GB1322640A - Selected 5-substituted-5-phenylalkyl barbituric acids analgetic compositions and method based thereon - Google Patents
Selected 5-substituted-5-phenylalkyl barbituric acids analgetic compositions and method based thereonInfo
- Publication number
- GB1322640A GB1322640A GB5089371A GB5089371A GB1322640A GB 1322640 A GB1322640 A GB 1322640A GB 5089371 A GB5089371 A GB 5089371A GB 5089371 A GB5089371 A GB 5089371A GB 1322640 A GB1322640 A GB 1322640A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- phenylalkyl
- substituted
- method based
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- -1 acetoxymethyl Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Making Paper Articles (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1322640 Analgesic medicines KENDALL CO 2 Nov 1971 [9 Nov 1970] 50893/71 Heading A5B [Also in Divisions C2 and C3] Pharmaceutical compositions in conventional forms for oral or parenteral administration and having analgesic activity comprise a compound of formula wherein m is 1 or 2; R 1 and R 2 independently represent hydrogen, methyl or ethyl, with the provisos that the radical -(-CR 1 R 2 -)- m contains not more than one ethyl group or more than two methyl groups, that when m is 1 said radical contains at least one hydrogen and that when m is 2 said radical contains at least two hydrogens; R 3 and R 4 independently represent hydrogen or methyl, or R 3 and R 4 are both methoxymethyl or are both acetoxymethyl; X is hydrogen, chlorine, -NO 2 or methoxy; and Z is -O-R<SP>1</SP> or -O-C-R<SP>1</SP> wherein R<SP>1</SP> is an alkyl radical containing 1 to 3 carbon atoms, or -OSi(R") 3 wherein R" is methyl or ethyl, and a physiologically acceptable carrier therefore.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8819370A | 1970-11-09 | 1970-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1322640A true GB1322640A (en) | 1973-07-11 |
Family
ID=22209926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5089371A Expired GB1322640A (en) | 1970-11-09 | 1971-11-02 | Selected 5-substituted-5-phenylalkyl barbituric acids analgetic compositions and method based thereon |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS554099B1 (en) |
| AR (2) | AR194578A1 (en) |
| AT (1) | AT321937B (en) |
| AU (1) | AU462551B2 (en) |
| BE (1) | BE775117A (en) |
| CH (1) | CH568987A5 (en) |
| DE (1) | DE2155469C2 (en) |
| DK (1) | DK135283B (en) |
| ES (1) | ES396825A1 (en) |
| FR (1) | FR2112555B1 (en) |
| GB (1) | GB1322640A (en) |
| IL (1) | IL38094A (en) |
| LU (1) | LU64226A1 (en) |
| NL (1) | NL174042C (en) |
| NO (1) | NO133497C (en) |
| SE (1) | SE385887B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000026259A1 (en) * | 1998-11-04 | 2000-05-11 | Montell Technology Company Bv | Components and catalysts for the polymerization of olefins |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3894023A (en) * | 1973-07-12 | 1975-07-08 | Kendall & Co | 5-Pivaloyloxy-5-(1-phenylethyl) barbituric acid |
| IT1196500B (en) * | 1986-07-16 | 1988-11-16 | Eniricerche Spa | MALONIC ACID DERIVATIVES AND METHODS FOR THEIR SYNTHESIS |
-
1971
- 1971-10-28 AR AR238748A patent/AR194578A1/en active
- 1971-11-02 GB GB5089371A patent/GB1322640A/en not_active Expired
- 1971-11-08 SE SE7114224A patent/SE385887B/en unknown
- 1971-11-08 LU LU64226D patent/LU64226A1/xx unknown
- 1971-11-08 NO NO4117/71A patent/NO133497C/no unknown
- 1971-11-08 IL IL38094A patent/IL38094A/en unknown
- 1971-11-08 DE DE2155469A patent/DE2155469C2/en not_active Expired
- 1971-11-09 NL NLAANVRAGE7115404,A patent/NL174042C/en not_active IP Right Cessation
- 1971-11-09 DK DK548371AA patent/DK135283B/en unknown
- 1971-11-09 JP JP8875071A patent/JPS554099B1/ja active Pending
- 1971-11-09 AT AT963871A patent/AT321937B/en not_active IP Right Cessation
- 1971-11-09 ES ES396825A patent/ES396825A1/en not_active Expired
- 1971-11-09 CH CH1628471A patent/CH568987A5/xx not_active IP Right Cessation
- 1971-11-09 FR FR7140132A patent/FR2112555B1/fr not_active Expired
- 1971-11-09 AU AU35494/71A patent/AU462551B2/en not_active Expired
- 1971-11-09 BE BE775117A patent/BE775117A/en not_active IP Right Cessation
-
1973
- 1973-06-05 AR AR248425A patent/AR194697A1/en active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000026259A1 (en) * | 1998-11-04 | 2000-05-11 | Montell Technology Company Bv | Components and catalysts for the polymerization of olefins |
| US6605562B1 (en) | 1998-11-04 | 2003-08-12 | Basell Poliolefine Italia S.P.A. | Components and catalysts for the polymerization of olefins |
| US6689850B2 (en) | 1998-11-04 | 2004-02-10 | Basell Poliolefine Italia S.P.A. | Process for the polymerization of olefins |
| US6699814B2 (en) | 1998-11-04 | 2004-03-02 | Basell Poliolefine Italia S.P.A. | Catalysts for the polymerization of olefins |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2155469C2 (en) | 1984-08-23 |
| NO133497B (en) | 1976-02-02 |
| BE775117A (en) | 1972-03-01 |
| DE2155469A1 (en) | 1972-05-10 |
| ES396825A1 (en) | 1974-06-16 |
| SE385887B (en) | 1976-07-26 |
| DK135283C (en) | 1977-09-05 |
| IL38094A (en) | 1975-11-25 |
| AR194578A1 (en) | 1973-07-31 |
| NO133497C (en) | 1976-05-12 |
| AR194697A1 (en) | 1973-07-31 |
| FR2112555A1 (en) | 1972-06-16 |
| IL38094A0 (en) | 1972-01-27 |
| AU462551B2 (en) | 1975-06-26 |
| AU3549471A (en) | 1973-05-17 |
| NL7115404A (en) | 1972-05-12 |
| FR2112555B1 (en) | 1975-12-26 |
| NL174042C (en) | 1984-04-16 |
| AT321937B (en) | 1975-04-25 |
| NL174042B (en) | 1983-11-16 |
| DK135283B (en) | 1977-03-28 |
| LU64226A1 (en) | 1972-05-29 |
| CH568987A5 (en) | 1975-11-14 |
| JPS554099B1 (en) | 1980-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SPA | Amended specification published | ||
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLE | Entries relating assignments, transmissions, licences in the register of patents | ||
| PCNP | Patent ceased through non-payment of renewal fee |