DK157615C - Analogifremgangsmaade til fremstilling af terapeutisk aktive imidazo oe1,5-aaaoe1,4aa diazepin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents
Analogifremgangsmaade til fremstilling af terapeutisk aktive imidazo oe1,5-aaaoe1,4aa diazepin-forbindelser eller farmaceutisk acceptable syreadditionssalte derafInfo
- Publication number
- DK157615C DK157615C DK404175A DK404175A DK157615C DK 157615 C DK157615 C DK 157615C DK 404175 A DK404175 A DK 404175A DK 404175 A DK404175 A DK 404175A DK 157615 C DK157615 C DK 157615C
- Authority
- DK
- Denmark
- Prior art keywords
- aaaoe1
- analogue
- preparation
- acid addition
- addition salts
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000004908 diazepines Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK534377A DK157681C (da) | 1974-09-11 | 1977-12-01 | Phenyl-oe2-(5-hydroxymethyl-1-imidazolyl)-phenylaa-methanonderivater til anvendelse som mellemprodukter ved fremstillingen af imidazooe1,5-aaaoe1,4aabenzodiazepinderivater |
| DK534177A DK157756C (da) | 1974-09-11 | 1977-12-01 | 3a,4-dihydro-imidazooe1,5-aaaoe1,4aadiazepiner til anvendelse som mellemprodukter ved fremstillingen af terapeutisk virksomme oe1,5-aaaoe1,4aadiazepiner |
| DK534477A DK158667C (da) | 1974-09-11 | 1977-12-01 | 5,6-dihydro-imidazooe1,5-aaaoe1,4aadiazepiner til anvendelse som mellemprodukter ved fremstillingen af farmakologisk aktive imidazooe1,5-aaaoe1,4aadiazepinforbindelser. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50492474A | 1974-09-11 | 1974-09-11 | |
| US50492474 | 1974-09-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK404175A DK404175A (da) | 1976-03-12 |
| DK157615B DK157615B (da) | 1990-01-29 |
| DK157615C true DK157615C (da) | 1990-06-25 |
Family
ID=24008278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK404175A DK157615C (da) | 1974-09-11 | 1975-09-10 | Analogifremgangsmaade til fremstilling af terapeutisk aktive imidazo oe1,5-aaaoe1,4aa diazepin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf |
Country Status (32)
| Country | Link |
|---|---|
| JP (1) | JPS51125099A (xx) |
| AT (1) | AT360023B (xx) |
| AU (1) | AU505998B2 (xx) |
| BE (1) | BE833248A (xx) |
| BR (1) | BR7505864A (xx) |
| CA (1) | CA1067491A (xx) |
| CH (2) | CH619953A5 (xx) |
| CU (1) | CU34346A (xx) |
| DD (1) | DD121640A5 (xx) |
| DE (1) | DE2540522A1 (xx) |
| DK (1) | DK157615C (xx) |
| ES (1) | ES440850A1 (xx) |
| FI (1) | FI63234C (xx) |
| FR (2) | FR2285890A1 (xx) |
| GB (1) | GB1527131A (xx) |
| HK (1) | HK63381A (xx) |
| HU (1) | HU174752B (xx) |
| IE (1) | IE41844B1 (xx) |
| IL (1) | IL48069A (xx) |
| KE (1) | KE3173A (xx) |
| LU (1) | LU73356A1 (xx) |
| MX (1) | MX160600A (xx) |
| MY (1) | MY8200214A (xx) |
| NL (1) | NL171060C (xx) |
| NO (4) | NO147109C (xx) |
| NZ (1) | NZ178635A (xx) |
| PH (2) | PH16152A (xx) |
| PL (1) | PL106563B1 (xx) |
| SE (4) | SE425785B (xx) |
| SU (1) | SU814278A3 (xx) |
| YU (1) | YU40267B (xx) |
| ZA (1) | ZA755418B (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125726A (en) | 1977-03-11 | 1978-11-14 | Hoffmann-La Roche Inc. | Imidazo[1,5-a][1,4]benzodiazepines |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| US4226768A (en) * | 1979-05-29 | 1980-10-07 | Hoffmann-La Roche Inc. | Process for the preparation of imidazobenzodiazepines |
| US4226771A (en) * | 1979-07-25 | 1980-10-07 | Hoffmann-La Roche Inc. | 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives |
| US4256637A (en) * | 1979-12-20 | 1981-03-17 | Hoffmann-La Roche Inc. | Intermediates for the production of imidazobenzodiazepines |
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| US4335042A (en) * | 1980-04-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Process to produce imidazobenzodiazepine intermediates |
| DE3329515C2 (de) * | 1983-08-16 | 1985-11-14 | Krohne Meßtechnik GmbH & Co KG, 4100 Duisburg | Elektrische Schaltanordnung für einen magnetisch-induktiven Meßwertgeber |
| ZA845757B (en) * | 1983-08-25 | 1985-04-24 | Hoffmann La Roche | Benzodiazepine derivatives |
| PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| FI880814A (fi) * | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | Imidazodiazepin-derivat. |
| AU6909194A (en) * | 1993-05-14 | 1994-12-12 | Board Of Regents, The University Of Texas System | Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole |
| IN184976B (xx) * | 1996-06-13 | 2000-10-14 | Ranbaxy Lab Ltd | |
| IT1399764B1 (it) * | 2010-05-04 | 2013-05-03 | F S I Fabbrica Italiana Sint | Procedimento per la sintesi di 4h-imidazo [1,5-a][1,4]benzodiazepine, in particolare di midazolam. |
| CN103086986B (zh) * | 2011-11-01 | 2015-11-04 | 上海医药工业研究院 | 1,4-苯二氮卓-n-亚硝胺类中间体的制备方法及其应用 |
| CN103804384B (zh) * | 2014-01-27 | 2016-01-20 | 李宏 | 苯并二氮杂卓类化合物的制备方法 |
| JP7023876B2 (ja) | 2016-03-18 | 2022-02-22 | ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド | α５含有ＧＡＢＡＡ受容体アゴニストによる神経変性および神経精神障害における認知症状および気分症状の処置 |
| US11447495B2 (en) | 2016-08-16 | 2022-09-20 | Uwm Research Foundation, Inc. | Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators |
| CN111410658B (zh) * | 2020-03-30 | 2021-03-26 | 江苏恩华药业股份有限公司 | 咪达唑仑或其药物组合物的杂质a和杂质b及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA721060B (en) * | 1970-10-30 | 1972-11-29 | Takeda Chemical Industries Ltd | Benzodiazepine derivatives |
| DE2056265A1 (en) * | 1970-11-16 | 1972-05-31 | Sumitomo Chemical Co. Ltd., Osaka (Japan) | Benzodiazepine derivs - from glycylamidobenzophenone derivs in dmso |
| JPS4932874B1 (xx) * | 1970-12-11 | 1974-09-03 | ||
| BE787251A (fr) * | 1971-08-04 | 1973-02-05 | Upjohn Co | Nouvelles benzodiazepines et leur preparation |
| BE790839A (fr) * | 1971-11-02 | 1973-04-30 | Upjohn Co | Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant |
| BE792972A (fr) * | 1971-12-20 | 1973-06-19 | Hoffmann La Roche | Derives de benzodiazepine |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| CA1005443A (en) * | 1972-06-22 | 1977-02-15 | Michio Nakanishi | Thienodiazepine compounds |
-
1975
- 1975-08-25 ZA ZA755418A patent/ZA755418B/xx unknown
- 1975-09-03 CH CH1141075A patent/CH619953A5/de not_active IP Right Cessation
- 1975-09-08 FI FI752517A patent/FI63234C/fi not_active IP Right Cessation
- 1975-09-08 NO NO753069A patent/NO147109C/no unknown
- 1975-09-08 SE SE7509991A patent/SE425785B/xx active Protection Beyond IP Right Term
- 1975-09-09 FR FR7527599A patent/FR2285890A1/fr active Granted
- 1975-09-09 MX MX201652A patent/MX160600A/es unknown
- 1975-09-09 NL NLAANVRAGE7510620,A patent/NL171060C/xx not_active IP Right Cessation
- 1975-09-09 NZ NZ178635A patent/NZ178635A/xx unknown
- 1975-09-09 LU LU73356A patent/LU73356A1/xx unknown
- 1975-09-09 IL IL48069A patent/IL48069A/xx unknown
- 1975-09-10 JP JP50109060A patent/JPS51125099A/ja active Granted
- 1975-09-10 PL PL1975204027A patent/PL106563B1/pl unknown
- 1975-09-10 HU HU75HO1835A patent/HU174752B/hu unknown
- 1975-09-10 YU YU2285/75A patent/YU40267B/xx unknown
- 1975-09-10 PH PH17566A patent/PH16152A/en unknown
- 1975-09-10 ES ES440850A patent/ES440850A1/es not_active Expired
- 1975-09-10 CA CA235,138A patent/CA1067491A/en not_active Expired
- 1975-09-10 AT AT697775A patent/AT360023B/de not_active IP Right Cessation
- 1975-09-10 AU AU84704/75A patent/AU505998B2/en not_active Expired
- 1975-09-10 GB GB37252/75A patent/GB1527131A/en not_active Expired
- 1975-09-10 BE BE159891A patent/BE833248A/xx not_active IP Right Cessation
- 1975-09-10 DD DD188275A patent/DD121640A5/xx unknown
- 1975-09-10 DK DK404175A patent/DK157615C/da not_active IP Right Cessation
- 1975-09-10 SU SU752170852A patent/SU814278A3/ru active
- 1975-09-11 BR BR7505864*A patent/BR7505864A/pt unknown
- 1975-09-11 CU CU34346A patent/CU34346A/es unknown
- 1975-09-11 IE IE1973/75A patent/IE41844B1/en unknown
- 1975-09-11 DE DE19752540522 patent/DE2540522A1/de active Granted
-
1976
- 1976-06-10 FR FR7617552A patent/FR2303016A1/fr active Granted
-
1979
- 1979-03-23 SE SE7902668A patent/SE449098B/sv not_active IP Right Cessation
- 1979-03-23 SE SE7902666A patent/SE440504B/sv not_active IP Right Cessation
- 1979-03-23 SE SE7902667A patent/SE433080B/sv not_active IP Right Cessation
- 1979-05-24 PH PH22557A patent/PH15091A/en unknown
-
1980
- 1980-09-12 NO NO802719A patent/NO147914C/no unknown
- 1980-09-12 NO NO802718A patent/NO146573C/no unknown
- 1980-09-12 NO NO802720A patent/NO148188C/no unknown
-
1981
- 1981-02-27 CH CH133781A patent/CH628053A5/de not_active IP Right Cessation
- 1981-11-24 KE KE3173A patent/KE3173A/xx unknown
- 1981-12-17 HK HK633/81A patent/HK63381A/xx unknown
-
1982
- 1982-12-30 MY MY214/82A patent/MY8200214A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |