IT8820172A0 - Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. - Google Patents

Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Info

Publication number
IT8820172A0
IT8820172A0 IT8820172A IT2017288A IT8820172A0 IT 8820172 A0 IT8820172 A0 IT 8820172A0 IT 8820172 A IT8820172 A IT 8820172A IT 2017288 A IT2017288 A IT 2017288A IT 8820172 A0 IT8820172 A0 IT 8820172A0
Authority
IT
Italy
Prior art keywords
cyclomethylen
amides
procedures
contain
preparation
Prior art date
Application number
IT8820172A
Other languages
English (en)
Other versions
IT1224627B (it
Inventor
Luigi Turbanti
Guido Cerbai
Marco Criscuoli
Original Assignee
Guidotti & C Spa Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidotti & C Spa Labor filed Critical Guidotti & C Spa Labor
Publication of IT8820172A0 publication Critical patent/IT8820172A0/it
Priority to IT8820172A priority Critical patent/IT1224627B/it
Priority to AT89106304T priority patent/ATE101126T1/de
Priority to ES89106304T priority patent/ES2061759T3/es
Priority to EP89106304A priority patent/EP0337348B1/en
Priority to DE68912811T priority patent/DE68912811T2/de
Priority to IL89895A priority patent/IL89895A0/xx
Priority to HU891735A priority patent/HU206194B/hu
Priority to PT90254A priority patent/PT90254B/pt
Priority to FI891712A priority patent/FI891712A/fi
Priority to UA4614855A priority patent/UA15920A/uk
Priority to SU894613962A priority patent/RU2004538C1/ru
Priority to DK173689A priority patent/DK173689A/da
Priority to NZ228688A priority patent/NZ228688A/en
Priority to CA000596331A priority patent/CA1314903C/en
Priority to NO891484A priority patent/NO177851C/no
Priority to PL1989278804A priority patent/PL159413B1/pl
Priority to CN89102213A priority patent/CN1037344A/zh
Priority to YU00738/89A priority patent/YU73889A/xx
Priority to AU32655/89A priority patent/AU611796B2/en
Priority to IN283/CAL/89A priority patent/IN169836B/en
Priority to MX1563589A priority patent/MX15635A/es
Priority to ZA892674A priority patent/ZA892674B/xx
Priority to BG88028A priority patent/BG60556B1/bg
Priority to JP1092774A priority patent/JPH026452A/ja
Priority to RO139231A priority patent/RO104347B1/ro
Priority to DD89327552A priority patent/DD294014A5/de
Priority to KR1019890004818A priority patent/KR900016097A/ko
Priority to SU894614855A priority patent/RU1838294C/ru
Application granted granted Critical
Publication of IT1224627B publication Critical patent/IT1224627B/it
Priority to US07/595,639 priority patent/US5095137A/en
Priority to IN1001/CAL/90A priority patent/IN172060B/en
Priority to IN1000/CAL/90A priority patent/IN172059B/en
Priority to HR940250A priority patent/HRP940250A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/61—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eyeglasses (AREA)
  • Polyamides (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
IT8820172A 1988-04-02 1988-04-12 Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. IT1224627B (it)

Priority Applications (32)

