MC2330A1 - Compositions contenant des sels de peptides formés avec des polyesters à terminaison carboxy et procédés pour leur production - Google Patents

Compositions contenant des sels de peptides formés avec des polyesters à terminaison carboxy et procédés pour leur production

Info

Publication number
MC2330A1
MC2330A1 MC2243A MC2243A MC2330A1 MC 2330 A1 MC2330 A1 MC 2330A1 MC 2243 A MC2243 A MC 2243A MC 2243 A MC2243 A MC 2243A MC 2330 A1 MC2330 A1 MC 2330A1
Authority
MC
Monaco
Prior art keywords
carboxy
production
methods
compositions containing
containing salts
Prior art date
Application number
MC2243A
Other languages
English (en)
Inventor
Hutchinson Francis Gowland
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of MC2330A1 publication Critical patent/MC2330A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593Polyesters, e.g. PLGA or polylactide-co-glycolide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
MC2243A 1992-05-28 1993-05-27 Compositions contenant des sels de peptides formés avec des polyesters à terminaison carboxy et procédés pour leur production MC2330A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB@@@@A GB9211268D0 (en) 1992-05-28 1992-05-28 Salts of basic peptides with carboxyterminated polyesters

Publications (1)

Publication Number Publication Date
MC2330A1 true MC2330A1 (fr) 1994-05-31

Family

ID=10716132

Family Applications (1)

Application Number Title Priority Date Filing Date
MC2243A MC2330A1 (fr) 1992-05-28 1993-05-27 Compositions contenant des sels de peptides formés avec des polyesters à terminaison carboxy et procédés pour leur production

Country Status (33)

