FR2416895A1 - Procede de production de maytansinoides - Google Patents

Procede de production de maytansinoides

Info

Publication number
FR2416895A1
FR2416895A1 FR7832040A FR7832040A FR2416895A1 FR 2416895 A1 FR2416895 A1 FR 2416895A1 FR 7832040 A FR7832040 A FR 7832040A FR 7832040 A FR7832040 A FR 7832040A FR 2416895 A1 FR2416895 A1 FR 2416895A1
Authority
FR
France
Prior art keywords
maytansinoids
production process
production
maytansinoid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7832040A
Other languages
English (en)
Other versions
FR2416895B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13707877A external-priority patent/JPS5470299A/ja
Priority claimed from JP1867578A external-priority patent/JPS54112896A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2416895A1 publication Critical patent/FR2416895A1/fr
Application granted granted Critical
Publication of FR2416895B1 publication Critical patent/FR2416895B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de production de maytansinoïde de formule :
FR7832040A 1977-11-14 1978-11-13 Procede de production de maytansinoides Granted FR2416895A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13707877A JPS5470299A (en) 1977-11-14 1977-11-14 Production of maytansine derivative
JP1867578A JPS54112896A (en) 1978-02-20 1978-02-20 Preparation of maytansines

Publications (2)

Publication Number Publication Date
FR2416895A1 true FR2416895A1 (fr) 1979-09-07
FR2416895B1 FR2416895B1 (fr) 1982-11-19

Family

ID=26355390

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7832040A Granted FR2416895A1 (fr) 1977-11-14 1978-11-13 Procede de production de maytansinoides

Country Status (9)

Country Link
US (2) US4137230A (fr)
CA (1) CA1097627A (fr)
CH (1) CH637398A5 (fr)
DE (1) DE2849090A1 (fr)
DK (1) DK503978A (fr)
FR (1) FR2416895A1 (fr)
GB (1) GB2009742B (fr)
IT (1) IT1100898B (fr)
SE (1) SE441830B (fr)

