GB2128984B - Diaza-bicyclic compounds - Google Patents

Diaza-bicyclic compounds

Info

Publication number
GB2128984B
GB2128984B GB08305505A GB8305505A GB2128984B GB 2128984 B GB2128984 B GB 2128984B GB 08305505 A GB08305505 A GB 08305505A GB 8305505 A GB8305505 A GB 8305505A GB 2128984 B GB2128984 B GB 2128984B
Authority
GB
United Kingdom
Prior art keywords
diaza
bicyclic compounds
bicyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08305505A
Other languages
English (en)
Other versions
GB8305505D0 (en
GB2128984A (en
Inventor
Michael Richard Attwood
Cedric Herbert Hassall
Robert Wilson Lambert
Geoffrey Lawton
Sally Redshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to GB08305505A priority Critical patent/GB2128984B/en
Publication of GB8305505D0 publication Critical patent/GB8305505D0/en
Priority to CA000427095A priority patent/CA1234568A/en
Priority to ZW98/83A priority patent/ZW9883A1/xx
Priority to DK194783A priority patent/DK160612C/da
Priority to IL68620A priority patent/IL68620A/xx
Priority to IT8321000A priority patent/IT1212738B/it
Priority to HU875409A priority patent/HU199842B/hu
Priority to HU831589A priority patent/HU195965B/hu
Priority to CU8335899A priority patent/CU21532A3/xx
Priority to NL8301640A priority patent/NL8301640A/nl
Priority to HU875410A priority patent/HU198935B/hu
Priority to HU541183A priority patent/HU198720B/hu
Priority to AU14364/83A priority patent/AU567873B2/en
Priority to MC821633A priority patent/MC1515A1/fr
Priority to DZ836846A priority patent/DZ540A1/fr
Priority to FR8307785A priority patent/FR2531956B1/fr
Priority to ES522291A priority patent/ES8407049A1/es
Priority to DE8383104668T priority patent/DE3381884D1/de
Priority to DE19833317290 priority patent/DE3317290A1/de
Priority to SE8302716A priority patent/SE461792B/sv
Priority to EP83104668A priority patent/EP0094095B1/de
Priority to AR292991A priority patent/AR240940A1/es
Priority to IE1084/83A priority patent/IE56480B1/en
Priority to LU84803A priority patent/LU84803A1/de
Priority to NO831675A priority patent/NO160368C/no
Priority to CS833303A priority patent/CS249128B2/cs
Priority to AT83104668T priority patent/ATE56718T1/de
Priority to KR1019830002033A priority patent/KR890002106B1/ko
Priority to US06/493,876 priority patent/US4512924A/en
Priority to DO1983004163A priority patent/DOP1983004163A/es
Priority to GR71331A priority patent/GR77462B/el
Priority to FI831661A priority patent/FI77244C/fi
Priority to PT76681A priority patent/PT76681B/pt
Priority to ES528626A priority patent/ES8505174A1/es
Priority to ES528627A priority patent/ES8601994A1/es
Priority to ES528631A priority patent/ES528631A0/es
Priority to ES528625A priority patent/ES528625A0/es
Priority to ES528629A priority patent/ES528629A0/es
Priority to ES528628A priority patent/ES8706672A1/es
Priority to ES528630A priority patent/ES8607970A1/es
Publication of GB2128984A publication Critical patent/GB2128984A/en
Priority to US06/697,559 priority patent/US4658024A/en
Application granted granted Critical
Publication of GB2128984B publication Critical patent/GB2128984B/en
Priority to ES554935A priority patent/ES8800170A1/es
Priority to US06/936,003 priority patent/US4772701A/en
Priority to FI871424A priority patent/FI81580C/fi
Priority to MYPI87001597A priority patent/MY102889A/en
Priority to CS914021A priority patent/CS402191A3/cs
Priority to SG811/92A priority patent/SG81192G/en
Priority to HK916/92A priority patent/HK91692A/xx
Priority to LU88299C priority patent/LU88299I2/fr
Priority to NL930055C priority patent/NL930055I2/nl
Priority to BG098502A priority patent/BG61123B2/bg
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
GB08305505A 1982-05-12 1983-02-28 Diaza-bicyclic compounds Expired GB2128984B (en)

Priority Applications (51)

