ES2085865T3 - Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean. - Google Patents

Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.

Info

Publication number
ES2085865T3
ES2085865T3 ES89306693T ES89306693T ES2085865T3 ES 2085865 T3 ES2085865 T3 ES 2085865T3 ES 89306693 T ES89306693 T ES 89306693T ES 89306693 T ES89306693 T ES 89306693T ES 2085865 T3 ES2085865 T3 ES 2085865T3
Authority
ES
Spain
Prior art keywords
methods
pharmaceutical compositions
dermorphine
analogs
therapeutic treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89306693T
Other languages
English (en)
Inventor
Peter W Schiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2085865T3 publication Critical patent/ES2085865T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE PROPORCIONAN PEPTIDOS QUE SON ADECUADOS PARA EL TRATAMIENTO DEL DOLOR Y DESORDENES GASTROINTESTINALES, TALES COMO DIARREA, Y ESTAN REPRESENTADOS POR LA ESTRUCTURA: (FIG. A), DONDE LOS VALORES DE LOS SUSTITUYENTES Y N SE DESCRIBEN EN LA ESPECIFICACION. TAMBIEN SE DESCRIBEN METODOS PARA PREPARAR ESTOS PEPTIDOS POR SINTESIS EN FASE SOLIDA Y EN DISOLUCION. SE PROPORCIONAN COMPOSICIONES FARMACEUTICAS QUE UTILIZAN ESTOS PEPTIDOS EN CANTIDAD FARMACEUTICAMENTE EFECTIVA Y METODOS DE TRATAMIENTO QUE LAS UTILIZAN
ES89306693T 1988-06-30 1989-06-30 Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean. Expired - Lifetime ES2085865T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA570874 1988-06-30

Publications (1)

Publication Number Publication Date
ES2085865T3 true ES2085865T3 (es) 1996-06-16

Family

ID=4138301

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89306693T Expired - Lifetime ES2085865T3 (es) 1988-06-30 1989-06-30 Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.

Country Status (8)

Country Link
US (1) US5312899A (es)
EP (1) EP0350221B1 (es)
AT (1) ATE136905T1 (es)
DE (1) DE68926269T2 (es)
ES (1) ES2085865T3 (es)
GR (1) GR3020139T3 (es)
HK (1) HK22797A (es)
SG (1) SG64368A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
ATE314394T1 (de) * 1993-08-13 2006-01-15 Uab Research Foundation Verfahren und zusammensetzungen zur stimulation und inhibition der aktivität von tgf-beta
SE9503924D0 (sv) * 1995-08-18 1995-11-07 Astra Ab Novel opioid peptides
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6184208B1 (en) 1994-06-29 2001-02-06 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5885958A (en) 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
SE9900961D0 (sv) * 1999-03-16 1999-03-16 Astra Ab Novel compounds
DE60143945D1 (de) * 2000-07-18 2011-03-10 Cornell Res Foundation Inc Medizinische verwendung von agonisten des mu-opioid rezeptors
US7316819B2 (en) 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
US7401046B2 (en) * 2001-07-25 2008-07-15 Chicago Board Options Exchange System and method for displaying option market information
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
DK2865385T3 (en) 2003-02-04 2016-12-19 Cornell Res Foundation Inc Applications of the aromatic-cationic peptide
MXPA05010817A (es) * 2003-04-08 2006-03-30 Progenics Pharm Inc Formulaciones farmaceuticas que contienen metilnaltrexona.
BRPI0409911A (pt) * 2003-05-01 2006-04-25 Cornell Res Foundation Inc método para liberar uma molécula em uma célula, e, complexo carreador
US20050215476A1 (en) * 2004-01-21 2005-09-29 Unigene Laboratories Inc. Amidated parathyroid hormone fragments and uses thereof
CA2554166C (en) * 2004-01-23 2014-07-29 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
US20050282756A1 (en) 2004-06-18 2005-12-22 Mehta Nozer M Oral delivery of peptide pharmaceutical compositions
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
CN101296704B (zh) 2005-09-16 2012-09-05 科内尔研究基金会 用于减少cd36表达的方法
WO2007112556A1 (en) * 2006-03-30 2007-10-11 Salpep Biotechnology Inc. Suppression and treatment of neuropathic pain
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
US20100305323A1 (en) 2007-03-29 2010-12-02 Smolenskaya Valeriya N Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
JP5461386B2 (ja) 2007-03-29 2014-04-02 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 末梢オピオイド受容体アンタゴニストおよびその使用
PT2139890E (pt) * 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2713150C (en) 2008-02-07 2016-01-05 Cornell University Methods for preventing or treating insulin resistance
EP2262520B1 (en) 2008-02-26 2017-05-03 Cornell University Compositions for prevention and treatment of renal injury
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
WO2010120431A2 (en) * 2009-03-20 2010-10-21 The General Hospital Corporation D/B/A Massachusetts General Hospital Methods for the prevention and treatment of burn injuries and secondary complications
US20110039766A1 (en) * 2009-08-12 2011-02-17 Szeto Hazel H Methods for preventing or treating metabolic syndrome
PL2470191T3 (pl) 2009-08-24 2014-09-30 Stealth Peptides Int Inc Sposoby i kompozycje do profilaktyki lub leczenia stanów okulistycznych
JP2013506696A (ja) * 2009-10-05 2013-02-28 コーネル ユニヴァーシティー 心不全の予防又は処置の方法
CN103987397A (zh) 2011-09-29 2014-08-13 梅约医学教育与研究基金会 芳族阳离子肽和使用它们的方法
WO2017156403A1 (en) * 2016-03-11 2017-09-14 Stealth Biotherapeutics Crystalline salt forms
US11034724B2 (en) 2017-04-05 2021-06-15 Stealth Biotherapeutics Corp. Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND THEIR USES
PL439243A1 (pl) * 2021-10-18 2023-04-24 Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
DE3435727A1 (de) * 1984-09-28 1986-04-10 Victor Dipl.-Chem. Dr.med. 6200 Wiesbaden Brantl Pharmakologisch aktive peptide

Also Published As

Publication number Publication date
US5312899A (en) 1994-05-17
SG64368A1 (en) 1999-04-27
GR3020139T3 (en) 1996-08-31
DE68926269T2 (de) 1996-08-14
DE68926269D1 (de) 1996-05-23
HK22797A (en) 1997-02-27
EP0350221A2 (en) 1990-01-10
ATE136905T1 (de) 1996-05-15
EP0350221B1 (en) 1996-04-17
EP0350221A3 (en) 1990-09-12

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