FR2559783B1 - Reactifs d'acide nucleique perfectionnes et procedes pour leur preparation - Google Patents

Reactifs d'acide nucleique perfectionnes et procedes pour leur preparation

Info

Publication number
FR2559783B1
FR2559783B1 FR858502188A FR8502188A FR2559783B1 FR 2559783 B1 FR2559783 B1 FR 2559783B1 FR 858502188 A FR858502188 A FR 858502188A FR 8502188 A FR8502188 A FR 8502188A FR 2559783 B1 FR2559783 B1 FR 2559783B1
Authority
FR
France
Prior art keywords
preparation
methods
nucleic acid
acid reagents
improved nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR858502188A
Other languages
English (en)
Other versions
FR2559783A1 (fr
Inventor
Airi Palva
Marjut Ranki
Hans Soderlund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of FR2559783A1 publication Critical patent/FR2559783A1/fr
Application granted granted Critical
Publication of FR2559783B1 publication Critical patent/FR2559783B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/705Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
FR858502188A 1984-02-17 1985-02-15 Reactifs d'acide nucleique perfectionnes et procedes pour leur preparation Expired - Lifetime FR2559783B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI840655A FI71768C (fi) 1984-02-17 1984-02-17 Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.

Publications (2)

Publication Number Publication Date
FR2559783A1 FR2559783A1 (fr) 1985-08-23
FR2559783B1 true FR2559783B1 (fr) 1990-03-02

Family

ID=8518568

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858502188A Expired - Lifetime FR2559783B1 (fr) 1984-02-17 1985-02-15 Reactifs d'acide nucleique perfectionnes et procedes pour leur preparation

Country Status (22)