Application Number Priority Date Filing Date Title
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds
CA000427095A CA1234568A (en) 1982-05-12 1983-04-29 Bicyclic pyrazolidine, pyridazine and diazepine derivatives
ZW98/83A ZW9883A1 (en) 1982-05-12 1983-04-29 Bicyclic compounds
DK194783A DK160612C (da) 1982-05-12 1983-05-02 Analogifremgangsmaade til fremstilling af ved begge n-atomer cyclopenta-, cyclohexa- og cyclohepta-annelerede pyrazol- og pyridazinderivater
IL68620A IL68620A (en) 1982-05-12 1983-05-06 Condensed pyrazolidine and pyridazinecarboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them
IT8321000A IT1212738B (it) 1982-05-12 1983-05-09 Composti biciclici ad attivita'anti-ipertensiva
HU875409A HU199842B (en) 1982-05-12 1983-05-09 Process for producing pyridazodiazepines and pharmaceutical compositions comprising same
HU831589A HU195965B (en) 1982-05-12 1983-05-09 Process for producing bicyclic diaza compounds and therapeutic preparations containing same
CU8335899A CU21532A3 (en) 1982-05-12 1983-05-09 Procedure for the production of bicyclic compounds
NL8301640A NL8301640A (nl) 1982-05-12 1983-05-09 Bicyclische verbindingen, werkwijze voor de bereiding ervan alsmede geneesmiddelen die deze verbindingen bevatten.
HU875410A HU198935B (en) 1982-05-12 1983-05-09 Process for producing bicyclic diaza compounds and pharmaceutical compositions comprising same
HU541183A HU198720B (en) 1983-02-28 1983-05-09 Process for producing pyridazodiazepines and pharmaceutical compositions containing them
AU14364/83A AU567873B2 (en) 1982-05-12 1983-05-09 (pyrazolo/pyridazo)(diazopines/pyridazines)
MC821633A MC1515A1 (fr) 1982-05-12 1983-05-10 Composes bicycliques
DZ836846A DZ540A1 (fr) 1982-05-12 1983-05-10 Composés bicycliques.
FR8307785A FR2531956B1 (fr) 1982-05-12 1983-05-10 Composes bicycliques, procede pour leur preparation et medicaments qui les contiennent
ES522291A ES8407049A1 (es) 1982-05-12 1983-05-11 Un procedimiento para la preparacion de compuestos biciclicos.
DE8383104668T DE3381884D1 (de) 1982-05-12 1983-05-11 Bicyclische carbonsaeuren und deren alkyl- und aralkylester.
DE19833317290 DE3317290A1 (de) 1982-05-12 1983-05-11 Bicyclische carbonsaeuren und deren alkyl- und aralkylester
SE8302716A SE461792B (sv) 1982-05-12 1983-05-11 Terapeutiskt verksamma bicykliska foereningar samt foerfarande foer framstaellning daerav
EP83104668A EP0094095B1 (de) 1982-05-12 1983-05-11 Bicyclische Carbonsäuren und deren Alkyl- und Aralkylester
AR292991A AR240940A1 (es) 1982-05-12 1983-05-11 Procedimiento para la preparacion de derivados de amino-substituido 1-carboxi-oxopirazolo- y -oxopiradazo/1,2-a/piridazina y -/1,2/ diazepina e intermediarios para uso exclusivo en dicho procedimiento"
IE1084/83A IE56480B1 (en) 1982-05-12 1983-05-11 Bicyclic carboxylic acids and alkyl and aralkyl esters thereof
LU84803A LU84803A1 (fr) 1982-05-12 1983-05-11 Bicyclische verbindungen
NO831675A NO160368C (no) 1982-05-12 1983-05-11 Analogifremgangsmaate for fremstilling av terapeutisk aktive bicykliske azoforbindelser.
