FR2574080B1 - Esters et amides d'amino-acides en tant qu'inhibiteurs de la renine - Google Patents

Esters et amides d'amino-acides en tant qu'inhibiteurs de la renine

Info

Publication number
FR2574080B1
FR2574080B1 FR858517860A FR8517860A FR2574080B1 FR 2574080 B1 FR2574080 B1 FR 2574080B1 FR 858517860 A FR858517860 A FR 858517860A FR 8517860 A FR8517860 A FR 8517860A FR 2574080 B1 FR2574080 B1 FR 2574080B1
Authority
FR
France
Prior art keywords
amides
esters
amino acids
renin inhibitors
renin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR858517860A
Other languages
English (en)
Other versions
FR2574080A1 (fr
Inventor
Denis E Ryono
Edward W Petrillo Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2574080A1 publication Critical patent/FR2574080A1/fr
Application granted granted Critical
Publication of FR2574080B1 publication Critical patent/FR2574080B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors
FR858517860A 1984-12-03 1985-12-03 Esters et amides d'amino-acides en tant qu'inhibiteurs de la renine Expired - Fee Related FR2574080B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/677,714 US4629724A (en) 1984-12-03 1984-12-03 Amino acid ester and amide renin inhibitors

Publications (2)

Publication Number Publication Date
FR2574080A1 FR2574080A1 (fr) 1986-06-06
FR2574080B1 true FR2574080B1 (fr) 1990-03-30

Family

ID=24719842

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858517860A Expired - Fee Related FR2574080B1 (fr) 1984-12-03 1985-12-03 Esters et amides d'amino-acides en tant qu'inhibiteurs de la renine

Country Status (7)

Country Link
US (1) US4629724A (fr)
JP (1) JPH0720990B2 (fr)
CA (1) CA1269497A (fr)
DE (1) DE3542567A1 (fr)
FR (1) FR2574080B1 (fr)
GB (1) GB2167759B (fr)
IT (1) IT1201499B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) * 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4749781A (en) * 1985-11-12 1988-06-07 E. R. Squibb & Sons, Inc. Aminocarbonyl renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
US4766109A (en) * 1986-10-17 1988-08-23 Schering Corporation Hydrophobic peptides
DE3635907A1 (de) * 1986-10-22 1988-04-28 Merck Patent Gmbh Hydroxy-aminosaeurederivate
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
US4981843A (en) * 1988-04-07 1991-01-01 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol derivatives
US5047399A (en) * 1988-07-13 1991-09-10 Schering Corporation Hydrophobic pseudo-peptides
AU655301B2 (en) * 1991-05-23 1994-12-15 Merrell Pharmaceuticals Inc. Inhibitors of cathepsin G and elastase for preventing connective tissue degradation
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5463104A (en) * 1992-08-25 1995-10-31 G. D. Searle & Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6022994A (en) * 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5783701A (en) 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
ATE184594T1 (de) * 1994-03-07 1999-10-15 Vertex Pharma Sulfonamidderivate als aspartylprotease- inhibitoren
HU221311B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
PL337755A1 (en) * 1997-05-08 2000-09-11 Smithkline Beecham Corp Protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU767728B2 (en) 1998-06-19 2003-11-20 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
AU4862799A (en) 1998-07-08 2000-02-01 G.D. Searle & Co. Retroviral protease inhibitors
TWI260322B (en) * 1999-02-12 2006-08-21 Vertex Pharma Inhibitors of aspartyl protease
SI1159278T1 (sl) * 1999-02-12 2006-06-30 Vertex Pharma Inhibitorji aspartil proteaze
JP4894375B2 (ja) * 2006-06-29 2012-03-14 アイシン精機株式会社 電動ポンプ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
EP0104041B1 (fr) * 1982-09-15 1988-07-27 Aktiebolaget Hässle Inhibiteurs d'enzyme
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds
US4539312A (en) * 1984-07-11 1985-09-03 E. R. Squibb & Sons, Inc. Use of diamino ketones as analgesic agents
US4616088A (en) * 1984-10-29 1986-10-07 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitor

Also Published As

Publication number Publication date
JPH0720990B2 (ja) 1995-03-08
US4629724A (en) 1986-12-16
IT8523049A0 (it) 1985-12-02
IT1201499B (it) 1989-02-02
CA1269497C (fr) 1990-05-22
CA1269497A (fr) 1990-05-22
FR2574080A1 (fr) 1986-06-06
GB2167759A (en) 1986-06-04
GB2167759B (en) 1988-09-21
JPS61137897A (ja) 1986-06-25
DE3542567A1 (de) 1986-06-05
GB8529058D0 (en) 1986-01-02

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Legal Events

Date Code Title Description
ST Notification of lapse