GB1527131A - Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing them - Google Patents
Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing themInfo
- Publication number
- GB1527131A GB1527131A GB37252/75A GB3725275A GB1527131A GB 1527131 A GB1527131 A GB 1527131A GB 37252/75 A GB37252/75 A GB 37252/75A GB 3725275 A GB3725275 A GB 3725275A GB 1527131 A GB1527131 A GB 1527131A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- imidazodiazepines
- benzo
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000005605 benzo group Chemical group 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- BMGXAZCDDYTVFV-UHFFFAOYSA-N imidazo[4,5-c]diazepine Chemical class C1=CN=NC2=NC=NC2=C1 BMGXAZCDDYTVFV-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IMXWNWBXKWASOM-UHFFFAOYSA-N 3h-imidazo[1,5-a][1,4]diazepine Chemical class N1=CC=CN2CN=CC2=C1 IMXWNWBXKWASOM-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1268878A GB1527132A (en) | 1974-09-11 | 1975-09-10 | Diazepine derivatives |
| GB1269078A GB1527134A (en) | 1974-09-11 | 1975-09-10 | Imidazo derivatives |
| GB1268978A GB1527133A (en) | 1974-09-11 | 1975-09-10 | Imidazodiazepine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50492474A | 1974-09-11 | 1974-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1527131A true GB1527131A (en) | 1978-10-04 |
Family
ID=24008278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37252/75A Expired GB1527131A (en) | 1974-09-11 | 1975-09-10 | Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing them |
Country Status (32)
| Country | Link |
|---|---|
| JP (1) | JPS51125099A (xx) |
| AT (1) | AT360023B (xx) |
| AU (1) | AU505998B2 (xx) |
| BE (1) | BE833248A (xx) |
| BR (1) | BR7505864A (xx) |
| CA (1) | CA1067491A (xx) |
| CH (2) | CH619953A5 (xx) |
| CU (1) | CU34346A (xx) |
| DD (1) | DD121640A5 (xx) |
| DE (1) | DE2540522A1 (xx) |
| DK (1) | DK157615C (xx) |
| ES (1) | ES440850A1 (xx) |
| FI (1) | FI63234C (xx) |
| FR (2) | FR2285890A1 (xx) |
| GB (1) | GB1527131A (xx) |
| HK (1) | HK63381A (xx) |
| HU (1) | HU174752B (xx) |
| IE (1) | IE41844B1 (xx) |
| IL (1) | IL48069A (xx) |
| KE (1) | KE3173A (xx) |
| LU (1) | LU73356A1 (xx) |
| MX (1) | MX160600A (xx) |
| MY (1) | MY8200214A (xx) |
| NL (1) | NL171060C (xx) |
| NO (4) | NO147109C (xx) |
| NZ (1) | NZ178635A (xx) |
| PH (2) | PH16152A (xx) |
| PL (1) | PL106563B1 (xx) |
| SE (4) | SE425785B (xx) |
| SU (1) | SU814278A3 (xx) |
| YU (1) | YU40267B (xx) |
| ZA (1) | ZA755418B (xx) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20100777A1 (it) * | 2010-05-04 | 2011-11-05 | Italiana Sint Spa | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
| CN103086986A (zh) * | 2011-11-01 | 2013-05-08 | 上海医药工业研究院 | 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用 |
| US10906909B2 (en) | 2016-03-18 | 2021-02-02 | Uwm Research Foundation, Inc. | Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with ALPHA5-containing GABAA receptor agonists |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125726A (en) | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4226771A (en) * | 1979-07-25 | 1980-10-07 | Hoffmann-La Roche Inc. | 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives |
| US4256637A (en) * | 1979-12-20 | 1981-03-17 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| US4335042A (en) * | 1980-04-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Process to produce imidazobenzodiazepine intermediates |
| DE3329515C2 (de) * | 1983-08-16 | 1985-11-14 | Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg | Elektrische Schaltanordnung für einen magnetisch-induktiven Meßwertgeber |