Families Citing this family (297)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265814A (en) * 1978-03-24 1981-05-05 Takeda Chemical Industries Matansinol 3-n-hexadecanoate
US4307016A (en) * 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
JPS5562090A (en) * 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5566585A (en) * 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164687A (en) * 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5566586A (en) * 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4256746A (en) * 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
US4263294A (en) * 1978-11-20 1981-04-21 Takeda Chemical Industries, Ltd. Maytansinoids, pharmaceutical compositions thereof and method of use thereof
JPS55102583A (en) * 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) * 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS55164685A (en) * 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164686A (en) * 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5622790A (en) * 1979-07-31 1981-03-03 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
US4315929A (en) * 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US5208020A (en) * 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
MXPA01013240A (es) 1999-06-25 2002-06-21 Genentech Inc Metodo de tratamiento utilizando conjugados de anticuerpo contra erbb-maytansionoide.
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
US20110313230A1 (en) 2001-05-11 2011-12-22 Terrance Grant Johns Specific binding proteins and uses thereof
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
US7803915B2 (en) * 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
ES2372321T3 (es) 2001-06-20 2012-01-18 Genentech, Inc. Composiciones y métodos para el diagnóstico y tratamiento de un tumor de pulmón.
US20050107595A1 (en) * 2001-06-20 2005-05-19 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20080085283A1 (en) * 2001-09-05 2008-04-10 Levinson Arthur D Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders
US20040235068A1 (en) * 2001-09-05 2004-11-25 Levinson Arthur D. Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders
NZ531674A (en) 2001-09-18 2009-03-31 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
KR20070087247A (ko) 2002-01-02 2007-08-27 제넨테크, 인크. 종양의 진단 및 치료 방법 및 이를 위한 조성물
CA2481507A1 (fr) 2002-04-16 2003-10-30 Genentech, Inc. Compositions et methodes permettant de diagnostiquer et de traiter une tumeur
US20090068178A1 (en) * 2002-05-08 2009-03-12 Genentech, Inc. Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin
US20040249130A1 (en) * 2002-06-18 2004-12-09 Martin Stanton Aptamer-toxin molecules and methods for using same
US20040022727A1 (en) * 2002-06-18 2004-02-05 Martin Stanton Aptamer-toxin molecules and methods for using same
US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
EP1633784B1 (fr) 2003-05-09 2011-07-13 Diadexus, Inc. Compositions d'anticorps anti-ovr110, et leur procede d'utilisation
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
PT3524611T (pt) 2003-05-20 2021-04-01 Immunogen Inc Agentes citotóxicos melhorados compreendendo novos maitansinóides
BRPI0411803A (pt) 2003-06-27 2006-05-23 Abgenix Inc anticorpos dirigidos aos mutantes de deleção de receptor de fator de crescimento epidérmico e seus usos
SI2784084T2 (sl) 2003-07-08 2024-02-29 Novartis Pharma Ag Antagonistična protitelesa proti IL-17 A/F heterolognim polipeptidom
KR20060069825A (ko) * 2003-08-01 2006-06-22 제넨테크, 인크. 제한된 다양성을 갖는 항체 ｃｄｒ 폴리펩티드 서열
JP4901478B2 (ja) 2003-11-17 2012-03-21 ジェネンテック， インコーポレイテッド 造血系起源の腫瘍の治療のための組成物と方法
PL1718677T3 (pl) 2003-12-19 2012-09-28 Genentech Inc Jednowartościowe fragmenty przeciwciała stosowane jako środki lecznicze
EP2286844A3 (fr) * 2004-06-01 2012-08-22 Genentech, Inc. Conjugués anticorps-médicament et procédés
PL1771474T3 (pl) 2004-07-20 2010-07-30 Genentech Inc Inhibitory białka angiopoetyno-4-podobnego, kombinacje i ich zastosowanie
JP5226308B2 (ja) 2004-07-26 2013-07-03 ジェネンテック， インコーポレイテッド 肝細胞増殖因子活性化を制御するための方法及び組成物
CA2486285C (fr) * 2004-08-30 2017-03-07 Viktor S. Goldmakher Immunoconjugues ciblant des cellules a expression du syndecan-1 et utilisation de ceux-ci
HUE058817T2 (hu) * 2004-09-03 2022-09-28 Genentech Inc Humanizált anti-béta7 antagonisták és alkalmazásaik
JP2008526883A (ja) 2005-01-07 2008-07-24 ディアデクサス インコーポレーテッド Ｏｖｒ１１０抗体組成物および使用方法
CA2600418A1 (fr) * 2005-03-07 2006-09-14 Archemix Corp. Aptameres stabilises d'apsm et leur utilisation comme agents therapeutiques contre le cancer de la prostate
US7858843B2 (en) 2005-06-06 2010-12-28 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
AU2006280321A1 (en) 2005-08-15 2007-02-22 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
AU2006283726C1 (en) 2005-08-24 2015-05-07 Immunogen, Inc. Process for preparing maytansinoid antibody conjugates
EP2465870A1 (fr) 2005-11-07 2012-06-20 Genentech, Inc. Polypeptides de liaison dotés de séquences hypvervariables VH/VL diversifiées et consensuelles
AU2006335053A1 (en) 2005-11-21 2007-07-19 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
AU2006342792A1 (en) 2005-12-02 2007-11-08 Genentech, Inc. Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R
KR101434682B1 (ko) * 2005-12-02 2014-08-27 제넨테크, 인크. 결합 폴리펩티드 및 이들의 용도
US20070237764A1 (en) * 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
