CR9452A - Agentes terapeuticos a base de peptidos de toxinas - Google Patents
Agentes terapeuticos a base de peptidos de toxinasInfo
- Publication number
- CR9452A CR9452A CR9452A CR9452A CR9452A CR 9452 A CR9452 A CR 9452A CR 9452 A CR9452 A CR 9452A CR 9452 A CR9452 A CR 9452A CR 9452 A CR9452 A CR 9452A
- Authority
- CR
- Costa Rica
- Prior art keywords
- therapeutic agents
- agents based
- independently
- toxin peptides
- dye
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
Abstract
Se revela una composicion de materia que tiene la siguiente formula: (I) (X1)a-(F1)d-(X2)b-(F2)e-(X3)c y sus multimeros, donde F1 y F2 son fracciones que prolongan la semivida, y d y e son cada uno, en forma independiente, 0 o 1, siempre que al menos uno de d y e sea 1; X1, X2 y X3 son cada uno, en forma independiente, -(L)f-P-(L)g-, y f y g son cada uno, en forma independiente, 0 o 1; P es un peptido de toxina de una longitud de no mas de 80 residuos de aminoacidos, aproximadamente, que comprende al menos dos enlaces disulfuro intrapeptidicos; L es un enlazador optativo; y a, b y c sea 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67434205P | 2005-04-22 | 2005-04-22 | |
US11/406,454 US7833979B2 (en) | 2005-04-22 | 2006-04-17 | Toxin peptide therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
CR9452A true CR9452A (es) | 2008-05-21 |
Family
ID=37894298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR9452A CR9452A (es) | 2005-04-22 | 2007-10-19 | Agentes terapeuticos a base de peptidos de toxinas |
Country Status (16)
Country | Link |
---|---|
US (2) | US7833979B2 (es) |
EP (1) | EP1896080A2 (es) |
JP (2) | JP5087536B2 (es) |
KR (2) | KR20100017942A (es) |
AR (1) | AR053234A1 (es) |
AU (1) | AU2006239928B8 (es) |
BR (1) | BRPI0607750A2 (es) |
CA (1) | CA2604999A1 (es) |
CR (1) | CR9452A (es) |
EA (1) | EA013470B1 (es) |
IL (1) | IL186527A0 (es) |
MX (1) | MX2007013031A (es) |
NO (1) | NO20076013L (es) |
NZ (1) | NZ562201A (es) |
TW (1) | TW200716748A (es) |
WO (1) | WO2006116156A2 (es) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192596B2 (en) * | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
GB0414272D0 (en) * | 2004-06-25 | 2004-07-28 | Cellpep Sa | OsK1 derivatives |
US8324158B2 (en) * | 2006-07-14 | 2012-12-04 | Georgia Tech Research Corporation | Methods for inhibiting CLC-2 channel with GATX2 |
US20090252703A1 (en) * | 2006-10-19 | 2009-10-08 | Gegg Jr Colin V | Use of alcohol co-solvents to improve pegylation reaction yields |
CA2667678A1 (en) * | 2006-10-25 | 2008-07-24 | Amgen Inc. | Toxin peptide therapeutic agents |
US20080260738A1 (en) * | 2007-04-18 | 2008-10-23 | Moore Margaret D | Single chain fc, methods of making and methods of treatment |
CN101802197A (zh) * | 2007-05-14 | 2010-08-11 | 比奥根艾迪克Ma公司 | 单链FC(ScFc)区、包含其的结合多肽及与其相关的方法 |
AU2007353147B2 (en) | 2007-05-14 | 2014-04-03 | Universidad Nacional Autonoma De Mexico | Vm23 and Vm24, two scorpion peptides that block human T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats |
CA2687141C (en) * | 2007-05-22 | 2014-04-01 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
WO2009064815A1 (en) * | 2007-11-13 | 2009-05-22 | The Scripps Research Institute | Production of cytotoxic antibody-toxin fusion in eukaryotic algae |
WO2009075773A2 (en) * | 2007-12-07 | 2009-06-18 | Goldstein Steven A | Identification of toxin ligands |
JP2011520914A (ja) | 2008-05-15 | 2011-07-21 | トランスモレキュラー, インコーポレイテッド | 転移腫瘍の処置 |
CA2731546C (en) | 2008-07-23 | 2013-11-19 | Hanmi Holdings Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