Country Link
US (3) US5889110A (fr)
JP (1) JPH08501064A (fr)
KR (1) KR100293882B1 (fr)
AT (1) AT407702B (fr)
AU (1) AU682310B2 (fr)
BE (1) BE1006143A3 (fr)
CA (1) CA2136751C (fr)
CH (2) CH690491A5 (fr)
CZ (1) CZ292449B6 (fr)
DE (2) DE4392401T1 (fr)
DK (1) DK176134B1 (fr)
ES (1) ES2107357B1 (fr)
FI (1) FI112603B (fr)
FR (1) FR2691631B1 (fr)
GB (3) GB9211268D0 (fr)
GR (1) GR1001550B (fr)
HK (1) HK133097A (fr)
HU (1) HUT70177A (fr)
IE (1) IE74715B1 (fr)
IL (1) IL105710A (fr)
IT (1) IT1271139B (fr)
LU (1) LU88559A1 (fr)
MC (1) MC2330A1 (fr)
NL (1) NL195056C (fr)
NO (1) NO311006B1 (fr)
NZ (1) NZ252268A (fr)
RU (1) RU2152225C1 (fr)
SE (1) SE501970C2 (fr)
SG (1) SG44645A1 (fr)
SK (1) SK280320B6 (fr)
TW (1) TW223018B (fr)
WO (1) WO1993024150A1 (fr)
ZA (1) ZA933358B (fr)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
PT949905E (pt) * 1996-12-20 2001-12-28 Alza Corp Composicao de gel injectavel de efeito retardado e processo para a sua preparacao
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20070009605A1 (en) * 1998-07-23 2007-01-11 Ignatious Francis X Encapsulation of water soluble peptides
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
EP1240896A3 (fr) * 1998-07-23 2003-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Encapsulation de peptides hydrosolubles
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
CO5160256A1 (es) * 1999-02-08 2002-05-30 Zentaris Ag Sales de peptidos farmaceuticamente activos para la liberacion sostenida y proceso de produccion
US7018645B1 (en) 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
JP2003535122A (ja) * 2000-06-02 2003-11-25 ザイコス インク. 生物活性物質のための送達システム
EP1353701B1 (fr) * 2000-10-31 2011-12-21 PR Pharmaceuticals, Inc. Methodes de production de compositions pour ameliorer l'administration de molecules bioactives
CA2451187C (fr) * 2001-06-22 2012-08-14 Southern Biosystems, Inc. Implants coaxiaux a liberation prolongee d'ordre 0
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
DK1429731T3 (da) * 2001-09-19 2007-05-14 Elan Pharma Int Ltd Nanopartikelformuleringer indeholdende insulin
CN101785861B (zh) * 2001-10-19 2014-08-13 爱德士实验室公司 用于药理活性化合物的可控释放的可注射组合物
NZ533436A (en) * 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
DE10206517A1 (de) * 2002-02-16 2003-09-04 Stoess & Co Gelatine Depotarzneimittel, Trägermaterialien für Depotarzneimittel und Verfahren zu deren Herstellung
EP1344520B1 (fr) * 2002-03-15 2007-10-03 Alrise Biosystems GmbH Microparticules et leur procédé de fabrication
US9101540B2 (en) * 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
DK1532985T3 (en) 2002-06-25 2016-12-05 Takeda Pharmaceuticals Co PROCEDURE FOR PREPARING A COMPOSITION WITH LONG-TERM RELEASE
AR039729A1 (es) * 2002-06-25 2005-03-09 Alza Corp Formulaciones de deposito de corta duracion
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CN1684663A (zh) * 2002-07-31 2005-10-19 阿尔萨公司 可注射的多模式聚合物储库组合物以及其用途
AU2002359397B2 (en) * 2002-07-31 2009-01-29 Durect Corporation Injectable depot compositions and uses thereof
CN102516417B (zh) 2002-09-06 2014-12-10 天蓝制药公司 用于传递治疗剂的以环糊精为基础的聚合物
JP2006508127A (ja) 2002-11-06 2006-03-09 アルザ・コーポレーション 制御された放出性デポー剤配合物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
SG192300A1 (en) 2003-01-28 2013-08-30 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of gastrointestinal disorders
DK1610822T4 (en) * 2003-04-02 2019-01-14 Ares Trading Sa Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant
US20040224024A1 (en) * 2003-04-23 2004-11-11 Massachusetts Institute Of Technology Controlled drug release formulations containing polyion complexes
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
CA2526099C (fr) * 2003-06-20 2013-02-05 Ares Trading Sa Formulations lyophilisees a base de fsh/lh
WO2005034852A2 (fr) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Biomateriaux et biocoacervats proteiniques, leurs procedes de fabrication et d'utilisation
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
EP1682537B1 (fr) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulateurs de l'adhesion cellulaire
CA2548822C (fr) 2003-12-08 2015-08-11 Gel-Del Technologies, Inc. Dispositifs d'administration de medicaments mucoadhesifs et procedes de fabrication et d'utilisation associes
WO2005074968A2 (fr) * 2004-02-10 2005-08-18 Universiteit Maastricht Utilisation medicale de peptides basiques
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US9028829B2 (en) * 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US7846201B2 (en) * 2004-02-20 2010-12-07 The Children's Hospital Of Philadelphia Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
EP1674082A1 (fr) * 2004-12-22 2006-06-28 Zentaris GmbH Procédé pour la manufacture des suspensions ou lyophilisates steriles des complexes mal-soluble de peptides basic, des formulations pharmaceutiques avec ces complexes et leur utilisation comme medicament