KR101538521B1 (ko) 2005-12-15 2015-07-22 제넨테크, 인크. 폴리유비퀴틴 표적화를 위한 방법 및 조성물
DK1973950T3 (en) 2006-01-05 2014-12-15 Genentech Inc ANTI-EphB4 ANTIBODIES AND METHODS FOR USING SAME
EP1806365A1 (fr) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Anticorps spécifiques pour la protéine alpha d'activation de fibroblastes et leurs immunoconjugués
RU2451031C2 (ru) 2006-01-20 2012-05-20 Дженентек, Инк. Антитела к эфрину в2 и способы их применения
EP2050335A1 (fr) 2006-02-17 2009-04-22 Genentech, Inc. Dislocation de gènes, compositions et procédés correspondants
AR059851A1 (es) 2006-03-16 2008-04-30 Genentech Inc Anticuerpos de la egfl7 y metodos de uso
EP2614839A3 (fr) 2006-04-05 2015-01-28 Genentech, Inc. Méthode d'utilisation du BOC/CDO pour moduler l'émission des signaux du hedgehog
EP2082645A1 (fr) 2006-04-19 2009-07-29 Genentech, Inc. Nouvelle dislocation de gènes, compositions et procédés correspondants
MX2008015132A (es) 2006-05-30 2008-12-10 Genentech Inc Anticuerpos e inmunoconjugados y sus usos.
ATE522625T1 (de) 2006-09-12 2011-09-15 Genentech Inc Verfahren und zusammensetzungen zur diagnose und behandlung von lungenkrebs mittels pdgfra-, kit- oder kdg-gen als genmarker
EP2061814B1 (fr) 2006-10-27 2012-06-06 Genentech, Inc. Anticorps et immunoconjugues, et leurs utilisations
JP5391073B2 (ja) 2006-11-27 2014-01-15 ディアデクサス インコーポレーテッド Ｏｖｒ１１０抗体組成物および使用方法
US9090693B2 (en) * 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CA2676766A1 (fr) 2007-02-09 2008-08-21 Genentech, Inc. Anticorps anti-robo4 et utilisations de ceux-ci
JP5618549B2 (ja) * 2007-03-15 2014-11-05 ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
WO2009012256A1 (fr) 2007-07-16 2009-01-22 Genentech, Inc. Anticorps anti-cd79b humanisés, immunoconjugués, et procédés d'utilisation
DK2474557T3 (da) 2007-07-16 2014-11-10 Genentech Inc Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
PT2220116E (pt) * 2007-11-12 2012-12-07 Theraclone Sciences Inc Composições e métodos para a terapia e o diagnóstico da gripe
US20110033476A1 (en) * 2007-11-12 2011-02-10 Theraclone Sciences Inc. Compositions and methods for the therapy and diagnosis of influenza
AR069501A1 (es) 2007-11-30 2010-01-27 Genentech Inc Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
JP5990365B2 (ja) 2007-12-26 2016-09-14 バイオテスト・アクチエンゲゼルシヤフト Ｃｄ１３８を標的とする剤及びその使用
WO2009080831A1 (fr) * 2007-12-26 2009-07-02 Biotest Ag Procédé permettant de réduire les effets secondaires cytotoxiques et d'améliorer l'efficacité des immunoconjugués
JP5817034B2 (ja) * 2007-12-26 2015-11-18 バイオテスト・アクチエンゲゼルシヤフト Ｃｄ１３８を標的とする免疫複合体及びその使用
MX2010007101A (es) * 2007-12-26 2011-07-01 Biotest Ag Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd138.
CN101977934B (zh) 2008-01-18 2014-09-17 健泰科生物技术公司 用于靶向k63连接的多聚遍在蛋白的方法和组合物
DK2657253T3 (en) 2008-01-31 2017-10-09 Genentech Inc Anti-CD79b antibodies and immune conjugates and methods of use
EP2257571B1 (fr) 2008-03-10 2015-03-04 Theraclone Sciences, Inc. Compositions et procédés pour le diagnostic et le traitement d'une infection à cytomégalovirus
EP2644204B1 (fr) 2008-03-18 2017-04-19 Genentech, Inc. Combinaisons de conjugué de médicament-anticorps anti-HER2 et du pertuzumab
SG10201402815VA (en) 2008-04-09 2014-09-26 Genentech Inc Novel compositions and methods for the treatment of immune related diseases
EP2279004B1 (fr) * 2008-05-16 2015-01-14 F. Hoffmann-La Roche AG Utilisation de biomarqueurs pour évaluer le traitement de troubles inflammatoires gastro-intestinaux avec des antagonistes de l'intégrine bêta7
EP2318832B1 (fr) 2008-07-15 2013-10-09 Academia Sinica Matrices de glycane sur des lames de verre revêtues d' aluminium de type ptfe et procédés associés
CN102170909B (zh) 2008-10-01 2015-11-25 霍夫曼-拉罗奇有限公司 抗-notch2抗体和使用方法
WO2010080528A1 (fr) 2008-12-17 2010-07-15 Genentech, Inc. Polythérapie contre le virus de l'hépatite c
SI3260136T1 (sl) 2009-03-17 2021-05-31 Theraclone Sciences, Inc. Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa
CN104447995A (zh) 2009-03-20 2015-03-25 霍夫曼-拉罗奇有限公司 双特异性抗-her抗体
SI3702371T1 (sl) * 2009-03-25 2023-01-31 Genentech, Inc. Protitelesa proti FGFR3 in postopki za uporabo le-teh
US8466260B2 (en) 2009-04-01 2013-06-18 Genentech, Inc. Anti-FcRH5 antibodies and immunoconjugates and methods of use
MX2011010159A (es) 2009-04-02 2011-10-17 Roche Glycart Ag Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla.
US8609101B2 (en) * 2009-04-23 2013-12-17 Theraclone Sciences, Inc. Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies
EP2432803A2 (fr) 2009-05-20 2012-03-28 Theraclone Sciences, Inc. Compositions et procédés pour le traitement et le diagnostic de la grippe
SG10201810743WA (en) 2009-06-03 2018-12-28 Immunogen Inc Conjugation methods
EP2711018A1 (fr) 2009-06-22 2014-03-26 MedImmune, LLC Régions Fc modifiées pour conjugaison spécifique d'un site
KR20120089253A (ko) 2009-07-31 2012-08-09 제넨테크, 인크. Ｂｖ８? 또는 ｇ?ｃｓｆ?길항제를 이용한 종양 전이의 억제
EP2473522B1 (fr) 2009-09-02 2016-08-17 Genentech, Inc. Mutant smoothened et ses méthodes d'utilisation
WO2011034605A2 (fr) 2009-09-16 2011-03-24 Genentech, Inc. Complexes protéiques contenant une super-hélice et/ou une attache et leurs utilisations
US20110076232A1 (en) 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
AR078471A1 (es) 2009-10-02 2011-11-09 Sanofi Aventis COMPUESTOS MAITANSINOIDES Y EL USO DE ESTOS PARA PREPARAR CONJUGADOS CON UN ANTICUERPO LOS CUALES SE UTILIZAN COMO AGENTES ANTICANCERIGENOS Y EL PROCEDIMIENTO DE PREPARACIoN DE ESTOS CONJUGADOS
