DE4392401B4 - Verfahren zur Herstellung einer Lösung oder Dispersion eines Peptid-Polyester-Salzes - Google Patents

Verfahren zur Herstellung einer Lösung oder Dispersion eines Peptid-Polyester-Salzes Download PDF

Info

Publication number
DE4392401B4
DE4392401B4 DE4392401A DE4392401A DE4392401B4 DE 4392401 B4 DE4392401 B4 DE 4392401B4 DE 4392401 A DE4392401 A DE 4392401A DE 4392401 A DE4392401 A DE 4392401A DE 4392401 B4 DE4392401 B4 DE 4392401B4
Authority
DE
Germany
Prior art keywords
peptide
dispersion
preparing
solution
polyester salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE4392401A
Other languages
English (en)
Other versions
DE4392401T1 (de
Inventor
Francis Gowland Hutchinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Application granted granted Critical
Publication of DE4392401B4 publication Critical patent/DE4392401B4/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE4392401A 1992-05-28 1993-05-25 Verfahren zur Herstellung einer Lösung oder Dispersion eines Peptid-Polyester-Salzes Expired - Fee Related DE4392401B4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB@@@@A GB9211268D0 (en) 1992-05-28 1992-05-28 Salts of basic peptides with carboxyterminated polyesters
PCT/GB1993/001079 WO1993024150A1 (en) 1992-05-28 1993-05-25 Salts of peptides with carboxy-terminated polyesters

Publications (1)

Publication Number Publication Date
DE4392401B4 true DE4392401B4 (de) 2007-05-16

Family

ID=10716132

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4392401A Expired - Fee Related DE4392401B4 (de) 1992-05-28 1993-05-25 Verfahren zur Herstellung einer Lösung oder Dispersion eines Peptid-Polyester-Salzes
DE4392401T Pending DE4392401T1 (de) 1992-05-28 1993-05-25 Salze von Peptiden mit carboxy-terminierten Polyestern

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE4392401T Pending DE4392401T1 (de) 1992-05-28 1993-05-25 Salze von Peptiden mit carboxy-terminierten Polyestern

Country Status (33)