CS833303A CS249128B2 (en) 1982-05-12 1983-05-11 Method of bicyclic compounds preparation
AT83104668T ATE56718T1 (de) 1982-05-12 1983-05-11 Bicyclische carbonsaeuren und deren alkyl- und aralkylester.
KR1019830002033A KR890002106B1 (ko) 1982-05-12 1983-05-11 2환 화합물의 제조방법
US06/493,876 US4512924A (en) 1982-05-12 1983-05-12 Pyridazo[1,2-a][1,2]diazepines
DO1983004163A DOP1983004163A (es) 1982-05-12 1983-05-12 Compuestos biciclicos
GR71331A GR77462B (enExample) 1982-05-12 1983-05-12
FI831661A FI77244C (fi) 1982-05-12 1983-05-12 Foerfarande foer framstaellning av nya farmakologiskt aktiva pyrazolo- och pyridazolo/1,2-a/diazepiner samt i detta foerfarande anvaendbara mellanprodukter.
PT76681A PT76681B (en) 1982-05-12 1983-05-12 Process for preparing oxo-pyrazolo pyridazo or diazephine-pyridazinic substituted derivatives and pharmaceutical compositions erewith
ES528626A ES8505174A1 (es) 1983-02-28 1984-01-02 Un procedimiento para la preparacion de compuestos biciclicos
ES528627A ES8601994A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de pirazolo-y piridazo-pirazolinas,-piridazinas y-diazepinas.
ES528631A ES528631A0 (es) 1983-02-28 1984-01-02 Un procedimiento para la preparacion de compuestos biciclicos
ES528625A ES528625A0 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de compuestos biciclicos
ES528629A ES528629A0 (es) 1983-02-28 1984-01-02 Un procedimiento para la preparacion de compuestos biciclicos
ES528628A ES8706672A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de pirazolo y piridazo-pirazolinas, piridazinas y diazepinas.
ES528630A ES8607970A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la obtencion de derivados de hexahidro-3-oxo-piridinas.
US06/697,559 US4658024A (en) 1982-05-12 1985-02-01 Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives
ES554935A ES8800170A1 (es) 1982-05-12 1986-05-14 Un procedimiento para la preparacion de pirazolo- y piridazo-pirazolinas, -piridazinas y -diacepinas
US06/936,003 US4772701A (en) 1982-05-12 1986-11-28 Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihypertensives
FI871424A FI81580C (fi) 1982-05-12 1987-04-01 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara pyridazopyridazinderivat och nya mellanprodukter.
MYPI87001597A MY102889A (en) 1982-05-12 1987-09-08 Pyridazo (1,2-a) (1,2) diazepines
CS914021A CS402191A3 (en) 1982-05-12 1991-12-23 Bicyclic carboxylic acids and their alkyl and aralkyl esters
SG811/92A SG81192G (en) 1982-05-12 1992-08-12 Bicyclic carboxylic acids and their alkyl and aralkyl esters
HK916/92A HK91692A (en) 1982-05-12 1992-11-19 Bicyclic carboxylic acids and their alkyl and aralkyl esters
LU88299C LU88299I2 (fr) 1982-05-12 1993-06-09 Cilazapril (Vascace / Inhibace)
NL930055C NL930055I2 (nl) 1982-05-12 1993-06-11 Bicyclische carbonzuren en de alkyl- en aralkylesters ervan.
BG098502A BG61123B2 (bg) 1982-05-12 1994-02-21 Бициклични карбоксилни киселини и техни алкилни и аралкилни естери