KR20120106940A (ko) 2009-10-19 2012-09-27 제넨테크, 인크. 간세포 성장 인자 활성화제의 조절제
BR112012009409A2 (pt) 2009-10-22 2017-02-21 Genentech Inc método de identificação de uma substância inibidora, molécula antagonista, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar a molécula, composição, artigo de fabricação, método de inibição de uma atividade biológica, método de tratamento de uma condição patológica, método para detectar msp em uma amostra e método para detectar hepsina em uma amostra
EP2491059B1 (fr) 2009-10-22 2015-02-25 F.Hoffmann-La Roche Ag Anticorps anti-hepsine et procédés d'utilisation de ceux-ci
WO2011056497A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Compositions de récepteur de l'activine de type iib et leurs méthodes d'utilisation
WO2011056494A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Combinaisons d'antagonistes de la kinase-1 du type récepteur de l'activine et d'antagonistes vegfr3
WO2011056502A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Compositions du gene recepteur de proteine morphogenetique osseuse type ii et procedes d'utilisation
BR112012010153B1 (pt) 2009-11-05 2022-05-03 Genentech, Inc Método de produção de um anticorpo
SG10201408598XA (en) 2009-11-30 2015-02-27 Genentech Inc Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid2 )
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US8486397B2 (en) 2009-12-11 2013-07-16 Genentech, Inc. Anti-VEGF-C antibodies and methods using same
CA2784385A1 (fr) 2009-12-23 2011-06-30 Genentech, Inc. Anticorps anti-bv8 et leurs utilisations
US20110159588A1 (en) 2009-12-30 2011-06-30 Kui Lin Methods for Modulating a PDGF-AA Mediated Biological Response
MA34057B1 (fr) 2010-02-23 2013-03-05 Genentech Inc Compositions et methodes pour le diagnostic et le traitement d'une tumeur
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
US10338069B2 (en) 2010-04-12 2019-07-02 Academia Sinica Glycan arrays for high throughput screening of viruses
WO2011133886A2 (fr) 2010-04-23 2011-10-27 Genentech, Inc. Production de protéines hétéromultimères
PE20130460A1 (es) 2010-05-03 2013-04-26 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores
MX336109B (es) 2010-06-03 2016-01-08 Genentech Inc Formacion de imagenes inmuno-tep de anticuerpos e inmunoconjugados y usos de lo mismo.
JP2013540701A (ja) 2010-08-12 2013-11-07 セラクローン サイエンシーズ， インコーポレイテッド 抗赤血球凝集素抗体組成物およびその使用方法
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
EP2926830B1 (fr) 2010-08-31 2017-08-02 Theraclone Sciences, Inc. Anticorps de neutralisation du virus de l'immunodéficience humaine (vih)
JP5866130B2 (ja) 2010-09-10 2016-02-17 アペクシジェン， インコーポレイテッド 抗ＩＬ−１β抗体およびその使用方法
DK2625197T3 (en) 2010-10-05 2016-10-03 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
ES2544608T3 (es) 2010-11-17 2015-09-02 Genentech, Inc. Conjugados de anticuerpo y de alaninil-maitansinol
WO2012085111A1 (fr) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée
WO2012092539A2 (fr) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Anticorps contre dll4 et leurs utilisations
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
BR112013019499B1 (pt) 2011-02-04 2023-01-10 Genentech, Inc. Proteína heteromultimérica variante ou anticorpo igg modificado, método para produzir uma proteína heteromultimérica variante ou anticorpo igg modificado, composição, método para preparar uma proteína heteromultimérica e proteína heteromultimérica variante
BR112013020743A2 (pt) 2011-02-14 2016-10-18 Theraclone Sciences Inc composições e métodos para a terapia e diagnóstico de influenza
KR20140043724A (ko) 2011-03-03 2014-04-10 아펙시젠, 인코포레이티드 항-il-6 수용체 항체 및 사용 방법
US20120315277A1 (en) 2011-03-15 2012-12-13 Theraclone Sciences, Inc. Compositions and Methods for the Therapy and Diagnosis of Influenza
SI2691155T1 (sl) 2011-03-29 2019-03-29 Immunogen, Inc. Priprava majtanzinoidnih konjugatov protiteles v postopku z enim korakom
JP6125489B2 (ja) 2011-04-29 2017-05-10 アペクシジェン， インコーポレイテッド 抗ｃｄ４０抗体および使用方法
MX2013013104A (es) 2011-05-09 2014-10-15 Univ Virginia Patent Found Composiciones y metodos para el tratamiento de cancer.
DK3415531T3 (da) 2011-05-27 2023-09-18 Glaxo Group Ltd Bcma (cd269/tnfrsf17)-bindende proteiner
RU2014109985A (ru) 2011-08-17 2015-09-27 Дженентек, Инк. Ингибирование ангиогенеза в рефрактерных опухолях
US8822651B2 (en) 2011-08-30 2014-09-02 Theraclone Sciences, Inc. Human rhinovirus (HRV) antibodies
EP2758437B1 (fr) 2011-09-22 2020-06-03 Amgen Inc. Protéines de liaison à un antigène cd27l
MX2014004991A (es) 2011-10-28 2014-05-22 Genentech Inc Combinaciones terapeuticas y metodos para tratar el melanoma.
WO2013067098A1 (fr) 2011-11-02 2013-05-10 Apexigen, Inc. Anticorps anti-kdr et procédés d'utilisation
KR20140091064A (ko) 2011-11-16 2014-07-18 암젠 인크 표피 성장 인자 결실 돌연변이체 vⅲ 관련 장애를 치료하는 방법
MX358680B (es) 2011-12-08 2018-08-31 Biotest Ag Usos de inmunoconjugados dirigidos a cd138.
CA2859755C (fr) 2011-12-23 2021-04-20 Pfizer Inc. Regions constantes d'anticorps modifies pour conjugaison specifique a un site, et leurs procedes et utilisations
WO2013106485A2 (fr) 2012-01-09 2013-07-18 The Scripps Research Institute Régions déterminant la complémentarité ultralongues et utilisations associées
JP2015509091A (ja) 2012-01-09 2015-03-26 ザ スクリプス リサーチ インスティテュート ヒト化抗体
