05 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
US11306105B2
(en)
|
2015-09-11 |
2022-04-19 |
Dana-Farber Cancer Institute, Inc. |
Cyano thienotriazolodiazepines and uses thereof
|
SG10202007099TA
(en)
|
2015-09-11 |
2020-08-28 |
Dana Farber Cancer Inst Inc |
Acetamide thienotriazoldiazepines and uses thereof
|
US10751306B2
(en)
|
2015-11-06 |
2020-08-25 |
The Johns Hopkins University |
Methods of treating liver fibrosis by administering 3-bromopyruvate
|
CN114957291A
(zh)
|
2015-11-25 |
2022-08-30 |
达纳-法伯癌症研究所股份有限公司 |
二价溴结构域抑制剂及其用途
|
CN105801582A
(zh)
*
|
2016-04-12 |
2016-07-27 |
合肥工业大学 |
一类新型二氢蝶啶酮类衍生物及其制备方法和在医药上的用途
|
DE102017005089A1
(de)
|
2016-05-30 |
2017-11-30 |
Bayer Pharma Aktiengesellschaft |
Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one
|
DE102017005091A1
(de)
|
2016-05-30 |
2017-11-30 |
Bayer Pharma Aktiengesellschaft |
Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one
|
CN106977584B
(zh)
*
|
2017-04-19 |
2019-12-06 |
吉林大学 |
靶向泛素化降解plk1和brd4蛋白的化合物及其应用
|
IL271491B2
(en)
|
2017-06-22 |
2023-09-01 |
Celgene Corp |
Treatment of carcinoma of the liver characterized by hepatitis b virus infection
|
WO2019126696A1
(en)
|
2017-12-22 |
2019-06-27 |
Dana-Farber Cancer Institute, Inc. |
Nek inhibitors and methods of use
|
WO2019145410A1
(en)
|
2018-01-25 |
2019-08-01 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia
|
CA3121202A1
(en)
|
2018-11-30 |
2020-06-04 |
Nuvation Bio Inc. |
Pyrrole and pyrazole compounds and methods of use thereof
|
CN110343109B
(zh)
*
|
2019-08-21 |
2021-11-23 |
郑州大学 |
一种二氢蝶啶酮-磺酰胺类衍生物及其药学上可接受的盐、其制备方法及其应用
|
TW202404636A
(zh)
|
2022-04-08 |
2024-02-01 |
美商英伊布里克斯公司 |
Dr5促效劑及plk1抑制劑或cdk抑制劑之組合療法
|