Application Number Priority Date Filing Date Title
IT8820172A IT1224627B (it) 1988-04-12 1988-04-12 Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
AT89106304T ATE101126T1 (de) 1988-04-12 1989-04-10 Amide von cyclomethylen-1,2 bicarbonsaeure mit therapeutischer wirkung, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zusammensetzungen.
ES89106304T ES2061759T3 (es) 1988-04-12 1989-04-10 Amidas de acidos ciclometilen-1,2-dicarboxilicos con actividad terapeutica, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
EP89106304A EP0337348B1 (en) 1988-04-12 1989-04-10 Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity, processes for their preparation and pharmaceutical compositions containing them
DE68912811T DE68912811T2 (de) 1988-04-12 1989-04-10 Amide von Cyclomethylen-1,2 bicarbonsäure mit therapeutischer Wirkung, Verfahren zu deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen.
IL89895A IL89895A0 (en) 1988-04-12 1989-04-10 Amides of cyclomethylene-1,2-bicarboxylic acids having therapeutical activity,processes for their preparation and pharmaceutical compositions containing them
HU891735A HU206194B (en) 1988-04-12 1989-04-11 Process for producing cyclomethylene-1,2-dicarboxylic acid derivatives and pharmaceutical compositions comprising same
PT90254A PT90254B (pt) 1988-04-12 1989-04-11 Processo para a preparacao de amidas de acidos ciclometileno -1,2-dicarboxilicos com actividade terapeutica e de composicoes farmaceuticas que as contem
FI891712A FI891712A (fi) 1988-04-12 1989-04-11 Terapeutiskt aktiva aminer av cyklometylen-1,2-bikarboxylsyror, foerfaranden foer deras framstaellning samt farmaceutiska kompositioner innehaollande dem.
UA4614855A UA15920A (uk) 1988-04-12 1989-04-11 Аміди циклометілеh-1, 2-дикарбоhових кислот, які мають гіпотеhзивhу активhість
SU894613962A RU2004538C1 (ru) 1988-04-12 1989-04-11 Способ получени амидов циклометилен-1,2-дикарбоновых кислот
DK173689A DK173689A (da) 1988-04-12 1989-04-11 Dicarboxylsyreamider
NZ228688A NZ228688A (en) 1988-04-12 1989-04-11 Amides of cycloalkane-1,2-dicarboxylic acids and pharmaceutical compositions thereof
CA000596331A CA1314903C (en) 1988-04-12 1989-04-11 Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity, processes for their preparation and pharmaceutical compositions containing them
NO891484A NO177851C (no) 1988-04-12 1989-04-11 Analogifremgangsmåte for fremstilling av cyklometylen-1,2-bikarboksylsyreamider med terapeutisk aktivitet
RO139231A RO104347B1 (en) 1988-04-12 1989-04-12 Production method of amids acids cyclomethylen - 1,2 - dicarboxylic
PL1989278804A PL159413B1 (pl) 1988-04-12 1989-04-12 cyklometyleno-1,2-dikarboksylowych PL PL PL PL PL PL
YU00738/89A YU73889A (en) 1988-04-12 1989-04-12 Amides of cyclomethylen-1,2-dicarboxylic acids and processes for obtaining thereof
AU32655/89A AU611796B2 (en) 1988-04-12 1989-04-12 Amides of cyclomethylen-1, 2-bicarboxylic acids having therapeutical activity, processes for their preparation and pharmaceutical compositions containing them
IN283/CAL/89A IN169836B (it) 1988-04-12 1989-04-12
MX1563589A MX15635A (es) 1988-04-12 1989-04-12 Amidas de acidos ciclometilen-1,2-dicarboxilicos y el procedimiento para su preparacion.
ZA892674A ZA892674B (en) 1988-04-12 1989-04-12 Amides of cyclomethylen-1,2-dicarboxylic acids having therapeutical activity,processes for their preparation and pharmaceutical compositions containing them
BG88028A BG60556B1 (bg) 1988-04-12 1989-04-12 Амиди на циклометилен-1,2-дикарбоксилни киселинис терапевтична активност,методи за получаването им и фармацевтични състави, които ги съдържат
JP1092774A JPH026452A (ja) 1988-04-12 1989-04-12 シクロメチレン―１，２―ジカルボン酸類のアミド類
CN89102213A CN1037344A (zh) 1988-04-12 1989-04-12 具有治疗活性的环亚甲基-1，2-二羧酸酰胺，制备它们的方法和含它们的药物组合物
DD89327552A DD294014A5 (de) 1988-04-12 1989-04-12 Verfahren zur herstellung von amiden von cyclomethylen-1,2-dicarbonsaeuren
KR1019890004818A KR900016097A (ko) 1988-04-12 1989-04-12 치료활성도를 가지는 시클로메틸렌-1,2-비카르복시산의 아미드, 이의 제조방법 및 이를 포함하는 제약학적 조성물
SU894614855A RU1838294C (ru) 1988-04-12 1989-08-28 Амиды циклометилен-1,2-дикарбоновых кислот, обладающие гипотензивной активностью
US07/595,639 US5095137A (en) 1988-04-02 1990-10-09 Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity
IN1001/CAL/90A IN172060B (it) 1988-04-12 1990-11-29
IN1000/CAL/90A IN172059B (it) 1988-04-12 1990-11-29
HR940250A HRP940250A2 (en) 1988-04-12 1994-04-15 Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8820172A IT1224627B (it) 1988-04-12 1988-04-12 Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Publications (2)

Publication Number Publication Date
IT8820172A0 true IT8820172A0 (it) 1988-04-12
IT1224627B IT1224627B (it) 1990-10-04

Family

ID=11164400

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8820172A IT1224627B (it) 1988-04-02 1988-04-12 Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Country Status (28)

Country Link
US (1) US5095137A (it)
EP (1) EP0337348B1 (it)
JP (1) JPH026452A (it)
KR (1) KR900016097A (it)
CN (1) CN1037344A (it)
AT (1) ATE101126T1 (it)
AU (1) AU611796B2 (it)
BG (1) BG60556B1 (it)
CA (1) CA1314903C (it)
DD (1) DD294014A5 (it)
DE (1) DE68912811T2 (it)
DK (1) DK173689A (it)
ES (1) ES2061759T3 (it)
FI (1) FI891712A (it)
HU (1) HU206194B (it)
IL (1) IL89895A0 (it)
IN (2) IN169836B (it)
IT (1) IT1224627B (it)
MX (1) MX15635A (it)
NO (1) NO177851C (it)
NZ (1) NZ228688A (it)
PL (1) PL159413B1 (it)
PT (1) PT90254B (it)
RO (1) RO104347B1 (it)
RU (2) RU2004538C1 (it)
UA (1) UA15920A (it)
YU (1) YU73889A (it)
ZA (1) ZA892674B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1252708B (it) * 1991-12-23 1995-06-26 Guidotti & C Spa Labor Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
IT1264860B1 (it) * 1993-06-21 1996-10-17 Guidotti & C Spa Labor Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US6028213A (en) 1998-04-16 2000-02-22 Eastman Chemical Company Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation
AU2007279092B2 (en) * 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
WO2008156831A2 (en) * 2007-06-20 2008-12-24 Vitae Pharmaceuticals, Inc. Renin inhibitors
US8106221B2 (en) 2007-06-20 2012-01-31 Vitae Pharmaceuticals, Inc. Renin inhibitors
TWI465251B (zh) 2008-01-08 2014-12-21 Lantheus Medical Imaging Inc 作為顯影劑的ｎ－烷氧基醯胺共軛物
AU2010271097B2 (en) 2009-07-08 2015-12-10 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4687841A (en) * 1985-10-18 1987-08-18 Monsanto Company Peptide hydroxamic acid derivatives

Also Published As

Publication number Publication date
FI891712A (fi) 1989-10-13
JPH026452A (ja) 1990-01-10
HU206194B (en) 1992-09-28
IL89895A0 (en) 1989-12-15
NO891484L (no) 1989-10-13
NO177851C (no) 1995-12-06
ES2061759T3 (es) 1994-12-16
HUT50105A (en) 1989-12-28
PL159413B1 (pl) 1992-12-31
RU2004538C1 (ru) 1993-12-15
RO104347B1 (en) 1993-04-15
AU3265589A (en) 1989-10-19
CA1314903C (en) 1993-03-23
DK173689A (da) 1989-10-13
KR900016097A (ko) 1990-11-12
ATE101126T1 (de) 1994-02-15
PT90254B (pt) 1994-07-29
FI891712A0 (fi) 1989-04-11
NO891484D0 (no) 1989-04-11
BG60556B1 (bg) 1995-08-28
IT1224627B (it) 1990-10-04
RU1838294C (ru) 1993-08-30
UA15920A (uk) 1997-06-30
NO177851B (no) 1995-08-28
DK173689D0 (da) 1989-04-11
EP0337348B1 (en) 1994-02-02
DE68912811T2 (de) 1994-06-16
DD294014A5 (de) 1991-09-19
PT90254A (pt) 1989-11-10
PL278804A1 (en) 1990-01-08
AU611796B2 (en) 1991-06-20
DE68912811D1 (de) 1994-03-17
IN169836B (it) 1991-12-28
US5095137A (en) 1992-03-10
IN172059B (it) 1993-03-27
ZA892674B (en) 1989-12-27
EP0337348A2 (en) 1989-10-18
EP0337348A3 (en) 1990-05-30
YU73889A (en) 1991-04-30
NZ228688A (en) 1992-03-26
MX15635A (es) 1993-12-01
CN1037344A (zh) 1989-11-22

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Effective date: 19940428