SE425785B - Analogiforfarande for framstellning av imidazo (1,5-a)(1,4) diazzepinderivat - Google Patents

Analogiforfarande for framstellning av imidazo (1,5-a)(1,4) diazzepinderivat

Info

Publication number
SE425785B
SE425785B SE7509991A SE7509991A SE425785B SE 425785 B SE425785 B SE 425785B SE 7509991 A SE7509991 A SE 7509991A SE 7509991 A SE7509991 A SE 7509991A SE 425785 B SE425785 B SE 425785B
Authority
SE
Sweden
Prior art keywords
diazzepine
derivatives
analogy procedure
preparing imidazo
imidazo
Prior art date
Application number
SE7509991A
Other languages
English (en)
Swedish (sv)
Other versions
SE7509991L (sv
Inventor
R I Fryer
A Walser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE7509991L publication Critical patent/SE7509991L/xx
Publication of SE425785B publication Critical patent/SE425785B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SE7509991A 1974-09-11 1975-09-08 Analogiforfarande for framstellning av imidazo (1,5-a)(1,4) diazzepinderivat SE425785B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50492474A 1974-09-11 1974-09-11

Publications (2)

Publication Number Publication Date
SE7509991L SE7509991L (sv) 1976-03-12
SE425785B true SE425785B (sv) 1982-11-08

Family

ID=24008278

Family Applications (4)

Application Number Title Priority Date Filing Date
SE7509991A SE425785B (sv) 1974-09-11 1975-09-08 Analogiforfarande for framstellning av imidazo (1,5-a)(1,4) diazzepinderivat
SE7902668A SE449098B (sv) 1974-09-11 1979-03-23 Fenyl-/2-(5-hydroxi-1-imidazolyl)fenyl/-metanonderivat till anvendning som mellanprodukter for framstellning av imidazo/1,5-a//1,4/bensodiazepinderivat
SE7902667A SE433080B (sv) 1974-09-11 1979-03-23 Mellanprodukt for framstellning av imidazo /1,5-a/ /1,4/ diazepinderivat
SE7902666A SE440504B (sv) 1974-09-11 1979-03-23 Mellanprodukt for framstellning av imidazo (1,5-a)(1,4)diazepiner

Family Applications After (3)

Application Number Title Priority Date Filing Date
SE7902668A SE449098B (sv) 1974-09-11 1979-03-23 Fenyl-/2-(5-hydroxi-1-imidazolyl)fenyl/-metanonderivat till anvendning som mellanprodukter for framstellning av imidazo/1,5-a//1,4/bensodiazepinderivat
SE7902667A SE433080B (sv) 1974-09-11 1979-03-23 Mellanprodukt for framstellning av imidazo /1,5-a/ /1,4/ diazepinderivat
SE7902666A SE440504B (sv) 1974-09-11 1979-03-23 Mellanprodukt for framstellning av imidazo (1,5-a)(1,4)diazepiner

Country Status (32)

Country Link
JP (1) JPS51125099A (xx)
AT (1) AT360023B (xx)
AU (1) AU505998B2 (xx)
BE (1) BE833248A (xx)
BR (1) BR7505864A (xx)
CA (1) CA1067491A (xx)
CH (2) CH619953A5 (xx)
CU (1) CU20892L (xx)
DD (1) DD121640A5 (xx)
DE (1) DE2540522A1 (xx)
DK (1) DK157615C (xx)
ES (1) ES440850A1 (xx)
FI (1) FI63234C (xx)
FR (2) FR2285890A1 (xx)
GB (1) GB1527131A (xx)
HK (1) HK63381A (xx)
HU (1) HU174752B (xx)
IE (1) IE41844B1 (xx)
IL (1) IL48069A (xx)
KE (1) KE3173A (xx)
LU (1) LU73356A1 (xx)
MX (1) MX160600A (xx)
MY (1) MY8200214A (xx)
NL (1) NL171060C (xx)
NO (4) NO147109C (xx)
NZ (1) NZ178635A (xx)
PH (2) PH16152A (xx)
PL (1) PL106563B1 (xx)
SE (4) SE425785B (xx)
SU (1) SU814278A3 (xx)
YU (1) YU40267B (xx)
ZA (1) ZA755418B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125726A (en) * 1977-03-11 1978-11-14 Hoffmann-La Roche Inc. Imidazo[1,5-a][1,4]benzodiazepines
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4226768A (en) * 1979-05-29 1980-10-07 Hoffmann-La Roche Inc. Process for the preparation of imidazobenzodiazepines
US4226771A (en) * 1979-07-25 1980-10-07 Hoffmann-La Roche Inc. 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives
US4256637A (en) * 1979-12-20 1981-03-17 Hoffmann-La Roche Inc. Intermediates for the production of imidazobenzodiazepines
FR2479818A1 (en) * 1980-04-03 1981-10-09 Roussel Uclaf 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione
US4335042A (en) * 1980-04-21 1982-06-15 Hoffmann-La Roche Inc. Process to produce imidazobenzodiazepine intermediates
DE3329515C2 (de) * 1983-08-16 1985-11-14 Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg Elektrische Schaltanordnung für einen magnetisch-induktiven Meßwertgeber
ZA845757B (en) * 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
US5843941A (en) * 1993-05-14 1998-12-01 Genentech, Inc. Ras farnesyl transferase inhibitors
IN184976B (xx) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
IT1399764B1 (it) * 2010-05-04 2013-05-03 F S I Fabbrica Italiana Sint Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam.
CN103086986B (zh) * 2011-11-01 2015-11-04 上海医药工业研究院 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用
CN103804384B (zh) * 2014-01-27 2016-01-20 李宏 苯并二氮杂卓类化合物的制备方法
EP3439665B1 (en) 2016-03-18 2022-06-29 UWM Research Foundation, Inc. Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists
WO2018035246A1 (en) 2016-08-16 2018-02-22 Uwm Research Foundation, Inc. Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma
CN111410658B (zh) * 2020-03-30 2021-03-26 江苏恩华药业股份有限公司 咪达唑仑或其药物组合物的杂质a和杂质b及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA716775B (en) * 1970-10-30 1972-06-28 Takeda Chemical Industries Ltd Benzodiazepine derivatives
DE2056265A1 (en) * 1970-11-16 1972-05-31 Sumitomo Chemical Co. Ltd., Osaka (Japan) Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso
JPS4932874B1 (xx) * 1970-12-11 1974-09-03
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
BE790839A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant
BE792972A (fr) * 1971-12-20 1973-06-19 Hoffmann La Roche Derives de benzodiazepine
FR2183716A1 (en) * 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
CA1005443A (en) * 1972-06-22 1977-02-15 Michio Nakanishi Thienodiazepine compounds

Also Published As

Publication number Publication date
JPS562073B2 (xx) 1981-01-17
GB1527131A (en) 1978-10-04
PH15091A (en) 1982-08-03
CH619953A5 (en) 1980-10-31
HU174752B (hu) 1980-03-28
YU228575A (en) 1983-01-21
FR2285890B1 (xx) 1981-12-31
FI63234C (fi) 1983-05-10
NL171060C (nl) 1983-02-01
LU73356A1 (xx) 1977-05-11
FI63234B (fi) 1983-01-31
NO146573B (no) 1982-07-19
SE7902668L (sv) 1979-03-23
NO147914C (no) 1983-07-06
FI752517A (xx) 1976-03-12
FR2303016B1 (xx) 1982-07-09
IE41844B1 (en) 1980-04-09
DE2540522A1 (de) 1976-04-08
MY8200214A (en) 1982-12-31
ES440850A1 (es) 1977-07-01
BE833248A (fr) 1976-03-10
AU505998B2 (en) 1979-12-13
ATA697775A (de) 1980-05-15
SU814278A3 (ru) 1981-03-15
DK157615C (da) 1990-06-25
NO802719L (no) 1976-03-12
BR7505864A (pt) 1976-08-03
NO148188B (no) 1983-05-16
NL7510620A (nl) 1976-03-15
NO802720L (no) 1976-03-12
SE449098B (sv) 1987-04-06
DE2540522C2 (xx) 1988-10-20
IL48069A (en) 1980-09-16
YU40267B (en) 1985-12-31
NO147109B (no) 1982-10-25
PL106563B1 (pl) 1979-12-31
DD121640A5 (xx) 1976-08-12
NO147109C (no) 1983-02-02
IE41844L (en) 1976-03-11
IL48069A0 (en) 1975-11-25
FR2303016A1 (fr) 1976-10-01
FR2285890A1 (fr) 1976-04-23
DK404175A (da) 1976-03-12
NO146573C (no) 1982-10-27
NO148188C (no) 1983-08-24
CU34346A (es) 1982-08-24
NZ178635A (en) 1982-12-21
SE440504B (sv) 1985-08-05
NO753069L (xx) 1976-03-12
DK157615B (da) 1990-01-29
KE3173A (en) 1982-01-08
CA1067491A (en) 1979-12-04
SE433080B (sv) 1984-05-07
SE7902666L (sv) 1979-03-23
HK63381A (en) 1981-12-24
MX160600A (es) 1993-09-01
SE7509991L (sv) 1976-03-12
PH16152A (en) 1983-07-12
ZA755418B (en) 1977-06-29
SE7902667L (sv) 1979-03-23
JPS51125099A (en) 1976-11-01
CH628053A5 (en) 1982-02-15
AT360023B (de) 1980-12-10
CU20892L (es) 1982-08-24
NO802718L (no) 1976-03-12
AU8470475A (en) 1977-03-17
NO147914B (no) 1983-03-28

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