FR2403334A1 - 5-substitue-10,11-dihydro-5h-dibenzo (a,d) cyclohepten-5,10-imines utile comme medicament - Google Patents

5-substitue-10,11-dihydro-5h-dibenzo (a,d) cyclohepten-5,10-imines utile comme medicament

Info

Publication number
FR2403334A1
FR2403334A1 FR7826533A FR7826533A FR2403334A1 FR 2403334 A1 FR2403334 A1 FR 2403334A1 FR 7826533 A FR7826533 A FR 7826533A FR 7826533 A FR7826533 A FR 7826533A FR 2403334 A1 FR2403334 A1 FR 2403334A1
Authority
FR
France
Prior art keywords
cyclohepten
dibenzo
dihydro
substitute
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826533A
Other languages
English (en)
French (fr)
Other versions
FR2403334B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2403334A1 publication Critical patent/FR2403334A1/fr
Application granted granted Critical
Publication of FR2403334B1 publication Critical patent/FR2403334B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR7826533A 1977-09-19 1978-09-15 5-substitue-10,11-dihydro-5h-dibenzo (a,d) cyclohepten-5,10-imines utile comme medicament Granted FR2403334A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (2)

Publication Number Publication Date
FR2403334A1 true FR2403334A1 (fr) 1979-04-13
FR2403334B1 FR2403334B1 (enExample) 1982-11-19

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826533A Granted FR2403334A1 (fr) 1977-09-19 1978-09-15 5-substitue-10,11-dihydro-5h-dibenzo (a,d) cyclohepten-5,10-imines utile comme medicament

Country Status (33)

Country Link
JP (1) JPS5463100A (enExample)
AR (1) AR231544A1 (enExample)
AT (1) AT370103B (enExample)
AU (1) AU520178B2 (enExample)
BE (1) BE870562A (enExample)
CA (1) CA1129850A (enExample)
CH (1) CH637954A5 (enExample)
CY (1) CY1283A (enExample)
DE (1) DE2840786A1 (enExample)
DK (1) DK153843C (enExample)
ES (7) ES473492A1 (enExample)
FI (1) FI65618C (enExample)
FR (1) FR2403334A1 (enExample)
GB (2) GB2061947B (enExample)
GR (1) GR65703B (enExample)
HK (1) HK30885A (enExample)
HU (1) HU180868B (enExample)
IE (1) IE47355B1 (enExample)
IL (1) IL55521A0 (enExample)
IT (1) IT1113279B (enExample)
KE (1) KE3501A (enExample)
LU (1) LU80262A1 (enExample)
NL (1) NL191488C (enExample)
NO (1) NO151861C (enExample)
NZ (1) NZ188361A (enExample)
PH (1) PH15920A (enExample)
PL (3) PL121605B1 (enExample)
PT (1) PT68544A (enExample)
SE (1) SE437520B (enExample)
SG (1) SG9585G (enExample)
SU (2) SU895288A3 (enExample)
YU (1) YU41432B (enExample)
ZA (1) ZA785291B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
WO2017093354A1 (en) 2015-11-30 2017-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nmdar antagonists for the treatment of diseases associated with angiogenesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892756A (en) * 1972-02-04 1975-07-01 Roussel Uclaf Novel dibenzocycloheptenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892756A (en) * 1972-02-04 1975-07-01 Roussel Uclaf Novel dibenzocycloheptenes

Also Published As

Publication number Publication date
ATA669778A (de) 1982-07-15
DK153843C (da) 1989-01-23
HU180868B (en) 1983-04-29
GR65703B (en) 1980-10-22
BE870562A (fr) 1979-03-19
NL191488B (nl) 1995-04-03
DK153843B (da) 1988-09-12
NZ188361A (en) 1982-06-29
ES483284A1 (es) 1980-09-01
FR2403334B1 (enExample) 1982-11-19
ES483286A1 (es) 1980-04-16
SG9585G (en) 1985-08-08
PH15920A (en) 1983-04-22
ES483287A1 (es) 1980-04-16
JPS5639315B2 (enExample) 1981-09-11
NL191488C (nl) 1995-08-04
ZA785291B (en) 1980-04-30
IE47355B1 (en) 1984-02-22
CH637954A5 (de) 1983-08-31
DK389978A (da) 1979-03-20
PL118478B1 (en) 1981-10-31
AU3966878A (en) 1980-03-13
GB2061947A (en) 1981-05-20
SU895288A3 (ru) 1981-12-30
PL209632A1 (pl) 1979-06-04
SU915800A3 (en) 1982-03-23
AR231544A1 (es) 1984-12-28
KE3501A (en) 1985-02-22
ES483288A1 (es) 1980-04-16
IE781866L (en) 1979-03-19
NO151861B (no) 1985-03-11
PL112834B1 (en) 1980-11-29
FI65618B (fi) 1984-02-29
HK30885A (en) 1985-04-26
IT7851126A0 (it) 1978-09-18
JPS5463100A (en) 1979-05-21
SE7809187L (sv) 1979-03-20
NO783017L (no) 1979-03-20
CA1129850A (en) 1982-08-17
AU520178B2 (en) 1982-01-21
GB2004872B (en) 1982-04-15
GB2061947B (en) 1982-08-04
YU41432B (en) 1987-06-30
DE2840786C2 (enExample) 1987-05-21
GB2004872A (en) 1979-04-11
CY1283A (en) 1985-07-05
DE2840786A1 (de) 1979-03-22
NL7808847A (nl) 1979-03-21
IL55521A0 (en) 1978-12-17
IT1113279B (it) 1986-01-20
AT370103B (de) 1983-03-10
PL121605B1 (en) 1982-05-31
SE437520B (sv) 1985-03-04
ES483285A1 (es) 1980-09-01
FI65618C (fi) 1984-06-11
LU80262A1 (fr) 1979-06-01
ES483283A1 (es) 1980-04-16
YU219678A (en) 1983-02-28
NO151861C (no) 1985-06-19
ES473492A1 (es) 1980-07-16
FI782680A7 (fi) 1979-03-20
PT68544A (en) 1978-10-01

Similar Documents

Publication Publication Date Title
HUP9600448A2 (hu) Naftilvegyületek, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, intermedierjeik és alkalmazásuk
MA26727A1 (fr) Derives nouveaux de pyrimidine inhibiteurs de sorbitol deshydrogenase, leur procede de preparation et compositions pharmaceutiques les contenant
BG104727A (en) Pharmaceutical composition of topiramate
FR2407921A1 (fr) Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes, utiles notamment comme agents cardiovasculaires, et leur procede de preparation
BE902874A (fr) Compositions therapeutiques et procede pour le traitement ou la prevention des maladies provoquees par le paf-acether
FR2401159A1 (fr) Derives de 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-one, leur procede de preparation et leur activite therapeutique
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
TNSN00250A1 (fr) Composes nouveaux inhibiteurs de pcp, procede pour leur preparation et compositions les contenant
FR2376858A1 (fr) Nouvelles imidazo(1,2-a)quinoxalines substituees en position 4, leur procede de preparation et medicament les contenant
FR2429797A1 (enExample)
TNSN97143A1 (fr) Derives de trans-piperazine-1-yl-spiro(cyclohexane-1, 1&#39;- isobenzofuranne), procede pour leur preparation et compositions pharmaceutiques les contenant
FI92320B (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten bisfenyylialkyylipiperatsiinijohdannaisten valmistamiseksi
FR2432520A1 (fr) Nouvelles imidazoquinoxalines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2420346A1 (fr) Medicaments contenant des alcenylxanthines et leur procede de preparation
FR2409268A1 (fr) Nouvelles imidazobenzoxazines et leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits
FR2446829A1 (fr) Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2384775A1 (fr) Derives de la morphine, leur procede de preparation et leur application comme medicament
GB1452868A (en) Propiophenone derivatives and preparation thereof
MX9707596A (es) Benzamidas, el uso de las mismas, composiciones que las contienen, para el tratamiento del transtorno neurodegenerativo, y procedimiento para la preparacion del mismo.
FR2392990A1 (fr) Medicament a base d&#39;un compose heterocyclique bicyclique condense
FR2397387A1 (fr) 4,4&#39;-bis-formyl-polyhalo-diphenoxyalcanes, procede de preparation et application a la synthese de 4,4&#39;-dicyano-polyhalo-diphenoxyalcanes
HUT50343A (en) Process for producing new condensed diazepinones and pharmaceutical compositions comprising same
TNSN99105A1 (fr) 2-aminopyridines contenant des substituants a noyau condenses
FR2391218A1 (fr) Composes d&#39;azacyclyle et procede pour leur preparation et leur application en tant que medicament
FR2383176A1 (fr) Amino aryl triazines 1-2-4 utilisables dans le traitement d&#39;algies diverses