FR11C0038I2 - Analogues macrocycliques, leurs procedes d'utilisation et de preparation - Google Patents

Analogues macrocycliques, leurs procedes d'utilisation et de preparation

Info

Publication number
FR11C0038I2
FR11C0038I2 FR11C0038C FR11C0038C FR11C0038I2 FR 11C0038 I2 FR11C0038 I2 FR 11C0038I2 FR 11C0038 C FR11C0038 C FR 11C0038C FR 11C0038 C FR11C0038 C FR 11C0038C FR 11C0038 I2 FR11C0038 I2 FR 11C0038I2
Authority
FR
France
Prior art keywords
preparation
methods
macrocyclic analogs
analogs
macrocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR11C0038C
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English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22219026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR11C0038(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of FR11C0038I1 publication Critical patent/FR11C0038I1/fr
Application granted granted Critical
Publication of FR11C0038I2 publication Critical patent/FR11C0038I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
FR11C0038C 1998-06-17 2011-09-09 Analogues macrocycliques, leurs procedes d'utilisation et de preparation Active FR11C0038I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8968298P 1998-06-17 1998-06-17
EP99928746A EP1087960B1 (en) 1998-06-17 1999-06-16 Macrocyclic analogs and methods of their use and preparation

Publications (2)

Publication Number Publication Date
FR11C0038I1 FR11C0038I1 (fr) 2011-10-14
FR11C0038I2 true FR11C0038I2 (fr) 2013-01-11

Family

ID=22219026

Family Applications (1)

Application Number Title Priority Date Filing Date
FR11C0038C Active FR11C0038I2 (fr) 1998-06-17 2011-09-09 Analogues macrocycliques, leurs procedes d'utilisation et de preparation

Country Status (24)

Country Link
US (4) US6214865B1 (ja)
EP (4) EP2272839B1 (ja)
JP (1) JP4454151B2 (ja)
KR (1) KR100798600B1 (ja)
CN (1) CN1216051C (ja)
AT (1) ATE502932T1 (ja)
AU (1) AU762998B2 (ja)
BE (1) BE2011C028I2 (ja)
BR (1) BRPI9911326B8 (ja)
CA (3) CA2632433C (ja)
CY (2) CY1111516T1 (ja)
DE (2) DE122011100031I1 (ja)
DK (1) DK1087960T3 (ja)
FR (1) FR11C0038I2 (ja)
HK (1) HK1035534A1 (ja)
HU (1) HU227912B1 (ja)
IL (1) IL139960A0 (ja)
LU (1) LU91854I2 (ja)
NO (5) NO328280B1 (ja)
NZ (1) NZ508597A (ja)
PT (1) PT1087960E (ja)
RU (1) RU2245335C2 (ja)
WO (1) WO1999065894A1 (ja)
ZA (1) ZA200007159B (ja)

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JP2007500240A (ja) * 2003-05-29 2007-01-11 アボット・ラボラトリーズ Ａｂｔ−７５１による持続投与レジメン
US20070196418A1 (en) * 2003-07-29 2007-08-23 Michael Lewis Drug delivery methods and devices
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US8093410B2 (en) 2007-10-03 2012-01-10 Eisai R&D Management Co., Ltd. Intermediates and methods for the synthesis of halichondrin B analogs
JP6001857B2 (ja) * 2008-04-04 2016-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂ類似体
EP2415464B1 (en) 2009-03-30 2017-05-10 Eisai R&D Management Co., Ltd. Method for producing liposome composition
RU2476216C1 (ru) * 2009-03-30 2013-02-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Липосомальная композиция
PE20120923A1 (es) 2009-03-30 2012-08-27 Eisai Randd Man Co Ltd Composiciones farmaceuticas comprendiendo liposomas que contiene eribulina o una sal del mismo
WO2010119890A1 (ja) * 2009-04-14 2010-10-21 日産化学工業株式会社 テトラヒドロピラン化合物の製造方法およびその中間体
CN102803254B (zh) 2010-01-26 2016-09-14 卫材R&D管理有限公司 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物
EP2686441B1 (en) 2011-03-18 2019-05-08 Eisai R&D Management Co., Ltd. Methods and uses for predicting response to eribulin
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ES2705950T3 (es) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
WO2013078559A1 (en) 2011-11-30 2013-06-06 Alphora Research Inc. Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
CN104024237B (zh) 2011-12-16 2016-02-24 阿方拉研究股份有限公司 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体
CA2860446C (en) * 2011-12-29 2017-01-10 Alphora Research Inc. 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
EP2831082B1 (en) * 2012-03-30 2019-02-20 Sandoz AG Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
AU2013353745A1 (en) 2012-12-04 2015-06-11 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of breast cancer
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ES2705698T3 (es) 2013-06-26 2019-03-26 Eisai R&D Man Co Ltd Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib
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CN103483352A (zh) * 2013-10-18 2014-01-01 李友香 抗肿瘤的药用原料药
CN114716453A (zh) 2013-11-04 2022-07-08 卫材R&D管理有限公司 软海绵素b的类似物合成中有用的大环化反应和中间体
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CN104860978A (zh) * 2014-02-20 2015-08-26 正大天晴药业集团股份有限公司 软海绵素b类似物的合成中间体
TW201617326A (zh) 2014-03-06 2016-05-16 Ａｌｐｈｏｒａ研發股份有限公司 （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物
KR20170039096A (ko) * 2014-05-28 2017-04-10 에자이 알앤드디 매니지먼트 가부시키가이샤 암의 치료에 있어서 에리불린의 용도
EP3160970A4 (en) 2014-06-30 2017-12-27 President and Fellows of Harvard College Synthesis of halichondrin analogs and uses thereof
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WO2016038624A1 (en) 2014-09-09 2016-03-17 Cipla Limited "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
CN105713031B (zh) * 2014-12-05 2021-05-07 正大天晴药业集团股份有限公司 一种用于制备艾日布林的中间体及其制备方法
DK3263106T3 (da) 2015-02-25 2024-01-08 Eisai R&D Man Co Ltd Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
CA2978226A1 (en) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
US10945990B2 (en) 2015-03-04 2021-03-16 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and eribulin for treating cancer
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
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US10597401B2 (en) 2015-05-08 2020-03-24 Albany Molecular Research, Inc. Methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
US10676481B2 (en) 2016-02-12 2020-06-09 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
WO2017188350A1 (ja) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍の成長を抑制する方法
WO2017203459A1 (en) 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
KR102404629B1 (ko) 2016-06-30 2022-06-02 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체
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JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
BR112019010494A2 (pt) 2016-11-23 2019-09-17 Dr Reddys Laboratories Ltd processo para a preparação de eribulina e intermediários do mesmo
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CN108341738B (zh) * 2017-01-24 2022-10-21 江苏恒瑞医药股份有限公司 用于制备艾日布林的方法及其中间体
CN108341828B (zh) * 2017-01-24 2021-04-06 江苏恒瑞医药股份有限公司 用于制备艾日布林的方法及其中间体
KR102634732B1 (ko) 2017-04-05 2024-02-13 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 마크로시클릭 화합물 및 그의 용도
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CN113135876A (zh) * 2020-01-16 2021-07-20 南通诺泰生物医药技术有限公司 艾日布林及其中间体的制备方法
JP2023511163A (ja) * 2020-01-22 2023-03-16 上海森輝医薬有限公司 エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用
KR102377262B1 (ko) 2020-05-11 2022-03-22 연성정밀화학(주) 결정성 에리불린 염
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US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
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JP6001857B2 (ja) 2008-04-04 2016-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂ類似体
CN102803254B (zh) 2010-01-26 2016-09-14 卫材R&D管理有限公司 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物

