ZA941724B - Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine - Google Patents

Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine

Info

Publication number
ZA941724B
ZA941724B ZA941724A ZA941724A ZA941724B ZA 941724 B ZA941724 B ZA 941724B ZA 941724 A ZA941724 A ZA 941724A ZA 941724 A ZA941724 A ZA 941724A ZA 941724 B ZA941724 B ZA 941724B
Authority
ZA
South Africa
Prior art keywords
chlorophenyl
ethyl
methylphenyl
enantiomers
phenylmethyl
Prior art date
Application number
ZA941724A
Other languages
English (en)
Inventor
Eric Cossement
Guy Bodson
Jean Gobert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of ZA941724B publication Critical patent/ZA941724B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
ZA941724A 1993-03-15 1994-03-11 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine ZA941724B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305282A GB9305282D0 (en) 1993-03-15 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (1)

Publication Number Publication Date
ZA941724B true ZA941724B (en) 1994-10-13

Family

ID=10732080

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA941724A ZA941724B (en) 1993-03-15 1994-03-11 Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine

Country Status (24)

Country Link
US (17) US5478941A (xx)
EP (3) EP1413307A1 (xx)
JP (3) JP3267434B2 (xx)
KR (1) KR100322415B1 (xx)
AT (2) ATE193889T1 (xx)
AU (1) AU678426B2 (xx)
CA (2) CA2443216C (xx)
DE (2) DE69424893T2 (xx)
DK (1) DK0617028T3 (xx)
ES (2) ES2147569T3 (xx)
FI (3) FI105477B (xx)
GB (1) GB9305282D0 (xx)
GR (1) GR3034340T3 (xx)
HK (1) HK1024232A1 (xx)
HU (1) HU219230B (xx)
NO (2) NO305908B1 (xx)
NZ (1) NZ260062A (xx)
PL (1) PL178546B1 (xx)
PT (1) PT617028E (xx)
RU (1) RU2118320C1 (xx)
SG (1) SG43683A1 (xx)
SI (2) SI0955295T1 (xx)
TW (1) TW237452B (xx)
ZA (1) ZA941724B (xx)

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KR101427100B1 (ko) 2007-10-23 2014-08-08 주식회사 씨트리 광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
US7989623B2 (en) * 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
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KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
US9566306B2 (en) 2012-04-16 2017-02-14 Zemtsov Enterprises, Llc Formulations and methods for treatment of wounds and inflammatory skin conditions
CN103613567A (zh) * 2012-11-09 2014-03-05 焦作福瑞堂制药有限公司 盐酸氯环利嗪的合成工艺
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

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Also Published As

Publication number Publication date
ATE193889T1 (de) 2000-06-15
CA2443216A1 (en) 1994-09-16
NO940881L (no) 1994-09-16
AU678426B2 (en) 1997-05-29
US20060229319A1 (en) 2006-10-12
US6436942B1 (en) 2002-08-20
EP0617028A1 (fr) 1994-09-28
ATE267185T1 (de) 2004-06-15
KR100322415B1 (ko) 2002-06-20
NO940881D0 (no) 1994-03-11
GB9305282D0 (en) 1993-05-05
SI0955295T1 (en) 2004-10-31
US20070142400A1 (en) 2007-06-21
DE69433802T2 (de) 2005-05-12
JP2006342190A (ja) 2006-12-21
EP0955295A1 (fr) 1999-11-10
CA2118859A1 (en) 1994-09-16
US20040072845A1 (en) 2004-04-15
US20060252934A1 (en) 2006-11-09
SG43683A1 (en) 1997-11-14
FI941134A (fi) 1994-09-16
NO306616B1 (no) 1999-11-29
EP0955295B1 (fr) 2004-05-19
US5792770A (en) 1998-08-11
PL178546B1 (pl) 2000-05-31
US20030105113A1 (en) 2003-06-05
US20030105112A1 (en) 2003-06-05
CA2118859C (en) 2004-07-13
FI19991729A (fi) 1999-08-16
FI19991730A (fi) 1999-08-16
JP2002201187A (ja) 2002-07-16
HU219230B (en) 2001-03-28
ES2147569T3 (es) 2000-09-16
NZ260062A (en) 1995-09-26
US20030204089A1 (en) 2003-10-30
AU5777194A (en) 1994-09-22
US20050176732A1 (en) 2005-08-11
SI0617028T1 (en) 2000-10-31
US20050182070A1 (en) 2005-08-18
JPH072816A (ja) 1995-01-06
EP0617028B1 (fr) 2000-06-14
US5478941A (en) 1995-12-26
PT617028E (pt) 2000-11-30
US20040122023A1 (en) 2004-06-24
RU2118320C1 (ru) 1998-08-27
NO990351L (no) 1999-01-26
NO305908B1 (no) 1999-08-16
CA2443216C (en) 2007-05-08
DE69433802D1 (de) 2004-06-24
DE69424893T2 (de) 2000-10-12
FI105914B (fi) 2000-10-31
EP1413307A1 (fr) 2004-04-28
TW237452B (xx) 1995-01-01
HU9400727D0 (en) 1994-06-28
NO990351D0 (no) 1999-01-26
FI105477B (fi) 2000-08-31
JP3880842B2 (ja) 2007-02-14
US20050182069A1 (en) 2005-08-18
JP3267434B2 (ja) 2002-03-18
FI941134A0 (fi) 1994-03-10
HUT70959A (en) 1995-11-28
FI105915B (fi) 2000-10-31
DE69424893D1 (de) 2000-07-20
US5703082A (en) 1997-12-30
ES2221262T3 (es) 2004-12-16
DK0617028T3 (da) 2000-09-04
GR3034340T3 (en) 2000-12-29
US20040122021A1 (en) 2004-06-24
HK1024232A1 (en) 2000-10-05
US20060229320A1 (en) 2006-10-12

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