Country Link
US (1) US4731325A (fr)
JP (1) JPS60188100A (fr)
AT (1) AT394578B (fr)
AU (1) AU577568B2 (fr)
BE (1) BE901671A (fr)
CA (1) CA1248895A (fr)
CH (1) CH671778A5 (fr)
DE (1) DE3505287C2 (fr)
DK (1) DK174675B1 (fr)
FI (1) FI71768C (fr)
FR (1) FR2559783B1 (fr)
GB (1) GB2156074B (fr)
HU (1) HU194938B (fr)
IE (1) IE57652B1 (fr)
IT (1) IT1183184B (fr)
LU (1) LU85768A1 (fr)
NL (1) NL193663C (fr)
NO (1) NO166543C (fr)
RO (1) RO92633B (fr)
SE (1) SE463103B (fr)
SU (1) SU1523053A3 (fr)
ZA (1) ZA85511B (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261776B1 (en) 1989-06-07 2001-07-17 Affymetrix, Inc. Nucleic acid arrays
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6310189B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Nucleotides and analogs having photoremoveable protecting groups
US6344316B1 (en) 1996-01-23 2002-02-05 Affymetrix, Inc. Nucleic acid analysis techniques
US6355432B1 (en) 1989-06-07 2002-03-12 Affymetrix Lnc. Products for detecting nucleic acids
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6410229B1 (en) 1995-09-15 2002-06-25 Affymetrix, Inc. Expression monitoring by hybridization to high density nucleic acid arrays
US6420169B1 (en) 1989-06-07 2002-07-16 Affymetrix, Inc. Apparatus for forming polynucleotides or polypeptides
US6451536B1 (en) 1990-12-06 2002-09-17 Affymetrix Inc. Products for detecting nucleic acids
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6566495B1 (en) 1989-06-07 2003-05-20 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1260372A (fr) * 1984-04-27 1989-09-26 Elazar Rabbani Methode d'hybridation pour la detection de materiaux genetiques
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4876187A (en) * 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US4910300A (en) * 1985-12-11 1990-03-20 Chiron Corporation Method for making nucleic acid probes
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
FI76119C (fi) * 1986-02-27 1988-09-09 Orion Yhtymae Oy Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet.
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5281518A (en) * 1986-05-01 1994-01-25 Washington Research Foundation Detection of a unique chlamydia strain associated with acute respiratory disease
WO1987006617A2 (fr) * 1986-05-01 1987-11-05 Washington Research Foundation Detection d'une souche unique de chlamydia associee a des maladies respiratoires aigues
US6270961B1 (en) * 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
CA1339351C (fr) * 1987-10-15 1997-08-26 Michael S. Urdea Multimeres d'acide nucleique et essais d'hybridation amplifiee d'acide nucleique
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US7811751B2 (en) * 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
WO1989012696A1 (fr) * 1988-06-24 1989-12-28 Amgen Inc. Procede et reactifs de detection de sequences d'acides nucleiques
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
CA2026573A1 (fr) * 1989-02-03 1990-08-04 John B. Findlay Article pour les essais de detection d'un acide nucleique predetermine
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5232829A (en) * 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
CA2039517C (fr) * 1990-04-03 2006-11-07 David Segev Amplification du signal d'une sonde d'adn
US5071962A (en) * 1990-05-31 1991-12-10 The United State Of America As Represented By The Department Of Health And Human Services Nucleotide, deduced amino acid sequence, isolation and purification of heat-shock chlamydial proteins
EP0466367B1 (fr) * 1990-06-28 1995-08-23 Wakunaga Seiyaku Kabushiki Kaisha Méthode pour la détection d'acides nucléiques
US5645994A (en) * 1990-07-05 1997-07-08 University Of Utah Research Foundation Method and compositions for identification of species in a sample using type II topoisomerase sequences
GB2262987A (en) * 1990-09-21 1993-07-07 Imp Cancer Res Tech Identification of organisms
GB9020621D0 (en) * 1990-09-21 1990-10-31 Imp Cancer Res Tech Identification of organisms
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US6569382B1 (en) 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6652808B1 (en) * 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US5556961A (en) * 1991-11-15 1996-09-17 Foote; Robert S. Nucleosides with 5'-O-photolabile protecting groups
ATE241426T1 (de) 1991-11-22 2003-06-15 Affymetrix Inc A Delaware Corp Verfahren zur herstellung von polymerarrays
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6864101B1 (en) 1991-11-22 2005-03-08 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
WO1993013221A1 (fr) * 1991-12-23 1993-07-08 Chiron Corporation Sondes pour chlamydiae utilisees dans des methodes d'hybridation en sandwich en phase de solution
WO1993013227A1 (fr) * 1991-12-23 1993-07-08 Chiron Corporation Sondes de cmv utilisees dans des methodes d'hybridation en sandwich a phase en solution
US5583211A (en) * 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US7713528B1 (en) 1993-02-18 2010-05-11 Enzo Therapeutics, Inc. Method for in vivo delivery of active compounds using reagent conjugate
AU7551094A (en) 1993-07-23 1995-02-20 Hyseq, Inc. Method for screening unknown organisms
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
US7172864B1 (en) 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US6315953B1 (en) 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US6254827B1 (en) 1993-11-01 2001-07-03 Nanogen, Inc. Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
US6375899B1 (en) 1993-11-01 2002-04-23 Nanogen, Inc. Electrophoretic buss for transport of charged materials in a multi-chamber system
US7314708B1 (en) 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6726880B1 (en) 1993-11-01 2004-04-27 Nanogen, Inc. Electronic device for performing active biological operations and method of using same
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix Inc Verfahren und Vorrichtung zum Verpacken von Chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US6306657B1 (en) * 1994-06-28 2001-10-23 Kalyx Biosciences, Inc. Polynucleotide probe and kit for amplifying signal detection in hybridization assays
US7857957B2 (en) * 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US20020042048A1 (en) 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species
US6309824B1 (en) 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
DE19741715A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
EP1028970A1 (fr) 1997-10-10 2000-08-23 President And Fellows Of Harvard College Amplification par replique de reseaux d'acides nucleiques
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
AU8826598A (en) 1997-10-10 1999-05-03 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
EP1038029A2 (fr) * 1997-12-12 2000-09-27 Digene Corporation Milieu de prelevement universel
US6355419B1 (en) 1998-04-27 2002-03-12 Hyseq, Inc. Preparation of pools of nucleic acids based on representation in a sample
US6232067B1 (en) * 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
AU4025300A (en) * 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
CA2372909A1 (fr) * 1999-03-30 2000-10-05 Nanogen, Inc. Discrimination polymorphe nucleotidique unique par test electronique dot blot sur des micropuces a semi-conducteurs
CN1204592C (zh) 1999-04-27 2005-06-01 赛弗根生物系统股份有限公司 气相离子谱仪的探头
EP1054259A1 (fr) * 1999-05-19 2000-11-22 Remacle, José Procédé d'identification de composé cible
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6465183B2 (en) * 1999-07-01 2002-10-15 Agilent Technologies, Inc. Multidentate arrays
JP2001017166A (ja) * 1999-07-02 2001-01-23 Fuji Photo Film Co Ltd Dnaチップ、dnaチップの検定キットおよびdnaチップの検定法
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
ES2441412T3 (es) * 2001-03-09 2014-02-04 Trovagene, Inc. Sondas conjugadas y detección óptica de analitos
EP2246438B1 (fr) 2001-07-12 2019-11-27 Illumina, Inc. Reactions multiplex d'acides nucléiques
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
US7622281B2 (en) 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US7314542B2 (en) * 2004-09-23 2008-01-01 Nanogen, Inc. Methods and materials for optimization of electronic transportation and hybridization reactions
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
WO2006121888A2 (fr) 2005-05-06 2006-11-16 Gen-Probe Incorporated Procedes de capture d'acide nucleique cible
WO2007070553A2 (fr) * 2005-12-12 2007-06-21 The Johns Hopkins University Reseaux a double quadrillage et multiquadrillage et procedes correspondants
WO2007123579A2 (fr) 2005-12-28 2007-11-01 Translational Therapeutics Thérapeutique reposant sur une perturbation de traduction
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
NZ576149A (en) 2006-09-29 2012-06-29 Translational Therapeutics Inc Eif4e regulon-based diagnostics
EP1912067A1 (fr) * 2006-10-12 2008-04-16 Eppendorf Array Technologies S.A. Procédé de quantification d'un composé cible issu d'un échantillon biologique à l'aide de puces à microreseau
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
WO2008085777A2 (fr) * 2007-01-03 2008-07-17 Xgenetics Inc. Procédé de détection précoce d'un cancer
US8288520B2 (en) * 2008-10-27 2012-10-16 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and system
EP2385979B1 (fr) * 2009-01-28 2017-08-16 QIAGEN Gaithersburg, Inc. Procédé de préparation d'un échantillon de grand volume spécifique à une séquence et dosage
US9797000B2 (en) * 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
JP5826752B2 (ja) 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
WO2011094514A1 (fr) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Procédés et compositions pour la purification et l'analyse multiplexée d'acides nucléiques séquence-spécifique
EP2529031B1 (fr) 2010-01-29 2014-07-09 QIAGEN Gaithersburg, Inc. Procédé de détermination de confirmation de la présence de hpv dans un echantillon
EP2572001A2 (fr) 2010-05-19 2013-03-27 QIAGEN Gaithersburg, Inc. Procédés et compositions pour purification séquence-spécifique et analyse multiplex d'acides nucléiques
CA2799205A1 (fr) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Analyse de capture hybride a resultats rapides et sondes associees tronquees de maniere strategique
CA2828224A1 (fr) 2011-02-24 2012-08-30 Qiagen Gaithersburg, Inc. Materiels et procedes de detection d'acide nucleique de hpv

