FR2403334A1 - 5-SUBSTITUTE-10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5,10-IMINES USEFUL AS A MEDICINAL PRODUCT - Google Patents

5-SUBSTITUTE-10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5,10-IMINES USEFUL AS A MEDICINAL PRODUCT

Info

Publication number
FR2403334A1
FR2403334A1 FR7826533A FR7826533A FR2403334A1 FR 2403334 A1 FR2403334 A1 FR 2403334A1 FR 7826533 A FR7826533 A FR 7826533A FR 7826533 A FR7826533 A FR 7826533A FR 2403334 A1 FR2403334 A1 FR 2403334A1
Authority
FR
France
Prior art keywords
cyclohepten
dibenzo
dihydro
substitute
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826533A
Other languages
French (fr)
Other versions
FR2403334B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2403334A1 publication Critical patent/FR2403334A1/en
Application granted granted Critical
Publication of FR2403334B1 publication Critical patent/FR2403334B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Abstract

L'invention concerne des composés chimiques nouveaux. Il s'agit de 5-substitué- 10,11 -dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imines, leurs dérivés et leurs sels pharmaceutiquement acceptables. Ces composés sont utiles comme agents anti-anxiété, agents de relâchement des muscles et dans le traitement de troubles extrapyramidaux comme dans la maladie de Parkinson.The invention relates to novel chemical compounds. These are 5-substituted-10,11 -dihydro-5H-dibenzo (a, d) cyclohepten-5,10-imines, their derivatives and their pharmaceutically acceptable salts. These compounds are useful as anti-anxiety agents, muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease.

FR7826533A 1977-09-19 1978-09-15 5-SUBSTITUTE-10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5,10-IMINES USEFUL AS A MEDICINAL PRODUCT Granted FR2403334A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (2)

Publication Number Publication Date
FR2403334A1 true FR2403334A1 (en) 1979-04-13
FR2403334B1 FR2403334B1 (en) 1982-11-19

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826533A Granted FR2403334A1 (en) 1977-09-19 1978-09-15 5-SUBSTITUTE-10,11-DIHYDRO-5H-DIBENZO (A, D) CYCLOHEPTEN-5,10-IMINES USEFUL AS A MEDICINAL PRODUCT

Country Status (33)

Country Link
JP (1) JPS5463100A (en)
AR (1) AR231544A1 (en)
AT (1) AT370103B (en)
AU (1) AU520178B2 (en)
BE (1) BE870562A (en)
CA (1) CA1129850A (en)
CH (1) CH637954A5 (en)
CY (1) CY1283A (en)
DE (1) DE2840786A1 (en)
DK (1) DK153843C (en)
ES (7) ES473492A1 (en)
FI (1) FI65618C (en)
FR (1) FR2403334A1 (en)
GB (2) GB2061947B (en)
GR (1) GR65703B (en)
HK (1) HK30885A (en)
HU (1) HU180868B (en)
IE (1) IE47355B1 (en)
IL (1) IL55521A0 (en)
IT (1) IT1113279B (en)
KE (1) KE3501A (en)
LU (1) LU80262A1 (en)
NL (1) NL191488C (en)
NO (1) NO151861C (en)
NZ (1) NZ188361A (en)
PH (1) PH15920A (en)
PL (3) PL118478B1 (en)
PT (1) PT68544A (en)
SE (1) SE437520B (en)
SG (1) SG9585G (en)
SU (2) SU895288A3 (en)
YU (1) YU41432B (en)
ZA (1) ZA785291B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
EP3383429B1 (en) 2015-11-30 2020-10-14 INSERM - Institut National de la Santé et de la Recherche Médicale Nmdar antagonists for the treatment of tumor angiogenesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892756A (en) * 1972-02-04 1975-07-01 Roussel Uclaf Novel dibenzocycloheptenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE829075A (en) * 1974-05-15 1975-11-14 9,10-DIHYDROANTHRACEN-9,10-IMINES SUBSTITUTES AND THEIR HETEROCYCLIC ANALOGUES (AZA)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892756A (en) * 1972-02-04 1975-07-01 Roussel Uclaf Novel dibenzocycloheptenes

Also Published As

Publication number Publication date
CY1283A (en) 1985-07-05
ES483284A1 (en) 1980-09-01
DK153843B (en) 1988-09-12
CH637954A5 (en) 1983-08-31
PL209632A1 (en) 1979-06-04
SU895288A3 (en) 1981-12-30
GB2004872A (en) 1979-04-11
GB2004872B (en) 1982-04-15
FI65618C (en) 1984-06-11
FI782680A (en) 1979-03-20
JPS5639315B2 (en) 1981-09-11
FR2403334B1 (en) 1982-11-19
ZA785291B (en) 1980-04-30
NO783017L (en) 1979-03-20
SG9585G (en) 1985-08-08
SU915800A3 (en) 1982-03-23
AR231544A1 (en) 1984-12-28
PL121605B1 (en) 1982-05-31
DK389978A (en) 1979-03-20
SE437520B (en) 1985-03-04
BE870562A (en) 1979-03-19
DE2840786C2 (en) 1987-05-21
KE3501A (en) 1985-02-22
PL112834B1 (en) 1980-11-29
HK30885A (en) 1985-04-26
IT1113279B (en) 1986-01-20
NO151861B (en) 1985-03-11
DK153843C (en) 1989-01-23
YU219678A (en) 1983-02-28
LU80262A1 (en) 1979-06-01
NL7808847A (en) 1979-03-21
IE781866L (en) 1979-03-19
NL191488C (en) 1995-08-04
AU520178B2 (en) 1982-01-21
CA1129850A (en) 1982-08-17
FI65618B (en) 1984-02-29
ES473492A1 (en) 1980-07-16
ES483288A1 (en) 1980-04-16
SE7809187L (en) 1979-03-20
DE2840786A1 (en) 1979-03-22
GR65703B (en) 1980-10-22
IE47355B1 (en) 1984-02-22
ES483287A1 (en) 1980-04-16
GB2061947A (en) 1981-05-20
YU41432B (en) 1987-06-30
ES483286A1 (en) 1980-04-16
NZ188361A (en) 1982-06-29
IL55521A0 (en) 1978-12-17
PL118478B1 (en) 1981-10-31
ES483285A1 (en) 1980-09-01
HU180868B (en) 1983-04-29
AT370103B (en) 1983-03-10
JPS5463100A (en) 1979-05-21
ATA669778A (en) 1982-07-15
IT7851126A0 (en) 1978-09-18
ES483283A1 (en) 1980-04-16
NO151861C (en) 1985-06-19
PT68544A (en) 1978-10-01
PH15920A (en) 1983-04-22
NL191488B (en) 1995-04-03
AU3966878A (en) 1980-03-13
GB2061947B (en) 1982-08-04

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