ES2061759T3 - Amidas de acidos ciclometilen-1,2-dicarboxilicos con actividad terapeutica, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents
Amidas de acidos ciclometilen-1,2-dicarboxilicos con actividad terapeutica, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2061759T3 ES2061759T3 ES89106304T ES89106304T ES2061759T3 ES 2061759 T3 ES2061759 T3 ES 2061759T3 ES 89106304 T ES89106304 T ES 89106304T ES 89106304 T ES89106304 T ES 89106304T ES 2061759 T3 ES2061759 T3 ES 2061759T3
- Authority
- ES
- Spain
- Prior art keywords
- cyclomethylene
- preparation
- amices
- procedures
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical group C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- -1 AMINO Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/61—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Eyeglasses (AREA)
- Polyamides (AREA)
Abstract
LAS AMIDAS DE ACIDO CICLOMETILENO- 1,2- BICARBOXILICO, TENIENDO LA FORMULA DESCRITA EN LA MEMORIA, ESTAN DOTADAS CON ACTIVIDAD DE INHIBICION ACE Y SON USADAS TERAPEUTICAMENTE COMO AGENTES ANTIHIPERTENSION. PARA SU PREPARACION ACIDO CICLOMETILENO- 1,2- BICARBOXILICO O UN DERIVADO DE EL SE CONDENSA CON UN AMINO DERIVADO CONTENIENDO UN GRUPO HIDROXAMICO PROTEGIDO, O CON UN AMINOESTER, Y ENTONCES EN EL CASO PRECEDENTE SE ELIMINAN LOS GRUPOS PROTEGIDOS, O EN EL ULTIMO CASO SE HACE REACCIONAR CON HIDROXILAMINA O N-ALQUILHIDROXILAMINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8820172A IT1224627B (it) | 1988-04-12 | 1988-04-12 | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061759T3 true ES2061759T3 (es) | 1994-12-16 |
Family
ID=11164400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89106304T Expired - Lifetime ES2061759T3 (es) | 1988-04-12 | 1989-04-10 | Amidas de acidos ciclometilen-1,2-dicarboxilicos con actividad terapeutica, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. |
Country Status (28)
Country | Link |
---|---|
US (1) | US5095137A (es) |
EP (1) | EP0337348B1 (es) |
JP (1) | JPH026452A (es) |
KR (1) | KR900016097A (es) |
CN (1) | CN1037344A (es) |
AT (1) | ATE101126T1 (es) |
AU (1) | AU611796B2 (es) |
BG (1) | BG60556B1 (es) |
CA (1) | CA1314903C (es) |
DD (1) | DD294014A5 (es) |
DE (1) | DE68912811T2 (es) |
DK (1) | DK173689A (es) |
ES (1) | ES2061759T3 (es) |
FI (1) | FI891712A (es) |
HU (1) | HU206194B (es) |
IL (1) | IL89895A0 (es) |
IN (2) | IN169836B (es) |
IT (1) | IT1224627B (es) |
MX (1) | MX15635A (es) |
NO (1) | NO177851C (es) |
NZ (1) | NZ228688A (es) |
PL (1) | PL159413B1 (es) |
PT (1) | PT90254B (es) |
RO (1) | RO104347B1 (es) |
RU (2) | RU2004538C1 (es) |
UA (1) | UA15920A (es) |
YU (1) | YU73889A (es) |
ZA (1) | ZA892674B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1252708B (it) * | 1991-12-23 | 1995-06-26 | Guidotti & C Spa Labor | Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
US5977160A (en) * | 1992-04-10 | 1999-11-02 | Brigham And Women's Hospital, Inc. | Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims |
IT1264860B1 (it) * | 1993-06-21 | 1996-10-17 | Guidotti & C Spa Labor | Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
US6028213A (en) | 1998-04-16 | 2000-02-22 | Eastman Chemical Company | Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation |
EP2046739B1 (en) * | 2006-07-24 | 2015-08-26 | UCB Biopharma SPRL | Substituted aniline derivatives |
WO2008156816A2 (en) | 2007-06-20 | 2008-12-24 | Vitae Pharmaceuticals, Inc. | Renin inhibitors |
WO2008156831A2 (en) * | 2007-06-20 | 2008-12-24 | Vitae Pharmaceuticals, Inc. | Renin inhibitors |
CN101970015B (zh) | 2008-01-08 | 2014-05-07 | 兰休斯医疗成像公司 | 作为显像剂的n-烷氧基酰胺共轭物 |
US8877157B2 (en) | 2009-07-08 | 2014-11-04 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4077998A (en) * | 1975-10-28 | 1978-03-07 | Morton-Norwich Products, Inc. | Phthaloyl amino acid hydroxamic acids |
US4687841A (en) * | 1985-10-18 | 1987-08-18 | Monsanto Company | Peptide hydroxamic acid derivatives |
-
1988
- 1988-04-12 IT IT8820172A patent/IT1224627B/it active
-
1989
- 1989-04-10 ES ES89106304T patent/ES2061759T3/es not_active Expired - Lifetime
- 1989-04-10 DE DE68912811T patent/DE68912811T2/de not_active Expired - Fee Related
- 1989-04-10 EP EP89106304A patent/EP0337348B1/en not_active Expired - Lifetime
- 1989-04-10 AT AT89106304T patent/ATE101126T1/de not_active IP Right Cessation
- 1989-04-10 IL IL89895A patent/IL89895A0/xx not_active IP Right Cessation
- 1989-04-11 HU HU891735A patent/HU206194B/hu not_active IP Right Cessation
- 1989-04-11 NZ NZ228688A patent/NZ228688A/en unknown
- 1989-04-11 UA UA4614855A patent/UA15920A/uk unknown
- 1989-04-11 RU SU894613962A patent/RU2004538C1/ru active
- 1989-04-11 PT PT90254A patent/PT90254B/pt not_active IP Right Cessation
- 1989-04-11 CA CA000596331A patent/CA1314903C/en not_active Expired - Fee Related
- 1989-04-11 NO NO891484A patent/NO177851C/no unknown
- 1989-04-11 FI FI891712A patent/FI891712A/fi not_active Application Discontinuation
- 1989-04-11 DK DK173689A patent/DK173689A/da not_active IP Right Cessation
- 1989-04-12 JP JP1092774A patent/JPH026452A/ja active Pending
- 1989-04-12 ZA ZA892674A patent/ZA892674B/xx unknown
- 1989-04-12 MX MX1563589A patent/MX15635A/es unknown
- 1989-04-12 PL PL1989278804A patent/PL159413B1/pl unknown
- 1989-04-12 RO RO139231A patent/RO104347B1/ro unknown
- 1989-04-12 IN IN283/CAL/89A patent/IN169836B/en unknown
- 1989-04-12 KR KR1019890004818A patent/KR900016097A/ko not_active Application Discontinuation
- 1989-04-12 AU AU32655/89A patent/AU611796B2/en not_active Ceased
- 1989-04-12 DD DD89327552A patent/DD294014A5/de not_active IP Right Cessation
- 1989-04-12 CN CN89102213A patent/CN1037344A/zh active Pending
- 1989-04-12 BG BG88028A patent/BG60556B1/bg unknown
- 1989-04-12 YU YU00738/89A patent/YU73889A/xx unknown
- 1989-08-28 RU SU894614855A patent/RU1838294C/ru active
-
1990
- 1990-10-09 US US07/595,639 patent/US5095137A/en not_active Expired - Fee Related
- 1990-11-29 IN IN1000/CAL/90A patent/IN172059B/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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