HK1014007A1 - Selective acylation of epsilon-amino groups in sinulin - Google Patents

Selective acylation of epsilon-amino groups in sinulin

Info

Publication number
HK1014007A1
HK1014007A1 HK98115124A HK98115124A HK1014007A1 HK 1014007 A1 HK1014007 A1 HK 1014007A1 HK 98115124 A HK98115124 A HK 98115124A HK 98115124 A HK98115124 A HK 98115124A HK 1014007 A1 HK1014007 A1 HK 1014007A1
Authority
HK
Hong Kong
Prior art keywords
sinulin
epsilon
amino groups
selective acylation
acylation
Prior art date
Application number
HK98115124A
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Victor John Chen
Aidas Bladas Kriauciunas
Brian Allen Moser
Jose Michael Hanquier
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1014007A1 publication Critical patent/HK1014007A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK98115124A 1994-11-17 1998-12-23 Selective acylation of epsilon-amino groups in sinulin HK1014007A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
HK1014007A1 true HK1014007A1 (en) 1999-09-17

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98115124A HK1014007A1 (en) 1994-11-17 1998-12-23 Selective acylation of epsilon-amino groups in sinulin

Country Status (28)

Country Link
US (2) US5646242A (de)
EP (2) EP0712862B1 (de)
JP (1) JP4312828B2 (de)
CN (1) CN1171742A (de)
AR (1) AR003915A1 (de)
AT (1) ATE328902T1 (de)
AU (2) AU691066B2 (de)
BR (1) BR9509652A (de)
CA (1) CA2205061A1 (de)
CO (1) CO4520285A1 (de)
CZ (1) CZ287731B6 (de)
DE (1) DE69535031T2 (de)
DK (1) DK0712862T3 (de)
ES (1) ES2264124T3 (de)
HK (1) HK1014007A1 (de)
HU (2) HU217585B (de)
IL (1) IL115972A (de)
IN (1) IN179820B (de)
NO (1) NO972185D0 (de)
NZ (1) NZ297256A (de)
PL (1) PL320556A1 (de)
PT (1) PT712862E (de)
RU (1) RU2155773C2 (de)
SI (1) SI0712862T1 (de)
TR (1) TR199501421A2 (de)
WO (1) WO1996015803A1 (de)
YU (1) YU71495A (de)
ZA (1) ZA959680B (de)

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US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
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US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
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CN101389650B (zh) * 2005-12-28 2012-10-10 诺沃-诺迪斯克有限公司 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
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US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
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CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
US10724025B2 (en) 2016-05-05 2020-07-28 Codexis, Inc. Penicillin-G acylases
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Also Published As

Publication number Publication date
ES2264124T3 (es) 2006-12-16
AU7885498A (en) 1998-11-05
SI0712862T1 (sl) 2006-10-31
IL115972A (en) 2000-09-28
EP1227107A1 (de) 2002-07-31
NO972185L (no) 1997-05-13
EP0712862B1 (de) 2006-06-07
EP0712862A2 (de) 1996-05-22
USRE37971E1 (en) 2003-01-28
NZ297256A (en) 2000-01-28
AU4237296A (en) 1996-06-17
IL115972A0 (en) 1996-01-31
AU691066B2 (en) 1998-05-07
NO972185D0 (no) 1997-05-13
BR9509652A (pt) 1997-09-16
CZ145697A3 (en) 1997-12-17
US5646242A (en) 1997-07-08
YU71495A (sh) 1998-09-18
AU720820B2 (en) 2000-06-15
ZA959680B (en) 1997-05-14
HU217585B (hu) 2000-02-28
EP0712862A3 (de) 1998-03-04
PT712862E (pt) 2006-08-31
CN1171742A (zh) 1998-01-28
MX9703506A (es) 1997-07-31
DE69535031D1 (de) 2006-07-20
RU2155773C2 (ru) 2000-09-10
ATE328902T1 (de) 2006-06-15
CZ287731B6 (en) 2001-01-17
TR199501421A2 (tr) 1996-06-21
DE69535031T2 (de) 2006-12-28
DK0712862T3 (da) 2006-09-25
WO1996015803A1 (en) 1996-05-30
IN179820B (de) 1997-12-13
JPH10509176A (ja) 1998-09-08
CO4520285A1 (es) 1997-10-15
JP4312828B2 (ja) 2009-08-12
PL320556A1 (en) 1997-10-13
HUT77737A (hu) 1998-07-28
CA2205061A1 (en) 1996-05-30
AR003915A1 (es) 1998-09-30
HU9903007D0 (en) 1999-11-29

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Effective date: 20151113