TW237452B - - Google Patents

Info

Publication number
TW237452B
TW237452B TW083102003A TW83102003A TW237452B TW 237452 B TW237452 B TW 237452B TW 083102003 A TW083102003 A TW 083102003A TW 83102003 A TW83102003 A TW 83102003A TW 237452 B TW237452 B TW 237452B
Authority
TW
Taiwan
Prior art keywords
ethyl
phenylmethylpiperazine
levorotatory
hydroxyethoxy
allergies
Prior art date
Application number
TW083102003A
Other languages
English (en)
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Application granted granted Critical
Publication of TW237452B publication Critical patent/TW237452B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
TW083102003A 1993-03-15 1994-03-08 TW237452B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305282A GB9305282D0 (en) 1993-03-15 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (1)

Publication Number Publication Date
TW237452B true TW237452B (zh) 1995-01-01

Family

ID=10732080

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083102003A TW237452B (zh) 1993-03-15 1994-03-08

Country Status (24)

Country Link
US (17) US5478941A (zh)
EP (3) EP1413307A1 (zh)
JP (3) JP3267434B2 (zh)
KR (1) KR100322415B1 (zh)
AT (2) ATE267185T1 (zh)
AU (1) AU678426B2 (zh)
CA (2) CA2118859C (zh)
DE (2) DE69424893T2 (zh)
DK (1) DK0617028T3 (zh)
ES (2) ES2147569T3 (zh)
FI (3) FI105477B (zh)
GB (1) GB9305282D0 (zh)
GR (1) GR3034340T3 (zh)
HK (1) HK1024232A1 (zh)
HU (1) HU219230B (zh)
NO (2) NO305908B1 (zh)
NZ (1) NZ260062A (zh)
PL (1) PL178546B1 (zh)
PT (1) PT617028E (zh)
RU (1) RU2118320C1 (zh)
SG (1) SG43683A1 (zh)
SI (2) SI0617028T1 (zh)
TW (1) TW237452B (zh)
ZA (1) ZA941724B (zh)

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US5831066A (en) 1988-12-22 1998-11-03 The Trustees Of The University Of Pennsylvania Regulation of bcl-2 gene expression
ES2122042T3 (es) * 1992-09-24 1998-12-16 Sepracor Inc Tratamiento de rinitis alergica y asma que emplea (-)cetirizina.
ES2128556T3 (es) * 1992-09-24 1999-05-16 Sepracor Inc Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura.
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
KR100327270B1 (ko) * 1994-01-14 2002-08-01 닛뽕쇼지가부시끼가이샤 디아자시클로알킨알킬술폰아미드유도체
CN1058638C (zh) * 1995-06-27 2000-11-22 中国药品生物制品检定所 胞内分枝杆菌变态反应原提取方法
JP3476475B2 (ja) 1997-06-04 2003-12-10 株式会社アズウェル ピペラジンスルホンアミド誘導体およびその塩の製造方法
US6384038B1 (en) 1998-04-14 2002-05-07 Sepracor Inc. Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
US6432961B1 (en) * 1998-08-18 2002-08-13 Ucb S.A. Method for preventing the onset of asthma
ATE280165T1 (de) * 1999-11-30 2004-11-15 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von 2-(4-(alpha-phenyl- p-chlorobenzyl)piperazin-1-yl)ethoxyessigsäure und zwischenprodukte dafür
JP2002249487A (ja) 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003297640A1 (en) * 2002-12-04 2004-06-23 Inc. Dr. Reddy's Laboratories Polymorphic forms of dihydrochloride salts of cetirizine and processes for preparation thereof
EP1620127A4 (en) * 2003-03-20 2007-04-04 Rinat Neuroscience Corp METHOD FOR TREATING TAXOL-INDUCED ANTI-FERROUS DISORDER
US7577727B2 (en) * 2003-06-27 2009-08-18 Newisys, Inc. Dynamic multiple cluster system reconfiguration
KR100503443B1 (ko) 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
ATE433444T1 (de) * 2005-03-03 2009-06-15 Ucb Farchim Sa Pyroglutamatsalze und deren verwendung bei der optischen trennung von zwischenprodukten für die synthese von dextrocetirizin und levocetirizin
HU227074B1 (en) * 2005-12-08 2010-06-28 Egis Gyogyszergyar Nyrt An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
US8049011B2 (en) * 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
US8084606B2 (en) * 2007-06-15 2011-12-27 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
US20090062305A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched cetirizine
US20090082364A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched levocedtirizine
KR101427100B1 (ko) 2007-10-23 2014-08-08 주식회사 씨트리 광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
PL2062881T3 (pl) 2007-11-21 2011-07-29 Synthon Bv Sposób wytwarzania N-(difenylometylo)piperazyn
US7989623B2 (en) * 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
KR100954755B1 (ko) * 2007-12-17 2010-04-27 한미약품 주식회사 (ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법
EP2307392A2 (en) * 2008-06-02 2011-04-13 Cipla Limited Processes for the synthesis of levocetirizine and intermediates for use therein
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20100145049A1 (en) * 2008-11-21 2010-06-10 Jie Zhu Process for making n-(diphenylmethyl)piperazines
MX2011011141A (es) * 2009-04-22 2012-02-13 Axikin Pharmaceuticals Inc Antagonistas ccr3 arisulfonamida.
CN101928223A (zh) * 2009-06-26 2010-12-29 华东理工大学 一种(r)-(-)-4-氯二苯甲胺的拆分方法
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
WO2013158318A1 (en) 2012-04-16 2013-10-24 Zemtsov Enterprises, Llc Formulations and methods for treatment of acne and inflammatory skin conditions
CN103613567A (zh) * 2012-11-09 2014-03-05 焦作福瑞堂制药有限公司 盐酸氯环利嗪的合成工艺
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

