RO76721A - PROCEDURE FOR PREPARATION OF 3.12-HYDROXY-4-PHENYL-CYCLOSANONE - Google Patents

PROCEDURE FOR PREPARATION OF 3.12-HYDROXY-4-PHENYL-CYCLOSANONE

Info

Publication number
RO76721A
RO76721A RO7899162A RO9916278A RO76721A RO 76721 A RO76721 A RO 76721A RO 7899162 A RO7899162 A RO 7899162A RO 9916278 A RO9916278 A RO 9916278A RO 76721 A RO76721 A RO 76721A
Authority
RO
Romania
Prior art keywords
cyclosanone
hydroxy
phenyl
procedure
preparation
Prior art date
Application number
RO7899162A
Other languages
French (fr)
Romanian (ro)
Inventor
Charles A Harbert
Michael R Johnson
Jr Lawrence S Melvin
Original Assignee
Pfizer Inc,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us
Publication of RO76721A publication Critical patent/RO76721A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/117Esters of phosphoric acids with cycloaliphatic alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24Halogenated derivatives
    • C07C39/42Halogenated derivatives containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48Preparation of compounds having groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48Preparation of compounds having groups
    • C07C41/50Preparation of compounds having groups by reactions producing groups
    • C07C41/56Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95Esters of quinone carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered
RO7899162A 1977-09-13 1978-09-13 PROCEDURE FOR PREPARATION OF 3.12-HYDROXY-4-PHENYL-CYCLOSANONE RO76721A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83310277A 1977-09-13 1977-09-13

Publications (1)

Publication Number Publication Date
RO76721A true RO76721A (en) 1982-10-11

Family

ID=25263433

Family Applications (5)

Application Number Title Priority Date Filing Date
RO7898209A RO77296A (en) 1977-09-13 1978-09-13 PROCESS FOR PREPARATION OF DERIVATIVES FROM 3 (2-HYDROXY) -4-SUBSTITUTE-PHENYL-CYCLOSALCANONE
RO7898208A RO77170A (en) 1977-09-13 1978-09-13 PROCESS FOR THE PREPARATION OF 3 (2-HYDROXY) -4-SUBTITU-PHENYL-CYCLOALKENONES, CYCLOALKENOLES, CYCLOALKANONES AND CYCLOALKANOLES DERIVATIVES
RO7898210A RO77297A (en) 1977-09-13 1978-09-13 PROCESS FOR THE PREPARATION OF 3 (2-HYDROXY-4-SUBSTITUTED) -PENYL-CYCLOHALCENALS AND CYCLOSALCANOL
RO7898207A RO77321A (en) 1977-09-13 1978-09-13 PROCESS FOR THE PREPARATION OF 3 (2-HYDROXY-4-SUBSTITU-P (ENYL) -CYCLOALCANONES DERIVATIVES
RO7899162A RO76721A (en) 1977-09-13 1978-09-13 PROCEDURE FOR PREPARATION OF 3.12-HYDROXY-4-PHENYL-CYCLOSANONE

Family Applications Before (4)

Application Number Title Priority Date Filing Date
RO7898209A RO77296A (en) 1977-09-13 1978-09-13 PROCESS FOR PREPARATION OF DERIVATIVES FROM 3 (2-HYDROXY) -4-SUBSTITUTE-PHENYL-CYCLOSALCANONE
RO7898208A RO77170A (en) 1977-09-13 1978-09-13 PROCESS FOR THE PREPARATION OF 3 (2-HYDROXY) -4-SUBTITU-PHENYL-CYCLOALKENONES, CYCLOALKENOLES, CYCLOALKANONES AND CYCLOALKANOLES DERIVATIVES
RO7898210A RO77297A (en) 1977-09-13 1978-09-13 PROCESS FOR THE PREPARATION OF 3 (2-HYDROXY-4-SUBSTITUTED) -PENYL-CYCLOHALCENALS AND CYCLOSALCANOL
RO7898207A RO77321A (en) 1977-09-13 1978-09-13 PROCESS FOR THE PREPARATION OF 3 (2-HYDROXY-4-SUBSTITU-P (ENYL) -CYCLOALCANONES DERIVATIVES

Country Status (11)

Country Link
JP (4) JPS5538367A (en)
BE (1) BE870404A (en)
CS (1) CS216502B2 (en)
DD (3) DD148334A5 (en)
HU (1) HU181937B (en)
PL (5) PL123771B1 (en)
PT (1) PT68543A (en)
RO (5) RO77296A (en)
SU (1) SU991944A3 (en)
YU (1) YU215478A (en)
ZA (1) ZA785180B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921994A (en) * 1980-09-19 1990-05-01 Pfizer Inc. Pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes and derivatives thereof
US4831059A (en) * 1980-09-19 1989-05-16 Pfizer Inc. Producing analgesia with pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes derivatives
US4835192A (en) * 1980-09-19 1989-05-30 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4933475A (en) * 1980-09-19 1990-06-12 Pfizer, Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4331602A (en) 1980-09-19 1982-05-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted]phenyl)naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4486609A (en) * 1981-03-16 1984-12-04 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4285867A (en) 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4591225A (en) * 1985-01-14 1986-05-27 Molex Incorporated Arrangement for interconnecting a printed circuit board with a multi-conductor cable
GB9007762D0 (en) * 1990-04-05 1990-06-06 Beecham Group Plc Novel compounds
EP2010165A2 (en) * 2006-04-24 2009-01-07 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
UA101004C2 (en) * 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof

Also Published As

Publication number Publication date
DD148631A5 (en) 1981-06-03
DD140454A5 (en) 1980-03-05
DD148334A5 (en) 1981-05-20
PL121079B1 (en) 1982-04-30
ZA785180B (en) 1979-08-29
BE870404A (en) 1979-03-12
PL209554A1 (en) 1979-06-04
PL122765B1 (en) 1982-08-31
JPS5639036A (en) 1981-04-14
JPS5930692B2 (en) 1984-07-28
SU991944A3 (en) 1983-01-23
JPS5930693B2 (en) 1984-07-28
PL122834B1 (en) 1982-08-31
RO77321A (en) 1981-08-17
PT68543A (en) 1978-10-01
YU215478A (en) 1983-06-30
JPS5753352B2 (en) 1982-11-12
CS216502B2 (en) 1982-11-26
PL123771B1 (en) 1982-11-30
RO77170A (en) 1981-06-22
RO77296A (en) 1981-06-22
PL122835B1 (en) 1982-08-31
JPS605579B2 (en) 1985-02-12
JPS5639031A (en) 1981-04-14
JPS5639035A (en) 1981-04-14
RO77297A (en) 1981-06-22
JPS5538367A (en) 1980-03-17
HU181937B (en) 1983-11-28

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