ATE314394T1 - Verfahren und zusammensetzungen zur stimulation und inhibition der aktivität von tgf-beta - Google Patents

Verfahren und zusammensetzungen zur stimulation und inhibition der aktivität von tgf-beta

Info

Publication number
ATE314394T1
ATE314394T1 AT94925878T AT94925878T ATE314394T1 AT E314394 T1 ATE314394 T1 AT E314394T1 AT 94925878 T AT94925878 T AT 94925878T AT 94925878 T AT94925878 T AT 94925878T AT E314394 T1 ATE314394 T1 AT E314394T1
Authority
AT
Austria
Prior art keywords
beta
tgf
latent
effective
tsp
Prior art date
Application number
AT94925878T
Other languages
English (en)
Inventor
Joanne E Murphy-Ullrich
David D Roberts
Henry C Krutzsch
Stacey Schultz-Cherry
Original Assignee
Uab Research Foundation
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation, Us Gov Health & Human Serv filed Critical Uab Research Foundation
Application granted granted Critical
Publication of ATE314394T1 publication Critical patent/ATE314394T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1019Tetrapeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1021Tetrapeptides with the first amino acid being acidic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT94925878T 1993-08-13 1994-08-12 Verfahren und zusammensetzungen zur stimulation und inhibition der aktivität von tgf-beta ATE314394T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10612093A 1993-08-13 1993-08-13
US23816994A 1994-05-04 1994-05-04
PCT/US1994/009193 WO1995005191A1 (en) 1993-08-13 1994-08-12 METHODS AND COMPOSITIONS FOR STIMULATING AND INHIBITING TGF-β ACTIVITY

Publications (1)

Publication Number Publication Date
ATE314394T1 true ATE314394T1 (de) 2006-01-15

Family

ID=26803316

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94925878T ATE314394T1 (de) 1993-08-13 1994-08-12 Verfahren und zusammensetzungen zur stimulation und inhibition der aktivität von tgf-beta

Country Status (8)

Country Link
US (1) US6384189B1 (de)
EP (1) EP0716609B1 (de)
JP (1) JPH09505555A (de)
AT (1) ATE314394T1 (de)
AU (1) AU697624B2 (de)
CA (1) CA2169360A1 (de)
DE (1) DE69434593D1 (de)
WO (1) WO1995005191A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0918795T3 (da) * 1997-03-17 2005-03-14 Abbott Lab Antiangiogene lægemidler til behandling af cancer, arthritis og retinopati
US5932545A (en) * 1997-03-17 1999-08-03 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
CA2240607A1 (en) 1997-08-13 1999-02-13 Kyowa Hakko Kogyo Co., Ltd. Novel vascular smooth muscle cell growth factor
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6121236A (en) 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
AU2610000A (en) * 1999-01-12 2000-08-01 Cambridge University Technical Services Limited Compounds and methods to inhibit or augment an inflammatory response
GB9915311D0 (en) * 1999-06-30 1999-09-01 Isis Innovation Modulation of dendritic cell maturation
ITMI20010995A1 (it) 2001-05-15 2002-11-15 Getters Spa Dispensatori di cesio e processo per il loro uso
US7223390B2 (en) * 2003-05-09 2007-05-29 Research Development Foundation Insertion of furin protease cleavage sites in membrane proteins and uses thereof
EA200800123A1 (ru) * 2005-06-24 2008-12-30 Кадила Хелзкэр Лимитед Пептиды, производные тромбоспондина-1, и способы лечения
US9614220B2 (en) 2007-01-29 2017-04-04 Umicore Doped and island-covered lithium cobaltite oxides
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
AU2013246040B2 (en) 2012-04-09 2018-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for generation of pluripotent and multipotent cells
KR101594032B1 (ko) * 2012-08-23 2016-02-15 강원대학교산학협력단 염증 또는 피부노화의 예방 또는 치료용 약학 조성물 및 염증 또는 피부노화 개선용 화장료 조성물
WO2014160183A1 (en) 2013-03-13 2014-10-02 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity
BR112015027569A2 (pt) * 2013-05-10 2017-09-19 Southern Res Inst compostos, composições, métodos e respectivos usos para tratar doenças por meio da inibição da atividade de tgf-ß
FR3024364B1 (fr) 2014-07-31 2016-09-02 Neuronax Oligopeptides particuliers comme medicaments anti-angiogeniques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2085865T3 (es) * 1988-06-30 1996-06-16 Astra Ab Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.
US5028425A (en) * 1988-07-07 1991-07-02 The United States Of America As Represented By The Department Of Health And Human Services Synthetic vaccine against P. falciparum malaria
US5192744A (en) 1990-01-12 1993-03-09 Northwestern University Method of inhibiting angiogenesis of tumors
US5190918A (en) 1990-02-22 1993-03-02 W. R. Grace & Co.-Conn. Peptide fragments and analogs of thrombospondin and methods of use
US5674503A (en) * 1990-07-24 1997-10-07 University Of Victoria Peptides capable of eliciting an immune response to leishmaniasis and methods of using the same
US5824647A (en) * 1990-12-12 1998-10-20 Postlethwaite; Arnold E. Chemotactic wound healing peptides
US5357041A (en) * 1991-12-06 1994-10-18 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin
US5770563A (en) * 1991-12-06 1998-06-23 The United States Of America As Represented By The Department Of Health And Human Services Heparin- and sulfatide binding peptides from the type I repeats of human thrombospondin and conjugates thereof
EP0673384A4 (de) * 1992-12-10 1996-10-09 Univ Minnesota Polypeptide nützlich in der behandlung von entzündlichen erkrankungen.
US5561107A (en) * 1993-06-04 1996-10-01 Demeter Biotechnologies, Ltd. Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides

Also Published As

Publication number Publication date
AU7565294A (en) 1995-03-14
EP0716609A4 (de) 1998-01-07
DE69434593D1 (de) 2006-02-02
CA2169360A1 (en) 1995-02-23
US6384189B1 (en) 2002-05-07
EP0716609B1 (de) 2005-12-28
JPH09505555A (ja) 1997-06-03
WO1995005191A1 (en) 1995-02-23
AU697624B2 (en) 1998-10-15
EP0716609A1 (de) 1996-06-19

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