GB1405135A - Antileukaemic ansa macrolides - Google Patents

Antileukaemic ansa macrolides

Info

Publication number
GB1405135A
GB1405135A GB3918172A GB3918172A GB1405135A GB 1405135 A GB1405135 A GB 1405135A GB 3918172 A GB3918172 A GB 3918172A GB 3918172 A GB3918172 A GB 3918172A GB 1405135 A GB1405135 A GB 1405135A
Authority
GB
United Kingdom
Prior art keywords
antileukaemic
macrolides
maytansine
ansa
ansa macrolides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3918172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kupchan S M
Original Assignee
Kupchan S M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kupchan S M filed Critical Kupchan S M
Priority to GB3918172A priority Critical patent/GB1405135A/en
Publication of GB1405135A publication Critical patent/GB1405135A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1405135 Anti-tumour medicaments S M KUPCHAN 23 Aug 1972 39181/72 Heading A5B [Also in Division C2] Pharmaceutical compositions, suitable for parenteral administration, contain macrolides of the formula: where R is CH 3 (Maytansine), CH 2 CH 3 (Maytanprine) or CH(CH 3 ) 2 (Maytabutine) or 9-O- (3-bromopropyl) maytansine and pharmaceutically acceptable carriers and, if desired, other active ingredients such as mechlorethamine hydrochloride, S-[bis (2-chloroethyl) amino] uracil, triethylenemelamine, actinomycin C or cyloheximide. The compounds possess activity tumor inhibitory activity.
GB3918172A 1972-08-23 1972-08-23 Antileukaemic ansa macrolides Expired GB1405135A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3918172A GB1405135A (en) 1972-08-23 1972-08-23 Antileukaemic ansa macrolides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3918172A GB1405135A (en) 1972-08-23 1972-08-23 Antileukaemic ansa macrolides

Publications (1)

Publication Number Publication Date
GB1405135A true GB1405135A (en) 1975-09-03

Family

ID=10408131

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3918172A Expired GB1405135A (en) 1972-08-23 1972-08-23 Antileukaemic ansa macrolides

Country Status (1)

Country Link
GB (1) GB1405135A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190580A (en) * 1977-11-14 1980-02-26 Takeda Chemical Industries, Ltd. Optically active maytansinoids and maytansinoid production method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190580A (en) * 1977-11-14 1980-02-26 Takeda Chemical Industries, Ltd. Optically active maytansinoids and maytansinoid production method

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Legal Events

Date Code Title Description
694A Case decided by the comptroller (rule 94(3)/1968)
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee