HK1030953A1 - Hydrophobically-modified hedgehog protein compositions and methods. - Google Patents

Hydrophobically-modified hedgehog protein compositions and methods.

Info

Publication number
HK1030953A1
HK1030953A1 HK01101512A HK01101512A HK1030953A1 HK 1030953 A1 HK1030953 A1 HK 1030953A1 HK 01101512 A HK01101512 A HK 01101512A HK 01101512 A HK01101512 A HK 01101512A HK 1030953 A1 HK1030953 A1 HK 1030953A1
Authority
HK
Hong Kong
Prior art keywords
protein
hydrophobically
methods
hydrophobic moiety
protein compositions
Prior art date
Application number
HK01101512A
Other languages
English (en)
Inventor
R Blake Pepinsky
Chenhui Zeng
Darren P Baker
Dingyi Wen
Kevin P Williams
Ellen A Garber
Kathryn L Strauch
Frederick R Taylor
Paul H Weinrub
Russell C Petter
Alphonse Galdes
Jeffrey Porter
Original Assignee
Biogen Inc
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc, Curis Inc filed Critical Biogen Inc
Publication of HK1030953A1 publication Critical patent/HK1030953A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Graft Or Block Polymers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK01101512A 1997-12-03 2001-03-01 Hydrophobically-modified hedgehog protein compositions and methods. HK1030953A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6742397P 1997-12-03 1997-12-03
US7893598P 1998-03-20 1998-03-20
US8968598P 1998-06-17 1998-06-17
US9980098P 1998-09-10 1998-09-10
PCT/US1998/025676 WO1999028343A2 (fr) 1997-12-03 1998-12-03 Compositions a base de proteines modifiees sur le plan hydrophobe et procedes d'elaboration

Publications (1)

Publication Number Publication Date
HK1030953A1 true HK1030953A1 (en) 2001-05-25

Family

ID=27490628

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01101512A HK1030953A1 (en) 1997-12-03 2001-03-01 Hydrophobically-modified hedgehog protein compositions and methods.

Country Status (26)

