GEP19970842B - Oxadiazole-alkyl-purine derivatives - Google Patents
Oxadiazole-alkyl-purine derivativesInfo
- Publication number
- GEP19970842B GEP19970842B GEAP19931402A GEAP1993001402A GEP19970842B GE P19970842 B GEP19970842 B GE P19970842B GE AP19931402 A GEAP19931402 A GE AP19931402A GE AP1993001402 A GEAP1993001402 A GE AP1993001402A GE P19970842 B GEP19970842 B GE P19970842B
- Authority
- GE
- Georgia
- Prior art keywords
- alkyl
- formula
- stands
- oxadiazole
- nitrogen atom
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 2
- -1 carboxyphenyl Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864230A HU197574B (en) | 1986-10-09 | 1986-10-09 | Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19970842B true GEP19970842B (en) | 1997-02-06 |
Family
ID=10967389
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19931402A GEP19970842B (en) | 1986-10-09 | 1993-08-12 | Oxadiazole-alkyl-purine derivatives |
| GEAP19931394A GEP19960657B (en) | 1986-10-09 | 1993-08-12 | Oxadiazole-alkyl-purine derivatives useful as antitussive agents |
| GEAP19931397A GEP19970817B (en) | 1986-10-09 | 1993-08-12 | Oxadiazole-alkyl-purine derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19931394A GEP19960657B (en) | 1986-10-09 | 1993-08-12 | Oxadiazole-alkyl-purine derivatives useful as antitussive agents |
| GEAP19931397A GEP19970817B (en) | 1986-10-09 | 1993-08-12 | Oxadiazole-alkyl-purine derivatives |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4840949A (en, 2012) |
| EP (1) | EP0264081B1 (en, 2012) |
| JP (1) | JPS63107980A (en, 2012) |
| KR (1) | KR960003612B1 (en, 2012) |
| CN (1) | CN1018644B (en, 2012) |
| AT (1) | ATE99685T1 (en, 2012) |
| AU (1) | AU595384B2 (en, 2012) |
| BG (1) | BG60403B2 (en, 2012) |
| CS (1) | CS276993B6 (en, 2012) |
| CY (1) | CY1843A (en, 2012) |
| DD (1) | DD262658A5 (en, 2012) |
| DE (1) | DE3788701D1 (en, 2012) |
| DK (1) | DK167806B1 (en, 2012) |
| ES (1) | ES2061465T3 (en, 2012) |
| FI (1) | FI87215C (en, 2012) |
| GE (3) | GEP19970842B (en, 2012) |
| HK (1) | HK78995A (en, 2012) |
| HU (1) | HU197574B (en, 2012) |
| IL (1) | IL84030A (en, 2012) |
| LT (1) | LT3685B (en, 2012) |
| LV (1) | LV10868B (en, 2012) |
| NO (1) | NO166323C (en, 2012) |
| PL (2) | PL268147A1 (en, 2012) |
| RU (1) | RU2007404C1 (en, 2012) |
| SU (2) | SU1602862A1 (en, 2012) |
| UA (2) | UA5572A1 (en, 2012) |
| YU (1) | YU47545B (en, 2012) |
| ZA (1) | ZA877333B (en, 2012) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU197574B (en) * | 1986-10-09 | 1989-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances |
| IT1199320B (it) * | 1986-12-16 | 1988-12-30 | Malesci Sas | 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione |
| HU198933B (en) * | 1987-11-02 | 1989-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new xanthine derivatives and pharmaceutical compositions comprising same as active ingredient |
| HU206884B (en) * | 1990-11-22 | 1993-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing purin derivatives and pharmaceutical compositions containing them |
| HUP9700654A2 (hu) * | 1997-03-26 | 1999-09-28 | Dezső Korbonits | Teobromin tartalmú köhögéscsillapító készítmények |
| US7914828B2 (en) * | 2008-10-17 | 2011-03-29 | Levine Brian M | Combination herbal product to benefit respiratory tract |
| US8106234B2 (en) * | 2009-05-07 | 2012-01-31 | OptMed, Inc | Methylidene malonate process |
| US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
| US8361519B2 (en) | 2010-11-18 | 2013-01-29 | Aadvantics Pharmaceuticals, Inc. | Combination herbal product to benefit respiratory tract in people exposed to smoke |
