FR2382441A1 - Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation - Google Patents
Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparationInfo
- Publication number
- FR2382441A1 FR2382441A1 FR7805319A FR7805319A FR2382441A1 FR 2382441 A1 FR2382441 A1 FR 2382441A1 FR 7805319 A FR7805319 A FR 7805319A FR 7805319 A FR7805319 A FR 7805319A FR 2382441 A1 FR2382441 A1 FR 2382441A1
- Authority
- FR
- France
- Prior art keywords
- preparation
- aminoalkyl
- new
- pyrrolidine
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La présente invention concerne des composés chimiques nouveaux et un procédé pour leur préparation. Il s'agit de dérivés nouveaux et sels d'addition correspondants qui répondent, sous forme de base libre, à la formule :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77387777A | 1977-03-03 | 1977-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2382441A1 true FR2382441A1 (fr) | 1978-09-29 |
FR2382441B1 FR2382441B1 (fr) | 1980-01-18 |
Family
ID=25099597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7805319A Granted FR2382441A1 (fr) | 1977-03-03 | 1978-02-24 | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation |
Country Status (13)
Country | Link |
---|---|
US (1) | US4145347A (fr) |
JP (1) | JPS53108966A (fr) |
AU (1) | AU514354B2 (fr) |
BE (1) | BE864269A (fr) |
CA (1) | CA1073457A (fr) |
DE (1) | DE2808067A1 (fr) |
DK (1) | DK151010C (fr) |
ES (1) | ES467288A1 (fr) |
FR (1) | FR2382441A1 (fr) |
GB (1) | GB1588082A (fr) |
HK (1) | HK59683A (fr) |
MY (1) | MY8400269A (fr) |
SG (1) | SG38583G (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0212588A1 (fr) * | 1985-08-16 | 1987-03-04 | Warner-Lambert Company | Amides de l'acide cycloalkyle(b)pyrrole-1(2H)acétique saturé et ses dérivés |
EP0213506A1 (fr) * | 1985-08-16 | 1987-03-11 | Warner-Lambert Company | Amides de l'acide cycloalkyl-c-pyrrole-2(1H)acétique saturé et leurs dérivés |
EP0236263A2 (fr) * | 1986-01-30 | 1987-09-09 | Ciba-Geigy Ag | Pyrrolidinones substituées |
EP0299493A2 (fr) * | 1987-07-15 | 1989-01-18 | Shionogi & Co., Ltd. | N-[(2-oxopyrrolidin-1-yl)acétyl]pipérazines et médicament contre la démence sénile |
EP0363489A1 (fr) * | 1988-04-18 | 1990-04-18 | 2-i MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT IMENI N.I. PIROGOVA | Procede pour obtenir un amide de 4-phenyl-2-pyrrolidone-1-acide acetique |
EP0515866A1 (fr) * | 1991-05-02 | 1992-12-02 | Daiichi Pharmaceutical Co., Ltd. | Utilisation de la N-(2,6-diméthetphényl)-2-(2-oxo-1-pyrrolidinyl)acétamide pour le traitement de la démence |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2924011C2 (de) * | 1979-06-13 | 1982-04-08 | A. Nattermann & Cie GmbH, 5000 Köln | Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten |
US4372960A (en) * | 1980-12-12 | 1983-02-08 | Warner-Lambert Company | Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators |
FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
US4607043A (en) * | 1983-02-09 | 1986-08-19 | Warner-Lambert Company | Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acids and derivatives as cognition activators |
US4525476A (en) * | 1983-05-26 | 1985-06-25 | Warner-Lambert Company | N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators |
US4469701A (en) * | 1983-06-23 | 1984-09-04 | Stauffer Chemical Company | Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof |
US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
US4638006A (en) * | 1985-09-24 | 1987-01-20 | Warner Lambert Company | Amnesia reversal with N,N-dialkylaminoalkyl-hexahydro-5-oxo 1H-pyrrolizine-3-carboxamides |