Country Link
US (1) US6444793B1 (fr)
EP (1) EP1036092B1 (fr)
JP (1) JP4289788B2 (fr)
KR (1) KR20010032753A (fr)
CN (1) CN1294595A (fr)
AT (1) ATE295372T1 (fr)
AU (1) AU757497B2 (fr)
BR (1) BR9815142A (fr)
CA (1) CA2309806A1 (fr)
CZ (1) CZ20002008A3 (fr)
DE (1) DE69830192T2 (fr)
DK (1) DK1036092T3 (fr)
EA (1) EA003739B1 (fr)
EE (1) EE200000308A (fr)
ES (1) ES2243018T3 (fr)
HK (1) HK1030953A1 (fr)
HU (1) HUP0100535A3 (fr)
IL (2) IL136137A0 (fr)
IS (1) IS2163B (fr)
MX (1) MXPA00005494A (fr)
NO (1) NO20002789L (fr)
NZ (1) NZ504752A (fr)
PL (1) PL197833B1 (fr)
PT (1) PT1036092E (fr)
TR (1) TR200001612T2 (fr)
WO (1) WO1999028343A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
EA003739B1 (ru) 1997-12-03 2003-08-28 Байоджен, Инк. Гидрофобно-модифицированные белки, способы их получения и их применение
US6897297B1 (en) 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
DK0953576T3 (da) * 1998-04-30 2006-03-20 Curis Inc Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
CA2348773C (fr) * 1998-11-02 2010-04-13 Biogen, Inc. Antagonistes fonctionnels de l'activite hedgehog
IL143403A0 (en) * 1998-12-03 2002-04-21 Biogen Inc Methods and compositions for treating disorders involving excitotoxicity
EP1025861A1 (fr) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Compositions pharmaceutiques des Proteines Hedgehog rendues hydrophobes, et leur utilisation
EP1183271A1 (fr) * 1999-06-01 2002-03-06 Biogen, Inc. Conjugues polymeres de proteines hedgehog et leurs utilisations
WO2001034654A1 (fr) * 1999-11-05 2001-05-17 Biogen, Inc. Proteines de fusion herisson et leurs utilisations
AU2005203058C1 (en) * 1999-11-05 2009-07-02 Curis, Inc. Hedgehog fusion proteins and uses
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
WO2003089454A2 (fr) * 2002-04-19 2003-10-30 California Institute Of Technology Bibliotheque de molecules d'acides nucleiques et de peptides dont les peptides contiennent des residus d'acides amines non naturels, et methodes de production associee
CA2573720A1 (fr) 2004-07-14 2006-02-23 University Of Utah Research Foundation Compositions et utilisations liees a des netrines
EP1862180A4 (fr) * 2005-03-25 2010-09-15 Takeda Pharmaceutical Agent prophylactique et therapeutique contre le cancer
EP1951869A1 (fr) * 2005-11-11 2008-08-06 Proteogen Bio S.R.L. Procédé de conversion de protéines actives solubles dans l'eau en protéines actives hydrophobes, utilisation de celui-ci pour la préparation de couches monomoléculaires de protéines actives orientées et appareils comprenant celles-ci
US8273747B2 (en) 2006-11-02 2012-09-25 Curis, Inc. Small organic molecule regulators of cell proliferation
KR100876657B1 (ko) * 2007-10-15 2009-01-07 한국기계연구원 표면개질된 마이크로비드와 마이크로비드 어레이칩의제조방법과 마이크로비드 어레이칩을 이용한 질병특이항원의 확인방법
JP5576801B2 (ja) * 2008-02-21 2014-08-20 ダーマケア・ニューロサイエンス・インスティテュート Ｍｎｔｆペプチドの美容および皮膚科用製剤
WO2009108868A2 (fr) * 2008-02-27 2009-09-03 Radiomedix Inc. Dérivés hedgehog radiomarqués utilisés en imagerie et en thérapie
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
CN103665095A (zh) * 2012-09-11 2014-03-26 中国人民解放军军事医学科学院卫生学环境医学研究所 一种疏水性多肽修饰抗体的合成方法
CN106924752B (zh) * 2015-12-30 2021-11-09 北京大学 制备蛋白质-聚氨基酸偶联物的方法
CN108147990B (zh) * 2016-12-02 2023-01-24 上海中医药大学 一种膜锚定元件及其应用
AR113792A1 (es) 2017-10-25 2020-06-10 Janssen Pharmaceuticals Inc Composiciones de péptidos tau fosforilados y sus usos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374548A (en) * 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5399347A (en) 1987-06-24 1995-03-21 Autoimmune, Inc. Method of treating rheumatoid arthritis with type II collagen
US5409611A (en) * 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
US5130297A (en) 1988-06-23 1992-07-14 Anergen, Inc. Conjugates useful in ameliorating autoimmunity MHC-II-peptide
US5824315A (en) * 1993-10-25 1998-10-20 Anergen, Inc. Binding affinity of antigenic peptides for MHC molecules
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5869602A (en) * 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
JP2002503088A (ja) * 1996-10-07 2002-01-29 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 新規ヘッジホッグ由来ポリペプチド
EA003739B1 (ru) 1997-12-03 2003-08-28 Байоджен, Инк. Гидрофобно-модифицированные белки, способы их получения и их применение

