DK0857718T3 - Endothelinantagonist - Google Patents

Endothelinantagonist

Info

Publication number
DK0857718T3
DK0857718T3 DK97925279T DK97925279T DK0857718T3 DK 0857718 T3 DK0857718 T3 DK 0857718T3 DK 97925279 T DK97925279 T DK 97925279T DK 97925279 T DK97925279 T DK 97925279T DK 0857718 T3 DK0857718 T3 DK 0857718T3
Authority
DK
Denmark
Prior art keywords
endothelin antagonist
alpha
chain
carbon atoms
active ingredient
Prior art date
Application number
DK97925279T
Other languages
English (en)
Inventor
Ryuji Ueno
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo Ag filed Critical Sucampo Ag
Application granted granted Critical
Publication of DK0857718T3 publication Critical patent/DK0857718T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S502/00—Catalyst, solid sorbent, or support therefor: product or process of making
    • Y10S502/50—Stabilized
    • Y10S502/503—Crush strength

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97925279T 1996-06-10 1997-06-04 Endothelinantagonist DK0857718T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14716696 1996-06-10
JP1019197 1997-01-23
PCT/JP1997/001892 WO1997047595A1 (en) 1996-06-10 1997-06-04 Endothelin antagonist

Publications (1)

Publication Number Publication Date
DK0857718T3 true DK0857718T3 (da) 2002-12-16

Family

ID=26345421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97925279T DK0857718T3 (da) 1996-06-10 1997-06-04 Endothelinantagonist

Country Status (14)

Country Link
US (2) US6242485B1 (da)
EP (1) EP0857718B1 (da)
JP (1) JP3187438B2 (da)
KR (1) KR19990036322A (da)
CN (3) CN100337632C (da)
AT (1) ATE222237T1 (da)
CA (1) CA2229183C (da)
DE (1) DE69714698T2 (da)
DK (1) DK0857718T3 (da)
ES (1) ES2182088T3 (da)
NO (1) NO980553L (da)
PT (1) PT857718E (da)
TW (1) TW418188B (da)
WO (1) WO1997047595A1 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2253826T3 (es) * 1997-09-09 2006-06-01 Duke University Prostaglandinas aromaticas tetrahidro sustituidas por c16-c20 utilizadas como agonistas fp.
DK1012137T3 (da) * 1997-09-09 2003-03-10 Procter & Gamble Aromatiske C-16-C-20-substituerede tetrahydro-prostaglandiner og deres anvendelse som prostaglandin FP-agonister
IL134839A0 (en) * 1997-09-09 2001-05-20 Procter & Gamble Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ATE401894T1 (de) 1997-11-28 2008-08-15 Sucampo Ag Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten
WO2000051980A1 (en) 1999-03-05 2000-09-08 The Procter & Gamble Company C16 unsaturated fp-selective prostaglandins analogs
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
AU2002307725B2 (en) * 2001-05-18 2008-07-10 Sucampo Ag Cathartic composition
WO2003020283A2 (en) * 2001-08-29 2003-03-13 Novartis Ag Method for treating diabetic retinopathy
CA2458471C (en) 2001-08-31 2012-07-31 Sucampo Ag Prostaglandin analogs as chloride channel opener
TWI331920B (en) * 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
WO2005018646A1 (ja) 2003-08-21 2005-03-03 Sucampo Ag 眼科用組成物
WO2004037268A1 (en) * 2002-10-23 2004-05-06 Sucampo Ag Prostaglandin compounds for the treatment of obesity
JP4889219B2 (ja) 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
US8337891B2 (en) * 2003-07-03 2012-12-25 Sucampo Ag Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI348386B (en) * 2003-08-12 2011-09-11 R Tech Ueno Ltd Composition and method for promoting hair growth
US7321057B2 (en) * 2004-08-02 2008-01-22 R-Tech Ueno, Ltd. Method for manufacturing prostaglandin analogue
CA2595898C (en) 2005-01-27 2015-04-28 Sucampo Ag Method and composition for treating central nervous system disorders
DK1853271T3 (da) 2005-03-04 2011-01-24 Sucampo Ag Fremgangsmåde og præparat til behandling af perifere vaskulære sygdomme
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
SI1864666T1 (sl) * 2005-03-31 2012-10-30 Asahi Glass Co Ltd Zaščitno sredstvo za retinalno nevronsko celico, vsebujoče derivat prostaglandina F2 alfa kot učinkovino
JP5711442B2 (ja) * 2005-04-12 2015-04-30 スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ 胃腸障害の処置のためのプロスタグランジン化合物およびプロトンポンプ阻害剤の併用
KR20140147142A (ko) 2006-01-24 2014-12-29 가부시키가이샤 아루떼꾸 우에노 바이-사이클릭 화합물을 함유하는 약학적 조성물 및 바이-사이클릭 화합물의 안정화 방법
CN104971056A (zh) 2006-01-24 2015-10-14 株式会社·R-技术上野 软明胶胶囊制剂
JP4851467B2 (ja) * 2006-02-07 2012-01-11 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
JPWO2007105691A1 (ja) 2006-03-13 2009-07-30 株式会社アールテック・ウエノ 水性組成物
US20100022568A1 (en) * 2006-04-13 2010-01-28 Actelion Pharmaceeuticals Ltd. Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
US8871752B2 (en) 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
CA2639240A1 (en) * 2008-08-29 2010-02-28 Alphora Research Inc. Prostaglandin synthesis and intermediates for use therein
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
JP2014510022A (ja) 2011-04-07 2014-04-24 スキャンポ・アーゲー 眼精疲労の処置方法
JP6193230B2 (ja) 2011-08-05 2017-09-06 スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ 統合失調症の処置方法
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
GB201418567D0 (en) * 2014-10-20 2014-12-03 Syngenta Participations Ag Improvements in or relating to organic compounds
AR105029A1 (es) 2015-06-19 2017-08-30 Sucampo Ag Composición farmacéutica que comprende derivado de ácido graso

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853951A (en) * 1971-07-14 1974-12-10 American Cyanamid Co Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en) * 1972-02-11 1977-04-19 American Cyanamid Company 3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
CA1027118A (en) * 1972-04-03 1978-02-28 Martin J. Weiss 3-alkyl-2-(6-carboxyhexyl) cyclopentanones and esters and salts thereof
US3981868A (en) * 1973-05-31 1976-09-21 American Cyanamid Company Derivatives of 9-oxo-13-trans-prostenoic acid amides
US3974195A (en) 1974-10-02 1976-08-10 The Upjohn Company 2A,2B-Dihomo-15-alkyl-PGF2.sub.α analogs
US4026909A (en) 1975-07-14 1977-05-31 The Upjohn Company Cis-13-PGF2.sub.α analogs
US4166187A (en) 1977-04-11 1979-08-28 The Upjohn Company 9-deoxy-9-methylene-16-phenyl-5,6-didehydro-pgf2 or 4,4,5,5-tetradehydro-pgf1 compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5140271A (en) 1989-12-26 1992-08-18 Texaco Inc. Watercut means and method with debris reducing test cell
US5292754A (en) 1990-03-08 1994-03-08 Shionogi & Co., Ltd. Treatment for hypertension or glaucoma in eyes
TW224942B (da) 1990-04-04 1994-06-11 Adka Ueno Kk
BE1004080A6 (fr) * 1990-04-18 1992-09-22 Centre Rech Metallurgique Procede pour le controle automatique de la qualite d'un composant de carrosserie automobile.
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
JPH07113012B2 (ja) * 1991-01-29 1995-12-06 株式会社アールテック・ウエノ 新規１５−ケト−プロスタグランジン類
DK0503887T3 (da) * 1991-03-14 1996-09-16 R Tech Ueno Ltd Fremme af sårheling med 15-ketoprostaglandinforbindelser

Also Published As

Publication number Publication date
JP3187438B2 (ja) 2001-07-11
CN101085756A (zh) 2007-12-12
CA2229183A1 (en) 1997-12-18
EP0857718B1 (en) 2002-08-14
AU716176B2 (en) 2000-02-17
CN1198737A (zh) 1998-11-11
CA2229183C (en) 2008-11-04
CN102126998B (zh) 2013-06-12
KR19990036322A (ko) 1999-05-25
ES2182088T3 (es) 2003-03-01
EP0857718A4 (en) 1999-07-28
DE69714698T2 (de) 2002-12-05
CN101085756B (zh) 2011-03-02
PT857718E (pt) 2002-11-29
TW418188B (en) 2001-01-11
DE69714698D1 (de) 2002-09-19
ATE222237T1 (de) 2002-08-15
NO980553L (no) 1998-04-07
NO980553D0 (no) 1998-02-09
CN100337632C (zh) 2007-09-19
CN102126998A (zh) 2011-07-20
EP0857718A1 (en) 1998-08-12
WO1997047595A1 (en) 1997-12-18
US6242485B1 (en) 2001-06-05
US6452039B1 (en) 2002-09-17
AU3047897A (en) 1998-01-07

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