DK2444079T3 (en) 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8945598B2 (en) 2005-12-29 2015-02-03 Cordis Corporation Low temperature drying methods for forming drug-containing polymeric compositions
EP1837014A1 (fr) * 2006-03-21 2007-09-26 Hexal Ag Implants sous-cutanés contenant un polymère de polylactide résistant à la dégradation et un analogue de la LH-RH
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
EP1917971A1 (fr) * 2006-10-27 2008-05-07 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Préparations à libération prolongée comprenant des polymères à poids moléculaire très bas
KR100816065B1 (ko) 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20090155176A1 (en) 2007-10-19 2009-06-18 Sarcode Corporation Compositions and methods for treatment of diabetic retinopathy
US20090163449A1 (en) * 2007-12-20 2009-06-25 Eastman Chemical Company Sulfo-polymer powder and sulfo-polymer powder blends with carriers and/or additives
US20090163603A1 (en) * 2007-12-20 2009-06-25 Eastman Chemical Company Sulfo-polymer powder and sulfo-polymer powder blends
EP2237770A4 (fr) 2007-12-26 2011-11-09 Gel Del Technologies Inc Particules de protéines biocompatibles, dispositifs à particules et leurs procédés
JOP20090061B1 (ar) * 2008-02-11 2021-08-17 Ferring Int Center Sa طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
WO2010009319A2 (fr) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
WO2010057177A2 (fr) 2008-11-17 2010-05-20 Gel-Del Technologies, Inc. Systèmes de greffe de vaisseaux à biocoacervats et biomatériaux protéiques et procédés pour leur fabrication et leur utilisation
US8822546B2 (en) * 2008-12-01 2014-09-02 Medtronic, Inc. Flowable pharmaceutical depot
JP5855568B2 (ja) 2009-09-15 2016-02-09 セルリアン・ファーマ・インコーポレイテッド 癌の治療法
US8378105B2 (en) 2009-10-21 2013-02-19 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
BR112012014947A2 (pt) * 2009-12-22 2019-09-24 Takeda Pharmaceuticals Co formulação de liberação prolongada,e, método para produzir a formulação de liberação prolongada
DE102010003615A1 (de) 2010-04-01 2011-10-06 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Herstellung eines Drug-Delivery-Systems auf der Basis von Polyelektrolytkomplexen
EP3566719A1 (fr) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Compositions et procédés pour le traitement de maladies auto-immunes et d'autres maladies
WO2011161531A1 (fr) 2010-06-24 2011-12-29 Torrent Pharmaceuticals Limited Composition pharmaceutique contenant de la goséréline pour un implant in situ
UY33465A (es) * 2010-06-25 2012-01-31 Takeda Pharmaceutical Formulacion de liberacion sostenida
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2012250776B2 (en) 2011-05-04 2017-06-15 Balance Therapeutics, Inc. Pentylenetetrazole derivatives
KR101467275B1 (ko) * 2011-12-19 2014-12-02 주식회사 삼양바이오팜 분산성이 향상된 생분해성 고분자 미립자의 조성물 및 그 제조방법
KR102157608B1 (ko) 2012-07-25 2020-09-18 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 저해제 및 그의 다형체
WO2014055493A1 (fr) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Procédés et systèmes s'appliquant à la précipitation de polymères et à la génération de particules
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
ES2804702T3 (es) * 2013-03-04 2021-02-09 Besins Healthcare Lu Sarl Composiciones farmacéuticas secas que comprenden nanopartículas de agente activo unidas a partículas de portador
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
WO2014151200A2 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
US20160220630A1 (en) 2013-10-10 2016-08-04 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
WO2015088990A1 (fr) 2013-12-09 2015-06-18 Durect Corporation Complexes de principes pharmaceutiquement actifs, complexes de polymères, et compositions et procédés les impliquant
EP4331670A3 (fr) 2015-01-07 2024-05-29 Tonix Pharma Limited Formulations d'oxytocine contenant du magnésium et procédés d'utilisation
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US10653744B2 (en) 2016-01-11 2020-05-19 Bausch Health Ireland Limited Formulations and methods for treating ulcerative colitis
CN105963258B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
US20210154147A1 (en) * 2018-10-19 2021-05-27 Ac Pharmaceuticals Co., Ltd. Preparation method of sustained-release microparticles
CN110954491B (zh) * 2019-12-09 2022-11-15 北京博恩特药业有限公司 用于测量醋酸戈舍瑞林缓释植入剂体外溶出度的方法
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
WO2022029220A1 (fr) 2020-08-05 2022-02-10 Ellipses Pharma Ltd Traitement du cancer à l'aide d'un conjugué polymère contenant de la cyclodextrine-inhibiteur de la topoisomérase et d'un inhibiteur de parp
AU2022323754A1 (en) 2021-08-05 2024-02-08 Medincell S.A. Pharmaceutical composition

