GB1399086A - Cephalosporin compounds - Google Patents

Cephalosporin compounds

Info

Publication number
GB1399086A
GB1399086A GB1508271A GB1508271A GB1399086A GB 1399086 A GB1399086 A GB 1399086A GB 1508271 A GB1508271 A GB 1508271A GB 1508271 A GB1508271 A GB 1508271A GB 1399086 A GB1399086 A GB 1399086A
Authority
GB
United Kingdom
Prior art keywords
syn
group
compounds
anti isomers
organic group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1508271A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26251025&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1399086(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB1508271A priority Critical patent/GB1399086A/en
Priority to JP47047149A priority patent/JPS5248997B1/ja
Priority to IL39429A priority patent/IL39429A/xx
Priority to BE783449A priority patent/BE783449A/xx
Priority to DE2265234A priority patent/DE2265234C2/de
Priority to SE7206296A priority patent/SE457795B/sv
Priority to IE644/72A priority patent/IE38172B1/xx
Priority to ZA723224A priority patent/ZA723224B/xx
Priority to CS723209A priority patent/CS245753B2/cs
Priority to CA141,965A priority patent/CA1027554A/en
Priority to ES402651A priority patent/ES402651A1/es
Priority to PL1972155354A priority patent/PL101031B1/pl
Priority to CA141,963A priority patent/CA1027933A/en
Priority to IE645/72A priority patent/IE37782B1/xx
Priority to IL39428A priority patent/IL39428A/en
Priority to DK237372A priority patent/DK155187C/da
Priority to CH705972A priority patent/CH591497A5/xx
Priority to NO721705A priority patent/NO154797C/no
Priority to YU1267/72A priority patent/YU41807B/xx
Priority to ES402650A priority patent/ES402650A1/es
Priority to HU72GA00001095A priority patent/HU172017B/hu
Priority to CS72839A priority patent/CS245754B2/cs
Priority to ZA723223A priority patent/ZA723223B/xx
Priority to DE2223375A priority patent/DE2223375C2/de
Priority to NLAANVRAGE7206403,A priority patent/NL166688C/xx
Priority to CY971A priority patent/CY971A/xx
Priority to JP4714872A priority patent/JPS531280B1/ja
Priority to DE19722223287 priority patent/DE2223287A1/de
Priority to BE783448A priority patent/BE783448A/xx
Priority to CH705872A priority patent/CH579571A5/xx
Priority to NL7206466A priority patent/NL7206466A/xx
Priority to AU42299/72A priority patent/AU475444B2/en
Priority to AT420872A priority patent/AT336786B/de
Priority to FR7217282A priority patent/FR2137898A1/fr
Priority to AT420772A priority patent/AT329176B/de
Priority to AU42298/72A priority patent/AU474163B2/en
Priority to FR7217283A priority patent/FR2137899B1/fr
Priority to MX484872U priority patent/MX5109E/es
Priority to FR7217284A priority patent/FR2137900B1/fr
Priority to US05/304,501 priority patent/US3932385A/en
Priority to PH14070A priority patent/PH13762A/en
Priority to US05/413,970 priority patent/US3966717A/en
Priority to US05/497,113 priority patent/US3974153A/en
Priority to PH16206A priority patent/PH11205A/en
Priority to ES430104A priority patent/ES430104A1/es
Priority to AT82575A priority patent/AT348672B/de
Priority to US05/587,065 priority patent/US4024137A/en
Priority to US05/587,064 priority patent/US4024133A/en
Publication of GB1399086A publication Critical patent/GB1399086A/en
Priority to BE159206A priority patent/BE832435R/fr
Priority to US05/618,167 priority patent/US4017515A/en
Priority to US05/627,905 priority patent/US3975376A/en
Priority to FR7537636A priority patent/FR2287231A1/fr
Priority to US05/642,304 priority patent/US4079178A/en
Priority to US05/668,247 priority patent/US4064346A/en
Priority to US05/669,818 priority patent/US4033950A/en
Priority to US05/762,943 priority patent/US4092477A/en
Priority to US05/762,942 priority patent/US4091209A/en
Priority to US05/762,927 priority patent/US4093803A/en
Priority to JP7426977A priority patent/JPS5328141A/ja
Priority to US05/852,808 priority patent/US4138555A/en
Priority to AT851477A priority patent/AT358730B/de
Priority to AT851577A priority patent/AT353966B/de
Priority to KE2895A priority patent/KE2895A/xx
Priority to HK660/78A priority patent/HK66078A/xx
Priority to MY466/78A priority patent/MY7800466A/xx
Priority to JP2128779A priority patent/JPS54135792A/ja
Priority to NLAANVRAGE7905299,A priority patent/NL177020C/xx
Priority to YU03213/79A priority patent/YU321379A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
GB1508271A 1971-05-14 1971-05-14 Cephalosporin compounds Expired GB1399086A (en)