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (3)

Publication Number Publication Date
GB8305505D0 GB8305505D0 (en) 1983-03-30
GB2128984A GB2128984A (en) 1984-05-10
GB2128984B true GB2128984B (en) 1985-05-22

Family

ID=26282820

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08305505A Expired GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Country Status (32)

Country Link
US (3) US4512924A (enExample)
EP (1) EP0094095B1 (enExample)
KR (1) KR890002106B1 (enExample)
AR (1) AR240940A1 (enExample)
AU (1) AU567873B2 (enExample)
BG (1) BG61123B2 (enExample)
CA (1) CA1234568A (enExample)
CS (2) CS249128B2 (enExample)
CU (1) CU21532A3 (enExample)
DE (2) DE3317290A1 (enExample)
DK (1) DK160612C (enExample)
DO (1) DOP1983004163A (enExample)
DZ (1) DZ540A1 (enExample)
ES (6) ES8407049A1 (enExample)
FI (1) FI77244C (enExample)
FR (1) FR2531956B1 (enExample)
GB (1) GB2128984B (enExample)
GR (1) GR77462B (enExample)
HK (1) HK91692A (enExample)
HU (3) HU195965B (enExample)
IE (1) IE56480B1 (enExample)
IL (1) IL68620A (enExample)
IT (1) IT1212738B (enExample)
LU (2) LU84803A1 (enExample)
MC (1) MC1515A1 (enExample)
MY (1) MY102889A (enExample)
NL (2) NL8301640A (enExample)
NO (1) NO160368C (enExample)
PT (1) PT76681B (enExample)
SE (1) SE461792B (enExample)
SG (1) SG81192G (enExample)
ZW (1) ZW9883A1 (enExample)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4902707A (en) * 1985-04-30 1990-02-20 Eli Lilly And Company Bicyclic pyrazolidinones, compositions and use
US4826992A (en) * 1985-04-30 1989-05-02 Eli Lilly And Company 2,3-(Dihydro) bicyclic pyrazolidinones
ATE60605T1 (de) * 1985-04-30 1991-02-15 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
US4940718A (en) * 1985-04-30 1990-07-10 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
US4832763A (en) * 1985-10-15 1989-05-23 Westinghouse Electric Corp. Method of stress-relief annealing a magnetic core containing amorphous material
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
US4956490A (en) * 1989-03-09 1990-09-11 Merck & Co., Inc. Process for preparing benzylpyruvic acids and esters
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
DE3917255A1 (de) * 1989-05-26 1990-11-29 Schopf Masch Verfahren und vorrichtung zum aufnehmen eines flugzeugbugfahrwerks durch einen flugzeugschlepper
US5011938A (en) * 1989-10-02 1991-04-30 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones
JPH075530B2 (ja) * 1989-11-21 1995-01-25 シェリング・コーポレーション カルボキシアルキルカルボニルアミノ酸エンドペプチダーゼ阻害剤
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
EP0487453B1 (de) * 1990-11-21 1996-05-22 Ciba-Geigy Ag Silylierte Acylphosphinoxide
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
AU672578B2 (en) * 1991-03-19 1996-10-10 Novartis Ag Novel herbicidally, acaricidally and insecticidally active compounds
TW216770B (enExample) * 1991-07-23 1993-12-01 Hoffmann La Roche
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
JPH06107661A (ja) * 1991-10-24 1994-04-19 Upjohn Co:The イミダゾール誘導体およびこれを有効成分とする医薬組成物
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
ES2138622T3 (es) * 1992-05-15 2000-01-16 Merrell Pharma Inc Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca.
DE59310189D1 (de) * 1992-05-18 2001-08-23 Hoffmann La Roche Asymmetrische Hydrierung
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5635502A (en) * 1992-10-30 1997-06-03 Merrell Pharmaceuticals Inc. Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ACE
JPH072859A (ja) * 1993-01-28 1995-01-06 Upjohn Co:The ピラゾール誘導体およびこれを有効成分とする医薬組成物
US5476395A (en) * 1993-03-01 1995-12-19 Methode Electronics, Inc. Planar fuse panel
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
ATE198551T1 (de) * 1993-07-15 2001-01-15 Hoffmann La Roche Pharmazeutische kombination, die einen hemmer des renin-angiotensin-systems und einen endothelin- antagonisten enthält
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
CA2183320C (en) * 1994-02-14 1999-10-26 Gary A. Flynn Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
KR100364947B1 (ko) * 1994-02-14 2003-03-06 메렐 파마슈티칼스 인크. 엔케팔리나제및ace의억제제로서유용한신규의머캅토아세틸아미도1,3,4,5-테트라히드로-벤조[c]아제핀-3-온디술파이드유도체
HUT76479A (en) * 1994-02-14 1997-09-29 Merrell Pharma Inc Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them
ATE209205T1 (de) * 1994-02-14 2001-12-15 Merrell Pharma Inc Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
CA2184696C (en) * 1994-03-24 2001-01-02 Gary A. Flynn Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
WO1995025519A1 (en) * 1994-03-24 1995-09-28 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
FR2777889B1 (fr) * 1998-04-27 2004-07-09 Hoechst Marion Roussel Inc Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
FR2777888B1 (fr) * 1998-04-27 2004-07-16 Hoechst Marion Roussel Inc Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