RU2644341C2 (ru) 2012-02-10 2018-02-08 Дженентек, Инк. Одноцепочечные антитела и другие гетеромультимеры
AU2013229786B2 (en) 2012-03-08 2017-06-22 Halozyme, Inc. Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof
AR090549A1 (es) 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
CA2867824A1 (fr) 2012-05-01 2013-11-07 Genentech, Inc. Anticorps anti-pmel17 et immunoconjugues
UY34813A (es) 2012-05-18 2013-11-29 Amgen Inc Proteínas de unión a antígeno dirigidas contra el receptor st2
EP2867253B1 (fr) 2012-06-27 2016-09-14 F. Hoffmann-La Roche AG Méthode de sélection et de production d'entités de ciblage personnalisées fortement sélectives et multi-spécifiques renfermant au moins deux entités de liaison différentes et leurs utilisations
CA2871882A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Methode de fabrication de conjugues d'anticorps a region fc comprenant au moins une entite de liaison qui se lie specifiquement a une cible et leurs utilisations
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
HUE055443T2 (hu) 2012-09-26 2021-11-29 Immunogen Inc Javított eljárások maytansinol acilezéséhez
SG10201702737TA (en) 2012-10-04 2017-05-30 Immunogen Inc Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
AU2013337903B2 (en) 2012-10-30 2018-08-16 Apexigen, Inc. Anti-CD40 antibodies and methods of use
TW201425336A (zh) 2012-12-07 2014-07-01 Amgen Inc Ｂｃｍａ抗原結合蛋白質
CN104650113A (zh) 2012-12-21 2015-05-27 百奥泰生物科技(广州)有限公司 类美登素衍生物及其制备方法和用途
CN103333246B (zh) 2012-12-21 2015-09-16 百奥泰生物科技(广州)有限公司 一种抗egfr受体的肿瘤生长抑制剂及其制备方法和用途
CN103254213B (zh) 2012-12-21 2015-02-25 百奥泰生物科技(广州)有限公司 类美登素酯的制备方法及用于所述方法的组合物
CN103288957B (zh) 2012-12-21 2015-01-28 百奥泰生物科技(广州)有限公司 一种抑制肿瘤生长的抗体药物衍生物及其制备方法和用途
EP2948478B1 (fr) 2013-01-25 2019-04-03 Amgen Inc. Anticorps ciblant cdh19 pour un mélanome
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
MX2015010777A (es) 2013-03-14 2016-04-25 Genentech Inc Anticuerpos e inmunoconjugados anti-b7-h4.
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
AP2015008656A0 (en) 2013-03-15 2015-08-31 Novartis Ag Antibody drug conjugates
EA201592285A1 (ru) 2013-05-30 2016-05-31 Байоджен Ма Инк. Антигенсвязывающие белки к рецептору онкостатина м
EP3013365B1 (fr) 2013-06-26 2019-06-05 Academia Sinica Antigènes rm2 et leur utilisation
WO2014210564A1 (fr) 2013-06-27 2014-12-31 Academia Sinica Conjugués de glycane et leur utilisation
WO2015017146A2 (fr) 2013-07-18 2015-02-05 Fabrus, Inc. Anticorps à régions de détermination de complémentarité ultralongues
CN111518199A (zh) 2013-07-18 2020-08-11 图鲁斯生物科学有限责任公司 具有超长互补决定区的人源化抗体
EP3738612A1 (fr) 2013-07-31 2020-11-18 Biontech AG Diagnostic et traitement du cancer impliquant des cellules souches cancéreuses
CN104341504B (zh) 2013-08-06 2017-10-24 百奥泰生物科技(广州)有限公司 双特异性抗体
US9782476B2 (en) 2013-09-06 2017-10-10 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
MX2016003256A (es) 2013-09-12 2016-06-07 Halozyme Inc Anticuerpos modificados del receptor de factor de crecimiento anti-epidermico y metodos de uso de los mismos.
KR20160055252A (ko) 2013-09-17 2016-05-17 제넨테크, 인크. 항-lgr5 항체의 사용 방법
ES2960807T3 (es) 2013-10-11 2024-03-06 Us Health Anticuerpos contra TEM8 y su uso
US20160280798A1 (en) 2013-11-06 2016-09-29 The United States Of America, As Represented By The Secretary Department Of Health & Human Service Alk antibodies, conjugates, and chimeric antigen receptors, and their use
US9562059B2 (en) * 2013-12-02 2017-02-07 Hong Kong Baptist University Anticancer maytansinoids with two fused macrocyclic rings
EA201691214A1 (ru) 2013-12-13 2016-12-30 Дженентек, Инк. Антитела к cd33 и иммуноконъюгаты
EP3082875B1 (fr) 2013-12-16 2020-11-25 Genentech, Inc. Composés peptidomimétiques et conjugués anticorps-médicament de ceux-ci
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017507118A (ja) 2014-01-16 2017-03-16 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ がんの処置および検出のための組成物および方法
RU2016130349A (ru) 2014-01-24 2018-03-01 Дженентек, Инк. Способы применения антител против steap1 и иммуноконъюгатов
WO2015120075A2 (fr) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened et méthodes d'utilisation de celui-ci
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
JP2017512765A (ja) 2014-04-11 2017-05-25 メディミューン，エルエルシー 二重特異性ｈｅｒ２抗体
ES2955736T3 (es) 2014-05-06 2023-12-05 Hoffmann La Roche Producción de proteínas heteromultiméricas usando células de mamífero
CN106414499A (zh) 2014-05-22 2017-02-15 基因泰克公司 抗gpc3抗体和免疫偶联物
KR102512592B1 (ko) 2014-05-27 2023-03-21 아카데미아 시니카 항-ｈｅｒ2 글리코항체 및 이의 용도
CA2950415A1 (fr) 2014-05-27 2015-12-03 Academia Sinica Glycoanticorps anti-cd20 et leurs utilisations
EP3149045B1 (fr) 2014-05-27 2023-01-18 Academia Sinica Compositions et procédés concernant des glycoformes universelles pour une efficacité d'anticorps améliorée
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
MX2017001946A (es) 2014-08-12 2017-06-19 Novartis Ag Conjugados de farmacos con anticuerpos anti-cdh6.
US20170260261A1 (en) 2014-08-28 2017-09-14 Bioatla, Llc Conditionally Active Chimeric Antigen Receptors for Modified T-Cells
KR102422375B1 (ko) 2014-09-08 2022-07-18 아카데미아 시니카 당지질을 사용한 인간 iNKT 세포 활성화
US10059768B2 (en) 2014-09-12 2018-08-28 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
TWI758784B (zh) 2014-09-12 2022-03-21 美商建南德克公司 抗her2抗體及免疫結合物
CA2958479A1 (fr) 2014-09-12 2016-03-17 Genentech, Inc. Anticorps anti-cll-1 et immunoconjugues