Also Published As

Publication number Publication date
CA2335300C (en) 2008-10-07
EP1087960A4 (en) 2004-12-01
US6469182B1 (en) 2002-10-22
NO328280B1 (no) 2010-01-25
CY1111516T1 (el) 2014-04-09
BRPI9911326B8 (pt) 2021-05-25
CY2011010I1 (el) 2014-04-09
FR11C0038I1 (fr) 2011-10-14
CA2632433A1 (en) 1999-12-23
KR100798600B1 (ko) 2008-01-28
AU762998C (en) 2000-01-05
CA2335300A1 (en) 1999-12-23
EP1087960A1 (en) 2001-04-04
RU2245335C2 (ru) 2005-01-27
EP1087960B1 (en) 2011-03-23
CA2755266A1 (en) 1999-12-23
NO20006316L (no) 2001-02-15
NO2011026I2 (no) 2012-06-11
LU91854I2 (fr) 2011-10-17
HUP0103357A2 (hu) 2002-01-28
US6365759B1 (en) 2002-04-02
NZ508597A (en) 2004-01-30
US6214865B1 (en) 2001-04-10
WO1999065894A1 (en) 1999-12-23
BR9911326A (pt) 2001-04-03
DE122011100031I1 (de) 2011-12-15
JP4454151B2 (ja) 2010-04-21
CA2755266C (en) 2014-08-12
AU4573999A (en) 2000-01-05
EP2272840B1 (en) 2012-08-22
CN1216051C (zh) 2005-08-24
JP2002518384A (ja) 2002-06-25
EP2277873A1 (en) 2011-01-26
EP2272839B1 (en) 2012-08-22
NO20093217L (no) 2001-02-15
HU227912B1 (en) 2012-05-29
NO2011018I1 (no) 2011-09-26
AU762998B2 (en) 2003-07-10
BR9911326B1 (pt) 2015-01-06
NO2011026I1 (no) 2012-01-09
EP2272839A1 (en) 2011-01-12
US8148554B2 (en) 2012-04-03
CA2632433C (en) 2012-02-07
US20110172446A1 (en) 2011-07-14
NO20006316D0 (no) 2000-12-12
ZA200007159B (en) 2001-12-04
EP2277873B1 (en) 2012-05-30
NO331183B1 (no) 2011-10-24
EP2272840A1 (en) 2011-01-12
HK1035534A1 (en) 2001-11-30
PT1087960E (pt) 2011-06-17
DK1087960T3 (da) 2011-06-14
BE2011C028I2 (en) 2018-08-24
HUP0103357A3 (en) 2002-10-28
CN1312804A (zh) 2001-09-12
NO2022019I1 (no) 2022-06-03
IL139960A0 (en) 2002-02-10
KR20010083050A (ko) 2001-08-31
CY2011010I2 (el) 2014-04-09
ATE502932T1 (de) 2011-04-15
DE69943296D1 (de) 2011-05-05

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