FR2597100A1 (fr) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
CA1305148C (fr) * | 1987-08-19 | 1992-07-14 | Hiromu Matsumura | Derives de carbamoylpyrrolidone et produits pharmaceutiques pour la demence senile |
JPH0696574B2 (ja) * | 1987-09-16 | 1994-11-30 | 三菱化成株式会社 | 4−ピペリジンカルボキサミド誘導体 |
JPH0696575B2 (ja) * | 1987-09-17 | 1994-11-30 | 三菱化成株式会社 | 4−アミノピリジン誘導体及びその酸付加塩 |
AT391692B (de) * | 1989-04-24 | 1990-11-12 | Fleischhacker Wilhelm Dr | Enantiomerenreine, in position 1 alkylierte 5-oxo-2-pyrrolidinpropansaeuren und deren ester, deren herstellung und verwendung |
IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
US6159990A (en) | 1997-06-18 | 2000-12-12 | Synaptic Pharmaceutical Corporation | Oxazolidinones as α1A receptor antagonists |
US6319932B1 (en) | 1998-11-10 | 2001-11-20 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1A adrenoceptor antagonists |
US6228870B1 (en) | 1998-11-10 | 2001-05-08 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1a adrenoceptor antagonists |
WO2002076451A1 (fr) * | 2001-03-22 | 2002-10-03 | Ucb, S.A. | Utilisation de certaines pyrrolidones substituees telles que la piracetame dans le traitement de maladies virales et autres affections |
EP1517893A2 (fr) * | 2003-02-03 | 2005-03-30 | Teva Pharmaceutical Industries Limited | Procede de production de levetiracetam |
ES2214147B1 (es) * | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
RU2232578C1 (ru) * | 2003-04-10 | 2004-07-20 | Ахапкина Валентина Ивановна | Вещество, обладающее антидепрессивной активностью |
US8420602B2 (en) * | 2004-09-14 | 2013-04-16 | Landon C. G. Miller | Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders |
US7157421B2 (en) * | 2004-12-27 | 2007-01-02 | Miller Landon C G | Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders |
CN102227217A (zh) | 2008-10-16 | 2011-10-26 | 约翰斯.霍普金斯大学 | 改善认知功能的方法和组合物 |
US8785661B2 (en) | 2009-05-13 | 2014-07-22 | Nektar Therapeutics | Oligome-containing pyrrolidine compounds |
PL389364A1 (pl) | 2009-10-23 | 2011-04-26 | Uniwersytet Jagielloński | Nowe zastosowanie pochodnych 2-pirolidonu |
EP2533645B1 (fr) * | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Procédés et compositions pour améliorer la fonction cognitive |
EP2919788A4 (fr) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | Méthodes et compositions pour le traitement de la schizophrénie |
WO2014087367A2 (fr) * | 2012-12-09 | 2014-06-12 | Mahesh Kandula | Compositions et procédés pour le traitement de maladies neurologiques et de leurs complications associées |
EP2968237A4 (fr) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Procédés et compositions pour améliorer la fonction cognitive |
DK2968220T3 (da) | 2013-03-15 | 2021-06-14 | Agenebio Inc | Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion |
BR112017025031B1 (pt) | 2015-05-22 | 2023-03-21 | Agenebio, Inc | Composições farmacêuticas de liberação prolongada de levetiracetam |
CN106083685B (zh) * | 2016-06-17 | 2019-08-23 | 东北制药集团股份有限公司 | 一种苯基吡拉西坦的制备方法 |
RU2748419C2 (ru) * | 2017-02-20 | 2021-05-25 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Производные 4-фенилпирролидона, обладающие противосудорожной и ноотропной активностью, как средства лечения эпилепсии и пароксизмальных состояний |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US446811A (en) * | 1891-02-17 | Machine for removing stems from tobacco-leaves | ||
GB614164A (en) * | 1944-07-29 | 1948-12-10 | Lilly Co Eli | Improvements in or relating to substituted acridines and process of making them |
DE1011886B (de) * | 1952-04-29 | 1957-07-11 | Waldemar Kutscher Dr Ing Dr Me | Verfahren zur Herstellung von Aminoalkylpyrrolen |
