FI65618B - FREQUENCY REQUIREMENT FOR THERAPEUTIC USE OF THERAPEUTIC 5-UBSTITUARADE 10,11-DIHYDRO-5H-DIBENSO (A D) CYCLOHEPTEN-5,1 0-MINER - Google Patents

FREQUENCY REQUIREMENT FOR THERAPEUTIC USE OF THERAPEUTIC 5-UBSTITUARADE 10,11-DIHYDRO-5H-DIBENSO (A D) CYCLOHEPTEN-5,1 0-MINER

Info

Publication number
FI65618B
FI65618B FI782680A FI782680A FI65618B FI 65618 B FI65618 B FI 65618B FI 782680 A FI782680 A FI 782680A FI 782680 A FI782680 A FI 782680A FI 65618 B FI65618 B FI 65618B
Authority
FI
Finland
Prior art keywords
therapeutic
ubstituarade
dibenso
cyclohepten
miner
Prior art date
Application number
FI782680A
Other languages
Finnish (fi)
Other versions
FI782680A (en
FI65618C (en
Inventor
Sandor Karady
Paul Stanley Anderson
Marcia Elizabeth Christy
Ben Edward Evans
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI782680A publication Critical patent/FI782680A/en
Publication of FI65618B publication Critical patent/FI65618B/en
Application granted granted Critical
Publication of FI65618C publication Critical patent/FI65618C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI782680A 1977-09-19 1978-09-01 FREQUENCY REQUIREMENT FOR THERAPEUTIC USE OF THERAPEUTIC 5-UBSTITUARADE 10,11-DIHYDRO-5H-DIBENSO (A D) CYCLOHEPTEN-5,1 0-MINER FI65618C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19
US83463977 1977-09-19

Publications (3)

Publication Number Publication Date
FI782680A FI782680A (en) 1979-03-20
FI65618B true FI65618B (en) 1984-02-29
FI65618C FI65618C (en) 1984-06-11

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782680A FI65618C (en) 1977-09-19 1978-09-01 FREQUENCY REQUIREMENT FOR THERAPEUTIC USE OF THERAPEUTIC 5-UBSTITUARADE 10,11-DIHYDRO-5H-DIBENSO (A D) CYCLOHEPTEN-5,1 0-MINER

Country Status (33)

Country Link
JP (1) JPS5463100A (en)
AR (1) AR231544A1 (en)
AT (1) AT370103B (en)
AU (1) AU520178B2 (en)
BE (1) BE870562A (en)
CA (1) CA1129850A (en)
CH (1) CH637954A5 (en)
CY (1) CY1283A (en)
DE (1) DE2840786A1 (en)
DK (1) DK153843C (en)
ES (7) ES473492A1 (en)
FI (1) FI65618C (en)
FR (1) FR2403334A1 (en)
GB (2) GB2004872B (en)
GR (1) GR65703B (en)
HK (1) HK30885A (en)
HU (1) HU180868B (en)
IE (1) IE47355B1 (en)
IL (1) IL55521A0 (en)
IT (1) IT1113279B (en)
KE (1) KE3501A (en)
LU (1) LU80262A1 (en)
NL (1) NL191488C (en)
NO (1) NO151861C (en)
NZ (1) NZ188361A (en)
PH (1) PH15920A (en)
PL (3) PL121605B1 (en)
PT (1) PT68544A (en)
SE (1) SE437520B (en)
SG (1) SG9585G (en)
SU (2) SU895288A3 (en)
YU (1) YU41432B (en)
ZA (1) ZA785291B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
US10583171B2 (en) 2015-11-30 2020-03-10 INSERM (Institut National de la Santé et de la Recherche Médicale) NMDAR antagonists for the treatment of diseases associated with angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (en) * 1972-02-04 1973-08-02 Roussel Uclaf NEW DIBENZOCYCLOHEPTENE DERIVATIVES AND THEIR PREPARATION
BE829075A (en) * 1974-05-15 1975-11-14 9,10-DIHYDROANTHRACEN-9,10-IMINES SUBSTITUTES AND THEIR HETEROCYCLIC ANALOGUES (AZA)

Also Published As

Publication number Publication date
HU180868B (en) 1983-04-29
AR231544A1 (en) 1984-12-28
FR2403334B1 (en) 1982-11-19
CY1283A (en) 1985-07-05
IT7851126A0 (en) 1978-09-18
ES483287A1 (en) 1980-04-16
IL55521A0 (en) 1978-12-17
YU219678A (en) 1983-02-28
ZA785291B (en) 1980-04-30
NL191488C (en) 1995-08-04
IE47355B1 (en) 1984-02-22
GR65703B (en) 1980-10-22
ES483288A1 (en) 1980-04-16
LU80262A1 (en) 1979-06-01
NO151861C (en) 1985-06-19
SU895288A3 (en) 1981-12-30
PH15920A (en) 1983-04-22
SE7809187L (en) 1979-03-20
BE870562A (en) 1979-03-19
AT370103B (en) 1983-03-10
SG9585G (en) 1985-08-08
SE437520B (en) 1985-03-04
AU520178B2 (en) 1982-01-21
DE2840786A1 (en) 1979-03-22
NO783017L (en) 1979-03-20
ES483286A1 (en) 1980-04-16
CA1129850A (en) 1982-08-17
GB2004872A (en) 1979-04-11
GB2004872B (en) 1982-04-15
DK389978A (en) 1979-03-20
PT68544A (en) 1978-10-01
IE781866L (en) 1979-03-19
ES483283A1 (en) 1980-04-16
JPS5463100A (en) 1979-05-21
NO151861B (en) 1985-03-11
DK153843C (en) 1989-01-23
FI782680A (en) 1979-03-20
PL118478B1 (en) 1981-10-31
GB2061947B (en) 1982-08-04
DE2840786C2 (en) 1987-05-21
YU41432B (en) 1987-06-30
ES483284A1 (en) 1980-09-01
IT1113279B (en) 1986-01-20
ATA669778A (en) 1982-07-15
PL121605B1 (en) 1982-05-31
SU915800A3 (en) 1982-03-23
GB2061947A (en) 1981-05-20
ES483285A1 (en) 1980-09-01
PL112834B1 (en) 1980-11-29
HK30885A (en) 1985-04-26
AU3966878A (en) 1980-03-13
NL191488B (en) 1995-04-03
NL7808847A (en) 1979-03-21
FR2403334A1 (en) 1979-04-13
PL209632A1 (en) 1979-06-04
JPS5639315B2 (en) 1981-09-11
KE3501A (en) 1985-02-22
ES473492A1 (en) 1980-07-16
CH637954A5 (en) 1983-08-31
FI65618C (en) 1984-06-11
NZ188361A (en) 1982-06-29
DK153843B (en) 1988-09-12

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Owner name: MERCK & CO INC.