AU2001286778B2 - Inhibitors of alpha4 mediated cell adhesion - Google Patents

Inhibitors of alpha4 mediated cell adhesion Download PDF

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Publication number
AU2001286778B2
AU2001286778B2 AU2001286778A AU2001286778A AU2001286778B2 AU 2001286778 B2 AU2001286778 B2 AU 2001286778B2 AU 2001286778 A AU2001286778 A AU 2001286778A AU 2001286778 A AU2001286778 A AU 2001286778A AU 2001286778 B2 AU2001286778 B2 AU 2001286778B2
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Australia
Prior art keywords
compound
group
dimethoxy
phenylalanine
formula
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Ceased
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AU2001286778A
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AU2001286778A1 (en
Inventor
Takayuki Kawaguchi
Toshiyuki Kume
Sumihiro Nomura
Ila Sircar
Mikiko Tsukimoto
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Mitsubishi Tanabe Pharma Corp
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Tanabe Seiyaku Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • General Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
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AU2001286778A 2000-08-31 2001-08-27 Inhibitors of alpha4 mediated cell adhesion Ceased AU2001286778B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22912800P 2000-08-31 2000-08-31
US60/229,128 2000-08-31
PCT/US2001/026594 WO2002018320A2 (en) 2000-08-31 2001-08-27 INHIBITORS OF α4 MEDIATED CELL ADHESION

Publications (2)

Publication Number Publication Date
AU2001286778A1 AU2001286778A1 (en) 2002-06-06
AU2001286778B2 true AU2001286778B2 (en) 2005-02-10

Family

ID=22859926

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001286778A Ceased AU2001286778B2 (en) 2000-08-31 2001-08-27 Inhibitors of alpha4 mediated cell adhesion
AU8677801A Pending AU8677801A (en) 2000-08-31 2001-08-27 Inhibitors of alpha4 mediated cell adhesion

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU8677801A Pending AU8677801A (en) 2000-08-31 2001-08-27 Inhibitors of alpha4 mediated cell adhesion

Country Status (28)

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US (6) US7026501B2 (enExample)
EP (1) EP1315694B1 (enExample)
JP (1) JP3899022B2 (enExample)
KR (1) KR100528049B1 (enExample)
CN (1) CN1229334C (enExample)
AR (1) AR034556A1 (enExample)
AT (1) ATE292615T1 (enExample)
AU (2) AU2001286778B2 (enExample)
BR (1) BR0113629A (enExample)
CA (1) CA2418054C (enExample)
CZ (1) CZ303460B6 (enExample)
DE (1) DE60109943T2 (enExample)
DK (1) DK1315694T3 (enExample)
ES (1) ES2240509T3 (enExample)
HK (1) HK1052684B (enExample)
HU (1) HUP0302693A3 (enExample)
IL (2) IL154305A0 (enExample)
MX (1) MXPA03001837A (enExample)
MY (1) MY129000A (enExample)
NO (1) NO327861B1 (enExample)
NZ (1) NZ524043A (enExample)
PL (1) PL206656B1 (enExample)
PT (1) PT1315694E (enExample)
RU (1) RU2250895C2 (enExample)
SI (1) SI1315694T1 (enExample)
TW (1) TWI224587B (enExample)
WO (1) WO2002018320A2 (enExample)
ZA (1) ZA200301039B (enExample)

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KR101274879B1 (ko) 2004-12-20 2013-06-14 에자이 알앤드디 매니지먼트 가부시키가이샤 1-시클로프로필메틸-4-[2-(3,3,5,5-테트라메틸시클로헥실)페닐]피페라진의 염 및 결정
BRPI0611243A2 (pt) 2005-06-09 2010-08-24 Ucb Pharma Sa composto, enanciâmeros, diastereoisâmeros do mesmo ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, e, uso de um composto
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ES2848152T3 (es) * 2007-08-24 2021-08-05 Tersera Therapeutics Llc Métodos de preparación de compuestos a base de 4-fenil-6-(2,2,2-trifluoro-1-feniletoxi)pirimidina
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EP3873897B1 (en) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases
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Citations (1)

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WO1999036393A1 (en) * 1998-01-20 1999-07-22 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4 MEDIATED CELL ADHESION

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