HK1023504A1 - Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound - Google Patents

Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound

Info

Publication number
HK1023504A1
HK1023504A1 HK00102572A HK00102572A HK1023504A1 HK 1023504 A1 HK1023504 A1 HK 1023504A1 HK 00102572 A HK00102572 A HK 00102572A HK 00102572 A HK00102572 A HK 00102572A HK 1023504 A1 HK1023504 A1 HK 1023504A1
Authority
HK
Hong Kong
Prior art keywords
compound
activity
pharmaceutical composition
platelet aggregation
aggregation antagonist
Prior art date
Application number
HK00102572A
Other languages
English (en)
Inventor
Andre Uzan
Alain H Curaudeau
Robert J Leadley
Christopher T Dunwiddie
Mark H Perrone
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21861879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1023504(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of HK1023504A1 publication Critical patent/HK1023504A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK00102572A 1996-11-27 2000-04-28 Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound HK1023504A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3187896P 1996-11-27 1996-11-27
PCT/US1997/021440 WO1998023279A1 (en) 1996-11-27 1997-11-24 PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND

Publications (1)

Publication Number Publication Date
HK1023504A1 true HK1023504A1 (en) 2000-09-15

Family

ID=21861879

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00102572A HK1023504A1 (en) 1996-11-27 2000-04-28 Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound

Country Status (28)

Country Link
US (2) US6103705A (cs)
EP (1) EP0946185B2 (cs)
JP (1) JP4498471B2 (cs)
KR (1) KR100512671B1 (cs)
CN (1) CN1121224C (cs)
AP (1) AP1390A (cs)
AT (1) ATE283062T1 (cs)
AU (1) AU754936B2 (cs)
BG (1) BG64542B1 (cs)
BR (1) BR9713141A (cs)
CA (1) CA2272317C (cs)
CZ (1) CZ298552B6 (cs)
DE (1) DE69731763T3 (cs)
DK (1) DK0946185T4 (cs)
EA (1) EA002475B1 (cs)
ES (1) ES2230624T5 (cs)
HK (1) HK1023504A1 (cs)
HU (1) HUP9903496A3 (cs)
IL (1) IL129877A (cs)
NO (1) NO327740B1 (cs)
OA (1) OA11049A (cs)
PL (1) PL189116B1 (cs)
PT (1) PT946185E (cs)
SI (1) SI0946185T2 (cs)
SK (1) SK286024B6 (cs)
UA (1) UA63929C2 (cs)
WO (1) WO1998023279A1 (cs)
ZA (1) ZA9710691B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0946185B2 (en) * 1996-11-27 2010-05-05 Aventis Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND
FR2764511B1 (fr) 1997-06-13 2000-09-08 Sanofi Sa Compositions pour le traitement et la prevention de la thrombose arterielle et utilisation d'un inhibiteur du facteur xa seul et/ou en combinaison avec un antiagregant plaquettaire
US6136794A (en) * 1998-02-02 2000-10-24 Merck & Co., Inc. Platelet aggregation inhibition using low molecular weight heparin in combination with a GP IIb/IIIa antagonist
WO2000029019A1 (en) * 1998-11-18 2000-05-25 G.D. Searle & Co. Restoration of platelet aggregation by antibody administration after gpiib/iiia antagonist treatment
CA2377734A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
BR0113886A (pt) * 2000-09-08 2003-07-15 Hamilton Civic Hospitals Res Composição, composição farmacêutica, tratamento de combinação para prevenir ou inibir a geração ou atividade de trombina num paciente, método para inibir ou prevenir a geração ou atividade de trombina num paciente, uso de uma composição ou tratamento de combinação, uso de uma composição, uso e kit
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CN100439361C (zh) 2003-03-07 2008-12-03 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
MXPA05009501A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
EP1537871A1 (en) * 2003-12-04 2005-06-08 Aventis Pharma S.A. Enoxaparin for the treatment of cancer
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
KR100601429B1 (ko) * 2004-07-09 2006-07-14 주식회사 대우일렉트로닉스 기계식 전자렌지의 댐퍼 구동회로
EP2014296A1 (en) * 2007-07-10 2009-01-14 PAION Deutschland GmbH Novel strategies for increasing the reperfusion in obstructed blood vessel
AR067345A1 (es) * 2007-07-10 2009-10-07 Paion Deutschland Gmbh Uso de trombomodulina para la preparacion de un medicamento trombolitico
CN101783857B (zh) * 2009-05-12 2011-11-30 上海海事大学 一种基于fpga在高分辨率成像系统中的图像矩阵化预处理方法
IT1400232B1 (it) * 2010-05-07 2013-05-24 Advance Holdings Ltd Composizione farmaceutica topica comprendente eparina
WO2011149110A1 (en) 2010-05-28 2011-12-01 Daiichi Sankyo Company, Limited Novel composition for the prevention and/or treatment of thromboembolism
EP2508892A1 (de) * 2011-04-04 2012-10-10 Siemens Healthcare Diagnostics Products GmbH Kontrollen und Kit für Thrombozytenaktivitätsteste
RU2554803C1 (ru) * 2014-06-26 2015-06-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики развития послеоперационных венозных тромбоэмболических осложнений у пациентов с колоректальным раком

