EA200800123A1 - Пептиды, производные тромбоспондина-1, и способы лечения - Google Patents
Пептиды, производные тромбоспондина-1, и способы леченияInfo
- Publication number
- EA200800123A1 EA200800123A1 EA200800123A EA200800123A EA200800123A1 EA 200800123 A1 EA200800123 A1 EA 200800123A1 EA 200800123 A EA200800123 A EA 200800123A EA 200800123 A EA200800123 A EA 200800123A EA 200800123 A1 EA200800123 A1 EA 200800123A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peptides
- tsp
- plaque
- stabilize
- disclosed
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 102000007614 Thrombospondin 1 Human genes 0.000 abstract 4
- 108010046722 Thrombospondin 1 Proteins 0.000 abstract 4
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
- 108060003393 Granulin Proteins 0.000 abstract 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 abstract 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 abstract 1
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 abstract 1
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 201000002818 limb ischemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Раскрыто лечение с использованием матрицеллюлярного белка тромбоспондина-1 (TSP-1) и родственных композиций для стабилизации атеросклеротической бляшки и уменьшения частоты случаев разрыва бляшки, приводящего, например, к инфаркту миокарда, инсульту и острой ишемии конечностей. Также раскрыты различные пептиды, включая некоторые синтетические пептиды, родственные TSP-1. Такие пептиды были использованы для стабилизации бляшки в различных контекстах, включая упомянутые выше болезненные состояния. Некоторые из этих пептидов содержат одну или несколько последовательностей, связанных с активными свитами TSP-1, для регуляции, например, активности TGF-β1 и ММР-9. Приведенные в качестве примера экспериментальные данные показывают, что репрезентативный пептид обеспечивает полезный эффект в результате системной инъекции этих пептидов.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69357405P | 2005-06-24 | 2005-06-24 | |
| PCT/US2006/024692 WO2007002534A2 (en) | 2005-06-24 | 2006-06-23 | Thrombospondin-1 derived peptides and treatment methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200800123A1 true EA200800123A1 (ru) | 2008-12-30 |
Family
ID=37595929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800123A EA200800123A1 (ru) | 2005-06-24 | 2006-06-23 | Пептиды, производные тромбоспондина-1, и способы лечения |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8546323B2 (ru) |
| EP (1) | EP1901761A4 (ru) |
| JP (1) | JP2008543345A (ru) |
| KR (1) | KR20080039878A (ru) |
| CN (1) | CN101267829A (ru) |
| AU (1) | AU2006261911B2 (ru) |
| BR (1) | BRPI0613357A2 (ru) |
| CA (1) | CA2613193A1 (ru) |
| EA (1) | EA200800123A1 (ru) |
| IL (1) | IL188310A0 (ru) |
| NO (1) | NO20076603L (ru) |
| UA (1) | UA94046C2 (ru) |
| WO (1) | WO2007002534A2 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2198873A1 (en) * | 2008-12-18 | 2010-06-23 | Aposcience AG | Pharmaceutical preparation comprising supernatant of blood mononuclear cell culture |
| EP2201954A1 (en) * | 2008-12-18 | 2010-06-30 | Aposcience AG | Pharmaceutical preparation |
| US20130211059A1 (en) * | 2010-08-24 | 2013-08-15 | University Of Miyazaki | Composition suppressing matrix-metalloproteinase activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09505555A (ja) * | 1993-08-13 | 1997-06-03 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ＴＧＦ−βの活性を刺激および阻害する方法および組成物 |
| US6458767B1 (en) * | 1994-05-04 | 2002-10-01 | The Uab Research Foundation | Use of peptides inhibitory for thrombospondin dependent TGF-β activation in the treatment of kidney disease |
| US7220557B2 (en) | 1997-04-24 | 2007-05-22 | Human Genome Sciences, Inc. | METH1 polynucleotides |
| EP1187849A1 (en) * | 1999-05-25 | 2002-03-20 | Human Genome Sciences, Inc. | Meth1 and meth2 polynucleotides and polypeptides |
| JP2004505609A (ja) * | 2000-04-03 | 2004-02-26 | オックスフォード グリコサイエンシズ（ユーケー） リミテッド | 核酸分子、ポリペプチド、ならびにアルツハイマー病の診断および処置を含むそれらの使用 |
| US20030134784A1 (en) * | 2000-08-17 | 2003-07-17 | Raitano Arthur B. | Nucleic acids and corresponding proteins entitled 83P2H3 and CaTrF2E11 useful in treatment and detection of cancer |
| WO2002039122A2 (en) | 2000-11-09 | 2002-05-16 | Vitivity, Inc. | Methods for the identification and the treatment of cardiovascular disease |
| WO2002061087A2 (en) * | 2000-12-19 | 2002-08-08 | Lifespan Biosciences, Inc. | Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides |
| JP4646315B2 (ja) * | 2001-12-07 | 2011-03-09 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 前立腺癌においてアップレギュレートされた内因性レトロウイルス |
-
2006
- 2006-06-23 EA EA200800123A patent/EA200800123A1/ru unknown
- 2006-06-23 US US11/922,791 patent/US8546323B2/en not_active Expired - Fee Related
- 2006-06-23 EP EP06785539A patent/EP1901761A4/en not_active Withdrawn
- 2006-06-23 KR KR1020087001866A patent/KR20080039878A/ko not_active Application Discontinuation
- 2006-06-23 CA CA002613193A patent/CA2613193A1/en not_active Abandoned
- 2006-06-23 UA UAA200714422A patent/UA94046C2/ru unknown
- 2006-06-23 AU AU2006261911A patent/AU2006261911B2/en not_active Ceased
- 2006-06-23 JP JP2008518477A patent/JP2008543345A/ja active Pending
- 2006-06-23 CN CNA2006800228079A patent/CN101267829A/zh active Pending
- 2006-06-23 BR BRPI0613357A patent/BRPI0613357A2/pt not_active IP Right Cessation
- 2006-06-23 WO PCT/US2006/024692 patent/WO2007002534A2/en active Application Filing
-
2007
- 2007-12-20 IL IL188310A patent/IL188310A0/en unknown
- 2007-12-21 NO NO20076603A patent/NO20076603L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007002534A3 (en) | 2007-12-06 |
| AU2006261911A1 (en) | 2007-01-04 |
| AU2006261911B2 (en) | 2010-05-13 |
| CN101267829A (zh) | 2008-09-17 |
| IL188310A0 (en) | 2008-04-13 |
| US8546323B2 (en) | 2013-10-01 |
| WO2007002534A2 (en) | 2007-01-04 |
| NO20076603L (no) | 2008-03-17 |
| CA2613193A1 (en) | 2007-01-04 |
| KR20080039878A (ko) | 2008-05-07 |
| EP1901761A2 (en) | 2008-03-26 |
| UA94046C2 (ru) | 2011-04-11 |
| US20090131314A1 (en) | 2009-05-21 |
| BRPI0613357A2 (pt) | 2017-02-21 |
| EP1901761A4 (en) | 2009-08-12 |
| JP2008543345A (ja) | 2008-12-04 |
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