Priority Applications (68)

Application Number Priority Date Filing Date Title
GB1508271A GB1399086A (en) 1971-05-14 1971-05-14 Cephalosporin compounds
JP47047149A JPS5248997B1 (sv) 1971-05-14 1972-05-12
IL39429A IL39429A (en) 1971-05-14 1972-05-12 (etherified oximino)acylamido chephalosporanic acid derivatives
BE783449A BE783449A (fr) 1971-05-14 1972-05-12 Perfectionnements relatifs aux antibiotiques
DE2265234A DE2265234C2 (de) 1971-05-14 1972-05-12 Zwischenprodukt für Antibiotika der Cephalosporinreihe, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
SE7206296A SE457795B (sv) 1971-05-14 1972-05-12 Analogifoerfarande foer framstaellning av 7-/alfa-oximino-acylamido/-3-cefem-4-karboxyl-syror
IE644/72A IE38172B1 (en) 1971-05-14 1972-05-12 Cephalosporin compounds
ZA723224A ZA723224B (en) 1971-05-14 1972-05-12 Improvements in or relating to antibiotics
CS723209A CS245753B2 (en) 1971-05-14 1972-05-12 Production method of 7 beta-acylamido-3-cefem-4-carboxyle acids
CA141,965A CA1027554A (en) 1971-05-14 1972-05-12 PREPARATION OF 7.beta.-(.alpha.-ETHERIFIED OXIMINO) ACYLAMIDO-CEPH-3-EM-4-CARBOXYLIC ACIDS
ES402651A ES402651A1 (es) 1971-05-14 1972-05-12 Procedimiento para la preparacion de derivados de la cefa- losperina.
PL1972155354A PL101031B1 (pl) 1971-05-14 1972-05-12 Sposob wytwarzania nowych pochodnych cefalosporyny
CA141,963A CA1027933A (en) 1971-05-14 1972-05-12 PREPARATION OF 6.beta.-(2-SUBSTITUTED OXYIMINO-2-SUBSTITUTED ACETAMIDO)-2,2-DIMETHYL-PENAM-3.alpha.-CARBOXYLIC ACIDS
IE645/72A IE37782B1 (en) 1971-05-14 1972-05-12 Penicillin compounds
IL39428A IL39428A (en) 1971-05-14 1972-05-12 Alpha-(etherified oximino) acylamino-penicillanic acid derivatives
DK237372A DK155187C (da) 1971-05-14 1972-05-12 Analogifremgangsmaade til fremstilling af cephalosporinforbindelser i den syn-isomere form eller ugiftige salte deraf
CH705972A CH591497A5 (sv) 1971-05-14 1972-05-12
NO721705A NO154797C (no) 1971-05-14 1972-05-12 Analogifremgangsmaate for fremstilling av cefalosporinforbindelser i den syn-isomere form eller ugiftige salter derav
YU1267/72A YU41807B (en) 1971-05-14 1972-05-12 Improved process for obtaining antibiotics
ES402650A ES402650A1 (es) 1971-05-14 1972-05-12 Procedimiento para la preparacion de derivados de la peni- cilina.
HU72GA00001095A HU172017B (hu) 1971-05-14 1972-05-12 Sposob poluchenija 7-beta-skobka-al'fa-oksiimino-skobka zakryta-acilamido-cef-3-em-4-karbonovykh kislot, zamehhennykh efirom v pozicii oksiimino-gruppa
CS72839A CS245754B2 (en) 1971-05-14 1972-05-12 Production method of 7beta-acylamido-3-cefem-4-carboxyl acids
ZA723223A ZA723223B (en) 1971-05-14 1972-05-12 Improvements in or relating to antibiotics
DE2223375A DE2223375C2 (de) 1971-05-14 1972-05-12 7β-(α-substit. Hydroxyiminoheteroarylacetamido)-cephalosporine und Verfahren zu ihrer Herstellung
NLAANVRAGE7206403,A NL166688C (nl) 1971-05-14 1972-05-12 Werkwijze voor het bereiden van een therapeutisch preparaat met anti-biotische werking, gevormd voortbrengsel, alsmede werkwijze voor het bereiden van een daarvoor geschikte 2-ether van een (6r,7r)-3-gesubstitueerde 7-(2-heteroaryl-2-hydroxyiminoacetamido)cef -3-em-4-carbonzuurverbinding.
CY971A CY971A (en) 1971-05-14 1972-05-12 Cephalosporin compounds
JP4714872A JPS531280B1 (sv) 1971-05-14 1972-05-12
DE19722223287 DE2223287A1 (de) 1971-05-14 1972-05-12 Antibiotika und Verfahren zu ihrer Herstellung
BE783448A BE783448A (fr) 1971-05-14 1972-05-12 Perfectionnements relatifs aux antibiotiques
CH705872A CH579571A5 (sv) 1971-05-14 1972-05-12
NL7206466A NL7206466A (sv) 1971-05-14 1972-05-12
AU42299/72A AU475444B2 (en) 1971-05-14 1972-05-15 Cephalosporin antibiotics
AT420872A AT336786B (de) 1971-05-14 1972-05-15 Verfahren zur herstellung von neuen cephalosporinderivaten
FR7217282A FR2137898A1 (en) 1971-05-14 1972-05-15 Alpha-oximino-penicillins - with antibacterial activity
