DE68926269D1 - Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge - Google Patents

Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge

Info

Publication number
DE68926269D1
DE68926269D1 DE68926269T DE68926269T DE68926269D1 DE 68926269 D1 DE68926269 D1 DE 68926269D1 DE 68926269 T DE68926269 T DE 68926269T DE 68926269 T DE68926269 T DE 68926269T DE 68926269 D1 DE68926269 D1 DE 68926269D1
Authority
DE
Germany
Prior art keywords
analogs
pharmaceutical compositions
manufacturing process
therapeutic treatment
dermorphin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68926269T
Other languages
English (en)
Other versions
DE68926269T2 (de
Inventor
Peter W Schiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE68926269D1 publication Critical patent/DE68926269D1/de
Publication of DE68926269T2 publication Critical patent/DE68926269T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE68926269T 1988-06-30 1989-06-30 Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge Expired - Fee Related DE68926269T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA570874 1988-06-30

Publications (2)

Publication Number Publication Date
DE68926269D1 true DE68926269D1 (de) 1996-05-23
DE68926269T2 DE68926269T2 (de) 1996-08-14

Family

ID=4138301

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926269T Expired - Fee Related DE68926269T2 (de) 1988-06-30 1989-06-30 Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge

Country Status (8)

Country Link
US (1) US5312899A (de)
EP (1) EP0350221B1 (de)
AT (1) ATE136905T1 (de)
DE (1) DE68926269T2 (de)
ES (1) ES2085865T3 (de)
GR (1) GR3020139T3 (de)
HK (1) HK22797A (de)
SG (1) SG64368A1 (de)

Families Citing this family (42)

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US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
JPH09505555A (ja) 1993-08-13 1997-06-03 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシーズ ＴＧＦ−βの活性を刺激および阻害する方法および組成物
SE9503924D0 (sv) 1995-08-18 1995-11-07 Astra Ab Novel opioid peptides
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6184208B1 (en) 1994-06-29 2001-02-06 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
SE9900961D0 (sv) * 1999-03-16 1999-03-16 Astra Ab Novel compounds
EP1303186B1 (de) * 2000-07-18 2011-01-26 Cornell Research Foundation, Inc. Medizinische verwendung von agonisten des mu-opioid rezeptors
US7316819B2 (en) 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
US7401046B2 (en) * 2001-07-25 2008-07-15 Chicago Board Options Exchange System and method for displaying option market information
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
DK1599216T3 (da) * 2003-02-04 2013-12-09 Cornell Res Foundation Inc Fremgangsmåde til forebyggelse af mitokondriel permeabilitets-transition
DK2368553T3 (en) * 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
DK2604285T3 (en) 2003-05-01 2014-12-01 Cornell Res Foundation Inc Method and carrier complex for delivering molecules to cells
WO2005072277A2 (en) * 2004-01-21 2005-08-11 Unigene Laboratories Inc. Amidated parathyroid hormone fragments and uses thereof
RU2376028C2 (ru) * 2004-01-23 2009-12-20 Корнелл Рисеч Фаундейшн, Инк. Способ уменьшения окислительного повреждения (варианты)
US20050282756A1 (en) 2004-06-18 2005-12-22 Mehta Nozer M Oral delivery of peptide pharmaceutical compositions
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AU2006292352B2 (en) * 2005-09-16 2012-02-09 Cornell Research Foundation, Inc. Methods for reducing CD36 expression
EP1998791A4 (de) * 2006-03-30 2009-11-04 Salpep Biotechnology Inc Unterdrückung und behandlung von neuropathischen schmerzen
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
WO2008121348A2 (en) * 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
ES2493590T3 (es) 2007-03-29 2014-09-12 Wyeth Llc Antagonistas de receptores opioides periféricos y usos de los mismos
CA2713568C (en) 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2252312B1 (de) 2008-02-07 2014-04-09 Cornell University Verfahren zur prävention oder behandlung von insulinresistenz
CN106975070A (zh) 2008-02-26 2017-07-25 康奈尔大学 用于防止和治疗急性肾损伤的方法
CA2676881C (en) * 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
EP3199173B1 (de) 2009-03-20 2019-04-24 The General Hospital Corporation d/b/a Massachusetts General Hospital D-arg-2'6'-dimethyltyrosin-lys-phe-nh2 zur verhinderung und behandlung von brandverletzungen
CA2770688C (en) * 2009-08-12 2018-06-05 Cornell University Methods for preventing or treating metabolic syndrome
EP2470191B1 (de) 2009-08-24 2014-05-07 Stealth Peptides International, Inc. Verfahren und zusammensetzungen zur prävention oder behandlung von augenleiden
CN103845724A (zh) 2009-10-05 2014-06-11 康奈尔大学 预防或治疗心力衰竭的方法
US9988422B2 (en) 2011-09-29 2018-06-05 Stealth Biotherapeutics Corp Aromatic-cationic peptides and methods for using same
JP7038675B2 (ja) 2016-03-11 2022-03-18 ステルス バイオセラピューティクス インコーポレイテッド 結晶塩形態
EP3606938A1 (de) 2017-04-05 2020-02-12 Stealth BioTherapeutics Corp Kristalline salzformen von boc-d-arg-dmt-lys-(boc)-phe-nh2
EP3681900A4 (de) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. Opioidagonistpeptide und verwendungen davon
PL439243A1 (pl) * 2021-10-18 2023-04-24 Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
DE3435727A1 (de) * 1984-09-28 1986-04-10 Victor Dipl.-Chem. Dr.med. 6200 Wiesbaden Brantl Pharmakologisch aktive peptide

Also Published As

Publication number Publication date
EP0350221B1 (de) 1996-04-17
EP0350221A2 (de) 1990-01-10
US5312899A (en) 1994-05-17
ATE136905T1 (de) 1996-05-15
GR3020139T3 (en) 1996-08-31
DE68926269T2 (de) 1996-08-14
SG64368A1 (en) 1999-04-27
HK22797A (en) 1997-02-27
EP0350221A3 (en) 1990-09-12
ES2085865T3 (es) 1996-06-16

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8339 Ceased/non-payment of the annual fee