| ZA845757B (en) * | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| FI880814A (fi) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | Imidazodiazepin-derivat. |
| AU6909194A (en) * | 1993-05-14 | 1994-12-12 | Board Of Regents, The University Of Texas System | Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole |
| IN184976B (xx) * | 1996-06-13 | 2000-10-14 | Ranbaxy Lab Ltd | |
| CN103804384B (zh) * | 2014-01-27 | 2016-01-20 | 李宏 | 苯并二氮杂卓类化合物的制备方法 |
| US11447495B2 (en) | 2016-08-16 | 2022-09-20 | Uwm Research Foundation, Inc. | Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators |
| CN111410658B (zh) * | 2020-03-30 | 2021-03-26 | 江苏恩华药业股份有限公司 | 咪达唑仑或其药物组合物的杂质a和杂质b及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA721060B (en) * | 1970-10-30 | 1972-11-29 | Takeda Chemical Industries Ltd | Benzodiazepine derivatives |
| DE2056265A1 (en) * | 1970-11-16 | 1972-05-31 | Sumitomo Chemical Co. Ltd., Osaka (Japan) | Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso |
| JPS4932874B1 (xx) * | 1970-12-11 | 1974-09-03 | ||
| BE787251A (fr) * | 1971-08-04 | 1973-02-05 | Upjohn Co | Nouvelles benzodiazepines et leur preparation |
| BE790839A (fr) * | 1971-11-02 | 1973-04-30 | Upjohn Co | Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant |
| BE792972A (fr) * | 1971-12-20 | 1973-06-19 | Hoffmann La Roche | Derives de benzodiazepine |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| CA1005443A (en) * | 1972-06-22 | 1977-02-15 | Michio Nakanishi | Thienodiazepine compounds |
-
1975
- 1975-08-25 ZA ZA755418A patent/ZA755418B/xx unknown
- 1975-09-03 CH CH1141075A patent/CH619953A5/de not_active IP Right Cessation
- 1975-09-08 FI FI752517A patent/FI63234C/fi not_active IP Right Cessation
- 1975-09-08 NO NO753069A patent/NO147109C/no unknown
- 1975-09-08 SE SE7509991A patent/SE425785B/xx active Protection Beyond IP Right Term
- 1975-09-09 FR FR7527599A patent/FR2285890A1/fr active Granted
- 1975-09-09 MX MX201652A patent/MX160600A/es unknown
- 1975-09-09 NL NLAANVRAGE7510620,A patent/NL171060C/xx not_active IP Right Cessation
- 1975-09-09 NZ NZ178635A patent/NZ178635A/xx unknown
- 1975-09-09 LU LU73356A patent/LU73356A1/xx unknown
- 1975-09-09 IL IL48069A patent/IL48069A/xx unknown
- 1975-09-10 JP JP50109060A patent/JPS51125099A/ja active Granted
- 1975-09-10 PL PL1975204027A patent/PL106563B1/pl unknown
- 1975-09-10 HU HU75HO1835A patent/HU174752B/hu unknown
- 1975-09-10 YU YU2285/75A patent/YU40267B/xx unknown
- 1975-09-10 PH PH17566A patent/PH16152A/en unknown
- 1975-09-10 ES ES440850A patent/ES440850A1/es not_active Expired
- 1975-09-10 CA CA235,138A patent/CA1067491A/en not_active Expired
- 1975-09-10 AT AT697775A patent/AT360023B/de not_active IP Right Cessation
- 1975-09-10 AU AU84704/75A patent/AU505998B2/en not_active Expired
- 1975-09-10 GB GB37252/75A patent/GB1527131A/en not_active Expired
- 1975-09-10 BE BE159891A patent/BE833248A/xx not_active IP Right Cessation
- 1975-09-10 DD DD188275A patent/DD121640A5/xx unknown
- 1975-09-10 DK DK404175A patent/DK157615C/da not_active IP Right Cessation
- 1975-09-10 SU SU752170852A patent/SU814278A3/ru active
- 1975-09-11 BR BR7505864*A patent/BR7505864A/pt unknown
- 1975-09-11 CU CU34346A patent/CU34346A/es unknown
- 1975-09-11 IE IE1973/75A patent/IE41844B1/en unknown
- 1975-09-11 DE DE19752540522 patent/DE2540522A1/de active Granted
-
1976
- 1976-06-10 FR FR7617552A patent/FR2303016A1/fr active Granted
-
1979
- 1979-03-23 SE SE7902668A patent/SE449098B/sv not_active IP Right Cessation
- 1979-03-23 SE SE7902666A patent/SE440504B/sv not_active IP Right Cessation
- 1979-03-23 SE SE7902667A patent/SE433080B/sv not_active IP Right Cessation
- 1979-05-24 PH PH22557A patent/PH15091A/en unknown
-
1980