Country Link
US (3) US5889110A (de)
JP (1) JPH08501064A (de)
KR (1) KR100293882B1 (de)
AT (1) AT407702B (de)
AU (1) AU682310B2 (de)
BE (1) BE1006143A3 (de)
CA (1) CA2136751C (de)
CH (2) CH690491A5 (de)
CZ (1) CZ292449B6 (de)
DE (2) DE4392401B4 (de)
DK (1) DK176134B1 (de)
ES (1) ES2107357B1 (de)
FI (1) FI112603B (de)
FR (1) FR2691631B1 (de)
GB (3) GB9211268D0 (de)
GR (1) GR1001550B (de)
HK (1) HK133097A (de)
HU (1) HUT70177A (de)
IE (1) IE74715B1 (de)
IL (1) IL105710A (de)
IT (1) IT1271139B (de)
LU (1) LU88559A1 (de)
MC (1) MC2330A1 (de)
NL (1) NL195056C (de)
NO (1) NO311006B1 (de)
NZ (1) NZ252268A (de)
RU (1) RU2152225C1 (de)
SE (1) SE501970C2 (de)
SG (1) SG44645A1 (de)
SK (1) SK280320B6 (de)
TW (1) TW223018B (de)
WO (1) WO1993024150A1 (de)
ZA (1) ZA933358B (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
ATE203157T1 (de) * 1996-12-20 2001-08-15 Alza Corp Injizierbare depotgelzubereitung und herstellungsverfahren
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
US20070009605A1 (en) * 1998-07-23 2007-01-11 Ignatious Francis X Encapsulation of water soluble peptides
EP1240896A3 (de) * 1998-07-23 2003-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Einkapseln von wasserlöslischen Peptiden
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
CO5160256A1 (es) * 1999-02-08 2002-05-30 Zentaris Ag Sales de peptidos farmaceuticamente activos para la liberacion sostenida y proceso de produccion
US7018645B1 (en) 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
EP1292285A4 (de) * 2000-06-02 2009-07-22 Eisai Corp North America Darreichungssystem für bioaktive stoffe
US6706289B2 (en) * 2000-10-31 2004-03-16 Pr Pharmaceuticals, Inc. Methods and compositions for enhanced delivery of bioactive molecules
EP1408876A4 (de) 2001-06-22 2004-09-22 Durect Corp Koaxiale implantate nullter ordnung mit verlängerter freisetzung
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
EP1429731B1 (de) * 2001-09-19 2007-01-03 Elan Pharma International Limited Nanopartikelzusammensetzungen enthaltend insulin
JP4850390B2 (ja) * 2001-10-19 2012-01-11 アイデックス ラボラトリーズ インコーポレイテッド 薬理学的に活性な化合物の制御送達のための注射用組成物
CA2467239A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
DE10206517A1 (de) * 2002-02-16 2003-09-04 Stoess & Co Gelatine Depotarzneimittel, Trägermaterialien für Depotarzneimittel und Verfahren zu deren Herstellung
ES2292655T3 (es) * 2002-03-15 2008-03-16 Alrise Biosystems Gmbh Microparticulas y procedimiento para su preparacion.
US9101540B2 (en) * 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
AR039729A1 (es) * 2002-06-25 2005-03-09 Alza Corp Formulaciones de deposito de corta duracion
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CA2490351C (en) * 2002-06-25 2011-11-01 Takeda Pharmaceutical Company Limited Process for producing sustained-release composition
ES2319400T3 (es) * 2002-07-31 2009-05-07 Durect Corporation Composiciones deposito inyectables y empleo de las mismas.
MXPA05001244A (es) * 2002-07-31 2005-06-08 Alza Corp Composiciones de deposito de polimero multimodal inyectable y usos de las mismas.
PT1534340E (pt) 2002-09-06 2012-03-13 Cerulean Pharma Inc Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente
MXPA05004927A (es) 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
SI1594517T1 (sl) 2003-01-28 2007-10-31 Microbia Inc Sestavki za zdravljenje gastrointestinalnih motenj
ATE492292T2 (de) * 2003-04-02 2011-01-15 Ares Trading Sa Flüssige oder gefriergetrocknete pharmazeutische zusammensetzung enthaltend fsh und/oder lh, das nichtionische tensid poloxamer 188 und ein antibakterielles mittel
US20040224024A1 (en) * 2003-04-23 2004-11-11 Massachusetts Institute Of Technology Controlled drug release formulations containing polyion complexes
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
EP1638595B1 (de) * 2003-06-20 2013-03-20 Ares Trading S.A. Gefriergetrocknete fsh / lh formulierungen
EP1660013A4 (de) 2003-08-26 2011-07-20 Gel Del Technologies Inc Protein-biomaterialien und biokoazervate und herstellungs- und verwendungsverfahren dafür
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
EP1682537B1 (de) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulatoren der zellulären adhäsion
WO2005055945A2 (en) 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
WO2005074968A2 (en) * 2004-02-10 2005-08-18 Universiteit Maastricht Medical use of basic peptides
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
US8562505B2 (en) * 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US7846201B2 (en) * 2004-02-20 2010-12-07 The Children's Hospital Of Philadelphia Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
US9028829B2 (en) * 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
EP1674082A1 (de) * 2004-12-22 2006-06-28 Zentaris GmbH Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
ES2614080T3 (es) 2005-05-17 2017-05-29 Sarcode Bioscience Inc. Composiciones y métodos para el tratamiento de trastornos oculares
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8945598B2 (en) 2005-12-29 2015-02-03 Cordis Corporation Low temperature drying methods for forming drug-containing polymeric compositions
EP1837014A1 (de) * 2006-03-21 2007-09-26 Hexal Ag Subkutane Implantate welche ein abbau-resistentes Polylactid-Polymer und ein LH-RH Analogon enthalten
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
EP1917971A1 (de) * 2006-10-27 2008-05-07 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Zusammensetzungen mit verlängerter Wirkstofffreigabe, enthaltend Polymere mit sehr niedrigem Molekulargewicht
KR100816065B1 (ko) 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
EP2170930B3 (de) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP3797775A1 (de) 2007-10-19 2021-03-31 Novartis AG Zusammensetzungen und verfahren zur behandlung von diabetischer retinopathie
US20090163603A1 (en) * 2007-12-20 2009-06-25 Eastman Chemical Company Sulfo-polymer powder and sulfo-polymer powder blends
US20090163449A1 (en) * 2007-12-20 2009-06-25 Eastman Chemical Company Sulfo-polymer powder and sulfo-polymer powder blends with carriers and/or additives
EP2237770A4 (de) 2007-12-26 2011-11-09 Gel Del Technologies Inc Biokompatible proteinteilchen, teilchenvorrichtungen und verfahren dafür
TWI442932B (zh) * 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US10016534B2 (en) 2008-11-17 2018-07-10 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
US8822546B2 (en) * 2008-12-01 2014-09-02 Medtronic, Inc. Flowable pharmaceutical depot
WO2011034954A1 (en) 2009-09-15 2011-03-24 Cerulean Pharma Inc. Treatment of cancer
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
CN102665690A (zh) * 2009-12-22 2012-09-12 武田药品工业株式会社 缓释制剂
DE102010003615A1 (de) * 2010-04-01 2011-10-06 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Herstellung eines Drug-Delivery-Systems auf der Basis von Polyelektrolytkomplexen
MX2012013100A (es) 2010-05-18 2013-01-22 Cerulean Pharma Inc Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades.
EP2585092A1 (de) 2010-06-24 2013-05-01 Torrent Pharmaceuticals Limited Pharmazeutische zusammensetzung mit goserelin für ein in-situ-implantat
SG186070A1 (en) * 2010-06-25 2013-01-30 Takeda Pharmaceutical Sustained-release formulation
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2012250776B2 (en) 2011-05-04 2017-06-15 Balance Therapeutics, Inc. Pentylenetetrazole derivatives
KR101467275B1 (ko) * 2011-12-19 2014-12-02 주식회사 삼양바이오팜 분산성이 향상된 생분해성 고분자 미립자의 조성물 및 그 제조방법
CN104797574B (zh) 2012-07-25 2019-11-22 原生质生物科学股份有限公司 Lfa-1抑制剂及其多晶型物
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
EP2958577A2 (de) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylat-cyclase-rezeptoragonisten zur verwendung bei der darmreinigung
CA2901015A1 (en) * 2013-03-04 2014-09-12 Besins Healthcare Luxembourg Sarl Dry pharmaceutical compositions comprising active agent nanoparticles bound to carrier particles
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
MY176976A (en) 2013-10-10 2020-08-28 Bausch Health Ireland Ltd Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
JP7030517B2 (ja) 2015-01-07 2022-03-07 トライジェミナ， インコーポレイテッド マグネシウム含有オキシトシン製剤および使用の方法
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
WO2017123634A1 (en) 2016-01-11 2017-07-20 Synergy Pharmaceuticals, Inc. Formulations and methods for treating ulcerative colitis
CN105963258B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
US20210154147A1 (en) * 2018-10-19 2021-05-27 Ac Pharmaceuticals Co., Ltd. Preparation method of sustained-release microparticles
CN110954491B (zh) * 2019-12-09 2022-11-15 北京博恩特药业有限公司 用于测量醋酸戈舍瑞林缓释植入剂体外溶出度的方法
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
EP4192509A1 (de) 2020-08-05 2023-06-14 Ellipses Pharma Ltd Behandlung von krebs mit einem cyclodextrinhaltigen polymer-topoisomerase-inhibitor-konjugat und einem parp-inhibitor
BR112024002231A2 (pt) 2021-08-05 2024-04-30 Medincell S A Composição farmacêutica