AT420772A AT329176B (de) 1971-05-14 1972-05-15 Verfahren zur herstellung von neuen penicillinen
AU42298/72A AU474163B2 (en) 1971-05-14 1972-05-15 6b-ACYLAMIDOPENAM-3A-CARBOXYLIC ACIDS
FR7217283A FR2137899B1 (sv) 1971-05-14 1972-05-15
MX484872U MX5109E (es) 1971-05-14 1972-05-15 Procedimiento para la preparacion de antibioticos de la serie de cefalosporina
FR7217284A FR2137900B1 (sv) 1971-05-14 1972-05-15
US05/304,501 US3932385A (en) 1971-05-14 1972-11-07 Penicillins having a 6β-(α-etherified oximino) acylamido group
PH14070A PH13762A (en) 1971-05-14 1972-11-10 7 beta-acylamido-ceph-3-em-4-carboxylic acid derivatives
US05/413,970 US3966717A (en) 1971-05-14 1973-11-08 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
US05/497,113 US3974153A (en) 1971-05-14 1974-08-13 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
PH16206A PH11205A (en) 1971-05-14 1974-08-23 (6r,7r)-7-(2-aryl-2-etherified oximino acetamido)-3carbamoyloxymethylceph-3-em-4carboxylic acids and pharmaceutical composition thereof
ES430104A ES430104A1 (es) 1971-05-14 1974-09-16 Procedimiento para la preparacion de derivados de la cefa- losporina.
AT82575A AT348672B (de) 1971-05-14 1975-02-04 Verfahren zur herstellung von neuen cephalosporinderivaten
US05/587,065 US4024137A (en) 1971-05-14 1975-06-16 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US05/587,064 US4024133A (en) 1971-05-14 1975-06-16 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
BE159206A BE832435R (fr) 1971-05-14 1975-08-14 Perfectionnements relatifs aux antibiotiques
US05/618,167 US4017515A (en) 1971-05-14 1975-09-30 α-(Etherified oximino) carboxylic acids and acid chlorides
US05/627,905 US3975376A (en) 1971-05-14 1975-10-31 Pencillins having a 6β-(α-etherified oximino) acylamido group
FR7537636A FR2287231A1 (fr) 1971-05-14 1975-12-09 Acides a (oximino etherifie) carboxyliques et leurs derives
US05/642,304 US4079178A (en) 1971-05-14 1975-12-19 Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position
US05/668,247 US4064346A (en) 1971-05-14 1976-03-18 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US05/669,818 US4033950A (en) 1971-05-14 1976-03-24 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US05/762,943 US4092477A (en) 1971-05-14 1977-01-26 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US05/762,942 US4091209A (en) 1971-05-14 1977-01-26 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position
US05/762,927 US4093803A (en) 1971-05-14 1977-01-26 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
JP7426977A JPS5328141A (en) 1971-05-14 1977-06-22 Production of novel carboxylic acid
US05/852,808 US4138555A (en) 1971-05-14 1977-11-18 (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides
AT851477A AT358730B (de) 1971-05-14 1977-11-28 Verfahren zur herstellung von neuen cephalos- porinderivaten
AT851577A AT353966B (de) 1971-05-14 1977-11-28 Verfahren zur herstellung von neuen cephalos- porinderivaten
KE2895A KE2895A (en) 1971-05-14 1978-10-19 Cephalosporin compounds
HK660/78A HK66078A (en) 1971-05-14 1978-11-16 Cephalosporin compounds
MY466/78A MY7800466A (en) 1971-05-14 1978-12-30 Cephalosporin compounds
JP2128779A JPS54135792A (en) 1971-05-14 1979-02-24 Manufacture of cephalosporin compound
NLAANVRAGE7905299,A NL177020C (nl) 1971-05-14 1979-07-06 Werkwijze voor het bereiden van een therapeutisch preparaat met antibiotische werking, therapeutisch voorwerp, alsmede werkwijze voor het bereiden van een daarvoor geschikte ether van een (6r, 7r)-3-gesubstitueerde 7-(2-heteroaryl-2-hydroxy-imino-aceetamido) cef-3-em-4-carbonzuurverbinding.
YU03213/79A YU321379A (en) 1971-05-14 1979-12-28 Improved process for obtaining antibiotics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1508271A GB1399086A (en) 1971-05-14 1971-05-14 Cephalosporin compounds
GB4588471 1971-10-01