PT3262071T (pt) 2014-09-23 2020-06-16 H Hoffnabb La Roche Ag Métodos de utilização de imunoconjugados anti-cd79b
AU2015324924B2 (en) 2014-10-01 2021-07-01 Medimmune, Llc Method of conjugating a polypeptide
MX2017003478A (es) 2014-11-05 2018-02-01 Genentech Inc Anticuerpos anti-fgfr2/3 y metodos para su uso.
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
EP3248013B1 (fr) 2015-01-24 2020-07-15 Academia Sinica Marqueurs de cancer et leurs procédés d'utilisation
EP3248005B1 (fr) 2015-01-24 2020-12-09 Academia Sinica Nouveaux composés conjugués de glycane et leurs méthodes d'utilisation
CA2975875A1 (fr) 2015-02-04 2016-08-11 Genentech, Inc. Mutant smoothened et methodes d'utilisation de celui-ci
CN107614020A (zh) 2015-03-18 2018-01-19 免疫生化公司 靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物
WO2016165762A1 (fr) 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Conjugués de médicaments comprenant des anticorps contre la claudine 18.2
KR20240093813A (ko) 2015-04-24 2024-06-24 제넨테크, 인크. 다중특이적 항원-결합 단백질
AU2016277121C1 (en) 2015-06-12 2022-07-14 Lentigen Technology, Inc. Method to treat cancer with engineered T-cells
EP3310813A1 (fr) 2015-06-17 2018-04-25 Novartis AG Conjugués anticorps-médicament
EP3359562B1 (fr) 2015-10-09 2019-12-04 Miltenyi Biotec Technology, Inc. Récepteur d'antigène chimérique et ses utilisations
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
JP6991978B2 (ja) 2016-01-27 2022-02-03 メディミューン，エルエルシー 定められるグリコシル化パターンを有する抗体を調製するための方法
CA3019952A1 (fr) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened et methodes d'utilisation dudit mutant
JP2019515876A (ja) 2016-03-08 2019-06-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｎ−グリカンおよびそのアレイのモジュール合成のための方法
WO2017161206A1 (fr) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugués contenant des anticorps à activité conditionnelle ou des fragments de liaison à un antigène associés, et procédés d'utilisation
CN109563164A (zh) 2016-04-15 2019-04-02 生物蛋白有限公司 抗axl抗体、抗体片段和它们的免疫缀合物以及其用途
PE20190353A1 (es) 2016-04-15 2019-03-07 Macrogenics Inc Moleculas de union b7-h3 novedosas, conjugados anticuerpo-farmaco de los mismos y metodos de uso de los mismos
WO2017196847A1 (fr) 2016-05-10 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps anti-nouveau récepteur variable d'antigène (vnar) et conjugués d'anticorps ciblant des antigènes tumoraux et viraux
HRP20221298T1 (hr) 2016-05-13 2022-12-23 Bioatla, Inc. Anti-ror2 protutijela, fragmenti protutijela, njihovi imunokonjugati i njihove uporabe
JP7022080B2 (ja) 2016-05-27 2022-02-17 ジェネンテック， インコーポレイテッド 部位特異的抗体－薬物複合体の特徴付けのための生化学分析的方法
WO2017214182A1 (fr) 2016-06-07 2017-12-14 The United States Of America. As Represented By The Secretary, Department Of Health & Human Services Anticorps entièrement humain ciblant pdi pour l'immunothérapie anticancéreuse
EP3494135A1 (fr) 2016-08-02 2019-06-12 The United States of America, as represented by The Secretary, Department of Health and Human Services Anticorps monoclonaux ciblant le glypican-2 (gpc2) et leur utilisation
CN109963868B (zh) 2016-08-22 2023-11-14 醣基生医股份有限公司 抗体、结合片段及使用方法
AU2017321894A1 (en) 2016-09-02 2019-03-14 Lentigen Technology, Inc. Compositions and methods for treating cancer with duoCARs
GB201615725D0 (en) 2016-09-15 2016-11-02 Polytherics Ltd Novel cytotoxic agents and conjugates thereof
KR102221364B1 (ko) 2016-11-21 2021-03-04 쿠레아브 게엠베하 항-gp73　항체　및　면역접합체
CA3045902A1 (fr) 2016-12-21 2018-06-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux humains specifiques a la flt3 et leur utilisation
EP4183798A1 (fr) 2017-01-09 2023-05-24 Lentigen Technology, Inc. Compositions et procédés pour le traitement du cancer avec immunothérapie anti-mésothéline
JOP20190187A1 (ar) 2017-02-03 2019-08-01 Novartis Ag مترافقات عقار جسم مضاد لـ ccr7
US10426797B2 (en) 2017-03-24 2019-10-01 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-CD33 immunotherapy
WO2018185618A1 (fr) 2017-04-03 2018-10-11 Novartis Ag Conjugués de médicament-anticorps anti-cdh6 et combinaisons d'anticorps anti-gitr et méthodes de traitement
AU2018268970A1 (en) 2017-05-19 2019-10-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibody targeting tnfr2 for cancer immunotherapy
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
WO2019005208A1 (fr) 2017-06-30 2019-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps de la mésothéline humaine et utilisations dans une thérapie anticancéreuse
CA3066953A1 (fr) 2017-06-30 2019-01-03 Lentigen Technology, Inc. Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation
JP7237926B2 (ja) 2017-07-31 2023-03-13 レンティジェン・テクノロジー・インコーポレイテッド 抗ｃｄ１９／ｃｄ２０免疫療法によりがんを処置するための組成物および方法
CN107446050A (zh) 2017-08-11 2017-12-08 百奥泰生物科技(广州)有限公司 Trop2阳性疾病治疗的化合物及方法
US10501539B2 (en) 2017-09-15 2019-12-10 Lentigen Technology Inc. Compositions and methods for treating cancer with anti-CD19 immunotherapy
JP7275118B2 (ja) 2017-10-16 2023-05-17 レンティジェン・テクノロジー・インコーポレイテッド 抗ｃｄ２２免疫療法によってがんを処置するための組成物および方法
CN111954677A (zh) 2017-12-20 2020-11-17 莱蒂恩技术公司 用于用免疫治疗来治疗hiv/aids的组合物和方法
EP3820903A1 (fr) 2018-07-12 2021-05-19 The United States of America, as represented by the Secretary, Department of Health and Human Services Anticorps monoclonal spécifique pour cd22 à maturation par affinité et utilisations associées
