FR2531956B1 - Composes bicycliques, procede pour leur preparation et medicaments qui les contiennent - Google Patents

Composes bicycliques, procede pour leur preparation et medicaments qui les contiennent

Info

Publication number
FR2531956B1
FR2531956B1 FR8307785A FR8307785A FR2531956B1 FR 2531956 B1 FR2531956 B1 FR 2531956B1 FR 8307785 A FR8307785 A FR 8307785A FR 8307785 A FR8307785 A FR 8307785A FR 2531956 B1 FR2531956 B1 FR 2531956B1
Authority
FR
France
Prior art keywords
preparation
medicaments containing
bicyclic compounds
bicyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8307785A
Other languages
English (en)
French (fr)
Other versions
FR2531956A1 (fr
Inventor
Michael Riehard Attwood
Cedric Herbert Hassall
Robert Wilson Lambert
Geoffrey Lawton
Sally Redshaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2531956A1 publication Critical patent/FR2531956A1/fr
Application granted granted Critical
Publication of FR2531956B1 publication Critical patent/FR2531956B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
FR8307785A 1982-05-12 1983-05-10 Composes bicycliques, procede pour leur preparation et medicaments qui les contiennent Expired FR2531956B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (2)

Publication Number Publication Date
FR2531956A1 FR2531956A1 (fr) 1984-02-24
FR2531956B1 true FR2531956B1 (fr) 1987-02-20

Family

ID=26282820

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8307785A Expired FR2531956B1 (fr) 1982-05-12 1983-05-10 Composes bicycliques, procede pour leur preparation et medicaments qui les contiennent

Country Status (32)

Country Link
US (3) US4512924A (enExample)
EP (1) EP0094095B1 (enExample)
KR (1) KR890002106B1 (enExample)
AR (1) AR240940A1 (enExample)
AU (1) AU567873B2 (enExample)
BG (1) BG61123B2 (enExample)
CA (1) CA1234568A (enExample)
CS (2) CS249128B2 (enExample)
CU (1) CU21532A3 (enExample)
DE (2) DE3317290A1 (enExample)
DK (1) DK160612C (enExample)
DO (1) DOP1983004163A (enExample)
DZ (1) DZ540A1 (enExample)
ES (6) ES8407049A1 (enExample)
FI (1) FI77244C (enExample)
FR (1) FR2531956B1 (enExample)
GB (1) GB2128984B (enExample)
GR (1) GR77462B (enExample)
HK (1) HK91692A (enExample)
HU (3) HU195965B (enExample)
IE (1) IE56480B1 (enExample)
IL (1) IL68620A (enExample)
IT (1) IT1212738B (enExample)
LU (2) LU84803A1 (enExample)
MC (1) MC1515A1 (enExample)
MY (1) MY102889A (enExample)
NL (2) NL8301640A (enExample)
NO (1) NO160368C (enExample)
PT (1) PT76681B (enExample)
SE (1) SE461792B (enExample)
SG (1) SG81192G (enExample)
ZW (1) ZW9883A1 (enExample)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
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ES528630A0 (es) 1986-06-16
FR2531956A1 (fr) 1984-02-24
IE831084L (en) 1983-11-12
CU21532A3 (en) 1987-06-09
DE3381884D1 (de) 1990-10-25
GR77462B (enExample) 1984-09-24
CS402191A3 (en) 1992-10-14
US4772701A (en) 1988-09-20
IL68620A0 (en) 1983-09-30
ES528627A0 (es) 1985-11-16
ES8505173A1 (es) 1985-05-16
ES8800170A1 (es) 1987-11-01
NL930055I1 (nl) 1993-09-01
DZ540A1 (fr) 2004-09-13
ZW9883A1 (en) 1984-11-21
DE3317290A1 (de) 1983-11-17
LU84803A1 (fr) 1985-03-21
GB8305505D0 (en) 1983-03-30
DOP1983004163A (es) 1988-09-20
DK194783A (da) 1983-11-13
IE56480B1 (en) 1991-08-14
CA1234568A (en) 1988-03-29
IT8321000A0 (it) 1983-05-09
AR240940A2 (es) 1991-03-27
DK160612B (da) 1991-04-02
NL930055I2 (nl) 1993-10-01
SE8302716D0 (sv) 1983-05-11
NO831675L (no) 1983-11-14
ES554935A0 (es) 1987-11-01
KR890002106B1 (ko) 1989-06-19
BG61123B2 (bg) 1996-11-29
PT76681B (en) 1986-05-20
KR840004754A (ko) 1984-10-24
HU198935B (en) 1989-12-28
US4512924A (en) 1985-04-23
AU1436483A (en) 1983-11-17
IT1212738B (it) 1989-11-30
AU567873B2 (en) 1987-12-10
ES8607970A1 (es) 1986-06-16
GB2128984B (en) 1985-05-22
PT76681A (en) 1983-06-01
CS249128B2 (en) 1987-03-12
EP0094095A3 (en) 1984-11-21
HU199842B (en) 1990-03-28
SG81192G (en) 1993-01-29
HU195965B (en) 1988-08-29
DK194783D0 (da) 1983-05-02
ES528628A0 (es) 1987-07-16
FI831661L (fi) 1983-11-13
LU88299I2 (fr) 1994-09-09
AR240940A1 (es) 1991-03-27
EP0094095B1 (de) 1990-09-19
DK160612C (da) 1991-09-23
ES522291A0 (es) 1984-08-16
FI77244C (fi) 1989-02-10
FI831661A0 (fi) 1983-05-12
IL68620A (en) 1987-11-30
SE461792B (sv) 1990-03-26
NL8301640A (nl) 1983-12-01
MC1515A1 (fr) 1984-02-10
ES8601994A1 (es) 1985-11-16
NO160368C (no) 1989-04-12
US4658024A (en) 1987-04-14
FI77244B (fi) 1988-10-31
NO160368B (no) 1989-01-02
ES8407049A1 (es) 1984-08-16
SE8302716L (sv) 1983-11-13
EP0094095A2 (de) 1983-11-16
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GB2128984A (en) 1984-05-10
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