AU2003200034B2 (en) * 1998-04-27 2006-07-20 Aventis Pharma S.A. New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en) * 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
FR2788276B1 (fr) * 1999-01-12 2001-02-16 Hoechst Marion Roussel Inc NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
WO2001021259A2 (en) * 1999-09-21 2001-03-29 Emory University Use and compositions for treating platelet-related disorders using anagrelide
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
AU2002230848B2 (en) 2000-12-14 2008-01-24 The Brigham And Women's Hospital, Inc. Inflammatory markers for detection and prevention of diabetes mellitus
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
ES2685697T3 (es) 2002-05-09 2018-10-10 The Brigham And Women's Hospital, Inc. 1L1RL-1 como un marcador de enfermedades cardiovasculares
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
CA2510320C (en) 2002-12-20 2012-10-09 St. James Associates Llc/Faber Research Series Coated particles for sustained-release pharmaceutical administration
US20060293517A1 (en) * 2003-03-06 2006-12-28 Yatendra Kumar Enantiomerically pure cilazapril, process for preparation
AU2003247159A1 (en) * 2003-07-07 2005-01-21 Hetero Drugs Limited A novel process for the preparation of cilazapril
DK2384753T3 (en) 2003-08-29 2016-04-11 Brigham & Womens Hospital Hydantoin derivatives as inhibitors of cell necrosis
JP4625812B2 (ja) 2003-12-05 2011-02-02 ザ クリーブランド クリニック ファウンデーション 心臓血管疾患に対するリスクマーカー
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
WO2005122682A2 (en) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Process for the preparation of esters of piperazic acid
EP2343553A1 (en) 2004-10-06 2011-07-13 The Brigham and Women's Hospital Relevance of achieved levels of markers of systemic inflammation following treatment
US20080306041A1 (en) * 2005-01-21 2008-12-11 Garvey David S Cardiovascular Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use
RU2433823C2 (ru) * 2005-01-31 2011-11-20 Милан Лэборетериз, Инк. Фармацевтическая композиция, содержащая гидроксилированный небиволол
NZ563759A (en) 2005-05-31 2010-06-25 Mylan Lab Inc Compositions comprising nebivolol, a hydralazine compound and an isosorbide nitrate
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
DE602006000402T8 (de) 2006-06-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Stabile Zubereitung enthaltend eine feuchtigkeitsempfindliche aktive Substanz und Verfahren zur Herstellung der Zubereitung.
US20070281000A1 (en) * 2006-06-02 2007-12-06 Michael Fox Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
EP2030025A2 (en) * 2006-06-07 2009-03-04 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
US20080008751A1 (en) * 2006-07-10 2008-01-10 Michael Fox Stable formulation comprising a combination of a moisture sensitive drug and a second drug and manufacturing procedure thereof
CN102317786A (zh) 2007-04-18 2012-01-11 特提斯生物科学公司 糖尿病相关性生物学标记物及其使用方法
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
GB2462022B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
EP2221299A3 (en) 2009-02-11 2010-11-03 Dr. Reddy's Laboratories Ltd. Preparation of cilazapril intermediates
EP2531163A1 (en) 2010-02-01 2012-12-12 The Hospital For Sick Children Remote ischemic conditioning for treatment and preventon of restenosis
JP2013523240A (ja) 2010-03-31 2013-06-17 ザ・ホスピタル・フォー・シック・チルドレン 心筋梗塞後の結果を改善するための遠隔虚血コンディショニングの使用
EP2555692A2 (en) 2010-04-08 2013-02-13 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
WO2012049646A1 (en) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of cilazapril
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.
AU2012284039B2 (en) 2011-07-18 2017-03-30 Critical Care Diagnostics, Inc. Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
CN104640856B (zh) 2012-05-11 2017-09-15 复位治疗公司 作为隐花色素调节剂的含有咔唑的磺酰胺类
AU2013296803B2 (en) 2012-08-01 2018-03-08 Eric Ostertag Free flowing, frozen compositions comprising a therapeutic agent
EP2968276A4 (en) 2013-03-15 2017-02-15 President and Fellows of Harvard College Hybrid necroptosis inhibitors
CN105517536B (zh) 2013-03-21 2019-08-16 优普顺药物公司美国分部 可注射的持续释放组合物及其用于治疗关节炎症及相关疼痛的方法
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
EP3206672B1 (en) 2015-10-27 2018-03-14 Eupraxia Pharmaceuticals Inc. Sustained release formulations of local anesthetics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
EP0047620B1 (en) * 1980-09-10 1985-03-13 Beecham Group Plc Aryl diazabicyclyl amides, a process for their preparation and use
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds

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FR2531956A1 (fr) 1984-02-24
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