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058481B1 (de) * 1981-02-16 1986-10-01 Zeneca Limited Pharmazeutische Zusammensetzungen für die kontinuierliche Freigabe des Wirkstoffes
EP0350246A2 (de) * 1988-07-05 1990-01-10 Takeda Chemical Industries, Ltd. Mikrokapsel mit verzögerter Freigabe für wasserlösliche Arzneistoffe
US4997643A (en) * 1989-07-12 1991-03-05 Union Carbide Chemicals And Plastics Company Inc. Polymeric salt delivery systems

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US5005602A (en) * 1985-12-24 1991-04-09 Dover Corporation Poppet valve assembly
FR2600894B1 (fr) * 1986-07-02 1989-01-13 Centre Nat Rech Scient Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
CH679207A5 (de) * 1989-07-28 1992-01-15 Debiopharm Sa
CA2065156A1 (en) * 1990-07-03 1992-01-04 Richard L. Dunn Intragingival delivery systems for treatment of periodontal disease
CA2046830C (en) * 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5672659A (en) * 1993-01-06 1997-09-30 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058481B1 (de) * 1981-02-16 1986-10-01 Zeneca Limited Pharmazeutische Zusammensetzungen für die kontinuierliche Freigabe des Wirkstoffes
EP0350246A2 (de) * 1988-07-05 1990-01-10 Takeda Chemical Industries, Ltd. Mikrokapsel mit verzögerter Freigabe für wasserlösliche Arzneistoffe
US4997643A (en) * 1989-07-12 1991-03-05 Union Carbide Chemicals And Plastics Company Inc. Polymeric salt delivery systems

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Lawter, J.R. [u.a.]: Drug Release From Poly (Gly- colide-Co-DL Lactide) Microcapsules. In: Proced. Inter. Symp. Control. Rel. Bioact. Mater. 1987, No. 14, S. 99-100 *

