HK1048310B - Novel sidechain-bearing taxanes and intermediates thereof - Google Patents

Novel sidechain-bearing taxanes and intermediates thereof Download PDF

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Publication number
HK1048310B
HK1048310B HK03100278.0A HK03100278A HK1048310B HK 1048310 B HK1048310 B HK 1048310B HK 03100278 A HK03100278 A HK 03100278A HK 1048310 B HK1048310 B HK 1048310B
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HK
Hong Kong
Prior art keywords
compound
salt
formula
optionally substituted
aryl
Prior art date
Application number
HK03100278.0A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1048310A1 (en
Inventor
A. Poss Michael
J. Kucera David
L. Moniot Jerome
K. Thottathil John
D. Trifunovich Ivan
Chen Shu-Hui
Wei Jianmei
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HK1048310A1 publication Critical patent/HK1048310A1/en
Publication of HK1048310B publication Critical patent/HK1048310B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK03100278.0A 1992-12-23 2003-01-10 Novel sidechain-bearing taxanes and intermediates thereof HK1048310B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99544392A 1992-12-23 1992-12-23
US995443 1992-12-23

Publications (2)

Publication Number Publication Date
HK1048310A1 HK1048310A1 (en) 2003-03-28
HK1048310B true HK1048310B (en) 2006-02-17

Family

ID=25541806

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100278.0A HK1048310B (en) 1992-12-23 2003-01-10 Novel sidechain-bearing taxanes and intermediates thereof

Country Status (22)

Country Link
EP (2) EP0626953A4 (https=)
JP (2) JP3492690B2 (https=)
KR (3) KR100327625B1 (https=)
CN (4) CN1590386A (https=)
AT (1) ATE309229T1 (https=)
AU (3) AU679206B2 (https=)
CA (1) CA2119261C (https=)
CZ (1) CZ292993B6 (https=)
DE (1) DE69333905T2 (https=)
DK (1) DK1251127T3 (https=)
ES (1) ES2252362T3 (https=)
FI (2) FI115056B (https=)
HK (1) HK1048310B (https=)
HU (3) HU0203995D0 (https=)
IL (13) IL121540A (https=)
NO (7) NO304521B1 (https=)
NZ (1) NZ261070A (https=)
PL (1) PL186176B1 (https=)
RU (1) RU2125042C1 (https=)
TW (1) TW247908B (https=)
WO (1) WO1994014787A1 (https=)
ZA (1) ZA939672B (https=)

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US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
ATE309235T1 (de) * 1995-09-12 2005-11-15 Zeneus Pharma Ltd Hydrolyse-einleitende hydrophobe taxane derivate
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5773629A (en) * 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
HUP0101457A3 (en) 1997-12-31 2003-01-28 Bristol Myers Squibb Co Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
US5969165A (en) * 1999-01-07 1999-10-19 508037 (Nb) Inc. Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
EP1391459A1 (en) * 1999-08-11 2004-02-25 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates
KR100634249B1 (ko) * 1999-08-11 2006-10-17 브리스톨-마이어스스퀴브컴파니 파클리탁셀 ｃ-4 메틸 카르보네이트 동족체의 제조 방법
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
AU2001290636A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
CZ2003837A3 (cs) * 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
US7605278B2 (en) 2002-08-04 2009-10-20 Natural Pharmaceuticals, Inc. Methods and compositions for converting taxane amides to paclitaxel or other taxanes
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
EP1737444A4 (en) 2004-03-05 2008-05-21 Univ Florida State Res Found C7-LACTYLOXA-SUBSTITUTED TAXANE
RS52438B (sr) * 2005-03-31 2013-02-28 Accord Healthcare Inc. Priprema taksana od 9-dihidro-13-acetilbakcatina iii
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
CN101835769A (zh) * 2007-08-22 2010-09-15 6570763加拿大有限公司 将9-二氢-13-乙酰基浆果赤霉素ⅲ转化为多烯紫杉醇或太平洋紫杉醇的方法
CN108686203A (zh) 2012-04-04 2018-10-23 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
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WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
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JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
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MX9308012A (es) * 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.

