AT370103B - METHOD FOR PRODUCING NEW 5-SUBST.-10, 11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEPTEN-5, 10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS - Google Patents
METHOD FOR PRODUCING NEW 5-SUBST.-10, 11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEPTEN-5, 10-IMINES AND THEIR SALTS AND OPTICAL ISOMERSInfo
- Publication number
- AT370103B AT370103B AT0669778A AT669778A AT370103B AT 370103 B AT370103 B AT 370103B AT 0669778 A AT0669778 A AT 0669778A AT 669778 A AT669778 A AT 669778A AT 370103 B AT370103 B AT 370103B
- Authority
- AT
- Austria
- Prior art keywords
- cyclohepten
- subst
- dibenzo
- imines
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT222582A AT373255B (en) | 1977-09-19 | 1982-06-08 | METHOD FOR PRODUCING NEW 5-SUBST.-10,11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEP EN-5,10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
AT222082A AT372957B (en) | 1977-09-19 | 1982-06-08 | METHOD FOR PRODUCING NEW 5-SUBST. 10,11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEP EN-5,10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
AT222182A AT372960B (en) | 1977-09-19 | 1982-06-08 | METHOD FOR PRODUCING NEW 5-SUBST. 10,11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEP EN-5,10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
AT222482A AT373254B (en) | 1977-09-19 | 1982-06-08 | METHOD FOR PRODUCING NEW 5-SUBST.-10,11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEP EN-5,10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
AT222282A AT372961B (en) | 1977-09-19 | 1982-06-08 | METHOD FOR PRODUCING NEW 5-SUBST. 10,11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEP EN-5,10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
AT222382A AT372962B (en) | 1977-09-19 | 1982-06-08 | METHOD FOR PRODUCING NEW 5-SUBST. 10,11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEP EN-5,10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83463977A | 1977-09-19 | 1977-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA669778A ATA669778A (en) | 1982-07-15 |
AT370103B true AT370103B (en) | 1983-03-10 |
Family
ID=25267426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0669778A AT370103B (en) | 1977-09-19 | 1978-09-15 | METHOD FOR PRODUCING NEW 5-SUBST.-10, 11-DIHYDRO-5H-DIBENZO (A, D) -CYCLOHEPTEN-5, 10-IMINES AND THEIR SALTS AND OPTICAL ISOMERS |
Country Status (33)
Country | Link |
---|---|
JP (1) | JPS5463100A (en) |
AR (1) | AR231544A1 (en) |
AT (1) | AT370103B (en) |
AU (1) | AU520178B2 (en) |
BE (1) | BE870562A (en) |
CA (1) | CA1129850A (en) |
CH (1) | CH637954A5 (en) |
CY (1) | CY1283A (en) |
DE (1) | DE2840786A1 (en) |
DK (1) | DK153843C (en) |
ES (7) | ES473492A1 (en) |
FI (1) | FI65618C (en) |
FR (1) | FR2403334A1 (en) |
GB (2) | GB2061947B (en) |
GR (1) | GR65703B (en) |
HK (1) | HK30885A (en) |
HU (1) | HU180868B (en) |
IE (1) | IE47355B1 (en) |
IL (1) | IL55521A0 (en) |
IT (1) | IT1113279B (en) |
KE (1) | KE3501A (en) |
LU (1) | LU80262A1 (en) |
NL (1) | NL191488C (en) |
NO (1) | NO151861C (en) |
NZ (1) | NZ188361A (en) |
PH (1) | PH15920A (en) |
PL (3) | PL118478B1 (en) |
PT (1) | PT68544A (en) |
SE (1) | SE437520B (en) |
SG (1) | SG9585G (en) |
SU (2) | SU895288A3 (en) |
YU (1) | YU41432B (en) |
ZA (1) | ZA785291B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4232158A (en) * | 1979-06-04 | 1980-11-04 | Merck & Co., Inc. | 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines |
US4477668A (en) * | 1982-04-07 | 1984-10-16 | Merck & Co., Inc. | Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine |
GB8719199D0 (en) * | 1987-08-13 | 1987-09-23 | Merck Sharp & Dohme | Chemical compounds |
US5686614A (en) * | 1995-04-11 | 1997-11-11 | Neurogen Corporation | Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution |
US5739337A (en) * | 1996-03-08 | 1998-04-14 | Neurogen Corporation | Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes |
EP3383429B1 (en) | 2015-11-30 | 2020-10-14 | INSERM - Institut National de la Santé et de la Recherche Médicale | Nmdar antagonists for the treatment of tumor angiogenesis |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE794904A (en) * | 1972-02-04 | 1973-08-02 | Roussel Uclaf | NEW DIBENZOCYCLOHEPTENE DERIVATIVES AND THEIR PREPARATION |
BE829075A (en) * | 1974-05-15 | 1975-11-14 | 9,10-DIHYDROANTHRACEN-9,10-IMINES SUBSTITUTES AND THEIR HETEROCYCLIC ANALOGUES (AZA) |
-
1978
- 1978-08-28 NL NL7808847A patent/NL191488C/en not_active IP Right Cessation
- 1978-08-31 SE SE7809187A patent/SE437520B/en not_active IP Right Cessation
- 1978-09-01 FI FI782680A patent/FI65618C/en not_active IP Right Cessation
- 1978-09-04 NO NO783017A patent/NO151861C/en unknown
- 1978-09-04 DK DK389978A patent/DK153843C/en not_active IP Right Cessation
- 1978-09-06 NZ NZ188361A patent/NZ188361A/en unknown
- 1978-09-06 PH PH21575A patent/PH15920A/en unknown
- 1978-09-06 IL IL7855521A patent/IL55521A0/en not_active IP Right Cessation
- 1978-09-08 GR GR57185A patent/GR65703B/en unknown
- 1978-09-08 AU AU39668/78A patent/AU520178B2/en not_active Expired
- 1978-09-12 PT PT68544A patent/PT68544A/en unknown
- 1978-09-13 CA CA311,197A patent/CA1129850A/en not_active Expired
- 1978-09-14 AR AR273708A patent/AR231544A1/en active
- 1978-09-15 AT AT0669778A patent/AT370103B/en not_active IP Right Cessation
- 1978-09-15 FR FR7826533A patent/FR2403334A1/en active Granted
- 1978-09-15 IE IE1866/78A patent/IE47355B1/en not_active IP Right Cessation
- 1978-09-15 CH CH969078A patent/CH637954A5/en not_active IP Right Cessation
- 1978-09-16 PL PL1978217435A patent/PL118478B1/en unknown
- 1978-09-16 PL PL1978225938A patent/PL121605B1/en unknown
- 1978-09-16 PL PL1978209632A patent/PL112834B1/en unknown
- 1978-09-18 ZA ZA785291A patent/ZA785291B/en unknown
- 1978-09-18 HU HU78ME2204A patent/HU180868B/en not_active IP Right Cessation
- 1978-09-18 BE BE190553A patent/BE870562A/en not_active IP Right Cessation
- 1978-09-18 IT IT51126/78A patent/IT1113279B/en active
- 1978-09-18 YU YU2196/78A patent/YU41432B/en unknown
- 1978-09-18 SU SU782665603A patent/SU895288A3/en active
- 1978-09-19 CY CY1283A patent/CY1283A/en unknown
- 1978-09-19 JP JP11420078A patent/JPS5463100A/en active Granted
- 1978-09-19 LU LU80262A patent/LU80262A1/en unknown
- 1978-09-19 GB GB8037685A patent/GB2061947B/en not_active Expired
- 1978-09-19 GB GB7837284A patent/GB2004872B/en not_active Expired
- 1978-09-19 DE DE19782840786 patent/DE2840786A1/en active Granted
- 1978-09-19 ES ES473492A patent/ES473492A1/en not_active Expired
-
1979
- 1979-08-09 ES ES483287A patent/ES483287A1/en not_active Expired
- 1979-08-09 ES ES483284A patent/ES483284A1/en not_active Expired
- 1979-08-09 ES ES483283A patent/ES483283A1/en not_active Expired
- 1979-08-09 ES ES483286A patent/ES483286A1/en not_active Expired
- 1979-08-09 ES ES483285A patent/ES483285A1/en not_active Expired
- 1979-08-09 ES ES483288A patent/ES483288A1/en not_active Expired
- 1979-11-02 SU SU792834514A patent/SU915800A3/en active
-
1985
- 1985-02-05 KE KE3501A patent/KE3501A/en unknown
- 1985-02-07 SG SG95/85A patent/SG9585G/en unknown
- 1985-04-18 HK HK308/85A patent/HK30885A/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELA | Expired due to lapse of time |