DK0857718T3 - Endothelinantagonist - Google Patents

Endothelinantagonist

Info

Publication number
DK0857718T3
DK0857718T3 DK97925279T DK97925279T DK0857718T3 DK 0857718 T3 DK0857718 T3 DK 0857718T3 DK 97925279 T DK97925279 T DK 97925279T DK 97925279 T DK97925279 T DK 97925279T DK 0857718 T3 DK0857718 T3 DK 0857718T3
Authority
DK
Denmark
Prior art keywords
endothelin antagonist
alpha
chain
carbon atoms
active ingredient
Prior art date
Application number
DK97925279T
Other languages
English (en)
Inventor
Ryuji Ueno
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo Ag filed Critical Sucampo Ag
Application granted granted Critical
Publication of DK0857718T3 publication Critical patent/DK0857718T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S502/00—Catalyst, solid sorbent, or support therefor: product or process of making
    • Y10S502/50—Stabilized
    • Y10S502/503—Crush strength

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97925279T 1996-06-10 1997-06-04 Endothelinantagonist DK0857718T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14716696 1996-06-10
JP1019197 1997-01-23
PCT/JP1997/001892 WO1997047595A1 (en) 1996-06-10 1997-06-04 Endothelin antagonist

Publications (1)

Publication Number Publication Date
DK0857718T3 true DK0857718T3 (da) 2002-12-16

Family

ID=26345421

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97925279T DK0857718T3 (da) 1996-06-10 1997-06-04 Endothelinantagonist

Country Status (14)

Country Link
US (2) US6242485B1 (da)
EP (1) EP0857718B1 (da)
JP (1) JP3187438B2 (da)
KR (1) KR19990036322A (da)
CN (3) CN102126998B (da)
AT (1) ATE222237T1 (da)
CA (1) CA2229183C (da)
DE (1) DE69714698T2 (da)
DK (1) DK0857718T3 (da)
ES (1) ES2182088T3 (da)
NO (1) NO980553L (da)
PT (1) PT857718E (da)
TW (1) TW418188B (da)
WO (1) WO1997047595A1 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0004436A3 (en) * 1997-09-09 2001-09-28 Procter & Gamble Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
DE69809268T2 (de) * 1997-09-09 2003-08-28 The Procter & Gamble Co., Cincinnati Aromatische c16-c20-substituierte tetrahydro-prostaglandine und ihre verwendung als prostaglandin f agonisten
BR9811774A (pt) * 1997-09-09 2000-08-29 Procter & Gamble Tetraidroprostaglandinas aromáticas substituìdas por c16-c20 úteis como agonistas fp
DE69839767D1 (de) 1997-11-28 2008-09-04 Sucampo Ag Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten
ATE281432T1 (de) 1999-03-05 2004-11-15 Univ Duke C-16 ungesätigte fp-selektive prostaglandin analoge
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
EP1389116B1 (en) 2001-05-18 2008-02-27 Sucampo AG Cathartic-inducing composition
WO2003020283A2 (en) * 2001-08-29 2003-03-13 Novartis Ag Method for treating diabetic retinopathy
WO2003030912A1 (en) 2001-08-31 2003-04-17 Sucampo Ag Prostaglandin analogs as chloride channel opener
TWI331920B (en) * 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
EP1545608A4 (en) 2002-06-28 2006-09-13 Centocor Inc CH1-DELETED MAMMED MUICETIC BODIES, COMPOSITIONS, METHODS AND APPLICATIONS
JP4705782B2 (ja) * 2002-10-23 2011-06-22 スキャンポ・アーゲー 肥満の処置のためのプロスタグランジン化合物
JP4889219B2 (ja) 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
EP1641462B1 (en) * 2003-07-03 2010-11-24 Sucampo AG Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI495471B (zh) * 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
EP1661573B1 (en) 2003-08-21 2013-09-25 Sucampo AG Ophtalmic composition comprising unoprostone ispopropyl ester and a viscosity agent
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
NZ556710A (en) 2005-01-27 2010-08-27 Sucampo Ag Method and composition for treating central nervous system disorders
NZ561414A (en) 2005-03-04 2010-10-29 Sucampo Ag Method and composition for treating peripheral vascular diseases
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
DK1864666T3 (da) * 2005-03-31 2012-10-29 Asahi Glass Co Ltd Beskyttelsesmiddel til en retinal neuronal celle indeholdende prostaglandin-F2-alfa-derivat som aktiv ingrediens
EP1871380B1 (en) * 2005-04-12 2011-10-19 Sucampo AG Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
NZ570191A (en) * 2006-01-24 2010-09-30 R Tech Ueno Ltd Soft-gelatin capsule formulation comprising a keto-prostaglandin compound
EP2682130A1 (en) 2006-01-24 2014-01-08 R-Tech Ueno, Ltd. Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
CA2856659C (en) * 2006-02-07 2015-09-22 R-Tech Ueno, Ltd. Prostaglandin derivatives
CN104224704A (zh) 2006-03-13 2014-12-24 株式会社·R-技术上野 水性组合物
MX2008013034A (es) * 2006-04-13 2008-10-17 Actelion Pharmaceuticals Ltd Antagonistas del receptor de endotelina para etapas tempranas de fibrosis pulmonar idiopatica.
US8871752B2 (en) 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
CA2639240A1 (en) * 2008-08-29 2010-02-28 Alphora Research Inc. Prostaglandin synthesis and intermediates for use therein
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
EP2694077A4 (en) 2011-04-07 2015-01-21 Sucampo Ag METHOD FOR TREATING ASTHENOPY
CN107903173A (zh) 2011-08-05 2018-04-13 苏坎波公司 治疗精神分裂症的方法
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
GB201418567D0 (en) * 2014-10-20 2014-12-03 Syngenta Participations Ag Improvements in or relating to organic compounds
WO2016203317A1 (en) 2015-06-19 2016-12-22 Sucampo Ag Pharmaceutical compositions comprising fatty acid derivative

