FR2382441A1 - Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation - Google Patents

Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation

Info

Publication number
FR2382441A1
FR2382441A1 FR7805319A FR7805319A FR2382441A1 FR 2382441 A1 FR2382441 A1 FR 2382441A1 FR 7805319 A FR7805319 A FR 7805319A FR 7805319 A FR7805319 A FR 7805319A FR 2382441 A1 FR2382441 A1 FR 2382441A1
Authority
FR
France
Prior art keywords
preparation
aminoalkyl
new
pyrrolidine
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805319A
Other languages
English (en)
Other versions
FR2382441B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of FR2382441A1 publication Critical patent/FR2382441A1/fr
Application granted granted Critical
Publication of FR2382441B1 publication Critical patent/FR2382441B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention concerne des composés chimiques nouveaux et un procédé pour leur préparation. Il s'agit de dérivés nouveaux et sels d'addition correspondants qui répondent, sous forme de base libre, à la formule :
FR7805319A 1977-03-03 1978-02-24 Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation Granted FR2382441A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77387777A 1977-03-03 1977-03-03

Publications (2)

Publication Number Publication Date
FR2382441A1 true FR2382441A1 (fr) 1978-09-29
FR2382441B1 FR2382441B1 (fr) 1980-01-18

Family

ID=25099597

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805319A Granted FR2382441A1 (fr) 1977-03-03 1978-02-24 Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation

Country Status (13)

Country Link
US (1) US4145347A (fr)
JP (1) JPS53108966A (fr)
AU (1) AU514354B2 (fr)
BE (1) BE864269A (fr)
CA (1) CA1073457A (fr)
DE (1) DE2808067A1 (fr)
DK (1) DK151010C (fr)
ES (1) ES467288A1 (fr)
FR (1) FR2382441A1 (fr)
GB (1) GB1588082A (fr)
HK (1) HK59683A (fr)
MY (1) MY8400269A (fr)
SG (1) SG38583G (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0212588A1 (fr) * 1985-08-16 1987-03-04 Warner-Lambert Company Amides de l'acide cycloalkyle(b)pyrrole-1(2H)acétique saturé et ses dérivés
EP0213506A1 (fr) * 1985-08-16 1987-03-11 Warner-Lambert Company Amides de l'acide cycloalkyl-c-pyrrole-2(1H)acétique saturé et leurs dérivés
EP0236263A2 (fr) * 1986-01-30 1987-09-09 Ciba-Geigy Ag Pyrrolidinones substituées
EP0299493A2 (fr) * 1987-07-15 1989-01-18 Shionogi & Co., Ltd. N-[(2-oxopyrrolidin-1-yl)acétyl]pipérazines et médicament contre la démence sénile
EP0363489A1 (fr) * 1988-04-18 1990-04-18 2-i MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT IMENI N.I. PIROGOVA Procede pour obtenir un amide de 4-phenyl-2-pyrrolidone-1-acide acetique
EP0515866A1 (fr) * 1991-05-02 1992-12-02 Daiichi Pharmaceutical Co., Ltd. Utilisation de la N-(2,6-diméthetphényl)-2-(2-oxo-1-pyrrolidinyl)acétamide pour le traitement de la démence

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2924011C2 (de) * 1979-06-13 1982-04-08 A. Nattermann & Cie GmbH, 5000 Köln Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
US4607043A (en) * 1983-02-09 1986-08-19 Warner-Lambert Company Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acids and derivatives as cognition activators
US4525476A (en) * 1983-05-26 1985-06-25 Warner-Lambert Company N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators
US4469701A (en) * 1983-06-23 1984-09-04 Stauffer Chemical Company Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
US4638006A (en) * 1985-09-24 1987-01-20 Warner Lambert Company Amnesia reversal with N,N-dialkylaminoalkyl-hexahydro-5-oxo 1H-pyrrolizine-3-carboxamides
FR2597100A1 (fr) * 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd Derives du pyroglutamide
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
CA1305148C (fr) * 1987-08-19 1992-07-14 Hiromu Matsumura Derives de carbamoylpyrrolidone et produits pharmaceutiques pour la demence senile
JPH0696574B2 (ja) * 1987-09-16 1994-11-30 三菱化成株式会社 ４−ピペリジンカルボキサミド誘導体
JPH0696575B2 (ja) * 1987-09-17 1994-11-30 三菱化成株式会社 ４−アミノピリジン誘導体及びその酸付加塩
AT391692B (de) * 1989-04-24 1990-11-12 Fleischhacker Wilhelm Dr Enantiomerenreine, in position 1 alkylierte 5-oxo-2-pyrrolidinpropansaeuren und deren ester, deren herstellung und verwendung
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
US6159990A (en) 1997-06-18 2000-12-12 Synaptic Pharmaceutical Corporation Oxazolidinones as α1A receptor antagonists
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
WO2002076451A1 (fr) * 2001-03-22 2002-10-03 Ucb, S.A. Utilisation de certaines pyrrolidones substituees telles que la piracetame dans le traitement de maladies virales et autres affections
EP1517893A2 (fr) * 2003-02-03 2005-03-30 Teva Pharmaceutical Industries Limited Procede de production de levetiracetam
ES2214147B1 (es) * 2003-02-28 2005-10-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
RU2232578C1 (ru) * 2003-04-10 2004-07-20 Ахапкина Валентина Ивановна Вещество, обладающее антидепрессивной активностью
US8420602B2 (en) * 2004-09-14 2013-04-16 Landon C. G. Miller Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders
US7157421B2 (en) * 2004-12-27 2007-01-02 Miller Landon C G Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
CN102227217A (zh) 2008-10-16 2011-10-26 约翰斯.霍普金斯大学 改善认知功能的方法和组合物
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
PL389364A1 (pl) 2009-10-23 2011-04-26 Uniwersytet Jagielloński Nowe zastosowanie pochodnych 2-pirolidonu
EP2533645B1 (fr) * 2010-02-09 2016-07-27 The Johns Hopkins University Procédés et compositions pour améliorer la fonction cognitive
EP2919788A4 (fr) 2012-11-14 2016-05-25 Univ Johns Hopkins Méthodes et compositions pour le traitement de la schizophrénie
WO2014087367A2 (fr) * 2012-12-09 2014-06-12 Mahesh Kandula Compositions et procédés pour le traitement de maladies neurologiques et de leurs complications associées
EP2968237A4 (fr) 2013-03-15 2016-08-31 Univ Johns Hopkins Procédés et compositions pour améliorer la fonction cognitive
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
BR112017025031B1 (pt) 2015-05-22 2023-03-21 Agenebio, Inc Composições farmacêuticas de liberação prolongada de levetiracetam
CN106083685B (zh) * 2016-06-17 2019-08-23 东北制药集团股份有限公司 一种苯基吡拉西坦的制备方法
RU2748419C2 (ru) * 2017-02-20 2021-05-25 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Производные 4-фенилпирролидона, обладающие противосудорожной и ноотропной активностью, как средства лечения эпилепсии и пароксизмальных состояний

