ITMI931099A1 - Sali di peptidi con poliesteri dotati di gruppi carbossilici terminali - Google Patents
Sali di peptidi con poliesteri dotati di gruppi carbossilici terminaliInfo
- Publication number
- ITMI931099A1 ITMI931099A1 IT93MI001099A ITMI931099A ITMI931099A1 IT MI931099 A1 ITMI931099 A1 IT MI931099A1 IT 93MI001099 A IT93MI001099 A IT 93MI001099A IT MI931099 A ITMI931099 A IT MI931099A IT MI931099 A1 ITMI931099 A1 IT MI931099A1
- Authority
- IT
- Italy
- Prior art keywords
- salts
- carboxyl groups
- terminal carboxyl
- peptidal
- polyesters
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
La presente invenzione riguarda nuovi sali costituiti da un catione derivato da un peptide contenente almeno un gruppo basico e un anione derivato da un poliestere dotato di gruppi carbossilici terminali, riguarda procedimenti per la preparazione di tali sali e l'impiego di tali sali nella preparazione di composizioni farmaceutiche a cessione protratta. I sali della presente invenzione possiedono svariate proprietà che sono utili nella formulazione di composizioni farmaceutiche a cessione protratta in cui i sali sono in forma pura oppure sono in miscela con un eccesso del peptide nella sua forma libera, non legata, oppure con un eccesso del poliestere libero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB@@@@A GB9211268D0 (en) | 1992-05-28 | 1992-05-28 | Salts of basic peptides with carboxyterminated polyesters |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI931099A0 ITMI931099A0 (it) | 1993-05-27 |
ITMI931099A1 true ITMI931099A1 (it) | 1994-11-27 |
IT1271139B IT1271139B (it) | 1997-05-27 |
Family
ID=10716132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI931099A IT1271139B (it) | 1992-05-28 | 1993-05-27 | Sali di peptidi con poliesteri dotati di gruppi carbossilici terminali |
Country Status (33)
Country | Link |
---|---|
US (3) | US5889110A (it) |
JP (1) | JPH08501064A (it) |
KR (1) | KR100293882B1 (it) |
AT (1) | AT407702B (it) |
AU (1) | AU682310B2 (it) |
BE (1) | BE1006143A3 (it) |
CA (1) | CA2136751C (it) |
CH (2) | CH688911A5 (it) |
CZ (1) | CZ292449B6 (it) |
DE (2) | DE4392401B4 (it) |
DK (1) | DK176134B1 (it) |
ES (1) | ES2107357B1 (it) |
FI (1) | FI112603B (it) |
FR (1) | FR2691631B1 (it) |
GB (3) | GB9211268D0 (it) |
GR (1) | GR1001550B (it) |
HK (1) | HK133097A (it) |
HU (1) | HUT70177A (it) |
IE (1) | IE74715B1 (it) |
IL (1) | IL105710A (it) |
IT (1) | IT1271139B (it) |
LU (1) | LU88559A1 (it) |
MC (1) | MC2330A1 (it) |
NL (1) | NL195056C (it) |
NO (1) | NO311006B1 (it) |
NZ (1) | NZ252268A (it) |
RU (1) | RU2152225C1 (it) |
SE (1) | SE501970C2 (it) |
SG (1) | SG44645A1 (it) |
SK (1) | SK280320B6 (it) |
TW (1) | TW223018B (it) |
WO (1) | WO1993024150A1 (it) |
ZA (1) | ZA933358B (it) |
Families Citing this family (104)
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PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US5005602A (en) * | 1985-12-24 | 1991-04-09 | Dover Corporation | Poppet valve assembly |
FR2600894B1 (fr) * | 1986-07-02 | 1989-01-13 | Centre Nat Rech Scient | Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications |
JP2827287B2 (ja) * | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US4997643A (en) * | 1989-07-12 | 1991-03-05 | Union Carbide Chemicals And Plastics Company Inc. | Polymeric salt delivery systems |
US5077049A (en) * | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