| CA2853073A1 (en) | 2011-10-19 | 2013-04-25 | Bioformix Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
| JP6345644B2 (ja) | 2012-03-30 | 2018-06-20 | シラス・インコーポレイテッド | インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系 |
| US10913875B2 (en) | 2012-03-30 | 2021-02-09 | Sirrus, Inc. | Composite and laminate articles and polymerizable systems for producing the same |
| WO2013181600A2 (en) | 2012-06-01 | 2013-12-05 | Bioformix Inc. | Optical material and articles formed therefrom |
| EP2920231B1 (en) | 2012-11-16 | 2020-05-06 | Sirrus, Inc. | Plastics bonding systems and methods |
| EP3712928A1 (en) | 2012-11-30 | 2020-09-23 | Sirrus, Inc. | Composite compositions for electronics applications |
| US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
| US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
| RU2754735C1 (ru) * | 2020-12-14 | 2021-09-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный технический университет" ФГБОУВО "ЯГТУ" | Способ получения 3,5-дизамещенных 1,2,4-оксадиазолов, содержащих алкенильный фрагмент |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190377B (en) * | 1982-03-12 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing theophyllinyl-alkyl-oxadiazoles |
| HU197574B (en) * | 1986-10-09 | 1989-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances |
-
1986
- 1986-10-09 HU HU864230A patent/HU197574B/hu not_active IP Right Cessation
-
1987
- 1987-09-29 ZA ZA877333A patent/ZA877333B/xx unknown
- 1987-09-29 IL IL84030A patent/IL84030A/xx not_active IP Right Cessation
- 1987-10-06 KR KR1019870011121A patent/KR960003612B1/ko not_active Expired - Fee Related
- 1987-10-08 YU YU185787A patent/YU47545B/sh unknown
- 1987-10-08 DK DK527087A patent/DK167806B1/da not_active IP Right Cessation
- 1987-10-08 AU AU79462/87A patent/AU595384B2/en not_active Ceased
- 1987-10-08 JP JP62254513A patent/JPS63107980A/ja active Granted
- 1987-10-08 NO NO874216A patent/NO166323C/no not_active IP Right Cessation
- 1987-10-09 UA UA4355201A patent/UA5572A1/uk unknown
- 1987-10-09 UA UA4203547A patent/UA26368A/uk unknown
- 1987-10-09 DD DD87307805A patent/DD262658A5/de not_active IP Right Cessation
- 1987-10-09 AT AT87114798T patent/ATE99685T1/de not_active IP Right Cessation
- 1987-10-09 EP EP87114798A patent/EP0264081B1/de not_active Expired - Lifetime
- 1987-10-09 US US07/107,693 patent/US4840949A/en not_active Expired - Fee Related
- 1987-10-09 FI FI874456A patent/FI87215C/fi not_active IP Right Cessation
- 1987-10-09 PL PL1987268147A patent/PL268147A1/xx unknown
- 1987-10-09 CN CN87107785A patent/CN1018644B/zh not_active Expired
- 1987-10-09 DE DE87114798T patent/DE3788701D1/de not_active Expired - Fee Related
- 1987-10-09 ES ES87114798T patent/ES2061465T3/es not_active Expired - Lifetime
- 1987-10-09 PL PL1987280763A patent/PL151206B1/pl unknown
- 1987-10-09 RU SU874203547A patent/RU2007404C1/ru active
- 1987-10-09 CS CS877327A patent/CS276993B6/cs not_active IP Right Cessation
-
1988
- 1988-02-19 SU SU884355201A patent/SU1602862A1/ru active
- 1988-09-19 SU SU884356424A patent/SU1635901A3/ru active
-
1993
- 1993-06-22 LV LVP-93-649A patent/LV10868B/lv unknown
- 1993-08-12 GE GEAP19931402A patent/GEP19970842B/en unknown
- 1993-08-12 GE GEAP19931394A patent/GEP19960657B/en unknown
- 1993-08-12 GE GEAP19931397A patent/GEP19970817B/en unknown
- 1993-11-10 LT LTIP1455A patent/LT3685B/lt not_active IP Right Cessation
- 1993-12-02 BG BG098265A patent/BG60403B2/bg unknown
-
1995
- 1995-05-18 HK HK78995A patent/HK78995A/xx not_active IP Right Cessation
-
1996
- 1996-03-08 CY CY184396A patent/CY1843A/xx unknown
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