US2744930A (en) * | 1954-08-04 | 1956-05-08 | Olin Mathieson | N, n-diphenyl-n'-aminoalkylene-urea derivatives |
GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
US3446811A (en) * | 1965-04-23 | 1969-05-27 | Parke Davis & Co | 2-phenoxy-2-phenyl acetamides |
US3509171A (en) * | 1967-09-14 | 1970-04-28 | Robins Co Inc A H | 3-amino-1-carbamyl and thiocarbamyl pyrrolidines |
NL7407140A (nl) * | 1974-03-07 | 1975-09-09 | Jose Maria Espinos Taya En Jos | Werkwijze voor de bereiding van een n-gesub- stitueerd pyrrolidon. |
-
1978
- 1978-02-23 BE BE185437A patent/BE864269A/fr not_active IP Right Cessation
- 1978-02-24 ES ES467288A patent/ES467288A1/es not_active Expired
- 1978-02-24 DK DK085478A patent/DK151010C/da not_active IP Right Cessation
- 1978-02-24 FR FR7805319A patent/FR2382441A1/fr active Granted
- 1978-02-24 CA CA297,654A patent/CA1073457A/fr not_active Expired
- 1978-02-24 GB GB7536/78A patent/GB1588082A/en not_active Expired
- 1978-02-24 JP JP1996078A patent/JPS53108966A/ja active Granted
- 1978-02-24 AU AU33598/78A patent/AU514354B2/en not_active Expired
- 1978-02-24 DE DE19782808067 patent/DE2808067A1/de active Granted
- 1978-03-07 US US05/884,464 patent/US4145347A/en not_active Expired - Lifetime
-
1983
- 1983-07-01 SG SG385/83A patent/SG38583G/en unknown
- 1983-11-24 HK HK596/83A patent/HK59683A/xx unknown
-
1984
- 1984-12-30 MY MY269/84A patent/MY8400269A/xx unknown
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0212588A1 (fr) * | 1985-08-16 | 1987-03-04 | Warner-Lambert Company | Amides de l'acide cycloalkyle(b)pyrrole-1(2H)acétique saturé et ses dérivés |
EP0213506A1 (fr) * | 1985-08-16 | 1987-03-11 | Warner-Lambert Company | Amides de l'acide cycloalkyl-c-pyrrole-2(1H)acétique saturé et leurs dérivés |
EP0236263A2 (fr) * | 1986-01-30 | 1987-09-09 | Ciba-Geigy Ag | Pyrrolidinones substituées |
EP0236263A3 (en) * | 1986-01-30 | 1989-04-19 | Ciba-Geigy Ag | Substituted pyrrolidinones |
EP0299493A2 (fr) * | 1987-07-15 | 1989-01-18 | Shionogi & Co., Ltd. | N-[(2-oxopyrrolidin-1-yl)acétyl]pipérazines et médicament contre la démence sénile |
EP0299493A3 (en) * | 1987-07-15 | 1990-05-23 | Shionogi & Co | N-û(2-oxopyrrolidin-1-yl)-acetyl¨piperazine derivatives and drug for senile dementia |
EP0363489A1 (fr) * | 1988-04-18 | 1990-04-18 | 2-i MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT IMENI N.I. PIROGOVA | Procede pour obtenir un amide de 4-phenyl-2-pyrrolidone-1-acide acetique |
EP0363489A4 (en) * | 1988-04-18 | 1991-09-11 | Mo Med Inst Pirogova | Method for obtaining 4-phenyl-2-pyrrolidone-acetic-1 acid amide |
EP0515866A1 (fr) * | 1991-05-02 | 1992-12-02 | Daiichi Pharmaceutical Co., Ltd. | Utilisation de la N-(2,6-diméthetphényl)-2-(2-oxo-1-pyrrolidinyl)acétamide pour le traitement de la démence |
US5886023A (en) * | 1991-05-02 | 1999-03-23 | Daiichi Pharmaceutical Co., Ltd. | Agent for improving dementia |
Also Published As
Publication number | Publication date |
---|---|
DK85478A (da) | 1978-09-04 |
DE2808067A1 (de) | 1978-09-07 |
DK151010B (da) | 1987-10-12 |
FR2382441B1 (fr) | 1980-01-18 |
GB1588082A (en) | 1981-04-15 |
BE864269A (fr) | 1978-06-16 |
AU514354B2 (en) | 1981-02-05 |
AU3359878A (en) | 1979-08-30 |
DK151010C (da) | 1988-06-13 |
HK59683A (en) | 1983-12-02 |
CA1073457A (fr) | 1980-03-11 |
ES467288A1 (es) | 1978-10-16 |
DE2808067C2 (fr) | 1989-01-19 |
MY8400269A (en) | 1984-12-31 |
JPS53108966A (en) | 1978-09-22 |
US4145347A (en) | 1979-03-20 |
JPS6141908B2 (fr) | 1986-09-18 |
SG38583G (en) | 1984-07-27 |
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