IT1199320B - 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione - Google Patents

8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione

Info

Publication number
IT1199320B
IT1199320B IT48749/86A IT4874986A IT1199320B IT 1199320 B IT1199320 B IT 1199320B IT 48749/86 A IT48749/86 A IT 48749/86A IT 4874986 A IT4874986 A IT 4874986A IT 1199320 B IT1199320 B IT 1199320B
Authority
IT
Italy
Prior art keywords
azaxantine
antibroncospastic
alchylaminoalkyl
triazolic
activity
Prior art date
Application number
IT48749/86A
Other languages
English (en)
Other versions
IT8648749A0 (it
IT8648749A1 (it
Inventor
Mauro Fedi
Carla Bacciarelli
Graziano Bonacchi
Original Assignee
Malesci Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Malesci Sas filed Critical Malesci Sas
Priority to IT48749/86A priority Critical patent/IT1199320B/it
Publication of IT8648749A0 publication Critical patent/IT8648749A0/it
Priority to EP87830440A priority patent/EP0272226B1/en
Priority to DE8787830440T priority patent/DE3774849D1/de
Priority to ES198787830440T priority patent/ES2038694T3/es
Priority to CA000554377A priority patent/CA1305704C/en
Priority to JP62318472A priority patent/JPS63246378A/ja
Publication of IT8648749A1 publication Critical patent/IT8648749A1/it
Priority to US07/236,219 priority patent/US4931437A/en
Application granted granted Critical
Publication of IT1199320B publication Critical patent/IT1199320B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT48749/86A 1986-12-16 1986-12-16 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione IT1199320B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT48749/86A IT1199320B (it) 1986-12-16 1986-12-16 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione
EP87830440A EP0272226B1 (en) 1986-12-16 1987-12-14 8-azaxanthines alkylaminoalkyl or heterocyclylalkyl-substituted on the triazole ring, the salts thereof which are physiologically acceptable, their pharmaceutical compositions having antibronchospastic acivity, and the process for preparing the same
DE8787830440T DE3774849D1 (de) 1986-12-16 1987-12-14 Alkylaminoalkylisch oder heterocyclylalkylisch an den triazolring substituierte 8-azaxanthine, ihre physiologisch vertraeglichen salze, ihre pharmazeutische zubereitungen mit antibronchospastischer wirkung und verfahren zu ihrer herstellung.
ES198787830440T ES2038694T3 (es) 1986-12-16 1987-12-14 Procedimiento para la preparacion de los derivados de la 8-azaxantina alquilaminoalquil o heterociclilalquil sustituida en el anillo de triazol, asi como sales de la misma aceptables en la terapeutica.
CA000554377A CA1305704C (en) 1986-12-16 1987-12-15 8-azaxanthines alkylaminoalkyl or heterocyclyalkyl-substituted on the triazole ring, the salts thereof which are physiologicallyacceptable, their pharmaceutical compositions having antibronchospastic activity, and the process for preparing the same
JP62318472A JPS63246378A (ja) 1986-12-16 1987-12-16 ８−アザキサンチン類、その製法及び医薬組成物
US07/236,219 US4931437A (en) 1986-12-16 1988-08-25 8-azaxanthine derivatives, and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48749/86A IT1199320B (it) 1986-12-16 1986-12-16 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione

Publications (3)

Publication Number Publication Date
IT8648749A0 IT8648749A0 (it) 1986-12-16
IT8648749A1 IT8648749A1 (it) 1988-06-16
IT1199320B true IT1199320B (it) 1988-12-30

Family

ID=11268379

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48749/86A IT1199320B (it) 1986-12-16 1986-12-16 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione

Country Status (7)

Country Link
US (1) US4931437A (it)
EP (1) EP0272226B1 (it)
JP (1) JPS63246378A (it)
CA (1) CA1305704C (it)
DE (1) DE3774849D1 (it)
ES (1) ES2038694T3 (it)
IT (1) IT1199320B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199320B (it) * 1986-12-16 1988-12-30 Malesci Sas 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
US6878715B1 (en) * 1994-02-18 2005-04-12 Cell Therapeutics, Inc. Therapeutic compounds for inhibiting interleukin-12 signals and method for using same
US6323201B1 (en) * 1994-12-29 2001-11-27 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
US6930101B1 (en) 1999-05-17 2005-08-16 The Regents Of The University Of California Thiazolopyrimidines useful as TNFα inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2543333A (en) * 1950-02-02 1951-02-27 American Cyanamid Co Derivatives of upsilon-triazolo (d) pyrimidine and methods of preparing the same
CH598308A5 (it) * 1974-12-06 1978-04-28 Ciba Geigy Ag
US4027025A (en) * 1976-03-01 1977-05-31 Burroughs Wellcome Co. 8-Azapurine derivatives
SU598900A1 (ru) * 1976-03-16 1978-03-25 Ленинградский химико-фармацевтический институт Способ получени производных 8-азаксантинов
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
IT1184139B (it) * 1985-01-23 1987-10-22 Proter Spa Composti ad attivita' mucolitica e broncodilatatrice,procedimento per la loro preparazione e composizioni farmaceutiche che licontengono come principi attivi
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
HU197574B (en) * 1986-10-09 1989-04-28 Chinoin Gyogyszer Es Vegyeszet Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances
IT1199320B (it) * 1986-12-16 1988-12-30 Malesci Sas 8-azaxantine alchilaminoalchil o eterociclilalchil sostituite sul nucleo triazolico,loro sali fisiologicamente accettabili,loro composizioni farmaceutiche ad attivita'antibroncospastica e relativo procedimento di preparazione

Also Published As

Publication number Publication date
US4931437A (en) 1990-06-05
EP0272226A2 (en) 1988-06-22
EP0272226B1 (en) 1991-11-27
IT8648749A0 (it) 1986-12-16
EP0272226A3 (en) 1989-08-30
IT8648749A1 (it) 1988-06-16
JPS63246378A (ja) 1988-10-13
DE3774849D1 (de) 1992-01-09
CA1305704C (en) 1992-07-28
ES2038694T3 (es) 1993-08-01

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951212