GB9305282D0 - Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine - Google Patents

Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Info

Publication number
GB9305282D0
GB9305282D0 GB939305282A GB9305282A GB9305282D0 GB 9305282 D0 GB9305282 D0 GB 9305282D0 GB 939305282 A GB939305282 A GB 939305282A GB 9305282 A GB9305282 A GB 9305282A GB 9305282 D0 GB9305282 D0 GB 9305282D0
Authority
GB
United Kingdom
Prior art keywords
chlorophenyl
ethyl
methylphenyl
enantiomers
sulphonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB939305282A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB939305282A priority Critical patent/GB9305282D0/en
Publication of GB9305282D0 publication Critical patent/GB9305282D0/en
Priority to TW083102003A priority patent/TW237452B/zh
Priority to US08/207,096 priority patent/US5478941A/en
Priority to AT99109564T priority patent/ATE267185T1/de
Priority to EP04002438A priority patent/EP1413307A1/fr
Priority to EP94870043A priority patent/EP0617028B1/fr
Priority to EP99109564A priority patent/EP0955295B1/fr
Priority to ES94870043T priority patent/ES2147569T3/es
Priority to ES99109564T priority patent/ES2221262T3/es
Priority to DE69424893T priority patent/DE69424893T2/de
Priority to DE69433802T priority patent/DE69433802T2/de
Priority to SG1995002010A priority patent/SG43683A1/en
Priority to SI9430329T priority patent/SI0617028T1/xx
Priority to PT94870043T priority patent/PT617028E/pt
Priority to SI9430468T priority patent/SI0955295T1/xx
Priority to DK94870043T priority patent/DK0617028T3/da
Priority to AT94870043T priority patent/ATE193889T1/de
Priority to NZ260062A priority patent/NZ260062A/en
Priority to FI941134A priority patent/FI105477B/fi
Priority to HU9400727A priority patent/HU219230B/hu
Priority to NO940881A priority patent/NO305908B1/no
Priority to ZA941724A priority patent/ZA941724B/xx
Priority to PL94302565A priority patent/PL178546B1/pl
Priority to AU57771/94A priority patent/AU678426B2/en
Priority to CA002443216A priority patent/CA2443216C/en
Priority to HU9901849A priority patent/HU221731B1/hu
Priority to HU9901848A priority patent/HU224070B1/hu
Priority to CA002118859A priority patent/CA2118859C/en
Priority to JP04254794A priority patent/JP3267434B2/ja
Priority to RU94008618A priority patent/RU2118320C1/ru
Priority to KR1019940005172A priority patent/KR100322415B1/ko
Priority to US08/460,844 priority patent/US5703082A/en
Priority to US08/947,859 priority patent/US5792770A/en
Priority to NO990351A priority patent/NO306616B1/no
Priority to US09/356,865 priority patent/US6436942B1/en
Priority to FI991730A priority patent/FI105915B/fi
Priority to FI991729A priority patent/FI105914B/fi
Priority to HK00102635.7A priority patent/HK1024232B/xx
Priority to GR20000402028T priority patent/GR3034340T3/el
Priority to JP2001356849A priority patent/JP3880842B2/ja
Priority to US10/141,933 priority patent/US20030105112A1/en
Priority to US10/162,576 priority patent/US20030105113A1/en
Priority to US10/385,522 priority patent/US20030204089A1/en
Priority to US10/679,376 priority patent/US20040072845A1/en
Priority to US10/724,640 priority patent/US20040122021A1/en
Priority to US10/724,611 priority patent/US20040122023A1/en
Priority to US11/106,613 priority patent/US20050176732A1/en
Priority to US11/106,456 priority patent/US20050182070A1/en
Priority to US11/106,528 priority patent/US20050182069A1/en
Priority to US11/453,987 priority patent/US20060229319A1/en
Priority to US11/453,986 priority patent/US20060229320A1/en
Priority to US11/487,331 priority patent/US20060252934A1/en
Priority to JP2006266195A priority patent/JP2006342190A/ja
Priority to US11/652,092 priority patent/US20070142400A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
GB939305282A 1993-03-05 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine Pending GB9305282D0 (en)

Priority Applications (54)