Publications (1)

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US5013730A (en) * 1987-07-23 1991-05-07 Ici-Pharma Cephem derivatives
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US4464368A (en) * 1978-11-15 1984-08-07 Glaxo Group Limited Cephalosporin antibiotics
FR2464960A1 (fr) * 1979-09-10 1981-03-20 Glaxo Group Ltd Nouvelle forme non hygroscopique d'une cephalosporine sodique, son procede de preparation et son application en therapeutique
US4503234A (en) * 1980-07-24 1985-03-05 Lonza Ltd. Production of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyimino acetic esters
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GB2137996A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Benzothienylglycyl cephalosporin derivatives
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US5064953A (en) * 1983-12-29 1991-11-12 Mochida Pharmaceutical Co., Ltd. Intermediates cephalosporin derivatives
US4888332A (en) * 1983-12-29 1989-12-19 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
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US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
US4677100A (en) * 1984-12-27 1987-06-30 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives
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US4956474A (en) * 1985-04-01 1990-09-11 Mochida Pharmaceutical Co., Ltd. Intermediates of cephalosporin compounds
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
US5017569A (en) * 1986-11-12 1991-05-21 Ici Pharma Cephalosporin derivatives
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4866055A (en) * 1986-11-25 1989-09-12 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives and their crystalline derivatives
US5057511A (en) * 1986-12-23 1991-10-15 Ici Pharma 3-heterocyclic thiomethyl cephalosporins
US5412093A (en) * 1986-12-23 1995-05-02 Ici Pharma 3-heterocyclic thiomethyl cephalosporins
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds
US5013730A (en) * 1987-07-23 1991-05-07 Ici-Pharma Cephem derivatives
US5008258A (en) * 1987-07-23 1991-04-16 I.C.I.-Pharma Cephalosporin derivatives
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US5202315A (en) * 1989-05-11 1993-04-13 Lucky, Ltd. Cephalosporin compounds

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DE2223375A1 (de) 1972-11-23
CY971A (en) 1978-12-22
CA1027554A (en) 1978-03-07
AT336786B (de) 1977-05-25
HK66078A (en) 1978-11-24
FR2137900B1 (sv) 1976-04-16
IE38172L (en) 1972-11-14
MY7800466A (en) 1978-12-31
IL39429A0 (en) 1972-07-26
NL166688C (nl) 1985-01-16
CS245754B2 (en) 1986-10-16
JPS54135792A (en) 1979-10-22
NL166688B (nl) 1981-04-15
FR2137899A1 (sv) 1972-12-29
SE457795B (sv) 1989-01-30
KE2895A (en) 1978-11-10
PH11205A (en) 1977-10-28
DE2223375C2 (de) 1985-05-15
ATA420872A (de) 1976-09-15
JPS5328141A (en) 1978-03-16
ES430104A1 (es) 1976-10-01
BE783449A (fr) 1972-11-13
YU126772A (en) 1982-02-28
JPS531280B1 (sv) 1978-01-17
YU321379A (en) 1982-02-28
DK155187B (da) 1989-02-27
NO154797C (no) 1986-12-29
IE38172B1 (en) 1978-01-18
FR2137899B1 (sv) 1976-08-20
CH591497A5 (sv) 1977-09-30
YU41807B (en) 1988-02-29
IL39429A (en) 1978-04-30
NO154797B (no) 1986-09-15
DE2265234C2 (de) 1983-02-10
DE2265234A1 (de) 1976-12-30
DK155187C (da) 1989-07-17
CS245753B2 (en) 1986-10-16
JPS6324993B2 (sv) 1988-05-23
FR2137900A1 (sv) 1972-12-29
NL7206403A (sv) 1972-11-16
ES402651A1 (es) 1975-11-01

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PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years