CA3107383A1 (fr) 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Utilisation d'un conjugue anticorps anti-cd5 -medicament (adc) dans une therapie cellulaire allogenique
WO2020033430A1 (fr) 2018-08-08 2020-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux à haute affinité ciblant le glypicane-2 et leurs utilisations
CN118291501A (zh) 2018-09-20 2024-07-05 莱蒂恩技术公司 用于用抗cd123免疫治疗来治疗癌症的组合物和方法
CA3114349A1 (fr) 2018-09-26 2020-04-02 Lentigen Technology, Inc. Compositions et procedes de traitement du cancer par immunotherapie anti-cd19/cd22
US11103533B2 (en) 2018-11-30 2021-08-31 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-CD38 immunotherapy
AU2018451747A1 (en) 2018-12-06 2021-06-17 F. Hoffmann-La Roche Ag Combination therapy of diffuse large B-cell lymphoma comprising an anti-CD79b immunoconjugates, an alkylating agent and an anti-CD20 antibody
CN113490510A (zh) 2019-01-08 2021-10-08 美国政府(由卫生和人类服务部的部长所代表) 用于治疗实体瘤的靶向间皮素的跨物种单结构域抗体
AU2020212534A1 (en) 2019-01-22 2021-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High affinity monoclonal antibodies targeting glypican-1 and methods of use
US11969443B2 (en) 2019-03-06 2024-04-30 Lentigen Technology, Inc. Compositions and methods for treating cancer with self-driving chimeric antigen receptors
US20220133904A1 (en) 2019-03-19 2022-05-05 Paul Scherrer Institut Transglutaminase conjugation method with a glycine based linker
BR112021022815A2 (pt) 2019-05-14 2021-12-28 Genentech Inc Métodos para tratar linfoma folicular, kits, imunoconjugados e polatuzumabe vedotina
CN114364801B (zh) 2019-05-30 2024-04-19 莱蒂恩技术公司 用于用抗bcma免疫治疗来治疗癌症的组合物和方法
CN114269783B (zh) 2019-07-02 2024-03-26 美国政府(由卫生和人类服务部的部长所代表) 结合egfrviii的单克隆抗体及其应用
JPWO2021010326A1 (fr) 2019-07-12 2021-01-21
EP4045090A1 (fr) 2019-10-18 2022-08-24 Genentech, Inc. Procédés d'utilisation d'immunoconjugués anti-cd79b pour traiter un lymphome diffus à grandes cellules b
EP4031250A1 (fr) 2019-10-22 2022-07-27 The United States of America, as represented by the Secretary, Department of Health and Human Services Nanocorps à haute affinité ciblant b7h3 (cd276) pour traiter des tumeurs solides multiples
WO2021118968A1 (fr) 2019-12-12 2021-06-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Conjugués anticorps-médicament spécifiques à cd276 et leurs utilisations
CA3175530A1 (fr) 2020-04-24 2021-10-28 Genentech, Inc. Procedes d'utilisation d'immunoconjugues anti-cd79b
US20230181756A1 (en) 2020-04-30 2023-06-15 Novartis Ag Ccr7 antibody drug conjugates for treating cancer
AU2021296423A1 (en) 2020-06-22 2023-02-02 Lentigen Technology, Inc. Compositions and methods for treating cancer with TSLPR-CD19 or TSLPR-CD22 immunotherapy
JP2023542910A (ja) 2020-09-18 2023-10-12 アラリス バイオテック アーゲー アミノ酸に基づくリンカーを使用したトランスグルタミナーゼコンジュゲーション方法
EP4232095A1 (fr) 2020-10-25 2023-08-30 Araris Biotech AG Moyens et procédés de fabrication de conjugués anticorps-lieur
WO2022093745A1 (fr) 2020-10-26 2022-05-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps à domaine unique ciblant une protéine de spicule de coronavirus responsable du sars et leurs utilisations
AU2021372997A1 (en) 2020-11-05 2023-06-22 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-cd19/cd22 immunotherapy
US20240218055A1 (en) 2021-04-29 2024-07-04 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Lassa virus-specific nanobodies and methods of their use
WO2022241446A1 (fr) 2021-05-12 2022-11-17 Genentech, Inc. Méthodes d'utilisation d'immunoconjugués anti-cd79b pour traiter un lymphome diffus à grandes cellules b
CA3220227A1 (fr) 2021-05-28 2022-12-01 Matthew Bruce Polytherapies pour traiter le cancer
EP4352099A1 (fr) 2021-06-09 2024-04-17 The United States of America, as represented by The Secretary, Department of Health and Human Services Anticorps à domaine unique hétérospécifiques ciblant pd-l1 pour le traitement de tumeurs solides
US11807685B2 (en) 2021-08-05 2023-11-07 The Uab Research Foundation Anti-CD47 antibody and uses thereof
TW202337499A (zh) 2021-08-07 2023-10-01 美商建南德克公司 使用抗ｃｄ７９ｂ免疫結合物治療瀰漫性大ｂ細胞淋巴瘤之方法
WO2023057893A1 (fr) 2021-10-05 2023-04-13 Glaxosmithkline Intellectual Property Development Limited Polythérapies pour le traitement du cancer
CN118159298A (zh) 2021-10-25 2024-06-07 阿拉里斯生物技术股份公司 生产抗体-接头偶联物的方法
WO2023161291A1 (fr) 2022-02-22 2023-08-31 Araris Biotech Ag Liaisons peptidiques comprenant deux ou plusieurs charges utiles
US11590169B1 (en) 2022-03-02 2023-02-28 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-CD123 immunotherapy
US20230338424A1 (en) 2022-03-02 2023-10-26 Lentigen Technology, Inc. Compositions and Methods for Treating Cancer with Anti-CD123 Immunotherapy
WO2024026107A2 (fr) 2022-07-28 2024-02-01 Lentigen Technology, Inc. Thérapies par récepteur antigénique chimérique pour le traitement de tumeurs solides
WO2024044743A1 (fr) 2022-08-26 2024-02-29 Lentigen Technology, Inc. Compositions et méthodes de traitement du cancer par immunothérapie anti-cd20/cd19 entièrement humaine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1336399A (en) * 1971-06-24 1973-11-07 Lepetit Spa 3-formylrifamycin sv derivatives
GB1405135A (en) * 1972-08-23 1975-09-03 Kupchan S M Antileukaemic ansa macrolides
DE2241418A1 (de) * 1972-08-23 1974-03-07 S Morris Kupchan Antileukaemische ansamakrolide
US3896111A (en) * 1973-02-20 1975-07-22 Research Corp Ansa macrolides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/67 *
EXBK/75 *

Also Published As

Publication number Publication date
GB2009742B (en) 1982-08-11
DK503978A (da) 1979-05-15
CA1097627A (fr) 1981-03-17
US4190580A (en) 1980-02-26
IT7829728A0 (it) 1978-11-13
DE2849090A1 (de) 1979-05-17
GB2009742A (en) 1979-06-20
US4137230A (en) 1979-01-30
SE441830B (sv) 1985-11-11
SE7811689L (sv) 1979-05-15
CH637398A5 (de) 1983-07-29
IT1100898B (it) 1985-09-28
FR2416895B1 (fr) 1982-11-19

Similar Documents

Publication Publication Date Title
FR2416895A1 (fr) Procede de production de maytansinoides
FR2377989A1 (fr) Procede de preparation des trimethylolalcanes
IT1107496B (it) Procedimento per la produzione di chinazoline sostituite mediante ciclizzazione di cianocarbossamidine
FR2400010A1 (fr) Procede de preparation de sulfobetaines
FR2367758A1 (fr) Procede pour la production de derives du furanne
FR2398065A1 (fr)
BE870612A (fr) Procede de production de composes heteromacrocyliques
FR2364196A1 (fr) Procede de preparation d'ethers
FR2377367A1 (fr) Procede de preparation d'alcoxy-cetones
FR2406640A1 (fr) Production de 2,6-diaminonebularines
FR2342339A1 (fr) Procede de production de polysaccharides par fermentation
FR2385670A1 (fr) Procede de preparation de 2,2-dimethylolalcanals
FR2408661B1 (fr) Procede de production d'aciers resulfures
FR2405927A1 (fr) Procede de preparation de composes azoiques
FR2381014A1 (fr) Procede pour la preparation d'ethers diphenyliques halogenomethyles
JPS55157562A (en) Novel intermediate useful for production of antitumor compounds
FR2393797A1 (fr) Preparation de sels quaternaires sulfoalkyle
BE862890A (fr) Procede de production de thiazoline-2-thiones
FR2383177A1 (fr) Procede de preparation de derives de 2,1,3-thiadiazine-4-one-2,2-dioxyde
FR2388816A1 (fr) Procede de production de composes cephem
FR2446841A1 (fr) Procede de preparation de 1a,3b-dihydroxy-d5-steroides
FR2368465A1 (fr) Procede de preparation de dichloronitranilines
BE863897A (fr) Procede de production de copolymeres butadiene-propylene
FR2393033A1 (fr) Procede de preparation d'un pigment bis-azomethinique
LU80038A1 (fr) Procede de production de compositions antibacteriennes

Legal Events

Date Code Title Description
ST Notification of lapse