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
EP0066908B1 (en) * 1981-05-21 1985-08-28 Akzo N.V. New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
DK196986D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
US4833155A (en) * 1986-11-25 1989-05-23 Syntex (U.S.A.) Inc. 3-(ω-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof
EP0275748B1 (fr) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés peptidiques et leur application notamment en thérapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
KR940009084B1 (ko) * 1988-05-18 1994-09-29 체크 포인트 시스템스, 인코오퍼레이티드 자기 및 공명회로 검출용 안테나 시스템
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
WO1991004746A1 (en) * 1989-09-29 1991-04-18 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
IL99538A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
WO1992013117A1 (en) * 1991-01-24 1992-08-06 Aerojet-General Corporation Electrochemical desensitization process
DE69232615T2 (de) * 1991-05-02 2003-01-30 Yeda Res & Dev Zusammensetzungen zur verhütung und/oder behandlung von pathologischen prozessen
WO1993008845A1 (en) * 1991-11-08 1993-05-13 Massachusetts Institute Of Technology Localized oligonucleotide therapy
HUT72896A (en) * 1993-03-29 1996-06-28 Du Pont Merck Pharma Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia
ATE199727T1 (de) * 1993-10-15 2001-03-15 Rhone Poulenc Rorer Pharma Antithrombotisch wirkende azacycloalkyl-alkanoyl- peptide und-pseudopeptide
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
WO1997035592A1 (en) * 1996-03-28 1997-10-02 G.D. Searle & Co. Iib/iiia antagonists co-administered with aspirin and/or heparin
EP0946185B2 (en) * 1996-11-27 2010-05-05 Aventis Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACTIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND

Also Published As

Publication number Publication date
CN1121224C (zh) 2003-09-17
KR100512671B1 (ko) 2005-09-07
BG103372A (en) 2000-01-31
ATE283062T1 (de) 2004-12-15
SI0946185T2 (sl) 2010-08-31
CN1238693A (zh) 1999-12-15
NO992555D0 (no) 1999-05-27
DE69731763T3 (de) 2010-12-30
BR9713141A (pt) 2000-02-08
WO1998023279A1 (en) 1998-06-04
ES2230624T3 (es) 2005-05-01
PT946185E (pt) 2005-02-28
NO992555L (no) 1999-05-27
DK0946185T4 (da) 2010-08-30
EP0946185B1 (en) 2004-11-24
OA11049A (en) 2002-02-18
JP4498471B2 (ja) 2010-07-07
ES2230624T5 (es) 2010-10-25
EA199900499A1 (ru) 2000-04-24
DE69731763T2 (de) 2005-06-30
HUP9903496A2 (hu) 2000-10-28
UA63929C2 (uk) 2004-02-16
PL189116B1 (pl) 2005-06-30
DK0946185T3 (da) 2005-03-21
AP9901517A0 (en) 1999-06-30
CZ298552B6 (cs) 2007-10-31
AU5454698A (en) 1998-06-22
JP2001506603A (ja) 2001-05-22
SK67399A3 (en) 2000-07-11
IL129877A0 (en) 2000-02-29
ZA9710691B (en) 1998-06-12
EA002475B1 (ru) 2002-06-27
EP0946185A1 (en) 1999-10-06
EP0946185B2 (en) 2010-05-05
IL129877A (en) 2004-08-31
CZ174299A3 (cs) 1999-09-15
HUP9903496A3 (en) 2001-03-28
BG64542B1 (bg) 2005-07-29
DE69731763D1 (de) 2004-12-30
AP1390A (en) 2005-04-15
KR20000057265A (ko) 2000-09-15
CA2272317C (en) 2001-01-30
SK286024B6 (sk) 2008-01-07
SI0946185T1 (en) 2005-06-30
AU754936B2 (en) 2002-11-28
NO327740B1 (no) 2009-09-14
EP0946185A4 (en) 2001-06-27
US6103705A (en) 2000-08-15
US20020032214A1 (en) 2002-03-14

Similar Documents

Publication Publication Date Title
HK1023504A1 (en) Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound
IL116323A0 (en) Tachykinin antagonists their preparation and pharmaceutical compositions containing them
NZ268969A (en) Morphinan derivatives and pharmaceutical compositions
IL115039A (en) Spiroazabicyclic compounds, their preparation and pharmaceutical compositions containing them
HUP0002209A3 (en) 4-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives and pharmaceutical compositions containing them
IL119078A (en) Substituted benzylaminopiperidine compounds and pharmaceutical compositions comprising them
PL305701A1 (en) Pharmaceutical agent
HUP0001494A3 (en) 3-phenoxy-, 3-dibenzo[a,d]cycloheptenyloxy-, 3-dibenz[b,f][1,4]oxazepinyloxy-1-amino-2-propanol derivatives and pharmaceutical compositions containing them
IL111518A0 (en) Isoquinolines, their preparation and pharmaceutical compositions containing them
IL134536A0 (en) Compounds possessing neuronal activity and pharmaceutical compositions containing the same
HUT74746A (en) Pharmaceutical compositions containing p antagonist
IL111011A0 (en) Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them
IL125775A0 (en) Use of a zwitterion composition and a pharmaceutical composition containing the same
IL139775A0 (en) A substituted triazolo-pyridazine derivative and pharmaceutical compositions made therefrom
GB9410898D0 (en) Pharmaceutical compositions having analgesic activity
HUP9902166A3 (en) Substituted benzamide derivatives having anticonvulsant activity, preparation and use thereof, pharmaceutical compositions containing these compounds
IL116279A0 (en) Cephem compounds and pharmaceutical compositions containing the same
IL123040A0 (en) Manganese complexes pharmaceutical compositions containg them and their use
IL109527A0 (en) Substituted piperazines, their preparation and pharmaceutical compostions containing them
IL115982A0 (en) Cyclolignan derivatives and pharmaceutical compositions containing the same
IL115537A0 (en) Phosphonosulfonate salts pharmaceutical compositions containing the same and methods for the preparation thereof
HU9402625D0 (en) 12-hetero-substituted-6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts and pharmaceutical compositions containing them
IL120100A0 (en) Tetrahydroisoquinoline derivatives and pharmaceutical compositions containing them
IL113649A0 (en) 8-amino-pyrido [1,2,3-d, e] [1,3,4] benzoxadiazine derivatives their preparation and pharmaceutical compositions containing them
GB9415617D0 (en) Pharmaceutical compound

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20121124