CH679207A5 (it) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
WO1992000718A1 (en) * | 1990-07-03 | 1992-01-23 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
CA2046830C (en) * | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
US5672659A (en) * | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
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1992
- 1992-05-28 GB GB@@@@A patent/GB9211268D0/en active Pending
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1993
- 1993-05-11 GB GB939309645A patent/GB9309645D0/en active Pending
- 1993-05-11 IE IE930358A patent/IE74715B1/en not_active IP Right Cessation
- 1993-05-13 ZA ZA933358A patent/ZA933358B/xx unknown
- 1993-05-16 IL IL10571093A patent/IL105710A/en not_active IP Right Cessation
- 1993-05-21 TW TW082104017A patent/TW223018B/zh not_active IP Right Cessation
- 1993-05-25 WO PCT/GB1993/001079 patent/WO1993024150A1/en not_active IP Right Cessation
- 1993-05-25 AT AT0901993A patent/AT407702B/de not_active IP Right Cessation
- 1993-05-25 DE DE4392401A patent/DE4392401B4/de not_active Expired - Fee Related
- 1993-05-25 SG SG1996004921A patent/SG44645A1/en unknown
- 1993-05-25 JP JP6500317A patent/JPH08501064A/ja active Pending
- 1993-05-25 AU AU40847/93A patent/AU682310B2/en not_active Ceased
- 1993-05-25 CH CH00311/94A patent/CH688911A5/de not_active IP Right Cessation
- 1993-05-25 KR KR1019940704279A patent/KR100293882B1/ko not_active IP Right Cessation
- 1993-05-25 CH CH00680/98A patent/CH690491A5/de not_active IP Right Cessation
- 1993-05-25 GB GB9423366A patent/GB2282066B/en not_active Expired - Fee Related
- 1993-05-25 HU HU9403371A patent/HUT70177A/hu unknown
- 1993-05-25 SK SK1434-94A patent/SK280320B6/sk not_active IP Right Cessation
- 1993-05-25 DE DE4392401T patent/DE4392401T1/de active Pending
- 1993-05-25 NL NL9320034A patent/NL195056C/nl not_active IP Right Cessation
- 1993-05-25 ES ES09450004A patent/ES2107357B1/es not_active Expired - Fee Related
- 1993-05-25 NZ NZ252268A patent/NZ252268A/en not_active IP Right Cessation
- 1993-05-25 CA CA002136751A patent/CA2136751C/en not_active Expired - Fee Related
- 1993-05-25 RU RU94046097/14A patent/RU2152225C1/ru not_active IP Right Cessation
- 1993-05-25 CZ CZ19942937A patent/CZ292449B6/cs not_active IP Right Cessation
- 1993-05-26 GR GR930100213A patent/GR1001550B/el not_active IP Right Cessation
- 1993-05-27 MC MC2243A patent/MC2330A1/xx unknown
- 1993-05-27 IT ITMI931099A patent/IT1271139B/it active IP Right Grant
- 1993-05-28 BE BE9300551A patent/BE1006143A3/fr not_active IP Right Cessation
- 1993-05-28 FR FR9306432A patent/FR2691631B1/fr not_active Expired - Fee Related
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1994
- 1994-11-23 LU LU88559A patent/LU88559A1/fr unknown
- 1994-11-25 NO NO19944535A patent/NO311006B1/no unknown
- 1994-11-25 FI FI945553A patent/FI112603B/fi active
- 1994-11-28 DK DK199401353A patent/DK176134B1/da not_active IP Right Cessation
- 1994-11-28 SE SE9404115A patent/SE501970C2/sv unknown
-
1995
- 1995-06-07 US US08/473,303 patent/US5889110A/en not_active Expired - Fee Related
-
1997
- 1997-06-26 HK HK133097A patent/HK133097A/xx not_active IP Right Cessation
-
1999
- 1999-01-22 US US09/235,270 patent/US6034175A/en not_active Expired - Fee Related
-
2001
- 2001-11-16 US US09/988,068 patent/US20020198315A1/en not_active Abandoned
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