ZA817929B - 5alpha-and 5beta-androstane-17beta-carboxylates - Google Patents

5alpha-and 5beta-androstane-17beta-carboxylates

Info

Publication number
ZA817929B
ZA817929B ZA817929A ZA817929A ZA817929B ZA 817929 B ZA817929 B ZA 817929B ZA 817929 A ZA817929 A ZA 817929A ZA 817929 A ZA817929 A ZA 817929A ZA 817929 B ZA817929 B ZA 817929B
Authority
ZA
South Africa
Prior art keywords
5beta
5alpha
17beta
androstane
carboxylates
Prior art date
Application number
ZA817929A
Inventor
Donald Emory Ayer
Carl Alvin Schlagel
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA817929B publication Critical patent/ZA817929B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • C07J71/0015Oxiranes at position 9(11)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005Ketals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J3/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA817929A 1980-12-22 1981-11-16 5alpha-and 5beta-androstane-17beta-carboxylates ZA817929B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21929380A 1980-12-22 1980-12-22

Publications (1)

Publication Number Publication Date
ZA817929B true ZA817929B (en) 1982-10-27

Family

ID=22818692

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA817929A ZA817929B (en) 1980-12-22 1981-11-16 5alpha-and 5beta-androstane-17beta-carboxylates

Country Status (8)

Country Link
JP (1) JPS57131000A (en)
BE (1) BE891585A (en)
DE (1) DE3149475A1 (en)
FR (1) FR2496668A1 (en)
GB (1) GB2089808A (en)
IT (1) IT1142142B (en)
NL (1) NL8105455A (en)
ZA (1) ZA817929B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8501693D0 (en) * 1985-04-04 1985-04-04 Draco Ab NOVEL 16,17-ACETALSUBSTITUTED ANDROSTANE-17BETA-CARBOXYLIC ACID ESTERS
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
WO1987002672A1 (en) * 1985-10-23 1987-05-07 The Upjohn Company Tetrahydro angiostatic steroids
KR101591482B1 (en) 2008-05-28 2016-02-03 레베라겐 바이오파마 인코포레이티드 - non-hormonal steroid modulators of nf-b for treatment of disease
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc Non-hormonal steroid modulators of nf- kappa b for treatment of disease
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828080A (en) * 1972-01-20 1974-08-06 Glaxo Lab Ltd Androstane-17beta-carboxylic acids and processes for the preparation thereof
SE452468B (en) * 1980-02-15 1987-11-30 Glaxo Group Ltd ANDROSTAN CARBATIOTS, PROCEDURE FOR PREPARING THESE AND COMPOSITIONS

Also Published As

Publication number Publication date
DE3149475A1 (en) 1982-07-15
BE891585A (en) 1982-06-22
GB2089808A (en) 1982-06-30
FR2496668A1 (en) 1982-06-25
IT1142142B (en) 1986-10-08
JPS57131000A (en) 1982-08-13
NL8105455A (en) 1982-07-16
IT8125692A0 (en) 1981-12-18

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