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US5005602A (en) * 1985-12-24 1991-04-09 Dover Corporation Poppet valve assembly
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4997643A (en) * 1989-07-12 1991-03-05 Union Carbide Chemicals And Plastics Company Inc. Polymeric salt delivery systems
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
CH679207A5 (fr) * 1989-07-28 1992-01-15 Debiopharm Sa
EP0489743A1 (fr) * 1990-07-03 1992-06-17 Vipont Pharmaceutical, Inc. Systemes d'administration intragingivale pour le traitement de maladies parodontales
CA2046830C (fr) * 1990-07-19 1999-12-14 Patrick P. Deluca Systeme d'administration des medicaments comprenant une interaction entre une proteine ou une polypeptide et un polymere hydrophobe biodegradable
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5672659A (en) * 1993-01-06 1997-09-30 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides

Also Published As

Publication number Publication date
WO1993024150A1 (fr) 1993-12-09
GB2282066B (en) 1996-11-06
CA2136751A1 (fr) 1993-12-09
GB2282066A (en) 1995-03-29
US20020198315A1 (en) 2002-12-26
ES2107357B1 (es) 1998-10-16
ES2107357A1 (es) 1997-11-16
IL105710A0 (en) 1993-09-22
IE74715B1 (en) 1997-07-30
FR2691631A1 (fr) 1993-12-03
SG44645A1 (en) 1997-12-19
FI945553A0 (fi) 1994-11-25
GR1001550B (el) 1994-04-29
SE9404115L (sv) 1994-11-28
ITMI931099A1 (it) 1994-11-27
US5889110A (en) 1999-03-30
LU88559A1 (fr) 1995-04-05
NZ252268A (en) 1996-12-20
AU682310B2 (en) 1997-10-02
DK135394A (da) 1994-11-28
TW223018B (en) 1994-05-01
HUT70177A (en) 1995-09-28
DK176134B1 (da) 2006-09-18
IE930358A1 (en) 1993-12-01
FR2691631B1 (fr) 1995-06-09
GB9423366D0 (en) 1995-01-25
SK280320B6 (sk) 1999-11-08
NO944535L (no) 1995-01-25
SK143494A3 (en) 1995-07-11
CH688911A5 (de) 1998-05-29
ZA933358B (en) 1994-09-15
HK133097A (en) 1997-10-24
BE1006143A3 (fr) 1994-05-24
ITMI931099A0 (it) 1993-05-27
CH690491A5 (de) 2000-09-29
DE4392401B4 (de) 2007-05-16
GB9211268D0 (en) 1992-07-15
JPH08501064A (ja) 1996-02-06
RU2152225C1 (ru) 2000-07-10
FI945553A (fi) 1995-01-25
CZ293794A3 (en) 1995-03-15
IT1271139B (it) 1997-05-27
IL105710A (en) 2001-03-19
GB9309645D0 (en) 1993-06-23
NO944535D0 (no) 1994-11-25
FI112603B (fi) 2003-12-31
DE4392401T1 (de) 1997-07-24
SE9404115D0 (sv) 1994-11-28
US6034175A (en) 2000-03-07
CA2136751C (fr) 2006-10-31
SE501970C2 (sv) 1995-07-03
HU9403371D0 (en) 1995-02-28
NL195056C (nl) 2003-07-01
ATA901993A (de) 2000-10-15
KR100293882B1 (ko) 2001-09-17
CZ292449B6 (cs) 2003-09-17
NL9320034A (nl) 1995-04-03
RU94046097A (ru) 1996-09-20
AU4084793A (en) 1993-12-30
AT407702B (de) 2001-05-25
NO311006B1 (no) 2001-10-01

Similar Documents

Publication Publication Date Title
MC2330A1 (fr) Compositions contenant des sels de peptides formés avec des polyesters à terminaison carboxy et procédés pour leur production
EP0735870A4 (fr) Utilisation d'inhibiteurs de pla 2? pour traiter la maladie d'alzheimer
HUP9603428A3 (en) Novel crystalmodification of cdch and process for producing it and pharmaceutical composition containing it
FR2696094B1 (fr) Nouvelles compositions pharmaceutiques contenant des cyclosporines.
HUT64047A (en) Process for producing compounds and pharmaceutical compositions suitable for the simultaneous inhibition of no-syntase and cyclogenase
ITVA920011A0 (it) Procedimento per la produzione di carta da alghe marine e carta cosi' ottenuta
MA23895A1 (fr) Amides therapeutiques et compositions les contenant
FR2574080B1 (fr) Esters et amides d'amino-acides en tant qu'inhibiteurs de la renine
FR2627511B1 (fr) Inhibiteurs de corrosion des aciers et compositions aqueuses d'halogenure de metal alcalin les contenant
WO1992016205A3 (fr) Nouveaux derives de 2-carboxyindoles ayant une action pharmaceutique
MA26426A1 (fr) Procedes et intermediaires pour la preparation de b-lactames monocycliques nouveaux et pour compositions pharmaceutiques les contenant
IL77083A0 (en) Pharmaceutical compositions containing certain dipeptides or salts thereof for the treatment of amyotrophic lateral sclerosis and the manufacture thereof
ZA968109B (en) Pharmaceutical composition which is useful for the transfection of nucleic acids and uses thereof
FI962603A (fi) Hydroksihapon tai sitä sisältävän tuotteen käyttö sekä siitä tehty valmiste
MA22870A1 (fr) Compositions detergentes contenant des polyesters modifies
DE3870572D1 (de) Zusammensetzung zum oberflaechlichen schutz von zink gegen "weissrost" und entsprechende verfahren.
IT8820172A0 (it) Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
DE69322127D1 (de) Verfahren zur Herstellung von Peptidderivaten und ihrer Salze
DE69614311D1 (de) Verfahren zur gyrometrischer Drehratenbestimmung und optischer Kreisel zur Durchführung des Verfahrens
DE59301311D1 (de) Verfahren zur Herstellung von Perfluoralkylsulfonylfluoriden sowie Elektroden zur Durchführung des Verfahrens
DZ1748A1 (fr) Sel de lysine du 6-chloro-5-fluoro-3-(2-thénoyl)-2-oxindole-1-carboxamide et composition pharmaceutique le contenant.
FR2615734B1 (fr) Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie
ITTO930551A1 (it) Procedimento per la produzione di leghe d'acciaio contenenti vanadio
FI102621B1 (fi) Kupari-alumiini-sinkki-seoksen käyttö korroosionkestävänä materiaalina
FR2705230B1 (fr) Compositions cosmétiques contenant des microcapsules qui comprennent des cristaux liquides d'ester cholestérylique.