NL191792C - Esters van een androstaan-17beta-carbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten. - Google Patents
Esters van een androstaan-17beta-carbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten.Info
- Publication number
- NL191792C NL191792C NL8100707A NL8100707A NL191792C NL 191792 C NL191792 C NL 191792C NL 8100707 A NL8100707 A NL 8100707A NL 8100707 A NL8100707 A NL 8100707A NL 191792 C NL191792 C NL 191792C
- Authority
- NL
- Netherlands
- Prior art keywords
- esters
- group
- alpha
- compounds
- 17beta
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 3
- WPHPGKZPCVMZPV-CWQDBKDDSA-N (8r,9s,10s,13s,14s,17s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-17-carbothioic s-acid Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(O)=S)[C@@H]4[C@@H]3CCC21 WPHPGKZPCVMZPV-CWQDBKDDSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- -1 alpha -isopropylidenedioxy group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000005997 bromomethyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000009467 reduction Effects 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8005174 | 1980-02-15 | ||
| GB8005174 | 1980-02-15 | ||
| GB8013339 | 1980-04-23 | ||
| GB8013339 | 1980-04-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8100707A NL8100707A (nl) | 1981-09-16 |
| NL191792B NL191792B (nl) | 1996-04-01 |
| NL191792C true NL191792C (nl) | 1996-08-02 |
Family
ID=26274505
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8100707A NL191792C (nl) | 1980-02-15 | 1981-02-13 | Esters van een androstaan-17beta-carbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten. |
| NL960029C NL960029I2 (nl) | 1980-02-15 | 1996-10-29 | Esters van een androstaan-17betacarbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL960029C NL960029I2 (nl) | 1980-02-15 | 1996-10-29 | Esters van een androstaan-17betacarbothiozuur, werkwijze ter bereiding van deze esters, en farmaceutische preparaten, die deze esters bevatten. |
Country Status (23)
| Country | Link |
|---|---|
| KR (1) | KR850000969B1 (xx) |
| AT (1) | AT395427B (xx) |
| AU (1) | AU544517B2 (xx) |
| BG (1) | BG60700B2 (xx) |
| CH (2) | CH651307A5 (xx) |
| CZ (1) | CZ281275B6 (xx) |
| DE (2) | DE3153379C2 (xx) |
| DK (1) | DK147022C (xx) |
| ES (5) | ES499394A0 (xx) |
| FI (1) | FI70904C (xx) |
| FR (2) | FR2477156A1 (xx) |
| HK (1) | HK58385A (xx) |
| IE (1) | IE51394B1 (xx) |
| IT (1) | IT1170717B (xx) |
| KE (1) | KE3526A (xx) |
| MX (1) | MX9202717A (xx) |
| MY (1) | MY8500757A (xx) |
| NL (2) | NL191792C (xx) |
| NZ (1) | NZ196260A (xx) |
| PT (1) | PT72502B (xx) |
| SE (1) | SE452468B (xx) |
| SG (1) | SG36885G (xx) |
| SK (1) | SK278140B6 (xx) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA817929B (en) * | 1980-12-22 | 1982-10-27 | Upjohn Co | 5alpha-and 5beta-androstane-17beta-carboxylates |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1436549A (en) * | 1972-06-15 | 1976-05-19 | Glaxo Lab Ltd | 17beta-mercaptocarbonyl-3alpha-hydroxy-steroids and their esters |
| GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
| GB1514476A (en) * | 1974-08-30 | 1978-06-14 | Glaxo Lab Ltd | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
| US4188385A (en) * | 1978-04-05 | 1980-02-12 | Syntex (U.S.A.) Inc. | Thioetianic acid derivatives |
| GB1580517A (en) * | 1978-04-06 | 1980-12-03 | Fowler I | Crutches |
-
1981
- 1981-02-13 SE SE8101010A patent/SE452468B/sv not_active IP Right Cessation
- 1981-02-13 DK DK62381A patent/DK147022C/da not_active IP Right Cessation
- 1981-02-13 PT PT72502A patent/PT72502B/pt unknown
- 1981-02-13 FR FR8102818A patent/FR2477156A1/fr active Granted
- 1981-02-13 KR KR1019810000442A patent/KR850000969B1/ko active
- 1981-02-13 DE DE3153379A patent/DE3153379C2/de not_active Expired - Lifetime
- 1981-02-13 DE DE19813105307 patent/DE3105307A1/de active Granted
- 1981-02-13 FI FI810444A patent/FI70904C/fi not_active IP Right Cessation
- 1981-02-13 AT AT0067481A patent/AT395427B/de not_active IP Right Cessation
- 1981-02-13 IE IE282/81A patent/IE51394B1/en active Protection Beyond IP Right Term
- 1981-02-13 ES ES499394A patent/ES499394A0/es active Granted
- 1981-02-13 NZ NZ196260A patent/NZ196260A/xx unknown
- 1981-02-13 NL NL8100707A patent/NL191792C/xx not_active IP Right Cessation
- 1981-02-13 IT IT47792/81A patent/IT1170717B/it active Protection Beyond IP Right Term
- 1981-02-13 CH CH3890/84A patent/CH651307A5/de not_active IP Right Cessation
- 1981-02-13 CH CH98281A patent/CH644615A5/de not_active IP Right Cessation
- 1981-02-13 AU AU67298/81A patent/AU544517B2/en not_active Expired
- 1981-08-17 FR FR8115812A patent/FR2485542A1/fr active Granted
-
1982
- 1982-02-12 ES ES509539A patent/ES8305379A1/es not_active Expired
- 1982-12-14 ES ES518161A patent/ES8402317A1/es not_active Expired
-
1983
- 1983-08-16 ES ES524985A patent/ES524985A0/es active Granted
-
1984
- 1984-04-30 ES ES532055A patent/ES532055A0/es active Granted
-
1985
- 1985-05-13 KE KE3526A patent/KE3526A/xx unknown
- 1985-05-16 SG SG368/85A patent/SG36885G/en unknown
- 1985-08-08 HK HK583/85A patent/HK58385A/xx not_active IP Right Cessation
- 1985-12-30 MY MY757/85A patent/MY8500757A/xx unknown
-
1991
- 1991-12-23 SK SK4034-91A patent/SK278140B6/sk unknown
- 1991-12-23 CZ CS914034A patent/CZ281275B6/cs unknown
-
1992
- 1992-06-05 MX MX9202717A patent/MX9202717A/es unknown
-
1993
- 1993-08-20 BG BG098060A patent/BG60700B2/bg unknown
-
1996
- 1996-10-29 NL NL960029C patent/NL960029I2/nl unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed | ||
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| AC1 | Application for a supplementary protection certificate |
Free format text: 960029, 961029 |
|
| KC1 | Grant of a supplementary protection certificate |
Free format text: 960029, 20010213, EXPIRES: 20050307 |
|
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Free format text: 20010213 |