HK1018053A1 - Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) - Google Patents

Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Info

Publication number
HK1018053A1
HK1018053A1 HK98113381A HK98113381A HK1018053A1 HK 1018053 A1 HK1018053 A1 HK 1018053A1 HK 98113381 A HK98113381 A HK 98113381A HK 98113381 A HK98113381 A HK 98113381A HK 1018053 A1 HK1018053 A1 HK 1018053A1
Authority
HK
Hong Kong
Prior art keywords
phenylamino
fluorophenyl
pyrrole
dihydroxy
delta
Prior art date
Application number
HK98113381A
Other languages
English (en)
Inventor
Ann T A Mckenzie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1018053(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HK1018053A1 publication Critical patent/HK1018053A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
HK98113381A 1995-07-17 1998-12-15 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) HK1018053A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17
PCT/US1996/011367 WO1997003958A1 (en) 1995-07-17 1996-07-08 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Publications (1)

Publication Number Publication Date
HK1018053A1 true HK1018053A1 (en) 1999-12-10

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98113381A HK1018053A1 (en) 1995-07-17 1998-12-15 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Country Status (33)

Country Link
US (1) US6121461A (hu)
JP (1) JP3296563B2 (hu)
KR (1) KR100431039B1 (hu)
CN (1) CN1081632C (hu)
AT (1) ATE207465T1 (hu)
AU (1) AU725368B2 (hu)
BG (1) BG63629B1 (hu)
BR (1) BR9610567A (hu)
CA (1) CA2220458C (hu)
CO (1) CO4700442A1 (hu)
CZ (1) CZ294109B6 (hu)
DK (1) DK0848704T3 (hu)
EA (1) EA000505B1 (hu)
EE (1) EE03607B1 (hu)
ES (1) ES2166456T3 (hu)
GE (1) GEP20002028B (hu)
HK (1) HK1018053A1 (hu)
HR (1) HRP960313B1 (hu)
HU (1) HU223598B1 (hu)
ID (1) ID16158A (hu)
IL (3) IL122162A (hu)
MX (1) MX9708857A (hu)
MY (1) MY118398A (hu)
NO (1) NO309899B1 (hu)
NZ (1) NZ312906A (hu)
PE (1) PE1798A1 (hu)
PL (1) PL192244B1 (hu)
RO (1) RO120068B1 (hu)
SK (1) SK284201B6 (hu)
TW (1) TW401399B (hu)
UA (1) UA44796C2 (hu)
WO (1) WO1997003958A1 (hu)
ZA (1) ZA966045B (hu)

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SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
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US20070265456A1 (en) * 2006-05-09 2007-11-15 Judith Aronhime Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
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CN103288702B (zh) * 2010-12-03 2015-09-16 上海科州药物研发有限公司 一种阿托伐他汀氨基酸盐的制备方法
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Also Published As

Publication number Publication date
JPH11509229A (ja) 1999-08-17
HUP9901687A3 (en) 2000-04-28
BR9610567A (pt) 1999-07-06
NO980208D0 (no) 1998-01-16
WO1997003958A1 (en) 1997-02-06
EA000505B1 (ru) 1999-10-28
UA44796C2 (uk) 2002-03-15
EE03607B1 (et) 2002-02-15
NZ312906A (en) 2000-12-22
AU6484196A (en) 1997-02-18
BG102186A (en) 1998-10-30
CA2220458C (en) 2002-09-24
MX9708857A (es) 1998-03-31
EE9800016A (et) 1998-08-17
TW401399B (en) 2000-08-11
HRP960313B1 (en) 2002-08-31
IL122162A (en) 1999-07-14
MY118398A (en) 2004-10-30
JP3296563B2 (ja) 2002-07-02
CZ294109B6 (cs) 2004-10-13
DK0848704T3 (da) 2002-02-04
EA199800129A1 (ru) 1998-08-27
HUP9901687A2 (hu) 1999-10-28
NO309899B1 (no) 2001-04-17
IL128863A0 (en) 2000-01-31
US6121461A (en) 2000-09-19
ZA966045B (en) 1997-02-04
IL177378A0 (en) 2006-12-10
CN1190957A (zh) 1998-08-19
HU223598B1 (hu) 2004-10-28
CA2220458A1 (en) 1997-02-06
CN1081632C (zh) 2002-03-27
PL324532A1 (en) 1998-06-08
ATE207465T1 (de) 2001-11-15
HRP960313A2 (en) 1998-04-30
CZ12398A3 (cs) 1998-06-17
IL122162A0 (en) 1998-04-05
PL192244B1 (pl) 2006-09-29
PE1798A1 (es) 1998-03-04
IL128863A (en) 2006-09-05
GEP20002028B (en) 2000-04-10
KR19990029044A (ko) 1999-04-15
ID16158A (id) 1997-09-11
BG63629B1 (bg) 2002-07-31
CO4700442A1 (es) 1998-12-29
NO980208L (no) 1998-01-16
KR100431039B1 (ko) 2004-08-25
ES2166456T3 (es) 2002-04-16
SK5998A3 (en) 1998-05-06
SK284201B6 (sk) 2004-10-05
RO120068B1 (ro) 2005-08-30
AU725368B2 (en) 2000-10-12

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