GT200600226A - Sintesis de (r)-n-metilnaltrexona - Google Patents

Sintesis de (r)-n-metilnaltrexona

Info

Publication number
GT200600226A
GT200600226A GT200600226A GT200600226A GT200600226A GT 200600226 A GT200600226 A GT 200600226A GT 200600226 A GT200600226 A GT 200600226A GT 200600226 A GT200600226 A GT 200600226A GT 200600226 A GT200600226 A GT 200600226A
Authority
GT
Guatemala
Prior art keywords
synthesis
methylntrexone
methyltrexone
mntx
naltrexone
Prior art date
Application number
GT200600226A
Other languages
English (en)
Inventor
Harold D Doshan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36997886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200600226(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200600226A publication Critical patent/GT200600226A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111—Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON LA SÍNTESIS ESTEREOSELECTIVA DE (R)-N-METILNALTREXONA (R-MNTX) QUE ES UN DERIVADO CUATERNARIO DE LA NALTREXONA POR LO QUE ES DE UTILIDAD EN PATOLOGÍAS DEL SISTEMA GASTROINTESTINAL.
GT200600226A 2005-05-25 2006-05-25 Sintesis de (r)-n-metilnaltrexona GT200600226A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68461605P 2005-05-25 2005-05-25

Publications (1)

Publication Number Publication Date
GT200600226A true GT200600226A (es) 2007-01-12

Family

ID=36997886

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600226A GT200600226A (es) 2005-05-25 2006-05-25 Sintesis de (r)-n-metilnaltrexona

Country Status (20)

Country Link
US (6) US7674904B2 (es)
EP (3) EP3219717A1 (es)
JP (4) JP5213704B2 (es)
CN (2) CN102721756A (es)
AR (1) AR057035A1 (es)
AU (1) AU2006249911C1 (es)
BR (1) BRPI0611162A2 (es)
CA (1) CA2609662C (es)
DK (1) DK1913001T3 (es)
ES (1) ES2429160T3 (es)
GT (1) GT200600226A (es)
HK (1) HK1244267A1 (es)
HN (1) HN2006019068A (es)
MX (1) MX2007014880A (es)
MY (1) MY151036A (es)
PL (1) PL1913001T3 (es)
PT (1) PT1913001E (es)
SI (1) SI1913001T1 (es)
TW (1) TWI383984B (es)
WO (1) WO2006127899A2 (es)

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US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AU2006220682B2 (en) 2005-03-07 2012-05-31 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
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AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
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TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200815451A (en) * 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
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JP2010510329A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体
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AU2014201056B2 (en) * 2007-03-29 2016-06-09 Progenics Pharmaceuticals, Inc. Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof
CA2682550C (en) * 2007-03-29 2016-05-17 Wyeth Peripheral opioid receptor antagonists and uses thereof
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