Also Published As

Publication number Publication date
DE69333905D1 (de) 2005-12-15
NO973254D0 (no) 1997-07-14
NO973255L (no) 1994-08-16
NO309426B1 (no) 2001-01-29
IL108161A0 (en) 1994-04-12
RU2125042C1 (ru) 1999-01-20
NO973253L (no) 1994-08-16
NO973256D0 (no) 1997-07-14
IL122209A0 (en) 1998-04-05
CA2119261C (en) 2006-01-31
CN1109026C (zh) 2003-05-21
AU3246397A (en) 1997-10-30
IL145280A (en) 2007-05-15
IL108161A (en) 1999-03-12
JP2003113166A (ja) 2003-04-18
KR950700269A (ko) 1995-01-16
HU225294B1 (en) 2006-09-28
IL145280A0 (en) 2002-06-30
CZ292993B6 (cs) 2004-01-14
AU715633B2 (en) 2000-02-10
NO943021L (no) 1994-08-16
EP1251127B1 (en) 2005-11-09
CN1094725A (zh) 1994-11-09
AU3246497A (en) 1997-10-09
KR100327625B1 (ko) 2002-11-07
CN1089761C (zh) 2002-08-28
NO973255D0 (no) 1997-07-14
NO304521B1 (no) 1999-01-04
KR100356448B1 (ko) 2002-10-19
EP0626953A4 (en) 1995-05-03
NO311217B1 (no) 2001-10-29
JPH07504444A (ja) 1995-05-18
IL121539A0 (en) 1998-02-08
FI943852A0 (fi) 1994-08-22
EP0626953A1 (en) 1994-12-07
FI943852L (fi) 1994-08-22
HUT75195A (en) 1997-04-28
IL121539A (en) 2004-07-25
FI20031464A7 (fi) 2003-10-07
IL122208A0 (en) 1998-04-05
KR100378612B1 (ko) 2003-04-03
NO973254L (no) 1994-08-16
ES2252362T3 (es) 2006-05-16
EP1251127A1 (en) 2002-10-23
CN1235973A (zh) 1999-11-24
NO943021D0 (no) 1994-08-16
CZ146594A3 (en) 1995-06-14
HU9401449D0 (en) 1994-09-28
WO1994014787A1 (en) 1994-07-07
CN1230542A (zh) 1999-10-06
DK1251127T3 (da) 2006-03-06
IL121542A (en) 2001-03-19
NO20033865L (no) 1994-08-16
IL121542A0 (en) 1998-02-08
PL186176B1 (pl) 2003-11-28
NO982744D0 (no) 1998-06-15
IL121540A (en) 2005-05-17
DE69333905T2 (de) 2006-08-03
HU222175B1 (hu) 2003-04-28
NO316071B1 (no) 2003-12-08
TW247908B (https=) 1995-05-21
JP3492690B2 (ja) 2004-02-03
CA2119261A1 (en) 1994-06-24
NO313802B1 (no) 2002-12-02
ZA939672B (en) 1995-06-23
FI115056B (fi) 2005-02-28
CN1590386A (zh) 2005-03-09
NZ261070A (en) 1997-10-24
ATE309229T1 (de) 2005-11-15
IL121540A0 (en) 1998-02-08
HU0203995D0 (en) 2003-04-28
NO20033865D0 (no) 2003-09-01
IL121541A0 (en) 1998-02-08
IL121541A (en) 2000-11-21
NO982744L (no) 1994-08-16
NO973253D0 (no) 1997-07-14
AU679206B2 (en) 1997-06-26
CN1150178C (zh) 2004-05-19
AU6014694A (en) 1994-07-19
NO314355B1 (no) 2003-03-10
HK1048310A1 (en) 2003-03-28
NO973256L (no) 1994-08-16
AU697836B2 (en) 1998-10-15

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091215