- 1980-09-12 NO NO802719A patent/NO147914C/no unknown
- 1980-09-12 NO NO802718A patent/NO146573C/no unknown
- 1980-09-12 NO NO802720A patent/NO148188C/no unknown
-
1981
- 1981-02-27 CH CH133781A patent/CH628053A5/de not_active IP Right Cessation
- 1981-11-24 KE KE3173A patent/KE3173A/xx unknown
- 1981-12-17 HK HK633/81A patent/HK63381A/xx unknown
-
1982
- 1982-12-30 MY MY214/82A patent/MY8200214A/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20100777A1 (it) * | 2010-05-04 | 2011-11-05 | Italiana Sint Spa | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
| EP2397470A1 (en) * | 2010-05-04 | 2011-12-21 | F.I.S. Fabbrica Italiana Sintetici S.p.A. | Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof |
| US8557981B2 (en) | 2010-05-04 | 2013-10-15 | F.I.S. Fabbrica Italiana Sintetici S.P.A. | Process for the synthesis of 4H-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof |
| CN103086986A (zh) * | 2011-11-01 | 2013-05-08 | 上海医药工业研究院 | 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用 |
| CN103086986B (zh) * | 2011-11-01 | 2015-11-04 | 上海医药工业研究院 | 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用 |
| US10906909B2 (en) | 2016-03-18 | 2021-02-02 | Uwm Research Foundation, Inc. | Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with ALPHA5-containing GABAA receptor agonists |
| US11753412B2 (en) | 2016-03-18 | 2023-09-12 | Uwm Research Foundation, Inc. | Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with Alpha5-containing GABAA receptor agonists |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1527131A (en) | Benzo or heterocyclic fused imidazodiazepines and pharmaceutical compositions containing them | |
| IE37056B1 (en) | Pyrrolo(3,4-b)pyrazine derivatives | |
| SE7710873L (sv) | Nya 1h-pyrazolo(3,4-b)pyridiner | |
| IE42979L (en) | Pyrazinyl piperazine derivatives | |
| CH613454A5 (en) | Process for the preparation of new benzodiazepine derivatives | |
| IE34205B1 (en) | Thienodiazepine derivatives | |
| IE780119L (en) | IMIDAZO(1,2-a) QUINOLINE-2-CARBOXYLIC ACIDS | |
| IE40335B1 (en) | Pyrazole derivatives, process for their preparation and their use as medicaments | |
| GB1213172A (en) | Dibenzothiazepine derivatives and production of the same | |
| ES390163A1 (es) | Procedimiento para la preparacion de amino-derivados de los acidos pirazolo (3,4-b) piridina-5-carboxilicos. | |
| GB1124157A (en) | Novel benzdiaz[1,4] epine derivatives and a process for the manufacture thereof | |
| IE34393L (en) | Dibenzodiazepines and pyridobenzodiazepines | |
| ES482280A1 (es) | Un procedimiento para la preparacion de nuevos derivados 2- (1h-imidazol-1-il)etoxi de pirazolo-3,4-b-piridina-5-metano-les. | |
| ES449446A1 (es) | Un procedimiento para la produccion de acidos 1-oxo-1h-6-pi-peridinogicamente activos y esteres de los mismos. | |
| GB1260857A (en) | IMIDAZO-3H-(4,5-b)-PYRIDINE DERIVATIVES | |
| GB1139146A (en) | Benzofuran derivatives and processes for preparing the same | |
| IE40722L (en) | Indolopiperidino -alkylphenothiazines | |
| AU5006679A (en) | Pyrano (3,2-c)quinoline derivatives | |
| GB1227965A (xx) | ||
| GB1097072A (en) | Substituted 1,2-cycloalkylene-5-oxo-2-imidazolines | |
| FR2215208A1 (en) | Basic esters of 2-phenyl -4 - alkyl-4-hexanoic acids - useful as spasmolytics | |
| GB1056327A (en) | Pyridobenzodiazepine derivatives | |
| JPS5384990A (en) | Novel nitrogen-containing heterocyclic compound and its preparation | |
| JPS5353697A (en) | Tricyclic triazolopyrimidine derivatives | |
| SE8007021L (sv) | Forfarande for framstellning av substituerade 6-aryl-4h-s-triazolo-(3,4-c)-tieno-(2,3-e)-1,4-diazepiner |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19950909 |