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ES2122042T3 (es) 1992-09-24 1998-12-16 Sepracor Inc Tratamiento de rinitis alergica y asma que emplea (-)cetirizina.
ES2128556T3 (es) 1992-09-24 1999-05-16 Sepracor Inc Tratamiento transdermico de la urticaria usando (+)-cetirizina opticamente pura.
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Also Published As

Publication number Publication date
US20060229320A1 (en) 2006-10-12
DK0617028T3 (da) 2000-09-04
NO306616B1 (no) 1999-11-29
US20070142400A1 (en) 2007-06-21
NO990351D0 (no) 1999-01-26
CA2443216C (en) 2007-05-08
ATE267185T1 (de) 2004-06-15
US5478941A (en) 1995-12-26
AU5777194A (en) 1994-09-22
SI0955295T1 (en) 2004-10-31
CA2443216A1 (en) 1994-09-16
NO940881L (no) 1994-09-16
JP3267434B2 (ja) 2002-03-18
US5703082A (en) 1997-12-30
JPH072816A (ja) 1995-01-06
EP0955295B1 (fr) 2004-05-19
NO940881D0 (no) 1994-03-11
NZ260062A (en) 1995-09-26
FI19991729A (fi) 1999-08-16
DE69424893D1 (de) 2000-07-20
HUT70959A (en) 1995-11-28
HK1024232A1 (en) 2000-10-05
JP2006342190A (ja) 2006-12-21
ZA941724B (en) 1994-10-13
DE69433802D1 (de) 2004-06-24
FI105477B (fi) 2000-08-31
CA2118859A1 (en) 1994-09-16
US20060229319A1 (en) 2006-10-12
SI0617028T1 (en) 2000-10-31
FI105915B (fi) 2000-10-31
US20030105113A1 (en) 2003-06-05
PT617028E (pt) 2000-11-30
US5792770A (en) 1998-08-11
HU9400727D0 (en) 1994-06-28
CA2118859C (en) 2004-07-13
FI19991730A (fi) 1999-08-16
US20040122021A1 (en) 2004-06-24
US20060252934A1 (en) 2006-11-09
US20050176732A1 (en) 2005-08-11
US20040072845A1 (en) 2004-04-15
GB9305282D0 (en) 1993-05-05
ATE193889T1 (de) 2000-06-15
ES2147569T3 (es) 2000-09-16
KR100322415B1 (ko) 2002-06-20
HU219230B (en) 2001-03-28
EP0617028B1 (fr) 2000-06-14
US20030105112A1 (en) 2003-06-05
DE69433802T2 (de) 2005-05-12
EP0955295A1 (fr) 1999-11-10
FI105914B (fi) 2000-10-31
RU2118320C1 (ru) 1998-08-27
ES2221262T3 (es) 2004-12-16
US20050182070A1 (en) 2005-08-18
EP1413307A1 (fr) 2004-04-28
EP0617028A1 (fr) 1994-09-28
NO990351L (no) 1999-01-26
JP2002201187A (ja) 2002-07-16
GR3034340T3 (en) 2000-12-29
DE69424893T2 (de) 2000-10-12
US20030204089A1 (en) 2003-10-30
US20050182069A1 (en) 2005-08-18
PL178546B1 (pl) 2000-05-31
US6436942B1 (en) 2002-08-20
FI941134A (fi) 1994-09-16
AU678426B2 (en) 1997-05-29
JP3880842B2 (ja) 2007-02-14
SG43683A1 (en) 1997-11-14
US20040122023A1 (en) 2004-06-24
NO305908B1 (no) 1999-08-16
FI941134A0 (fi) 1994-03-10

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