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853951A (en) * 1971-07-14 1974-12-10 American Cyanamid Co Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en) * 1972-02-11 1977-04-19 American Cyanamid Company 3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
CA1027118A (en) * 1972-04-03 1978-02-28 Martin J. Weiss 3-alkyl-2-(6-carboxyhexyl) cyclopentanones and esters and salts thereof
US3981868A (en) * 1973-05-31 1976-09-21 American Cyanamid Company Derivatives of 9-oxo-13-trans-prostenoic acid amides
US3974195A (en) * 1974-10-02 1976-08-10 The Upjohn Company 2A,2B-Dihomo-15-alkyl-PGF2.sub.α analogs
US4026909A (en) * 1975-07-14 1977-05-31 The Upjohn Company Cis-13-PGF2.sub.α analogs
US4166187A (en) * 1977-04-11 1979-08-28 The Upjohn Company 9-deoxy-9-methylene-16-phenyl-5,6-didehydro-pgf2 or 4,4,5,5-tetradehydro-pgf1 compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5140271A (en) 1989-12-26 1992-08-18 Texaco Inc. Watercut means and method with debris reducing test cell
US5292754A (en) * 1990-03-08 1994-03-08 Shionogi & Co., Ltd. Treatment for hypertension or glaucoma in eyes
TW249226B (da) * 1990-04-04 1995-06-11 Aderk Ueno Kk
BE1004080A6 (fr) * 1990-04-18 1992-09-22 Centre Rech Metallurgique Procede pour le controle automatique de la qualite d'un composant de carrosserie automobile.
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
JPH07113012B2 (ja) * 1991-01-29 1995-12-06 株式会社アールテック・ウエノ 新規１５−ケト−プロスタグランジン類
ES2093774T3 (es) * 1991-03-14 1997-01-01 R Tech Ueno Ltd Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.

Also Published As

Publication number Publication date
CA2229183C (en) 2008-11-04
AU3047897A (en) 1998-01-07
AU716176B2 (en) 2000-02-17
CN101085756A (zh) 2007-12-12
DE69714698T2 (de) 2002-12-05
EP0857718A1 (en) 1998-08-12
JP3187438B2 (ja) 2001-07-11
CN101085756B (zh) 2011-03-02
TW418188B (en) 2001-01-11
DE69714698D1 (de) 2002-09-19
PT857718E (pt) 2002-11-29
CN1198737A (zh) 1998-11-11
ES2182088T3 (es) 2003-03-01
KR19990036322A (ko) 1999-05-25
EP0857718A4 (en) 1999-07-28
WO1997047595A1 (en) 1997-12-18
CN100337632C (zh) 2007-09-19
ATE222237T1 (de) 2002-08-15
EP0857718B1 (en) 2002-08-14
NO980553L (no) 1998-04-07
CA2229183A1 (en) 1997-12-18
US6242485B1 (en) 2001-06-05
NO980553D0 (no) 1998-02-09
US6452039B1 (en) 2002-09-17
CN102126998B (zh) 2013-06-12
CN102126998A (zh) 2011-07-20

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