Application Number Priority Date Filing Date Title
GB939305282A GB9305282D0 (en) 1993-03-15 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
TW083102003A TW237452B (https=) 1993-03-15 1994-03-08
US08/207,096 US5478941A (en) 1993-03-15 1994-03-08 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine
AT99109564T ATE267185T1 (de) 1993-03-15 1994-03-09 Therapeutisch wirksame linksdrehende und rechtsdrehende 1-((4-chlorphenyl)phenylmethyl) piperazine
EP04002438A EP1413307A1 (fr) 1993-03-15 1994-03-09 1-(4-chlorophényl)phénylméthyl pipérazines de forme lévogyre ou dextrogyre thérapeutiquement actives
EP94870043A EP0617028B1 (fr) 1993-03-15 1994-03-09 Enantiomères de la 1-[(4-chlorophényl)phénylméthyl]-4-[(4-méthylphényl)sulfonyl] pipérazine
EP99109564A EP0955295B1 (fr) 1993-03-15 1994-03-09 1-((4-chlorophényl) phénylméthyl) pipérazines de forme lévogyre ou dextrogyre thérapeutiquement actives
ES94870043T ES2147569T3 (es) 1993-03-15 1994-03-09 Enantiomeros de la 1-((4-clorofenil)fenilmetil)-4-((4-metilfenil)sulfonil)piperazina.
ES99109564T ES2221262T3 (es) 1993-03-15 1994-03-09 1-((4-CLOROFENIL)FENILMEILl)PIPERAZINAS DE FORMA LEVOGIRA O DEXTROGIRA TERAPEUTICAMENTE ACTIVAS.
DE69424893T DE69424893T2 (de) 1993-03-15 1994-03-09 Enantiomere von 1-[(4-Chlorophenyl)phenylmethyl]-4-[(4-Methylphenyl)sulfonyl]piperazin
DE69433802T DE69433802T2 (de) 1993-03-15 1994-03-09 Therapeutisch wirksame linksdrehende und rechtsdrehende 1-((4-Chlorphenyl)phenylmethyl) Piperazine
SG1995002010A SG43683A1 (en) 1993-03-15 1994-03-09 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4- [(4-methylphenyl)sufonyl]piperazine
SI9430329T SI0617028T1 (en) 1993-03-15 1994-03-09 Enantiomers of 1-((4-chlorophenyl)phenylmethyl)-4-((4-methylphenyl)sulfonyl) piperazine
PT94870043T PT617028E (pt) 1993-03-15 1994-03-09 Enantiomeros de 1-(4-clorofenil)fenilmetil-4-(4-metilfenil)sulfonil piperzina
SI9430468T SI0955295T1 (en) 1993-03-15 1994-03-09 Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl) piperazines
DK94870043T DK0617028T3 (da) 1993-03-15 1994-03-09 Enantiomerer af 1-[(4-chlorphenyl)phenylmethyl]-4(4-methylphenyl)sulfonyl]piperazin
AT94870043T ATE193889T1 (de) 1993-03-15 1994-03-09 Enantiomere von 1-((4-chlorophenyl)phenylmethyl)- 4-((4-methylphenyl)sulfonyl)piperazin
NZ260062A NZ260062A (en) 1993-03-15 1994-03-10 Enantiomers of 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(4-methylphenyl)sulphonyl]piperazine
FI941134A FI105477B (fi) 1993-03-15 1994-03-10 1-[(4-kloorifenyyli)fenyylimetyyli]-4-[(4-metyylifenyyli)sulfonyyli]piperatsiinin enantiomeerit ja menetelmä niiden valmistamiseksi
HU9400727A HU219230B (en) 1993-03-15 1994-03-11 1-[(4-chloro-phenyl)-phenyl-methyl]-4-[(4-methyl-phenyl)-sulfonyl]-piperazine enanthiomeres and process for producing them
NO940881A NO305908B1 (no) 1993-03-15 1994-03-11 Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse
ZA941724A ZA941724B (en) 1993-03-15 1994-03-11 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine
PL94302565A PL178546B1 (pl) 1993-03-15 1994-03-11 Nowe, zasadniczo czyste optycznie, enancjomery prawoskrętne lub lewoskrętne 1-[(4-chlorofenylo)fenylometylo] piperazyny i sposób ich wytwarzania
AU57771/94A AU678426B2 (en) 1993-03-15 1994-03-11 Enantiomers of 1-{4-chlorophenyl)phenylmethyl}-4-{(4- methylphenyl)sulfonyl}piperazine
CA002443216A CA2443216C (en) 1993-03-15 1994-03-11 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine
HU9901849A HU221731B1 (hu) 1993-03-15 1994-03-11 Eljárás 1-[(4-klór-fenil)-fenil-metil]-piperazin enantiomerjeinek előállítására
HU9901848A HU224070B1 (hu) 1993-03-15 1994-03-11 Eljárás 1-[(4-klór-fenil)-fenil-metil]-piperazin enantiomerek előállítására, ezek új képviselői, és ezeket tartalmazó gyógyszerkészítmények
CA002118859A CA2118859C (en) 1993-03-15 1994-03-11 Enantiomers of 1-[(4-chlorophenyl)-phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine
JP04254794A JP3267434B2 (ja) 1993-03-15 1994-03-14 １−〔（４−クロロフェニル）フェニルメチル〕−４−〔（４−メチルフェニル）スルホニル〕ピペラジンの 鏡像体およびその製造法
RU94008618A RU2118320C1 (ru) 1993-03-15 1994-03-14 Энантиомеры 1-[(4-хлорфенил)фенилметил]-4-[(4-метилфенил)сульфонил]пиперазина, способ их получения, способ получения энантиомеров 1-[(4-хлорфенил)фенилметил]пиперазина, энантиомеры 1-[(4-хлорфенил)фенилметил]пиперазина,энантиомеры производных 1-[(4-хлорфенил)фенилметил]пиперазина
KR1019940005172A KR100322415B1 (ko) 1993-03-15 1994-03-14 1-[(4-클로로페닐)페닐메틸]-4-[(4-메틸페닐)술포닐]피페라진의거울상이성체
US08/460,844 US5703082A (en) 1993-03-15 1995-06-05 Enantiomers of 1- (4-chlorophenyl)phenylmethyl!- (4-methylphenyl)sulfonyl!pi
US08/947,859 US5792770A (en) 1993-03-15 1997-10-09 Enantiomers of 1- (4-chlorophenyl)phenylmethyl!-4- (4-methylphenyl) sulfonyl!piperazine
NO990351A NO306616B1 (no) 1993-03-15 1999-01-26 Fremgangsmåte for fremstilling av den venstredreiende og höyredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin
US09/356,865 US6436942B1 (en) 1993-03-15 1999-07-19 Enantiomers of 1[(4-chloro-phenyl) phenylmethyl]-4-[(4-methylphenyl) sulfony]piperazine
FI991730A FI105915B (fi) 1993-03-15 1999-08-16 Menetelmä valmistaa 1-[(4-kloorifenyyli)fenyylimetyyli]-piperatsiinin enantiomeereja
FI991729A FI105914B (fi) 1993-03-15 1999-08-16 Menetelmä valmistaa farmaseuttisesti vaikuttavaa 1-[(4-kloorifenyyli)fenyylimetyyli]-4-[(4-metyylifenyyli)sulfonyyli]piperatsiinin vasemmalle tai oikealle kiertävää enantiomeeria
HK00102635.7A HK1024232B (en) 1993-03-15 2000-05-02 Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl)piperazines
GR20000402028T GR3034340T3 (en) 1993-03-15 2000-09-06 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulfonyl piperazine.
JP2001356849A JP3880842B2 (ja) 1993-03-15 2001-11-22 １−〔（４−クロロフェニル）フェニルメチル〕ピペラジンの鏡像体およびその製造法
US10/141,933 US20030105112A1 (en) 1993-03-15 2002-05-10 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine
US10/162,576 US20030105113A1 (en) 1993-03-15 2002-06-06 Enantiomers of 1-[ (4-chlorophenyl) phenylmethyl ] -4-[ (4-methylphenyl) sulfonyl ] piperazine
US10/385,522 US20030204089A1 (en) 1993-03-15 2003-03-12 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine
US10/679,376 US20040072845A1 (en) 1993-03-15 2003-10-07 Enantiomers of 1-[ (4-chlorophenyl) phenylmethyl ] -4-[ (4-methylphenyl) sulfonyl] piperazine
US10/724,640 US20040122021A1 (en) 1993-03-15 2003-12-02 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl)-4-[(4-methylphenyl)sulfonyl) piperazine
US10/724,611 US20040122023A1 (en) 1993-03-15 2003-12-02 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine
US11/106,613 US20050176732A1 (en) 1993-03-15 2005-04-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine
US11/106,456 US20050182070A1 (en) 1993-03-15 2005-04-15 Method for the treatment of allergic conditions
US11/106,528 US20050182069A1 (en) 1993-03-15 2005-04-15 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine
US11/453,987 US20060229319A1 (en) 1993-03-05 2006-06-16 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl)-4-[(4-methylphenyl)sulfonyl] piperazine
US11/453,986 US20060229320A1 (en) 1993-03-15 2006-06-16 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine
US11/487,331 US20060252934A1 (en) 1993-03-15 2006-07-17 Enantiomers of 1-[(4-chlorophenyl) phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine
JP2006266195A JP2006342190A (ja) 1993-03-15 2006-09-29 １−〔（４−クロロフェニル）フェニルメチル〕ピペラジンの鏡像体およびその製造法
US11/652,092 US20070142400A1 (en) 1993-03-15 2007-01-11 Enantjomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl] piperazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305282A GB9305282D0 (en) 1993-03-15 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (1)

Publication Number Publication Date
GB9305282D0 true GB9305282D0 (en) 1993-05-05

Family

ID=10732080

Family Applications (1)

Application Number Title Priority Date Filing Date
GB939305282A Pending GB9305282D0 (en) 1993-03-05 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Country Status (23)

Country Link
US (17) US5478941A (https=)
EP (3) EP1413307A1 (https=)
JP (3) JP3267434B2 (https=)
KR (1) KR100322415B1 (https=)
AT (2) ATE267185T1 (https=)
AU (1) AU678426B2 (https=)
CA (2) CA2118859C (https=)
DE (2) DE69424893T2 (https=)
DK (1) DK0617028T3 (https=)
ES (2) ES2221262T3 (https=)
FI (3) FI105477B (https=)
GB (1) GB9305282D0 (https=)
GR (1) GR3034340T3 (https=)
HU (1) HU219230B (https=)
NO (2) NO305908B1 (https=)
NZ (1) NZ260062A (https=)
PL (1) PL178546B1 (https=)
PT (1) PT617028E (https=)
RU (1) RU2118320C1 (https=)
SG (1) SG43683A1 (https=)
SI (2) SI0617028T1 (https=)
TW (1) TW237452B (https=)
ZA (1) ZA941724B (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831066A (en) 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
ES2128556T3 (es) * 1992-09-24 1999-05-16 Sepracor Inc Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura.
ES2122042T3 (es) * 1992-09-24 1998-12-16 Sepracor Inc Tratamiento de rinitis alergica y asma que emplea (-)cetirizina.
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
ES2159622T3 (es) * 1994-01-14 2001-10-16 Azwell Inc Derivado del diazacicloalcanoalquilsulfonamida.
CN1058638C (zh) * 1995-06-27 2000-11-22 中国药品生物制品检定所 胞内分枝杆菌变态反应原提取方法
JP3476475B2 (ja) 1997-06-04 2003-12-10 株式会社アズウェル ピペラジンスルホンアミド誘導体およびその塩の製造方法
US6384038B1 (en) * 1998-04-14 2002-05-07 Sepracor Inc. Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
US6432961B1 (en) * 1998-08-18 2002-08-13 Ucb S.A. Method for preventing the onset of asthma
PE20001566A1 (es) * 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
CZ304892B6 (cs) * 1999-11-30 2015-01-07 EGIS Gyógyszergyár Rt. Způsob přípravy {2-[4-(α-fenyl-p-chlorbenzyl)piperazin-1-yl]ethoxy}octové kyseliny a nové meziprodukty
JP2002249487A (ja) 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
PE20040167A1 (es) * 2002-03-28 2004-05-26 Novartis Ag Amidas del acido sulfamico
WO2004050647A2 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of dihydrochloride salts of cetirizine and processes for preparation thereof
JP2006520806A (ja) * 2003-03-20 2006-09-14 ライナット ニューロサイエンス コーポレイション タキソール誘導性腸障害を処置する方法
US7577727B2 (en) * 2003-06-27 2009-08-18 Newisys, Inc. Dynamic multiple cluster system reconfiguration
KR100503443B1 (ko) 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
AU2006222298B2 (en) * 2005-03-03 2011-02-24 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227074B1 (en) * 2005-12-08 2010-06-28 Egis Gyogyszergyar Nyrt An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
US8049011B2 (en) * 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
WO2008152650A1 (en) 2007-06-15 2008-12-18 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
US20090062305A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched cetirizine
US20090082364A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched levocedtirizine
KR101427100B1 (ko) 2007-10-23 2014-08-08 주식회사 씨트리 광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
US7989623B2 (en) * 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
ES2361343T3 (es) 2007-11-21 2011-06-16 Synthon B.V. Procedimiento para obtener n-(difenilmetil)piperazinas.
KR100954755B1 (ko) * 2007-12-17 2010-04-27 한미약품 주식회사 (ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법
WO2009147389A2 (en) * 2008-06-02 2009-12-10 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20100145049A1 (en) * 2008-11-21 2010-06-10 Jie Zhu Process for making n-(diphenylmethyl)piperazines
RU2539591C2 (ru) * 2009-04-22 2015-01-20 Аксикин Фармасьютикалз, Инк. Антагонисты арилсульфонамида ccr3
CN101928223A (zh) * 2009-06-26 2010-12-29 华东理工大学 一种(r)-(-)-4-氯二苯甲胺的拆分方法
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
WO2013158319A1 (en) 2012-04-16 2013-10-24 Zemtsov Enterprises, Llc Formulations and methods for treatment of wounds and inflammatory skin conditions
CN103613567A (zh) * 2012-11-09 2014-03-05 焦作福瑞堂制药有限公司 盐酸氯环利嗪的合成工艺
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE523901A (https=) *
CA568380A (en) * 1959-01-06 Morren Henri Ethers of piperazine and method of their preparation
BE540057A (https=) *
US2899436A (en) * 1959-08-11 chjch
US2709169A (en) * 1955-05-24 X c chs
GB752331A (en) * 1948-09-30 1956-07-11 Abbott Lab Improvements in or relating to n, n-disubstituted piperazines and process of preparing the same
US2861072A (en) * 1952-07-19 1958-11-18 Abbott Lab Preparation of piperazine derivatives
US2709167A (en) * 1952-09-10 1955-05-24 Geigy Ag J R Chromium-containing monoazo dyestuffs
US2897436A (en) * 1954-09-29 1959-07-28 Amchem Prod Indicating and control apparatus for electrolyte concentration and the like
US3406174A (en) * 1964-10-23 1968-10-15 Sandoz Ag Benzylsulfamides
FI75816C (fi) * 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.
US4749700A (en) * 1984-10-23 1988-06-07 Nastech Pharmaceutical Co, Inc. Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same
DE3640247A1 (de) * 1986-11-25 1988-05-26 Basf Ag Fungizide cyclohexylamine
US4975426A (en) * 1987-06-08 1990-12-04 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
JP2559463B2 (ja) * 1988-06-01 1996-12-04 ダイセル化学工業株式会社 不斉中心に２個の芳香族基を有する化合物の光学分割方法
JPH0239947A (ja) * 1988-07-29 1990-02-08 Seikosha Co Ltd 印字ヘッド
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
US5087627A (en) * 1989-03-15 1992-02-11 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
EP0475251B1 (en) * 1990-09-10 1997-03-26 Mitsubishi Denki Kabushiki Kaisha Coding apparatus for digital image data
ES2128556T3 (es) * 1992-09-24 1999-05-16 Sepracor Inc Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura.
ES2122042T3 (es) 1992-09-24 1998-12-16 Sepracor Inc Tratamiento de rinitis alergica y asma que emplea (-)cetirizina.
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

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