Also Published As

Publication number Publication date
SE501970C2 (sv) 1995-07-03
ZA933358B (en) 1994-09-15
ITMI931099A1 (it) 1994-11-27
AT407702B (de) 2001-05-25
LU88559A1 (fr) 1995-04-05
DK135394A (da) 1994-11-28
IE930358A1 (en) 1993-12-01
US5889110A (en) 1999-03-30
RU94046097A (ru) 1996-09-20
CA2136751C (en) 2006-10-31
HK133097A (en) 1997-10-24
CH688911A5 (de) 1998-05-29
NL9320034A (nl) 1995-04-03
ES2107357A1 (es) 1997-11-16
US20020198315A1 (en) 2002-12-26
CH690491A5 (de) 2000-09-29
ES2107357B1 (es) 1998-10-16
GB2282066B (en) 1996-11-06
SE9404115D0 (sv) 1994-11-28
GB9423366D0 (en) 1995-01-25
FR2691631A1 (fr) 1993-12-03
SG44645A1 (en) 1997-12-19
FI945553A (fi) 1995-01-25
ITMI931099A0 (it) 1993-05-27
NO311006B1 (no) 2001-10-01
CZ293794A3 (en) 1995-03-15
AU4084793A (en) 1993-12-30
SE9404115L (sv) 1994-11-28
HUT70177A (en) 1995-09-28
TW223018B (en) 1994-05-01
ATA901993A (de) 2000-10-15
IE74715B1 (en) 1997-07-30
WO1993024150A1 (en) 1993-12-09
GB9211268D0 (en) 1992-07-15
BE1006143A3 (fr) 1994-05-24
HU9403371D0 (en) 1995-02-28
IL105710A0 (en) 1993-09-22
GB9309645D0 (en) 1993-06-23
NO944535D0 (no) 1994-11-25
AU682310B2 (en) 1997-10-02
SK143494A3 (en) 1995-07-11
DK176134B1 (da) 2006-09-18
US6034175A (en) 2000-03-07
IT1271139B (it) 1997-05-27
GB2282066A (en) 1995-03-29
NL195056C (nl) 2003-07-01
FI112603B (fi) 2003-12-31
RU2152225C1 (ru) 2000-07-10
JPH08501064A (ja) 1996-02-06
FR2691631B1 (fr) 1995-06-09
MC2330A1 (fr) 1994-05-31
FI945553A0 (fi) 1994-11-25
IL105710A (en) 2001-03-19
NO944535L (no) 1995-01-25
NZ252268A (en) 1996-12-20
GR1001550B (el) 1994-04-29
KR100293882B1 (ko) 2001-09-17
SK280320B6 (sk) 1999-11-08
CA2136751A1 (en) 1993-12-09
DE4392401T1 (de) 1997-07-24
CZ292449B6 (cs) 2003-09-17

Similar Documents

Publication Publication Date Title
DE4392401B4 (de) Verfahren zur Herstellung einer Lösung oder Dispersion eines Peptid-Polyester-Salzes
DE69326101T2 (de) Verfahren zur Herstellung eines geformten gebundenen Nahrungsmittels
DE69328220D1 (de) Verfahren zur Herstellung einer Phasenschiebermaske oder eines Phasenschiebermasken-Rohlings
DE69125118T2 (de) Verfahren zur Herstellung eines Diamant-Überzuges
DE69301845D1 (de) Verfahren zur Herstellung eines Bisphenols
DE69303585D1 (de) Verfahren zur Herstellung eines Motivs
DE69307577D1 (de) Verfahren zur Herstellung eines Biphenylderivates
DE69014040D1 (de) Verfahren zur Herstellung von Alkylglykoside oder wässriger Lösung davon.
DE69229931D1 (de) Verfahren zur Herstellung von Fruktose enthaltender Lösung
DE69026757T2 (de) Verfahren zur Herstellung einer Silberhalogenidemulsion
DE69207818T2 (de) Verfahren zur Herstellung von einer Fluorverbindung
AT363600B (de) Verfahren zur herstellung einer waesserigen loesung eines rafoxanide-polyvinylpyrrolidon-komplexes
DE69609933D1 (de) Verfahren zur Herstellung einer Lösung eines Alkalisalzes von Anthrahydrochinon
DE59306359D1 (de) Verfahren zur Herstellung von Alkoholen oder Aminen
DE59406129D1 (de) Verfahren zur Herstellung einer Plastisol-Zusammensetzung
DE69208385T2 (de) Verfahren zur Herstellung von N-Alkyl-N-Methylamin oder N-Alkenyl-N-Methylamin
DE69313420T2 (de) Verfahren zur Herstellung von 4-Nitrosodiphenylamin oder dessen Salzen
DE69211395D1 (de) Verfahren zur Herstellung einer Rhodium-Nitrat-Lösung
DE69119941T2 (de) Verfahren zur Herstellung eines 3-Formylcephem-Derivats
DE69301452D1 (de) Verfahren zur Herstellung eines teilsubstituierten Fluorosilans
DE69117667D1 (de) Verfahren zur Herstellung eines Bandkabels
DE69305286D1 (de) Verfahren zur Herstellung von 3-Oxo-2-pentyl-1-cyclopentenessigsäurealkylester
AT374343B (de) Verfahren zur herstellung eines salzlecksteines
DE69127404T2 (de) Verfahren zur Herstellung einer Silberhalogenidemulsion
ATA1687A (de) Verfahren zur herstellung eines 1,5-benzothiazepinderivates oder eines salzes davon

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee