ATE355302T1 - N-substituierte d-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation - Google Patents

N-substituierte d-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation

Info

Publication number
ATE355302T1
ATE355302T1 AT00949729T AT00949729T ATE355302T1 AT E355302 T1 ATE355302 T1 AT E355302T1 AT 00949729 T AT00949729 T AT 00949729T AT 00949729 T AT00949729 T AT 00949729T AT E355302 T1 ATE355302 T1 AT E355302T1
Authority
AT
Austria
Prior art keywords
peptide
beta
substituted
strand
nalpha
Prior art date
Application number
AT00949729T
Other languages
English (en)
Inventor
Kelvin Stott
Original Assignee
Senexis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senexis Ltd filed Critical Senexis Ltd
Application granted granted Critical
Publication of ATE355302T1 publication Critical patent/ATE355302T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00949729T 1999-07-28 2000-07-28 N-substituierte d-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation ATE355302T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9917725.5A GB9917725D0 (en) 1999-07-28 1999-07-28 Peptides

Publications (1)

Publication Number Publication Date
ATE355302T1 true ATE355302T1 (de) 2006-03-15

Family

ID=10858097

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00949729T ATE355302T1 (de) 1999-07-28 2000-07-28 N-substituierte d-aminosäuren enthaltende peptide,zur prävention der beta-strang assoziation

Country Status (13)

Country Link
US (1) US7060671B1 (de)
EP (1) EP1204679B1 (de)
JP (1) JP2003505470A (de)
AT (1) ATE355302T1 (de)
AU (1) AU767396B2 (de)
CA (1) CA2379241A1 (de)
DE (1) DE60033668T2 (de)
DK (1) DK1204679T3 (de)
ES (1) ES2282125T3 (de)
GB (1) GB9917725D0 (de)
NZ (1) NZ516442A (de)
PT (1) PT1204679E (de)
WO (1) WO2001007474A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60043616D1 (de) 1999-07-21 2010-02-11 Univ Pennsylvania Herstellung von verbindungen zur bestimmung der hypoxie
ES2180417B1 (es) * 2001-03-14 2004-05-16 Consejo Superior De Investigaciones Cientificas Nueva proteina sobreexpresada en cancer de prostata.
DE10117281A1 (de) * 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1380290A1 (de) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-Beta-Strukturweg und seine therapeutische Relevanz
EP2386861A3 (de) 2005-07-13 2012-07-18 Crossbeta Biosciences B.V. Cross-Beta-Struktur-bindende Verbindungen
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
GB2432586B (en) * 2005-11-25 2010-01-13 Univ Open Treatment of neurodegenerative disorders
JP2007217330A (ja) * 2006-02-16 2007-08-30 Dainippon Sumitomo Pharma Co Ltd 新規ペプチド
US8188046B2 (en) 2006-10-16 2012-05-29 University Of South Florida Amyloid beta peptides and methods of use
WO2008106657A2 (en) * 2007-03-01 2008-09-04 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
GB0716885D0 (en) * 2007-08-30 2007-10-10 United Arab Emirates Universit Diagnostic agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2214247C (en) * 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US6034211A (en) * 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
NZ514414A (en) * 1999-03-04 2004-02-27 Praecis Pharm Inc Modulators of beta-amyloid peptide aggregation comprising D-amino acids

Also Published As

Publication number Publication date
DE60033668D1 (de) 2007-04-12
NZ516442A (en) 2003-10-31
AU6300400A (en) 2001-02-13
ES2282125T3 (es) 2007-10-16
DE60033668T2 (de) 2007-06-21
PT1204679E (pt) 2007-05-31
CA2379241A1 (en) 2001-02-01
DK1204679T3 (da) 2007-04-02
EP1204679A1 (de) 2002-05-15
GB9917725D0 (en) 1999-09-29
JP2003505470A (ja) 2003-02-12
WO2001007474A1 (en) 2001-02-01
EP1204679B1 (de) 2007-02-28
AU767396B2 (en) 2003-11-06
US7060671B1 (en) 2006-06-13

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