FR2477156A1 - Carbothioates d'androstanes, leur procede de preparation, composes pour leur preparation et leur application en therapeutique - Google Patents

Carbothioates d'androstanes, leur procede de preparation, composes pour leur preparation et leur application en therapeutique Download PDF

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Publication number
FR2477156A1
FR2477156A1 FR8102818A FR8102818A FR2477156A1 FR 2477156 A1 FR2477156 A1 FR 2477156A1 FR 8102818 A FR8102818 A FR 8102818A FR 8102818 A FR8102818 A FR 8102818A FR 2477156 A1 FR2477156 A1 FR 2477156A1
Authority
FR
France
Prior art keywords
sep
alpha
group
hydroxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8102818A
Other languages
English (en)
French (fr)
Other versions
FR2477156B1 (bg
Inventor
Gordon Hanley Phillipps
Christopher Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2477156A1 publication Critical patent/FR2477156A1/fr
Application granted granted Critical
Publication of FR2477156B1 publication Critical patent/FR2477156B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8102818A 1980-02-15 1981-02-13 Carbothioates d'androstanes, leur procede de preparation, composes pour leur preparation et leur application en therapeutique Granted FR2477156A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8005174 1980-02-15
GB8013339 1980-04-23

Publications (2)

Publication Number Publication Date
FR2477156A1 true FR2477156A1 (fr) 1981-09-04
FR2477156B1 FR2477156B1 (bg) 1984-11-16

Family

ID=26274505

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8102818A Granted FR2477156A1 (fr) 1980-02-15 1981-02-13 Carbothioates d'androstanes, leur procede de preparation, composes pour leur preparation et leur application en therapeutique
FR8115812A Granted FR2485542A1 (fr) 1980-02-15 1981-08-17 Composes pour la preparation de carbothioates d'androstanes

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8115812A Granted FR2485542A1 (fr) 1980-02-15 1981-08-17 Composes pour la preparation de carbothioates d'androstanes

Country Status (23)

Country Link
KR (1) KR850000969B1 (bg)
AT (1) AT395427B (bg)
AU (1) AU544517B2 (bg)
BG (1) BG60700B2 (bg)
CH (2) CH651307A5 (bg)
CZ (1) CZ281275B6 (bg)
DE (2) DE3105307A1 (bg)
DK (1) DK147022C (bg)
ES (5) ES8207194A1 (bg)
FI (1) FI70904C (bg)
FR (2) FR2477156A1 (bg)
HK (1) HK58385A (bg)
IE (1) IE51394B1 (bg)
IT (1) IT1170717B (bg)
KE (1) KE3526A (bg)
MX (1) MX9202717A (bg)
MY (1) MY8500757A (bg)
NL (2) NL191792C (bg)
NZ (1) NZ196260A (bg)
PT (1) PT72502B (bg)
SE (1) SE452468B (bg)
SG (1) SG36885G (bg)
SK (1) SK278140B6 (bg)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2496668A1 (fr) * 1980-12-22 1982-06-25 Upjohn Co 5a-androstane-17b-carboxylates et 5 b-androstane-17b-carboxylates, leur preparation et leur utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2189033A1 (bg) * 1972-06-15 1974-01-25 Glaxo Lab Ltd
FR2282899A1 (fr) * 1974-08-30 1976-03-26 Glaxo Lab Ltd Steroides de la serie de l'androstane, leur preparation et leurs applications
EP0004741A2 (en) * 1978-04-05 1979-10-17 Syntex (U.S.A.) Inc. Thio etianic acid derivatives, their preparation and pharmaceutical use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1580517A (en) * 1978-04-06 1980-12-03 Fowler I Crutches

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2189033A1 (bg) * 1972-06-15 1974-01-25 Glaxo Lab Ltd
FR2282899A1 (fr) * 1974-08-30 1976-03-26 Glaxo Lab Ltd Steroides de la serie de l'androstane, leur preparation et leurs applications
EP0004741A2 (en) * 1978-04-05 1979-10-17 Syntex (U.S.A.) Inc. Thio etianic acid derivatives, their preparation and pharmaceutical use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2496668A1 (fr) * 1980-12-22 1982-06-25 Upjohn Co 5a-androstane-17b-carboxylates et 5 b-androstane-17b-carboxylates, leur preparation et leur utilisation

Also Published As

Publication number Publication date
IT1170717B (it) 1987-06-03
CZ403491A3 (en) 1994-03-16
FR2477156B1 (bg) 1984-11-16
MY8500757A (en) 1985-12-31
FR2485542A1 (fr) 1981-12-31
DE3105307A1 (de) 1981-12-10
SG36885G (en) 1985-11-15
DK147022C (da) 1984-08-27
DK147022B (da) 1984-03-19
CH651307A5 (de) 1985-09-13
NL960029I1 (nl) 1997-02-03
MX9202717A (es) 1992-06-30
IE51394B1 (en) 1986-12-24
ES499394A0 (es) 1982-09-01
AU544517B2 (en) 1985-06-06
NL8100707A (nl) 1981-09-16
NL191792B (nl) 1996-04-01
DK62381A (da) 1981-08-16
ES509539A0 (es) 1983-04-01
PT72502A (en) 1981-03-01
BG60700B2 (bg) 1995-12-29
FI810444L (fi) 1981-08-16
FR2485542B1 (bg) 1983-06-10
IT8147792A0 (it) 1981-02-13
ES8402317A1 (es) 1984-01-16
NL960029I2 (nl) 1997-04-01
ES518161A0 (es) 1984-01-16
ES8305379A1 (es) 1983-04-01
ES8207194A1 (es) 1982-09-01
SE452468B (sv) 1987-11-30
FI70904B (fi) 1986-07-18
ES524985A0 (es) 1985-01-01
ES8502447A1 (es) 1985-01-01
KR850000969B1 (ko) 1985-07-02
DE3105307C2 (bg) 1988-09-29
NL191792C (nl) 1996-08-02
PT72502B (en) 1982-02-05
AT395427B (de) 1992-12-28
SE8101010L (sv) 1981-08-16
AU6729881A (en) 1981-08-20
ES8600936A1 (es) 1985-10-16
NZ196260A (en) 1983-11-30
IE810282L (en) 1981-08-15
DE3153379C2 (bg) 1992-11-19
SK403491A3 (en) 1996-02-07
ATA67481A (de) 1992-05-15
KE3526A (en) 1985-06-07
ES532055A0 (es) 1985-10-16
CZ281275B6 (cs) 1996-08-14
HK58385A (en) 1985-08-16
KR830005262A (ko) 1983-08-03
FI70904C (fi) 1986-10-27
SK278140B6 (en) 1996-02-07
CH644615A5 (de) 1984-08-15

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Legal Events

Date Code Title Description
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: FLUTICASONE PROPONIATE; NAT. REGISTRATION NO/DATE: NL16604 19921028; FIRST REGISTRATION: GB - PL0045/0153 19900308

Spc suppl protection certif: 93C0018

Filing date: 19930615

CP Supplementary protection certificate (spc) filed

Free format text: 93C0018, 930615

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 93C0018, 930615

CP Supplementary protection certificate (spc) filed
CP Supplementary protection certificate (spc) filed

Free format text: 93C0018, 930615

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 93C0018, 930615

CY Supplementary certificate of protection granted (eec regulation of 18 june 1992)

Free format text: 93C0018, 930615, EXPIRES:20050308