HK1052684B - Inhibitors of alpha 4 mediated cell adhesion - Google Patents

Inhibitors of alpha 4 mediated cell adhesion Download PDF

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Publication number
HK1052684B
HK1052684B HK03105043.3A HK03105043A HK1052684B HK 1052684 B HK1052684 B HK 1052684B HK 03105043 A HK03105043 A HK 03105043A HK 1052684 B HK1052684 B HK 1052684B
Authority
HK
Hong Kong
Prior art keywords
compound
group
dimethoxy
phenylalanine
formula
Prior art date
Application number
HK03105043.3A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1052684A1 (en
Inventor
Kawaguchi Takayuki
Nomura Sumihiro
Tsukimoto Mikiko
Kume Toshiyuki
Sircar Ila
Original Assignee
Tanabe Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of HK1052684A1 publication Critical patent/HK1052684A1/en
Publication of HK1052684B publication Critical patent/HK1052684B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
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  • Neurosurgery (AREA)
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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
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HK03105043.3A 2000-08-31 2001-08-27 Inhibitors of alpha 4 mediated cell adhesion HK1052684B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22912800P 2000-08-31 2000-08-31
US60/229,128 2000-08-31
PCT/US2001/026594 WO2002018320A2 (en) 2000-08-31 2001-08-27 INHIBITORS OF α4 MEDIATED CELL ADHESION

Publications (2)

Publication Number Publication Date
HK1052684A1 HK1052684A1 (en) 2003-09-26
HK1052684B true HK1052684B (en) 2005-07-22

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HK03105043.3A HK1052684B (en) 2000-08-31 2001-08-27 Inhibitors of alpha 4 mediated cell adhesion

Country Status (28)

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US (6) US7026501B2 (enExample)
EP (1) EP1315694B1 (enExample)
JP (1) JP3899022B2 (enExample)
KR (1) KR100528049B1 (enExample)
CN (1) CN1229334C (enExample)
AR (1) AR034556A1 (enExample)
AT (1) ATE292615T1 (enExample)
AU (2) AU8677801A (enExample)
BR (1) BR0113629A (enExample)
CA (1) CA2418054C (enExample)
CZ (1) CZ303460B6 (enExample)
DE (1) DE60109943T2 (enExample)
DK (1) DK1315694T3 (enExample)
ES (1) ES2240509T3 (enExample)
HK (1) HK1052684B (enExample)
HU (1) HUP0302693A3 (enExample)
IL (2) IL154305A0 (enExample)
MX (1) MXPA03001837A (enExample)
MY (1) MY129000A (enExample)
NO (1) NO327861B1 (enExample)
NZ (1) NZ524043A (enExample)
PL (1) PL206656B1 (enExample)
PT (1) PT1315694E (enExample)
RU (1) RU2250895C2 (enExample)
SI (1) SI1315694T1 (enExample)
TW (1) TWI224587B (enExample)
WO (1) WO2002018320A2 (enExample)
ZA (1) ZA200301039B (enExample)

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JP3899022B2 (ja) 2007-03-28
CN1449377A (zh) 2003-10-15
EP1315694B1 (en) 2005-04-06
CA2418054A1 (en) 2002-03-07
CZ2003487A3 (cs) 2003-06-18
US20100113820A1 (en) 2010-05-06
NO20030885D0 (no) 2003-02-25
AU2001286778B2 (en) 2005-02-10
IL154305A0 (en) 2003-09-17
PL206656B1 (pl) 2010-09-30
IL154305A (en) 2010-11-30
CN1229334C (zh) 2005-11-30
US20050282900A1 (en) 2005-12-22
HK1052684A1 (en) 2003-09-26
NZ524043A (en) 2004-08-27
TWI224587B (en) 2004-12-01
JP2004507519A (ja) 2004-03-11
CZ303460B6 (cs) 2012-09-26
KR100528049B1 (ko) 2005-11-15
ES2240509T3 (es) 2005-10-16
US20090111879A1 (en) 2009-04-30
WO2002018320A2 (en) 2002-03-07
DE60109943D1 (de) 2005-05-12
AR034556A1 (es) 2004-03-03
MY129000A (en) 2007-03-30
AU8677801A (en) 2002-03-13
US20110077299A1 (en) 2011-03-31
PT1315694E (pt) 2005-07-29
WO2002018320A3 (en) 2002-06-06
US20030176498A1 (en) 2003-09-18
SI1315694T1 (en) 2005-10-31
ATE292615T1 (de) 2005-04-15
US7671090B2 (en) 2010-03-02
US7872151B2 (en) 2011-01-18
US7456217B2 (en) 2008-11-25
HUP0302693A3 (en) 2005-05-30
EP1315694A2 (en) 2003-06-04
PL365668A1 (en) 2005-01-10
DE60109943T2 (de) 2006-02-09
MXPA03001837A (es) 2003-10-15
NO20030885L (no) 2003-02-25
US20130289109A1 (en) 2013-10-31
US8501809B2 (en) 2013-08-06
NO327861B1 (no) 2009-10-05
CA2418054C (en) 2008-08-05
US7026501B2 (en) 2006-04-11
ZA200301039B (en) 2004-02-09
BR0113629A (pt) 2003-07-22
RU2250895C2 (ru) 2005-04-27
DK1315694T3 (da) 2005-08-08
HUP0302693A2 (hu) 2003-12-29
KR20030059099A (ko) 2003-07-07

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