FR2285890A1 - Derives de diazepine - Google Patents

Derives de diazepine

Info

Publication number
FR2285890A1
FR2285890A1 FR7527599A FR7527599A FR2285890A1 FR 2285890 A1 FR2285890 A1 FR 2285890A1 FR 7527599 A FR7527599 A FR 7527599A FR 7527599 A FR7527599 A FR 7527599A FR 2285890 A1 FR2285890 A1 FR 2285890A1
Authority
FR
France
Prior art keywords
diazepine derivatives
diazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7527599A
Other languages
English (en)
French (fr)
Other versions
FR2285890B1 (xx
Inventor
Rodney Ian Fryer
Armin Walser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2285890A1 publication Critical patent/FR2285890A1/fr
Application granted granted Critical
Publication of FR2285890B1 publication Critical patent/FR2285890B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR7527599A 1974-09-11 1975-09-09 Derives de diazepine Granted FR2285890A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50492474A 1974-09-11 1974-09-11

Publications (2)

Publication Number Publication Date
FR2285890A1 true FR2285890A1 (fr) 1976-04-23
FR2285890B1 FR2285890B1 (xx) 1981-12-31

Family

ID=24008278

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7527599A Granted FR2285890A1 (fr) 1974-09-11 1975-09-09 Derives de diazepine
FR7617552A Granted FR2303016A1 (fr) 1974-09-11 1976-06-10 Derives de (1,5-a) (1,4)-diazepine

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7617552A Granted FR2303016A1 (fr) 1974-09-11 1976-06-10 Derives de (1,5-a) (1,4)-diazepine

Country Status (32)

Country Link
JP (1) JPS51125099A (xx)
AT (1) AT360023B (xx)
AU (1) AU505998B2 (xx)
BE (1) BE833248A (xx)
BR (1) BR7505864A (xx)
CA (1) CA1067491A (xx)
CH (2) CH619953A5 (xx)
CU (1) CU34346A (xx)
DD (1) DD121640A5 (xx)
DE (1) DE2540522A1 (xx)
DK (1) DK157615C (xx)
ES (1) ES440850A1 (xx)
FI (1) FI63234C (xx)
FR (2) FR2285890A1 (xx)
GB (1) GB1527131A (xx)
HK (1) HK63381A (xx)
HU (1) HU174752B (xx)
IE (1) IE41844B1 (xx)
IL (1) IL48069A (xx)
KE (1) KE3173A (xx)
LU (1) LU73356A1 (xx)
MX (1) MX160600A (xx)
MY (1) MY8200214A (xx)
NL (1) NL171060C (xx)
NO (4) NO147109C (xx)
NZ (1) NZ178635A (xx)
PH (2) PH16152A (xx)
PL (1) PL106563B1 (xx)
SE (4) SE425785B (xx)
SU (1) SU814278A3 (xx)
YU (1) YU40267B (xx)
ZA (1) ZA755418B (xx)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125726A (en) 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
FR2479818A1 (en) * 1980-04-03 1981-10-09 Roussel Uclaf 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4226768A (en) * 1979-05-29 1980-10-07 Hoffmann-La Roche Inc. Process for the preparation of imidazobenzodiazepines
US4226771A (en) * 1979-07-25 1980-10-07 Hoffmann-La Roche Inc. 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives
US4256637A (en) * 1979-12-20 1981-03-17 Hoffmann-La Roche Inc. Intermediates for the production of imidazobenzodiazepines
US4335042A (en) * 1980-04-21 1982-06-15 Hoffmann-La Roche Inc. Process to produce imidazobenzodiazepine intermediates
DE3329515C2 (de) * 1983-08-16 1985-11-14 Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg Elektrische Schaltanordnung für einen magnetisch-induktiven Meßwertgeber
ZA845757B (en) * 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
EP0763537A3 (en) * 1993-05-14 1997-10-22 Genentech Inc Non-peptides farnesyl transfer inhibitors
IN184976B (xx) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
IT1399764B1 (it) * 2010-05-04 2013-05-03 F S I Fabbrica Italiana Sint Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.
CN103086986B (zh) * 2011-11-01 2015-11-04 上海医药工业研究院 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用
CN103804384B (zh) * 2014-01-27 2016-01-20 李宏 苯并二氮杂卓类化合物的制备方法
HUE059774T2 (hu) * 2016-03-18 2023-01-28 Uwm Res Foundation Inc Kognitív és hangulati szimptómák kezelése neurodegeneratív és neuropszichiátriai betegségekben ALFA5-öt tartalmazó GABAA receptoragonistákkal
JP7013446B2 (ja) 2016-08-16 2022-02-15 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法
CN111410658B (zh) * 2020-03-30 2021-03-26 江苏恩华药业股份有限公司 咪达唑仑或其药物组合物的杂质a和杂质b及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA721060B (en) * 1970-10-30 1972-11-29 Takeda Chemical Industries Ltd Benzodiazepine derivatives
DE2056265A1 (en) * 1970-11-16 1972-05-31 Sumitomo Chemical Co. Ltd., Osaka (Japan) Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso
JPS4932874B1 (xx) * 1970-12-11 1974-09-03
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
BE790839A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant
BE792972A (fr) * 1971-12-20 1973-06-19 Hoffmann La Roche Derives de benzodiazepine
FR2183716A1 (en) * 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
CA1005443A (en) * 1972-06-22 1977-02-15 Michio Nakanishi Thienodiazepine compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125726A (en) 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
FR2479818A1 (en) * 1980-04-03 1981-10-09 Roussel Uclaf 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione

Also Published As

Publication number Publication date
HK63381A (en) 1981-12-24
NO147109C (no) 1983-02-02
KE3173A (en) 1982-01-08
NO147914B (no) 1983-03-28
DK157615C (da) 1990-06-25
NL7510620A (nl) 1976-03-15
JPS51125099A (en) 1976-11-01
NO148188C (no) 1983-08-24
SE433080B (sv) 1984-05-07
SE7902666L (sv) 1979-03-23
SE7509991L (sv) 1976-03-12
NZ178635A (en) 1982-12-21
SE425785B (sv) 1982-11-08
FR2285890B1 (xx) 1981-12-31
NO146573B (no) 1982-07-19
NO148188B (no) 1983-05-16
FI752517A (xx) 1976-03-12
PL106563B1 (pl) 1979-12-31
HU174752B (hu) 1980-03-28
AU505998B2 (en) 1979-12-13
SE449098B (sv) 1987-04-06
AU8470475A (en) 1977-03-17
NO753069L (xx) 1976-03-12
CU20892L (es) 1982-08-24
PH16152A (en) 1983-07-12
DK404175A (da) 1976-03-12
FR2303016B1 (xx) 1982-07-09
SE7902667L (sv) 1979-03-23
CH628053A5 (en) 1982-02-15
ATA697775A (de) 1980-05-15
ZA755418B (en) 1977-06-29
CA1067491A (en) 1979-12-04
FR2303016A1 (fr) 1976-10-01
JPS562073B2 (xx) 1981-01-17
DE2540522A1 (de) 1976-04-08
PH15091A (en) 1982-08-03
FI63234B (fi) 1983-01-31
NL171060C (nl) 1983-02-01
NO147109B (no) 1982-10-25
NO147914C (no) 1983-07-06
NO802720L (no) 1976-03-12
AT360023B (de) 1980-12-10
YU228575A (en) 1983-01-21
BR7505864A (pt) 1976-08-03
MY8200214A (en) 1982-12-31
NO802718L (no) 1976-03-12
GB1527131A (en) 1978-10-04
IE41844B1 (en) 1980-04-09
SU814278A3 (ru) 1981-03-15
ES440850A1 (es) 1977-07-01
SE7902668L (sv) 1979-03-23
NO802719L (no) 1976-03-12
DE2540522C2 (xx) 1988-10-20
CU34346A (es) 1982-08-24
YU40267B (en) 1985-12-31
FI63234C (fi) 1983-05-10
NO146573C (no) 1982-10-27
IE41844L (en) 1976-03-11
MX160600A (es) 1993-09-01
IL48069A (en) 1980-09-16
DK157615B (da) 1990-01-29
BE833248A (fr) 1976-03-10
LU73356A1 (xx) 1977-05-11
IL48069A0 (en) 1975-11-25
DD121640A5 (xx) 1976-08-12
SE440504B (sv) 1985-08-05
CH619953A5 (en) 1980-10-31

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Legal Events

Date Code Title Description
TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0113, 920430

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0113, 750909

CL Concession to grant licences