CA1269497C - Ester et amide d'acides amines inhibiteurs de la renine - Google Patents

Ester et amide d'acides amines inhibiteurs de la renine

Info

Publication number
CA1269497C
CA1269497C CA496343A CA496343A CA1269497C CA 1269497 C CA1269497 C CA 1269497C CA 496343 A CA496343 A CA 496343A CA 496343 A CA496343 A CA 496343A CA 1269497 C CA1269497 C CA 1269497C
Authority
CA
Canada
Prior art keywords
amino acid
acid ester
renin inhibitors
amide
amide renin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA496343A
Other languages
English (en)
Other versions
CA1269497A (fr
Inventor
Denis E Ryono
Edward W Petrillo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000496343A priority Critical patent/CA1269497A/fr
Application granted granted Critical
Publication of CA1269497C publication Critical patent/CA1269497C/fr
Publication of CA1269497A publication Critical patent/CA1269497A/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000496343A 1984-12-03 1985-11-27 Ester et amide d'acides amines inhibiteurs de la renine Expired - Lifetime CA1269497A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000496343A CA1269497A (fr) 1984-12-03 1985-11-27 Ester et amide d'acides amines inhibiteurs de la renine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/677,714 US4629724A (en) 1984-12-03 1984-12-03 Amino acid ester and amide renin inhibitors
US677,714 1984-12-03
CA000496343A CA1269497A (fr) 1984-12-03 1985-11-27 Ester et amide d'acides amines inhibiteurs de la renine

Publications (2)

Publication Number Publication Date
CA1269497C true CA1269497C (fr) 1990-05-22
CA1269497A CA1269497A (fr) 1990-05-22

Family

ID=24719842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000496343A Expired - Lifetime CA1269497A (fr) 1984-12-03 1985-11-27 Ester et amide d'acides amines inhibiteurs de la renine

Country Status (7)

Country Link
US (1) US4629724A (fr)
JP (1) JPH0720990B2 (fr)
CA (1) CA1269497A (fr)
DE (1) DE3542567A1 (fr)
FR (1) FR2574080B1 (fr)
GB (1) GB2167759B (fr)
IT (1) IT1201499B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040122000A1 (en) * 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4749781A (en) * 1985-11-12 1988-06-07 E. R. Squibb & Sons, Inc. Aminocarbonyl renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
US4766109A (en) * 1986-10-17 1988-08-23 Schering Corporation Hydrophobic peptides
DE3635907A1 (de) * 1986-10-22 1988-04-28 Merck Patent Gmbh Hydroxy-aminosaeurederivate
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
US4981843A (en) * 1988-04-07 1991-01-01 E. R. Squibb & Sons, Inc. N-heterocyclic alcohol derivatives
US5047399A (en) * 1988-07-13 1991-09-10 Schering Corporation Hydrophobic pseudo-peptides
DE69229552T2 (de) * 1991-05-23 1999-12-23 Merrell Pharma Inc Hemmstoffe für kathepsin-g und elastase zur verhütung von bindegewebsabbau
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US6022994A (en) * 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1994004491A1 (fr) * 1992-08-25 1994-03-03 G.D. Searle & Co. N-(alcanoylamino)-2-hydroxypropyl)-sulfamides utiles comme inhibiteurs de proteases retrovirales
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
US5783701A (en) 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
WO1995024385A1 (fr) * 1994-03-07 1995-09-14 Vertex Pharmaceuticals Incorporated Derives de sulfamides en tant qu'inhibiteurs de protease d'aspartyle
DK0762887T3 (da) * 1994-06-02 2002-01-14 Merrell Pharma Inc Acylerede enolderivater som prodrugs for elastase-hæmmere
KR100366328B1 (ko) * 1994-06-02 2003-03-06 메렐 파마슈티칼스 인크. 엘라스타제의퍼플루오로알킬케톤억제제및이들의제조방법
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
WO1998050342A1 (fr) * 1997-05-08 1998-11-12 Smithkline Beecham Corporation Inhibiteurs de proteases
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
ATE285396T1 (de) * 1998-06-19 2005-01-15 Vertex Pharma Sulfonamide als aspartyl-protease-inhibitoren
US6538006B1 (en) 1998-07-08 2003-03-25 Pharmacia Corporation Retroviral protease inhibitors
DK1159278T3 (da) * 1999-02-12 2006-04-10 Vertex Pharma Inhibitorer af aspartylprotease
TNSN00027A1 (fr) * 1999-02-12 2005-11-10 Vertex Pharma Inhibiteurs de l'aspartyle protease
JP4894375B2 (ja) * 2006-06-29 2012-03-14 アイシン精機株式会社 電動ポンプ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
DE3377497D1 (en) * 1982-09-15 1988-09-01 Haessle Ab Enzyme inhibitors
EP0118223A1 (fr) * 1983-02-07 1984-09-12 Aktiebolaget Hässle Inhibiteurs d'enzymes
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds
US4539312A (en) * 1984-07-11 1985-09-03 E. R. Squibb & Sons, Inc. Use of diamino ketones as analgesic agents
US4616088A (en) * 1984-10-29 1986-10-07 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitor

Also Published As

Publication number Publication date
IT8523049A0 (it) 1985-12-02
GB8529058D0 (en) 1986-01-02
JPH0720990B2 (ja) 1995-03-08
CA1269497A (fr) 1990-05-22
IT1201499B (it) 1989-02-02
FR2574080B1 (fr) 1990-03-30
JPS61137897A (ja) 1986-06-25
FR2574080A1 (fr) 1986-06-06
US4629724A (en) 1986-12-16
DE3542567A1 (de) 1986-06-05
GB2167759A (en) 1986-06-04
GB2167759B (en) 1988-09-21

Similar Documents

Publication Publication Date Title
CA1269497C (fr) Ester et amide d'acides amines inhibiteurs de la renine
CA1274346C (fr) Derives amides et esters d'acides amines inhibant la resine
EP0223437A3 (fr) Inhibiteurs aminocarbonyles de la rénine
DE3368639D1 (en) Amino and substituted amino phosphinylalkanoyl compounds
DE3277302D1 (en) Phosphorus containing compounds
MY137301A (en) Peptide analogs as irreversible interleukin-1b protease inhibitors
ES8800958A1 (es) Un procedimiento para preparar nuevos dipeptidos con actividad inhibidora de renina.
CA2200192A1 (fr) Inhibiteurs amidino et guanidino substitues d'enzymes semblables a la trypsine
CA2267879A1 (fr) Succinamides heteroaryle et leur utilisation comme inhibiteurs de metalloproteinases
TW327172B (en) Novel mercaptoacetylamide bicyclic lactam derivatives
IE861458L (en) 2-thio or oxo-4-aryl or heterocyclo-1, 5(2h)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters
EP0310070A3 (fr) Alpha-aminoacyl-bêta-aminoacyl aminodiols comme agents anti-hypertensifs
ES8305695A1 (es) Procedimiento para preparar derivados de amidas.
EP0310072A3 (fr) Bêta-succinamidoacyl aminodiols non peptidiques comme agents anti-hypertensifs
EP0313847A3 (fr) Alpha-succinamidoacyl aminodiols non peptidiques comme agents anti-hypertensifs
ES2002469A6 (es) Un procedimiento para la preparacion de nuevos di -.tri -. y tetrapeptidos inhibidores de renina.
CA1269496C (fr) Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides
ES8707549A1 (es) Un procedimiento para preparar compuestos peptidicos sustituidos
NZ211632A (en) Substituted aminothiol dipeptide derivatives and intermediates
EP0249445A3 (fr) Phosphonates aminoalcanoylamino alkyl substitués inhibiteurs d'enzymes convertissant l'angiotensine
FI883134A0 (fi) Fluorhaltiga renin-inhibitorer.
EP0216280A3 (en) Use of alkenylsuccinic monoamides as corrosion inhibitors
ES8700658A1 (es) Un procedimiento para preparar compuestos relacionados con histargina
ES457563A1 (es) Procedimiento para la obtencion de derivados de dipeptidos.
DE69634203D1 (de) Cis-9,10-octadecenoamidase

Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19951122