WO2010033207A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
WO2010033221A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
US20110171163A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of ziconotide peptides |
US8252228B1 (en) * | 2008-10-13 | 2012-08-28 | Abbott Cardiovascular Systems Inc. | Methods for sterilizing carriers for treatment of a kidney |
WO2010108153A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
US20120134984A1 (en) * | 2009-06-01 | 2012-05-31 | Olga Lubman | Molecules with extended half-lives and uses thereof |
JP2013511279A (ja) | 2009-11-20 | 2013-04-04 | アムジエン・インコーポレーテツド | 抗Orai1抗原結合蛋白及びその使用 |
EP2531206B1 (en) * | 2010-02-04 | 2017-05-31 | Morphotek, Inc. | Chlorotoxin polypeptides and conjugates and uses thereof |
EP2569330B1 (en) * | 2010-05-11 | 2016-09-28 | Fred Hutchinson Cancer Research Center | Chlorotoxin variants, conjugates, and methods for their use |
JP2013535692A (ja) | 2010-08-10 | 2013-09-12 | アムジエン・インコーポレーテツド | 標的抗体に対する中和抗体検出用インビトロ二重機能標的結合アッセイ |
EP2725034B1 (en) | 2010-09-22 | 2019-04-03 | Amgen Inc. | Carrier immunoglobulins with no specificity for human tissues and uses thereof |
AU2012228990B2 (en) | 2011-03-16 | 2017-04-06 | Amgen Inc. | Potent and selective inhibitors of Nav1.3 and Nav1.7 |
CN103687608B (zh) | 2011-06-06 | 2018-06-26 | 奇尼塔一有限责任公司 | 基于shk的医药组合物以及其制备和使用方法 |
WO2013052507A1 (en) * | 2011-10-03 | 2013-04-11 | The Regents Of The University Of California | TREATMENT OF OBESITY AND OBESITY-RELATED DISORDERS BY PHARMACOLOGICAL TARGETING OF Kv1.3 POTASSIUM CHANNELS |
EP2834268B1 (en) | 2011-10-28 | 2018-07-04 | University of Debrecen | Modified peptide toxins |
WO2013065343A1 (ja) * | 2011-10-31 | 2013-05-10 | 株式会社 島津製作所 | 非ペプチドヒンジ部含有フレキシブル抗体様分子 |
EP3663314A1 (en) | 2012-01-09 | 2020-06-10 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
KR102238317B1 (ko) | 2012-05-17 | 2021-04-12 | 익스텐드 바이오사이언시즈, 인크. | 개선된 약물 전달용 캐리어 |
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ES2782248T3 (es) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila |
BR112015013515A2 (pt) | 2012-12-10 | 2017-11-14 | Hutchinson Fred Cancer Res | métodos de geração de uma biblioteca de candidatos a fármaco definida por massa, e para identificar peptídeos possuindo uma propriedade farmacológica |
EP2935311B1 (en) | 2012-12-20 | 2021-03-31 | Amgen Inc. | Apj receptor agonists and uses thereof |
US10179808B2 (en) * | 2013-01-25 | 2019-01-15 | Janssen Biotech, Inc. | Kv1.3 antagonists and methods of use |
ES2968398T3 (es) * | 2013-02-14 | 2024-05-09 | Univ Arkansas | Composiciones y métodos para potenciar las respuestas inmunitarias a Eimeria o limitar la infección por Eimeria |
UY35397A (es) | 2013-03-12 | 2014-10-31 | Amgen Inc | INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7 |
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KR20100017942A (ko) | 2010-02-16 |
AU2006239928B2 (en) | 2010-12-02 |
JP2012100671A (ja) | 2012-05-31 |
AU2006239928B8 (en) | 2011-03-31 |
EA200702313A1 (ru) | 2008-06-30 |
WO2006116156A3 (en) | 2007-10-04 |
JP5087536B2 (ja) | 2012-12-05 |
JP5220915B2 (ja) | 2013-06-26 |
TW200716748A (en) | 2007-05-01 |
AU2006239928A1 (en) | 2006-11-02 |
EA013470B1 (ru) | 2010-04-30 |
AR053234A1 (es) | 2007-04-25 |
EP1896080A2 (en) | 2008-03-12 |
NZ562201A (en) | 2011-03-31 |
US7833979B2 (en) | 2010-11-16 |
MX2007013031A (es) | 2007-12-12 |
NO20076013L (no) | 2008-01-22 |
CA2604999A1 (en) | 2006-11-02 |
KR20080021606A (ko) | 2008-03-07 |
BRPI0607750A2 (pt) | 2009-11-24 |
US20070071764A1 (en) | 2007-03-29 |
JP2008538506A (ja) | 2008-10-30 |
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