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4293652A (en) * 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
GB8306426D0 (en) * 1983-03-09 1983-04-13 Malcolm A D B Detecting polynucleotide sequence
CA1260372A (fr) * 1984-04-27 1989-09-26 Elazar Rabbani Methode d'hybridation pour la detection de materiaux genetiques
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440667B1 (en) 1989-06-07 2002-08-27 Affymetrix Inc. Analysis of target molecules using an encoding system
US6566495B1 (en) 1989-06-07 2003-05-20 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6310189B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Nucleotides and analogs having photoremoveable protecting groups
US6261776B1 (en) 1989-06-07 2001-07-17 Affymetrix, Inc. Nucleic acid arrays
US6747143B2 (en) 1989-06-07 2004-06-08 Affymetrix, Inc. Methods for polymer synthesis
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6660234B2 (en) 1989-06-07 2003-12-09 Affymetrix, Inc. Apparatus for polymer synthesis
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6646243B2 (en) 1989-06-07 2003-11-11 Affymetrix, Inc. Nucleic acid reading and analysis system
US6403957B1 (en) 1989-06-07 2002-06-11 Affymetrix, Inc. Nucleic acid reading and analysis system
US6403320B1 (en) 1989-06-07 2002-06-11 Affymetrix, Inc. Support bound probes and methods of analysis using the same
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6630308B2 (en) 1989-06-07 2003-10-07 Affymetrix, Inc. Methods of synthesizing a plurality of different polymers on a surface of a substrate
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6420169B1 (en) 1989-06-07 2002-07-16 Affymetrix, Inc. Apparatus for forming polynucleotides or polypeptides
US6329143B1 (en) 1989-06-07 2001-12-11 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6355432B1 (en) 1989-06-07 2002-03-12 Affymetrix Lnc. Products for detecting nucleic acids
US6395491B1 (en) 1989-06-07 2002-05-28 Affymetrix, Inc. Method of information storage and recovery
US6491871B1 (en) 1989-06-07 2002-12-10 Affymetrix, Inc. System for determining receptor-ligand binding affinity
US6610482B1 (en) 1989-06-07 2003-08-26 Affymetrix, Inc. Support bound probes and methods of analysis using the same
US6600031B1 (en) 1989-06-07 2003-07-29 Affymetrix, Inc. Methods of making nucleic acid or oligonucleotide arrays
US6576424B2 (en) 1989-06-07 2003-06-10 Affymetrix Inc. Arrays and methods for detecting nucleic acids
US6291183B1 (en) 1989-06-07 2001-09-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US6544739B1 (en) 1990-12-06 2003-04-08 Affymetrix, Inc. Method for marking samples
US6451536B1 (en) 1990-12-06 2002-09-17 Affymetrix Inc. Products for detecting nucleic acids
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6548257B2 (en) 1995-09-15 2003-04-15 Affymetrix, Inc. Methods of identifying nucleic acid probes to quantify the expression of a target nucleic acid
US6410229B1 (en) 1995-09-15 2002-06-25 Affymetrix, Inc. Expression monitoring by hybridization to high density nucleic acid arrays
US6344316B1 (en) 1996-01-23 2002-02-05 Affymetrix, Inc. Nucleic acid analysis techniques
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning

Also Published As

Publication number Publication date
NO166543B (no) 1991-04-29
RO92633A (fr) 1987-10-30
JPS60188100A (ja) 1985-09-25
IE850202L (en) 1985-08-17
LU85768A1 (fr) 1985-07-24
DE3505287C2 (de) 1994-01-20
CH671778A5 (fr) 1989-09-29
FI840655A (fi) 1985-08-18
GB8503900D0 (en) 1985-03-20
NO850554L (no) 1985-08-19
US4731325A (en) 1988-03-15
FI840655A0 (fi) 1984-02-17
SU1523053A3 (ru) 1989-11-15
HU194938B (en) 1988-03-28
IT1183184B (it) 1987-10-05
SE8500733D0 (sv) 1985-02-15
FI71768B (fi) 1986-10-31
GB2156074B (en) 1988-03-16
FR2559783A1 (fr) 1985-08-23
IT8519432A0 (it) 1985-02-07
GB2156074A (en) 1985-10-02
SE463103B (sv) 1990-10-08
NL8500424A (nl) 1985-09-16
AU3842285A (en) 1985-08-22
ATA44185A (de) 1991-10-15
AU577568B2 (en) 1988-09-29
FI71768C (fi) 1987-02-09
SE8500733L (sv) 1985-08-18
DK58985A (da) 1985-08-18
JPH0463679B2 (fr) 1992-10-12
DK58985D0 (da) 1985-02-08
ZA85511B (en) 1985-11-27
RO92633B (ro) 1987-10-31
AT394578B (de) 1992-05-11
DE3505287A1 (de) 1985-09-05
IE57652B1 (en) 1993-02-10
CA1248895A (fr) 1989-01-17
NO166543C (no) 1991-08-07
NL193663C (nl) 2000-06-06
NL193663B (nl) 2000-02-01
HUT37459A (en) 1985-12-28
DK174675B1 (da) 2003-08-25
BE901671A (fr) 1985-05-29

Similar Documents

Publication Publication Date Title
FR2559783B1 (fr) Reactifs d'acide nucleique perfectionnes et procedes pour leur preparation
EP0415901A3 (en) Improved nucleic acid probes
FR2575493B1 (fr) Methode pour l'identification d'acides nucleiques
AU3866185A (en) Nucleic acid probe
FR2555199B1 (fr) Procede de clivage d'adn bicatenaire en n'importe quel point donne
MA20739A1 (fr) Procede de preparation d'hydroxyalkylxanthines tertiaires
FR2556726B1 (fr) Compositions a base d'oligonucleotides monocatenaires et procede pour leur preparation
FR2624852B1 (fr) Procede de preparation d'une surface d'une structure refractaire et composition de particules destinee a ce procede
FR2554809B1 (fr) Procede de preparation de l'acide acrylique
AU1049988A (en) Non-radioactive nucleic acid probes
FR2560201B1 (fr) Nouvelles resines amino-formaldehyde et procede pour leur preparation
FR2618351B1 (fr) Emulsions gelifiees transparentes et leur procede d'obtention
FR2558832B1 (fr) Derives de l'acide carbamique et leur procede d'obtention
FR2565590B1 (fr) Procede de preparation d'aminohydroxycephamcarboxylates
FR2590258B1 (fr) Halogenures de (tetraseleno-5, 6, 11, 12 tetracenes)2 difluores, procede pour les preparer et leur application
FR2575559B1 (fr) Procede d'affichage
MC1740A1 (fr) Glyocides et procede pour leur preparation
IT8619802A1 (it) Processo per l'affinazione di ghisa fosforosa
RO92794A (fr) Procede pour la preparation des esters d'acide 2-brome-4-methylimœdazole-5-carboxilique
BE866414A (fr) Procede et reactif pour le dosage de l'acide urique
FR2590762B3 (fr) Chassis pour l'agriculture
FR2577222B1 (fr) Procede pour la preparation de l'acide 1-(3-mercapto-25-methylpropionyl)-pyrrolidine-(25)-carboxylique
FR2535205B1 (fr) Solution pour injection a base de substances antirhumatismales et d'une cobalamine et procede pour sa preparation
FR2578539B1 (fr) Nouveaux benzamides de l'acide 2,4,6-trimethoxybenzoique, leur procede de preparation et leur utilisation
FR2569194B3 (fr) Procede de preparation d'une aminolactone

Legal Events

Date Code Title Description
TP Transmission of property
TP Transmission of property