Also Published As

Publication number Publication date
EA003739B1 (ru) 2003-08-28
EE200000308A (et) 2001-10-15
KR20010032753A (ko) 2001-04-25
HUP0100535A2 (hu) 2001-06-28
IS2163B (is) 2006-11-15
PL341430A1 (en) 2001-04-09
IL136137A0 (en) 2001-05-20
CA2309806A1 (fr) 1999-06-10
HUP0100535A3 (en) 2003-09-29
NZ504752A (en) 2002-10-25
WO1999028343A3 (fr) 1999-08-12
DK1036092T3 (da) 2005-08-15
TR200001612T2 (tr) 2001-01-22
EA200000605A1 (ru) 2000-12-25
DE69830192T2 (de) 2006-01-12
PL197833B1 (pl) 2008-04-30
IL136137A (en) 2009-09-22
EP1036092A2 (fr) 2000-09-20
DE69830192D1 (de) 2005-06-16
CZ20002008A3 (cs) 2001-11-14
NO20002789L (no) 2000-08-02
WO1999028343A9 (fr) 1999-10-14
PT1036092E (pt) 2005-09-30
JP2001525336A (ja) 2001-12-11
BR9815142A (pt) 2000-10-10
MXPA00005494A (es) 2003-05-19
JP4289788B2 (ja) 2009-07-01
ATE295372T1 (de) 2005-05-15
EP1036092B1 (fr) 2005-05-11
CN1294595A (zh) 2001-05-09
NO20002789D0 (no) 2000-05-31
ES2243018T3 (es) 2005-11-16
US6444793B1 (en) 2002-09-03
AU1996699A (en) 1999-06-16
AU757497B2 (en) 2003-02-20
WO1999028343A2 (fr) 1999-06-10
IS5499A (is) 2000-05-15

Similar Documents

Publication Publication Date Title
IL136137A0 (en) Hydrophobically-modified protein compositions and methods
De Caro et al. Porcine pancreatic lipase. Completion of the primary structure
IL115199A (en) Composition comprising a polynucleic acid molecule in a liposome and method using said composition
WO1996034107A3 (fr) Proteines antivirales, sequences d'adn codant pour ces proteines et utilisations
AU4981101A (en) Subtilisin variants
CA2301046A1 (fr) Proteines marquees 13c, 15n, 2h destinees a des determinations de structure par rmn et procede de preparation associe
BR9811675A (pt) Genes isolados para proteìna da membrana de célula dentrìtica
WO1999006557A3 (fr) Proteines de membrane cellulaire mammalienne et reactifs associes
WO2000000600A3 (fr) Vecteurs lentiviraux
WO1999028876A3 (fr) Compositions proteiniques modifiees de maniere hydrophobe et leurs procedes de fabrication
Ogishima et al. Partial amino acid sequences of two mitochondrial and two microsomal cytochrome P-450's from adrenal cortex
WO1999022005A3 (fr) D-glucosaminyle 3-o-sulfotransferases de sulfate d'heparane et utilisations associees
WO1998031810A3 (fr) Chemokines de mammiferes, recepteurs, reactifs, utilisations
CY1105486T1 (el) Τροποποιημενες υδροφοβικα συνθεσεις πρωτεϊνων ακανθοχοιρου και μεθοδοι παρασκευης αυτων
AU3063699A (en) Isolated mammalian membrane protein genes and related reagents
WO2001096593A3 (fr) Nouvelles proteines motrices et procedes d'utilisation de ces proteines
WO2002012541A3 (fr) Nouvelles proteines moteurs et leurs procedes d'utilisation
AU2001235894A1 (en) Novel mammalian secreted group iii phospholipase a2
WO2000034335A3 (fr) Genes mammiferes et reactifs connexes
BR0213772A (pt) Molécula de ácido nucleico isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina
WO2001025430A3 (fr) Nouvelles proteines membranaires humaines
WO2000032746A3 (fr) Acides nucleiques et polypeptides netrinoïdes et ependyminoïdes et leurs utilisations
Weinstein et al. Selective reductive cleavage of a threonine peptide bond in polymyxin antibiotics
WO2001098314A3 (fr) Proteines motrices et modalites d'utilisation
RU94046405A (ru) Птг-соединения и содержащий их фармацевтический состав, способ получения желаемых полипептидов, нуклеотидная последовательность, бактериальный вектор экспрессии, бактериальные хозяйские клетки и составной белок

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091203