GR1001550B - Αλατα βασικών πεπτιδίων με πολυεστέρες που έχουν ακραία ομάδα καρβοξύ. - Google Patents
Αλατα βασικών πεπτιδίων με πολυεστέρες που έχουν ακραία ομάδα καρβοξύ.Info
- Publication number
- GR1001550B GR1001550B GR930100213A GR930100213A GR1001550B GR 1001550 B GR1001550 B GR 1001550B GR 930100213 A GR930100213 A GR 930100213A GR 930100213 A GR930100213 A GR 930100213A GR 1001550 B GR1001550 B GR 1001550B
- Authority
- GR
- Greece
- Prior art keywords
- salts
- carboxy
- peptides
- release
- terminated polyesters
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Abstract
Αυτή η εφεύρεση αναφέρεται σε νέα άλατα, που συνίσταται από ένα κατιόν, που παράγεται από ένα πεπτίδιο που περιέχει τουλάχιστον μία βασική ομάδα και ένα ανιόν που παράγεται από ένα πολυεστέρα καρβόξυ - τελειομένο, μέθοδος δια την βιομηχανική κατασκευή αυτών των αλάτων, και την χρήση τέτοιων αλάτων εις την κατασκευή φαρμακευτικών συνθέσεων εκτεταμένης ελευθέρωσης. Τα άλατα της εφεύρεσης έχουν μία ποικιλία ιδιοτήτων, που είναι χρήσιμες εις την τυποποίηση φαρμακευτικών συνθέσεων εκτεταμένης ελευθέρωσης, είτε τα άλατα είναι υπό καθαρή μορφή είτε ειναι εν μείγματι είτε με μία περίσσεια του πεπτιδίου υπό την ελευθέρωση και αδέσμευτη μορφή αυτού, είτε με μία περίσσεια του ελευθέρου πολυεστέρα.ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB@@@@A GB9211268D0 (en) | 1992-05-28 | 1992-05-28 | Salts of basic peptides with carboxyterminated polyesters |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1001550B true GR1001550B (el) | 1994-04-29 |
Family
ID=10716132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR930100213A GR1001550B (el) | 1992-05-28 | 1993-05-26 | Αλατα βασικών πεπτιδίων με πολυεστέρες που έχουν ακραία ομάδα καρβοξύ. |
Country Status (33)
Country | Link |
---|---|
US (3) | US5889110A (el) |
JP (1) | JPH08501064A (el) |
KR (1) | KR100293882B1 (el) |
AT (1) | AT407702B (el) |
AU (1) | AU682310B2 (el) |
BE (1) | BE1006143A3 (el) |
CA (1) | CA2136751C (el) |
CH (2) | CH690491A5 (el) |
CZ (1) | CZ292449B6 (el) |
DE (2) | DE4392401T1 (el) |
DK (1) | DK176134B1 (el) |
ES (1) | ES2107357B1 (el) |
FI (1) | FI112603B (el) |
FR (1) | FR2691631B1 (el) |
GB (3) | GB9211268D0 (el) |
GR (1) | GR1001550B (el) |
HK (1) | HK133097A (el) |
HU (1) | HUT70177A (el) |
IE (1) | IE74715B1 (el) |
IL (1) | IL105710A (el) |
IT (1) | IT1271139B (el) |
LU (1) | LU88559A1 (el) |
MC (1) | MC2330A1 (el) |
NL (1) | NL195056C (el) |
NO (1) | NO311006B1 (el) |
NZ (1) | NZ252268A (el) |
RU (1) | RU2152225C1 (el) |
SE (1) | SE501970C2 (el) |
SG (1) | SG44645A1 (el) |
SK (1) | SK280320B6 (el) |
TW (1) | TW223018B (el) |
WO (1) | WO1993024150A1 (el) |
ZA (1) | ZA933358B (el) |
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WO2021146215A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
US20230285576A1 (en) | 2020-08-05 | 2023-09-14 | Ellipses Pharma Ltd | Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor |
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US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
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US5005602A (en) * | 1985-12-24 | 1991-04-09 | Dover Corporation | Poppet valve assembly |
FR2600894B1 (fr) * | 1986-07-02 | 1989-01-13 | Centre Nat Rech Scient | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
JP2827287B2 (ja) * | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
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US4997643A (en) * | 1989-07-12 | 1991-03-05 | Union Carbide Chemicals And Plastics Company Inc. | Polymeric salt delivery systems |
US5077049A (en) * | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
CH679207A5 (el) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
CA2065156A1 (en) * | 1990-07-03 | 1992-01-04 | Richard L. Dunn | Intragingival delivery systems for treatment of periodontal disease |
CA2046830C (en) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
US5672659A (en) * | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
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1992
- 1992-05-28 GB GB@@@@A patent/GB9211268D0/en active Pending
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1993
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- 1993-05-25 CZ CZ19942937A patent/CZ292449B6/cs not_active IP Right Cessation
- 1993-05-25 SK SK1434-94A patent/SK280320B6/sk not_active IP Right Cessation
- 1993-05-25 KR KR1019940704279A patent/KR100293882B1/ko not_active IP Right Cessation
- 1993-05-25 DE DE4392401T patent/DE4392401T1/de active Pending
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- 1993-05-25 CH CH00680/98A patent/CH690491A5/de not_active IP Right Cessation
- 1993-05-25 JP JP6500317A patent/JPH08501064A/ja active Pending
- 1993-05-25 RU RU94046097/14A patent/RU2152225C1/ru not_active IP Right Cessation
- 1993-05-25 CH CH00311/94A patent/CH688911A5/de not_active IP Right Cessation
- 1993-05-25 DE DE4392401A patent/DE4392401B4/de not_active Expired - Fee Related
- 1993-05-25 SG SG1996004921A patent/SG44645A1/en unknown
- 1993-05-25 AT AT0901993A patent/AT407702B/de not_active IP Right Cessation
- 1993-05-25 WO PCT/GB1993/001079 patent/WO1993024150A1/en not_active IP Right Cessation
- 1993-05-25 GB GB9423366A patent/GB2282066B/en not_active Expired - Fee Related
- 1993-05-25 AU AU40847/93A patent/AU682310B2/en not_active Ceased
- 1993-05-25 ES ES09450004A patent/ES2107357B1/es not_active Expired - Fee Related
- 1993-05-25 HU HU9403371A patent/HUT70177A/hu unknown
- 1993-05-25 CA CA002136751A patent/CA2136751C/en not_active Expired - Fee Related
- 1993-05-26 GR GR930100213A patent/GR1001550B/el not_active IP Right Cessation
- 1993-05-27 MC MC2243A patent/MC2330A1/xx unknown
- 1993-05-27 IT ITMI931099A patent/IT1271139B/it active IP Right Grant
- 1993-05-28 BE BE9300551A patent/BE1006143A3/fr not_active IP Right Cessation
- 1993-05-28 FR FR9306432A patent/FR2691631B1/fr not_active Expired - Fee Related
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1994
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- 1994-11-25 NO NO19944535A patent/NO311006B1/no unknown
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- 1994-11-28 SE SE9404115A patent/SE501970C2/sv unknown
- 1994-11-28 DK DK199401353A patent/DK176134B1/da not_active IP Right Cessation
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1995
- 1995-06-07 US US08/473,303 patent/US5889110A/en not_active Expired - Fee Related
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1997
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1999
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2001
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