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US446811A (en) * 1891-02-17 Machine for removing stems from tobacco-leaves
GB614164A (en) * 1944-07-29 1948-12-10 Lilly Co Eli Improvements in or relating to substituted acridines and process of making them
DE1011886B (de) * 1952-04-29 1957-07-11 Waldemar Kutscher Dr Ing Dr Me Verfahren zur Herstellung von Aminoalkylpyrrolen
US2744930A (en) * 1954-08-04 1956-05-08 Olin Mathieson N, n-diphenyl-n'-aminoalkylene-urea derivatives
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
US3446811A (en) * 1965-04-23 1969-05-27 Parke Davis & Co 2-phenoxy-2-phenyl acetamides
US3509171A (en) * 1967-09-14 1970-04-28 Robins Co Inc A H 3-amino-1-carbamyl and thiocarbamyl pyrrolidines
NL7407140A (nl) * 1974-03-07 1975-09-09 Jose Maria Espinos Taya En Jos Werkwijze voor de bereiding van een n-gesub- stitueerd pyrrolidon.

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0212588A1 (fr) * 1985-08-16 1987-03-04 Warner-Lambert Company Amides de l'acide cycloalkyle(b)pyrrole-1(2H)acétique saturé et ses dérivés
EP0213506A1 (fr) * 1985-08-16 1987-03-11 Warner-Lambert Company Amides de l'acide cycloalkyl-c-pyrrole-2(1H)acétique saturé et leurs dérivés
EP0236263A2 (fr) * 1986-01-30 1987-09-09 Ciba-Geigy Ag Pyrrolidinones substituées
EP0236263A3 (en) * 1986-01-30 1989-04-19 Ciba-Geigy Ag Substituted pyrrolidinones
EP0299493A2 (fr) * 1987-07-15 1989-01-18 Shionogi & Co., Ltd. N-[(2-oxopyrrolidin-1-yl)acétyl]pipérazines et médicament contre la démence sénile
EP0299493A3 (en) * 1987-07-15 1990-05-23 Shionogi & Co N-û(2-oxopyrrolidin-1-yl)-acetyl¨piperazine derivatives and drug for senile dementia
EP0363489A1 (fr) * 1988-04-18 1990-04-18 2-i MOSKOVSKY GOSUDARSTVENNY MEDITSINSKY INSTITUT IMENI N.I. PIROGOVA Procede pour obtenir un amide de 4-phenyl-2-pyrrolidone-1-acide acetique
EP0363489A4 (en) * 1988-04-18 1991-09-11 Mo Med Inst Pirogova Method for obtaining 4-phenyl-2-pyrrolidone-acetic-1 acid amide
EP0515866A1 (fr) * 1991-05-02 1992-12-02 Daiichi Pharmaceutical Co., Ltd. Utilisation de la N-(2,6-diméthetphényl)-2-(2-oxo-1-pyrrolidinyl)acétamide pour le traitement de la démence
US5886023A (en) * 1991-05-02 1999-03-23 Daiichi Pharmaceutical Co., Ltd. Agent for improving dementia

Also Published As

Publication number Publication date
DK85478A (da) 1978-09-04
DE2808067A1 (de) 1978-09-07
DK151010B (da) 1987-10-12
FR2382441B1 (fr) 1980-01-18
GB1588082A (en) 1981-04-15
BE864269A (fr) 1978-06-16
AU514354B2 (en) 1981-02-05
AU3359878A (en) 1979-08-30
DK151010C (da) 1988-06-13
HK59683A (en) 1983-12-02
CA1073457A (fr) 1980-03-11
ES467288A1 (es) 1978-10-16
DE2808067C2 (fr) 1989-01-19
MY8400269A (en) 1984-12-31
JPS53108966A (en) 1978-09-22
US4145347A (en) 1979-03-20
JPS6141908B2 (fr) 1986-09-18
SG38583G (en) 1984-07-27

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